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Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

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Neural Regeneration Research 2022年第2期17卷 409-417页

作者： Yi-Tong Lin Qing-Qing Shi Lei Zhang Cai-Ping Yue Zhi-Jun He Xue-Xia Li Qian-Jun He Qiong Liu Xiu-Bo Du College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Bay laboratory ShenzhenGuangdong ProvinceChina

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic(3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China(approval No. AEWC-20140615-002) on June 15, 2014.

关键词： Alzheimer's disease amyloid-β anti-inflammation bioenergetics gut microbiota hydrogen therapy neurodegenerative disease neurofibrillary tangles

Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

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Chinese Science Bulletin 2013年第3期58卷 291-298页

作者： SHEN YuanYuan WANG TianFu CHIN ChienTing DIAO XianFen CHEN SiPing guangdong key laboratory for biomedical measurements and ultrasound imaging National-Regional key Technology Engineering laboratory for Medical ultrasound

The interaction between microbubble and elastic microvessel wall has been hypothesized to be important in the mechanisms of therapeutic ultrasound applications.In this study,a 2D axisymmetric finite element numerical model is established to study the interaction between elastic microvessel wall and oscillating microbubble in low frequency ultrasound field using fluid solid interaction method.The numerical results show that the bubble oscillation induces the vessel wall dilation and depression.The von Mises stress distribution over the microvessel wall is heterogeneous and the maximum value of the midpoint on the inner vessel wall could reach 0.23 MPa and 1.32 MPa under PNP 0.2 MPa and 0.5 MPa,respectively.When the bubble collapses,the circumferential stress decreases rapidly and the transmural pressure increases dramatically.Noticeably,the circumferential stress becomes compressive with the maximum magnitude 1.83 MPa under PNP 0.5 MPa,larger than the maximum tension value.It is possible that the rapid compression stress during bubble collapse plays important role in mechanical effect on microvessel wall endothelial lining disruption.

关键词：相互作用有限元法超声场微血管弹性微泡低频数值模型

Novel photo-theranostic GdB_(6) nanoparticles for fluorescence imaging and NIR-photothermal therapy

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Chinese Chemical Letters 2021年第11期32卷 3487-3490页

作者： Yuqi Chen Mengna Jiang Liwei Xiong Xianxian Yao Mingjian Fan Danyang Chen Qi Jiang Zhaokui Jin Qianjun He Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundMarshall Laboratory of Biomedical EngineeringSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518060China Hubei key laboratory of Plasma Chemistry and Advanced Materials Wuhan Institute of TechnologyWuhan 430205China

The development of multifunctional theranostic nano-agents is an important resolution for personalized treatment of cancer.In this work,we synthesized a new kind of gadolinium boride nanoparticles(GBN)by a microwave-assisted chemical etching method,and discovered their optical characteristics including fluorescence imaging and near-infrared(NIR)photothermal conversion capability.Bright greenishyellow fluorescence enabled for intracellular localization,while effective NIR-photothermal conversion supported photothermal therapy(PTT).In vitro and in vivo results indicated that GBN exhibited a superior antitumor performance and high biocompatibility.This study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment.

关键词： Gadolinium boride Nanomedicine Photothermal therapy Fluorescence imaging Theranostics

Terpyridine-Grafted Nitrogen-Terminal Endowing Cyanine with Metal-Ion-Regulated Photophysical Properties for Cancer Theranostics

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Research 2023年第4期2023卷 117-130页

作者： Junfei Zhu Gang He Peng-Hang Chen Yajie Zhang Yafei Zhang Shan Lei Yu Zhang Meng Li Peng Huang Jing Lin Marshall laboratory of biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China

Heptamethine cyanines(Cy7)are one of the most important dyes in bioimaging and phototherapy,but they often suffer from poor photostability or limited photothermal conversion efficiency.Here,a facile molecular engineering approach to regulating the photophysical properties of Cy7 by metal ions is demonstrated.By innovatively modifying the nitrogen with functional groups,a novel terpyridine-grafted nitrogen-terminated Cy7 scaffold(denoted as CydtPy)was synthesized and exhibited tunable photophysical properties when chelating with various metal ions(Mn^(2+),Fe^(2+),etc.).In comparison with metal-ion-free PEGylated CydtPy(LET-11),Mn^(2+)-chelated LET-11(namely,LET-11-Mn)exhibited the increased fluorescence emission intensity,and Fe^(2+)-chelated LET-11(namely,LET-11-Fe)showed the enhanced photostability with~2-fold increase in photothermal conversion efficiency.By simply switching the chelated metal ion species,LET-11-Mn or LET-11-Fe could be used for near-infrared fluorescence imaging,magnetic resonance imaging,or photoacoustic imaging.Furthermore,LET-11-Fe displayed superior synergistic efficacy of photothermal therapy and chemodynamic therapy both in vitro and in vivo.This work not only provides a new strategy for regulating the photophysical properties of cyanine dyes but also establishes a versatile nanoplatform for cancer theranostics.

关键词： versatile terminated cyanine

Deep Learning in Medical ultrasound Analysis: A Review

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Engineering 2019年第2期5卷 261-275页

作者： Shengfeng Liu Yi Wang Xin Yang Baiying Lei Li Liu Shawn Xiang Li Dong Ni Tianfu Wang National-Regional key Technology Engineering laboratory for Medical ultrasound & Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging & School of biomedical Engineering Health Science Center Shenzhen University Shenzhen 518060 China Department of Computer Science and Engineering The Chinese University of Hong Kong Hong Kong China

ultrasound (US) has become one of the most commonly performed imaging modalities in clinical practice. It is a rapidly evolving technology with certain advantages and with unique challenges that include low imaging quality and high variability. From the perspective of image analysis, it is essential to develop advanced automatic US image analysis methods to assist in US diagnosis and/or to make such assessment more objective and accurate. Deep learning has recently emerged as the leading machine learning tool in various research fields, and especially in general imaging analysis and computer vision. Deep learning also shows huge potential for various automatic US image analysis tasks. This review first briefly introduces several popular deep learning architectures, and then summarizes and thoroughly discusses their applications in various specific tasks in US image analysis, such as classification, detection, and segmentation. Finally, the open challenges and potential trends of the future application of deep learning in medical US image analysis are discussed.

关键词： Deep learning Medical ultrasound analysis Classification Segmentation Detection

Role of intestinal probiotics in the modulation of lipid metabolism:implications for therapeutic treatments

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Food Science and Human Wellness 2023年第5期12卷 1439-1449页

作者： Xiaoran Song Yanan Liu Xin Zhang Peifang Weng Ruilin Zhang Zufang Wu Central laboratory Shenzhen University General HospitalShenzhen 518055China College of Food and Pharmaceutical Sciences Ningbo UniversityNingbo 315800China guangdong key laboratory for biomedical measurements and ultrasound imaging Department of Biomedical EngineeringSchool of MedicineShenzhen UniversityShenzhen 518060China

Currently, accumulating pieces of evidence indicate that probiotics, living in the gastrointestinal tract, play an important role in regulating host metabolism. As a tool, probiotics have great potential for treating lipid metabolism diseases. However, the relationship between probiotics and abnormal lipid metabolism is still unclear, and the mechanism of action has been become a focus of microbiome research. Therefore, taking intestinal probiotics as the starting point, this article combs the relationship between probiotics and lipid metabolism. Moreover, we discuss the underlying mechanisms of intestinal probiotics regulating lipid metabolism and summarize the therapeutic strategies for abnormal lipids metabolism. This article provides a reference for the further utilization of probiotics in the field of functional foods(food industry). Meanwhile, it will benefit the clinical diagnosis and treatment of lipid metabolism diseases.

关键词： Probiotics Lipid metabolism Intestinal flora

Stimulated emission-depletion-based point-scanning structured illumination microscopy

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Chinese Optics Letters 2024年第3期22卷 95-100页

作者：汪磊王美婷王璐玮郑晓敏陈嘉杰吴文帅严伟于斌屈军乐高志邵永红 guangdong key laboratory for biomedical measurements and ultrasound imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China key laboratory of Opto-electronic Information Science and Technology of Jiangxi Province Nanchang Hangkong UniversityNanchang 330063China College of Physics and Optoelectronics Engineering Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceShenzhen UniversityShenzhen 518060China Department of Bioengineering and COMSET Clemson UniversityClemson SC 29634US

Wide-field linear structured illumination microscopy(LSIM)extends resolution beyond the diffraction limit by moving unresolvable high-frequency information into the passband of the microscopy in the form of moiréfringes.However,due to the diffraction limit,the spatial frequency of the structured illumination pattern cannot be larger than the microscopy cutoff frequency,which results in a twofold resolution improvement over wide-field microscopes.This Letter presents a novel approach in point-scanning LSIM,aimed at achieving higher-resolution improvement by combining stimulated emission depletion(STED)with point-scanning structured illumination microscopy(ps SIM)(STED-ps SIM).The according structured illumination pattern whose frequency exceeds the microscopy cutoff frequency is produced by scanning the focus of the sinusoidally modulated excitation beam of STED microscopy.The experimental results showed a 1.58-fold resolution improvement over conventional STED microscopy with the same depletion laser power.

关键词： stimulated emission depletion structured illumination microscopy superresolution microscopy

Sonocatalytic hydrogen/hole-combined therapy for anti-biofilm and infected diabetic wound healing

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National Science Review 2023年第5期10卷 262-271页

作者： Qingqing Xu Shengqiang Chen Lingdong Jiang Chao Xia Lingting Zeng Xiaoqing Cai Zhaokui Jin Shucun Qin Wenjiang Ding Qianjun He Taishan Institute for Hydrogen biomedical Research School of Basic Medical SciencesThe Second Affiliated Hospital of Shandong First Medical University&Shandong Academy of Medical Sciences guangdong key laboratory for biomedical measurements and ultrasound imaging School of Biomedical EngineeringMedical SchoolShenzhen University Shanghai key laboratory of Hydrogen Science&Center of Hydrogen Science School of Materials Science and EngineeringShanghai Jiao Tong University

It is a great challenge to effectively eradicate biofilm and cure biofilm-infected diseases because dense extracellular polymeric substance matrix prevents routine antibacterial agents from penetrating into biofilm.H2is an emerging energy-regulating molecule possessing both high biosafety and high tissue permeability.In this work,we propose a concept of sonocatalytic hydrogen/hole-combined ’inside/outside-cooperation’anti-biofilm for promoting bacteria-infected diabetic wound healing based on two-dimensional piezoelectric nanomaterials.Proof-of-concept experiments using C3N4nanosheets as a representative piezoelectric catalyst with wide band gap and high biosafety have verified that sonocatalytically generated H2and holes rapidly penetrate into biofilm to inhibit bacterial energy metabolism and oxidatively deprive polysaccharides/NADH in biofilm to destroy the bacterial membrane/electron transport chain,respectively,inside/outside-cooperatively eradicating biofilm.A bacteria-infected diabetic wound model is used to confirm the excellent in vivo antibacterial performance of sonocatalytic hydrogen/hole-combined therapy,remarkably improving bacteria-infe cted diabetic wound healing.The proposed strategy of sonocatalytic hole/hydrogen-combined ’inside/outside-cooperation’ will make a highway for treatment of deep-seated biofilm infection.

关键词： nanocatalytic medicine hydrogen therapy biofilm diabetic foot piezoelectric catalysis

Advances in antioxidative nanozymes for treating ischemic stroke

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再生工程(英文)

再生工程(英文) 2023年第1期4卷 95-102页

作者： Jingyang Shan Xia Liu Xiuping Li Yunru Yu Bin Kong Lijie Ren Department of Neurology Shenzhen Institute of Translational MedicineThe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalGuangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingNational-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China Pharmaceutical Sciences laboratory Åbo Akademi UniversityTurku 20520Finland

Ischemic stroke is one of the most common public diseases that increase mortality.In the ischemic brain,blood flow restoration can cause the generation of excess reactive oxygen species(ROS).Endogenous anti-oxidases in the living system,including catalase(CAT)and superoxide dismutase(SOD),can consume the excess ROS by catalysis to regulate inflammation.However,these natural enzymes are difficult to be widely used in the treatment of stroke.Taking advantages of high stability,low cost,and long-term storage,antioxidative nanozymes-mediated treatments have been proven as a promising method against ischemic stroke.To highlight the progress,we summarize the advances in nanozymes with the antioxidative ability for treating ischemic stroke.It is believed that such a promising therapeutic strategy of antioxidative nanozymes will significantly contribute to the field of ischemic stroke.We expect that antioxidative nanozymes will play significant roles in both basic research and clinical applications.

关键词： Nanozymes Reactive oxygen species Antioxidative ability Blood brain barrier Ischemic stroke