Interaction between microbubble and elastic microvessel in low frequency ultrasound field using finite element method

作     者：SHEN YuanYuan WANG TianFu CHIN ChienTing DIAO XianFen CHEN SiPing 

作者机构：Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging National-Regional Key Technology Engineering Laboratory for Medical Ultrasound 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：2013年第58卷第3期

页      面：291-298页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by the National Natural Science Foundation of China (61031003,81101171) Chinese Postdoctoral Science Foundation(20100470903) Shenzhen Science and Technology Planning Project(CXB201005240009A) 

主　　题：相互作用 有限元法 超声场 微血管 弹性 微泡 低频 数值模型 

摘      要：The interaction between microbubble and elastic microvessel wall has been hypothesized to be important in the mechanisms of therapeutic ultrasound *** this study,a 2D axisymmetric finite element numerical model is established to study the interaction between elastic microvessel wall and oscillating microbubble in low frequency ultrasound field using fluid solid interaction *** numerical results show that the bubble oscillation induces the vessel wall dilation and *** von Mises stress distribution over the microvessel wall is heterogeneous and the maximum value of the midpoint on the inner vessel wall could reach 0.23 MPa and 1.32 MPa under PNP 0.2 MPa and 0.5 MPa,*** the bubble collapses,the circumferential stress decreases rapidly and the transmural pressure increases ***,the circumferential stress becomes compressive with the maximum magnitude 1.83 MPa under PNP 0.5 MPa,larger than the maximum tension *** is possible that the rapid compression stress during bubble collapse plays important role in mechanical effect on microvessel wall endothelial lining disruption.