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Study on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy based on expert consensus

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Journal of Traditional chinese medicine 2025年第1期45卷 167-175页

作者： WANG Dan HUANG Xiaoyan LI Ping HONG Xiaofan ZHANG Yumin WANG Rongrong BAO Kun LIANG Xing Nephrology Department Qianxinan Autonomous Prefecture Hospital of Traditional Chinese Medicine Nephrology Department Guangdong Provincial Hospital of Chinese Medicine guangdong provincial Key Laboratory of chinese medicine for Prevention and Treatment of Refractory Chronic Disease the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of chinese medicine the Second Affiliated Hospital of Guangzhou University of Chinese Medicine State Key Laboratory of Dampness Syndrome of chinese medicine The Second Affiliated Hospital of Guangzhou University of Chinese Medicine guangdong-Hong Kong-Macau Joint Lab on chinese medicine and Immune Disease Research

OBJECTIVE: To reach consensus on the diagnostic criteria of syndrome of dampness obstruction in idiopathic membranous nephropathy(IMN) patients by literature research and expert investigation(interviews and a Delphi method). METHODS: Our study was consistent with T/CACM 1336-2020. We searched the monographs and references published in the past 40 years(1983-2022), and established the diagnostic criteria pool of waterdampness syndrome and dampness-turbidity syndrome in Traditional chinese medicine(TCM) based on literature by using frequency statistics and correlation analysis. Expert investigation(interview method and two rounds of Delphi method) was used to form the diagnostic criteria of water-dampness syndrome and dampnessturbidity syndrome of idiopathic membranous nephropathy. Clinical diagnostic test research was carried out, and compared with “Diagnostic Criteria for dampness syndrome”(T/CACM 1454-2023) to evaluate the authenticity, reliability and clinical application value of the standard. RESULTS: A total of 122 relevant guides, standards, monographs and documents were included through searching books and chinese databases. Four experts were interviewed and two rounds of delphi method(75 experts nationwide) were carried out. The experts' opinions are relatively concentrated and the differences are small. Based on the weight of each index, the diagnostic criteria indexes of water-dampness syndrome and dampness-turbidity syndrome were selected. After discussion by the core group members, the diagnostic model of "necessary symptoms and optional symptoms" was established, and the final diagnostic criteria of waterdampness syndrome and dampness-turbidity syndrome were established. One hundred and ninety-one inpatients and outpatients of guangdong provincial hospital of chinese medicine from January 2021 to February 2023 were included in Diagnostic test study. There was no statistical difference in gender, age and course of disease(P > 0.05). The sensitivity and s

关键词： combination of disease and syndrome diagnostic tests, routine glomerulonephritis, membranous syndrome diagnostic criteria syndrome of dampness obstruction

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Modified Pulsatilla decoction alleviates 5-fluorouracil-induced intestinal mucositis by modulating the TLR4/MyD88/NF-κB pathway and gut microbiota

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World Journal of Gastroenterology 2025年第7期31卷 110-129页

作者： Yi-Tong Qiu Xin-Yi Luo Ya-Feng Deng Xue Zheng Jian-Guo Qiu Lin-Sheng Zhang Xiao-Qi Huang Xue-Bao Zheng Hai-Yang Huang School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 525000Guangdong ProvinceChina Druggability Research Team Dongguan Institute of Guangzhou University of Chinese MedicineDongguan 523808Guangdong ProvinceChina Institute of Traditional chinese medicine Dongguan Hospital of Traditional Chinese MedicineDongguan 523000Guangdong ProvinceChina

BACKGROUND Modified Pulsatilla decoction(PD),a PD with licorice and ejiao,is a classic Traditional chinese medicine formula with significant efficacy in treating intestinal mucositis(IM)induced by tumor ***,its specific molecular and biological mechanisms remain *** To investigate the therapeutic effect and mechanism of modified PD in *** This study used an IM mouse model established using 5-fluorouracil injections to investigate the effects of the modified PD(3,6,and 12 g/kg)in *** primary chemical components of the modified PD were identified using liquid chromatography-mass *** weight loss,diarrhea scores,intestinal length,histopathological scores,and inflammatory cytokine levels were measured to evaluate the effects of the modified PD in *** on the TLR4/MyD88/NF-κB pathway were evaluated using western blot *** intestinal microbiota was characterized using Illumina NovaSeq *** The results showed that modified PD significantly improved weight loss and diarrhea and shortened the intestines in IM ***,modified PD suppressed the TLR4/MyD88/NF-κB pathway and downregulated the expression of reactive oxygen species,lipopolysaccharides,and pro-inflammatory cytokines(IL-1β,TNF-α,IFN-γ,IL-6,IL-8,and IL-17),while increasing the expression of the anti-inflammatory cytokine ***,modified PD protected the intestinal mucosal barrier by increasing the expression of tight junction proteins(occludin-1,claudin-1,and ZO-1)and ***,16S rDNA sequencing revealed that modified PD improved intestinal *** Our research offers new insights into the potential mechanism of modified PD in alleviating IM and provides experimental evidence supporting its pharmaceutical application in clinical IM treatment.

关键词： Modified Pulsatilla decoction Intestinal mucositis Oxidative stress Gut microbiota,TLR4/MyD88/NF-κB pathway Inflammatory response

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Pneumonia caused by co-infection with Pneumocystis jirovecii and Trichosporon coremiiforme

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World Journal of Emergency medicine 2025年第1期16卷 99-100页

作者： Gaofeng Zhu Linqiang Huang Wenhong Zhong Hongke Zeng Department of Emergency medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Critical Care medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China

Fungal infections are relatively common among patients with systemic lupus erythematosus (SLE), and patients may be infected simultaneously or sequentially with multiple fungal species. Physicians need to select appropriate antifungal agents and therapeutic regimens based on the type and severity of the infection. Herein, we report a young SLE patient who developed concurrent pulmonary infection with Pneumocystis jirovecii and Trichosporon coremiiforme. The patient presented with a variety of imaging manifestations,with specific features evolving as the disease progressed.

关键词： infection Pneumocystis patients

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Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong Ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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HMGB2 knockdown ameliorates retinal ganglion cell injury by inhibiting NLRP3 inflammasome activation after retinal ischemia

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 39-50页

作者： Lin-Ping Xue Hai-Song Feng Hubei University of chinese medicine Wuhan 430065Hubei ProvinceChina Department of Encephalopathy Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430070Hubei ProvinceChina

AIM:To explore the neuroprotective effects of high mobility group box 2(HMGB2)knockdown on retinal ganglion cells(RGCs)in the retinal ischemia-reperfusion injury(RIRI).METHODS:Oxygen-glucose deprivation(OGD)-injured RGCs from postnatal three-day C57BL/6 mice pups and high intraocular pressure(IOP)-induced RIRI mice were used as cellular and animal models of *** expression of HMGB2 in the retina of RIRI mice and OGD-injured RGCs was detected through reverse transcription-polymerase chain reaction(RT-qPCR)and Western *** effects of HMGB2 silencing on the morphological changes,RGCs survival,and cell apoptosis in mouse retinal tissues were observed through H&E staining,immunofluorescence staining with RNA-binding protein with multiple splicing(RBPMS)antibody,and TUNEL staining,*** viability and apoptosis were examined by CCK-8 and flow cytometry *** levels of proteins associated with NOD-like receptor thermal protein domain associated protein 3(NLRP3)-mediated pyroptosis[NLRP3,Caspase-1,GSDMD-N,interleukin(IL)-1β,IL-18]in vivo and in vitro were measured by Western ***:HMGB2 protein and NLRP3 were upregulated in the retina of RIRI mice and OGD-injured RGCs(P<0.001).The retina was edematous,accompanied by disorganized cell arrangement and decreased thickness of all layers,and obvious vacuoles in ganglion cell ***2 silencing alleviated the reduction in total retinal thickness and the severity of retinal tissue damage as well as suppressed RGC loss and retinal cell apoptosis in RIRI ***-induced RGC apoptosis was ameliorated after downregulation of HMGB2 in *** injection of the AAV-sh-HMGB2 and si-HMGB2 resulted in significantly decrease of NLRP3,Caspase-1,GSDMD-N,IL-1β,and IL-18 protein levels in the retinal tissues of RIRI mice and OGD-injured RGCs,respectively(all P<0.001).CONCLUSION:HMGB2 knockdown protects against RGC apoptosis and pyroptosis after RIRI through suppressing NLRP3 inflammasome activ

关键词： HMGB2 retinal ischemia-reperfusion injury retinal ganglion cell apoptosis pyroptosis NLRP3 mice

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Integrated medicine Treatment of Rare Bone Marrow Tuberculosis in Systemic Lupus Erythematosus and Potentiating and Detoxifying Effects of chinese medicine:A Case Report

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chinese Journal of Integrative medicine 2025年第2期31卷 153-156页

作者： CHEN Wu HUANG Lin SHI Wei-man MA Ke WEN Cheng-ping DAI Qiao-ding School of Basic Medical Science Zhejiang Chinese Medical UniversityHangzhou(310000)China The Key Laboratory of chinese medicine Rheumatology of Zhejiang Province Hangzhou(310000)China Department of Rheumatology and Immunology The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou(310000)China

Systemic lupus erythematosus(SLE)is an autoimmune disease that affects multiple organ systems.(1,2)Patients with SLE who undergo long-term immunosuppressive and glucocorticoids therapy are at an elevated risk of devel... 详细信息

关键词： Systemic tuberculosis erythematosus

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Meningeal lymphatic vessel crosstalk with central nervous system immune cells in aging and neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 763-778页

作者： Minghuang Gao Xinyue Wang Shijie Su Weicheng Feng Yaona Lai Kongli Huang Dandan Cao Qi Wang Science and Technology Innovation Center Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina The Sixth Affiliated hospital Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Meningeal lymphatic vessels form a relationship between the nervous system and periphery, which is relevant in both health and disease. Meningeal lymphatic vessels not only play a key role in the drainage of brain metabolites but also contribute to antigen delivery and immune cell activation. The advent of novel genomic technologies has enabled rapid progress in the characterization of myeloid and lymphoid cells and their interactions with meningeal lymphatic vessels within the central nervous system. In this review, we provide an overview of the multifaceted roles of meningeal lymphatic vessels within the context of the central nervous system immune network, highlighting recent discoveries on the immunological niche provided by meningeal lymphatic vessels. Furthermore, we delve into the mechanisms of crosstalk between meningeal lymphatic vessels and immune cells in the central nervous system under both homeostatic conditions and neurodegenerative diseases, discussing how these interactions shape the pathological outcomes. Regulation of meningeal lymphatic vessel function and structure can influence lymphatic drainage, cerebrospinal fluid-borne immune modulators, and immune cell populations in aging and neurodegenerative disorders, thereby playing a key role in shaping meningeal and brain parenchyma immunity.

关键词： central nervous system meningeal lymphatic vessels immunity myeloid cells lymphatic cells neurodegenerative disease

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Chlorogenic acid induces hepatocellular carcinoma cell ferroptosis via PTGS2/AKR1C3/GPX4 axis-mediated reprogramming of arachidonic acid metabolism

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 202-220页

作者： Ling Wu Hong-Yao Chen Jing-Ting Zhang Ren-Yi Yang Zhi-Bin Wang Pei-Sen Xue Wei Peng Ke-Xiong Li Wen-Hui Gao Pu-Hua Zeng College of Traditional chinese medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Department of Oncology Hunan Provincial Hospital of Integrated Traditional Chinese and Western ChineseChangsha 410006Hunan ProvinceChina Cancer Research Institute of Hunan Academy of Traditional chinese medicine Hunan Provincial Hospital of Integrated Traditional Chinese and Western ChineseChangsha 410006Hunan ProvinceChina

BACKGROUND Ferroptosis is an iron-dependent programmed non-apoptotic cell death characterized by the accumulation of free iron ions and lipid *** is associated with the inactivation of glutathione peroxidase(GPX)and the accumulation of lipid peroxides within *** is closely related to the occurrence and development of hepatocellular carcinoma(HCC).Chlorogenic acid(CGA),an important bioactive component found in 61 traditional chinese medicines such as Eucommia ulmoides,has been extensively studied for its effects on various malignant ***,the specific role and potential mechanism of CGA in HCC remain *** To elucidate the anti-tumor characteristics and potential mechanisms of CGA in inducing ferroptosis in HCC *** The effects of CGA on the proliferation,migration,and invasion of HCC cells were evaluated through in vitro *** analysis combined with network pharmacology was used to study the potential targets and molecular mechanisms of CGA intervention in HCC *** vitro experiments were conducted to verify and explore the anti-HCC effects and mechanisms of CGA through the ferroptosis *** In vitro experiments showed that CGA dose-dependently inhibited the proliferation,invasion,and migration of HCC *** analysis combined with network pharmacology revealed that the pathway of CGA intervention in HCC cell ferroptosis was mainly enriched in the prostaglandin endoperoxide synthase 2(PTGS2)/aldoketo reductase family 1 member C3(AKR1C3)/GPX4 signaling pathway,which was associated with arachidonic *** vitro experiments further confirmed that CGA-induced ferroptosis in HCC cells was related to mitochondrial damage through the reprogramming of arachidonic acid metabolism by regulating the PTGS2/AKR1C3/GPX4 signaling *** This study demonstrates that CGA inhibits HCC cell proliferation,migration,and invasion by inducing ferroptosis through the PTGS2/A

关键词： Chlorogenic acid Hepatocellular carcinoma Ferroptosis Prostaglandin endoperoxide synthase 2/aldo-keto reductase family 1 member C3/glutathione peroxidase 4 axis Bioinformatics In vitro experiment

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Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

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World Journal of Gastroenterology 2025年第9期31卷 100-134页

作者： Xue-Jiao Liu Ye-li-ya Ye-er-tai Yue-Bo Jia Chen-Heng Wu Xiang-Xiang Wang Ke-Ming Yang Xuan Yao Jiang-Hong Ling Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200021China School of Traditional chinese medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalShenzhen 518033Guangdong ProvinceChina guangdong Shaxi Pharmaceutical Co. LtdZhongshan 528471Guangdong ProvinceChina

BACKGROUND Runchangningshen paste(RCNSP)is a paste made of four medicinal and edible homologous chinese medicine mixed with *** is known for its ability to nourish yin and blood as well as to loosen the bowel to relieve *** pathophysiology of functional constipation(FC)is associated with a reduction in mucin-2(MUC2)secretion and microbial *** To investigate the underlying mechanism of RCNSP against FC through MUC2 and the gut mucosal *** Ultra-performance liquid chromatography tandem mass spectrometry characterized RCNSP composition to elucidate the material basis of *** model was induced via loperamide gavage(16 mg/kg)twice daily for 7 *** defecation function and gastrointestinal motility to assess constipation *** and eosin and Alcian blue-periodic acid-schiff staining analyzed colonic mucosal *** electron microscope was used to observe the ultrastructure of goblet cells(GCs).Immunofluorescence colocalization,quantitative PCR,and western blot assessed the impact of RCNSP on gene and protein expression within the NLRP6/autophagy pathway.16S rDNA was employed to sequence the gut mucosal *** RCNSP contained 12 components with potential laxative *** enhanced defecation function,accelerated gastrointestinal motility,and maintained colonic mucosal *** treatment significantly increased GC abundance and MUC2 production while preserving GC *** the molecular level,RCNSP enhanced the colocalized expression of key regulatory proteins and modulated mRNA and protein expressions in the NLRP6/autophagy *** 16S rDNA sequencing analysis,RCNSP significantly altered the mucosal microbiota ***,it increased beneficial bacterial strains while reducing harmful ***,RCNSP reduced butyrate-producing bacteria like Proteobacteria,Enterobacteriaceae,Blautia,and Eubacterium and decreased hydrogen sulfide-

关键词： Traditional chinese medicine Functional constipation NLRP6 Autophagy Mucosal microbiota Mucin Goblet cells

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Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： Tian-Hao Guo Sheng-Wei Hong Wen-Jian Zhu Yi-Fan Hui Wen-Li Qiu Yan Wu Xuan Li Fei Ke Liu Li Hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

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