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Microwave-assisted synthesis of colorimetric and fluorometric dual-functional hybrid carbon nanodots for Fe^(3+) detection and bioimaging

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Chinese Chemical Letters 2021年第10期32卷 3189-3194页

作者： Yupeng Shi Jingjing Liu Yong Zhang Jianfeng Bao Jingliang Cheng Changqing Yi Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging(Henan Province) Department of MRIThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China guangdong provincial engineering and technology center of advanced and portable medical devices School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China

Carbon nanodots(CDs) based fluorescent nanoprobes have recently drawn much attention in chemo-/bio-sensing and ***,it is still challenging to integrate the colorimetric and fluorometric dual readouts into a single ***,novel hybrid CDs(HCDs) are prepared by a simple microwave-assisted reaction of citric acid(CA),branched polyethyleneimine(BPEI) and potassium thiocyanate(KSCN).As-prepared HCDs show extraordinary properties,including excitation-dependent emission,satisfactory fluorescence quantum yield(46.8%),excellent biocompatibility and optical ***,the fluorescence intensity at 450 nm exhibits linear correlation over the Fe^(3+)concentration from 1 mmol/L to 150 mmol/L with a detection limit(LOD) of 52 nmol/***,the solution color changes from colorless to orange,and the absorbance at 460 nm increased linearly with Fe^(3+)concentration ranging from 0.02 mmol/L to 5 mmol/L(LOD:3.4 mmol/L).All the evidence illustrates that the HCDs can be conditioned for specific Fe^(3+)sensing with colorimetric and fluorometric dual readouts,which has also been verified with paper-based *** possible mechanism is attributed to the specific interactions between surface functional groups on the HCDs and Fe^(3+).Additionally,the HCDs are successfully applied in sensing Fe^(3+)in wastewater and living cells,demonstrating its potential applications in future environment monitoring and disease diagnosis.

关键词： Paper-based chip Carbon nanodots Colorimetric Fluorescence Fe^(3+)ions detection Dual-functional

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Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles

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Chinese Chemical Letters 2022年第8期33卷 4101-4106页

作者： Mengfei Hou Wandi Chen Junkai Zhao Deshen Dai Mo Yang Changqing Yi guangdong provincial engineering and technology center of advanced and portable medical devices School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center For Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Department of Biomedical engineering The Hong Kong Polytechnic UniversityHong KongChina

Fluorescence(FL)imaging guided photodynamic therapy(PDT)is becoming highly desirable for personalized therapy and precision *** this study,fluorescent polymer nanoparticles TCPP@PEI/PGA were facilely synthesized through electrostatic interaction-mediated self-assembly of porphyrins tetra(4-carboxyphenyl)porphine(TCPP)and polyethylenimine(PEI),and subsequent surface modification withγ-poly(glutamic acid)(γ-PGA).TCPP served a dual function as the FL imaging probe and the *** as-prepared TCPP@PEI/PGA nanoparticles showed excellent water-solubility and biocompatibility,while having outstanding capabilities of in vivo bioimaging and~1 O_(2) *** bioimaging of mice and effective killing of CT 26 cells as well as CT 26 tumor-bearing mice upon laser irradiation were successfully demonstrated when using TCPP@PEI/PGA as theranostic *** study provides a simple but robust method to design and synthesize porphyrin-based polymer nanoparticles for theranostics.

关键词： Porphyrins Fluorescence imaging Photodynamic therapy Theranostics

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Design of portable electrochemiluminescence sensing systems for point-of-care-testing applications

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Chinese Chemical Letters 2023年第5期34卷 88-103页

作者： Shuqi Xia Jiangfei Pan Deshen Dai Zong Dai Mengsu Yang Changqing Yi guangdong provincial engineering and technology center of advanced and portable medical devices School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China Research Institute of Sun Yat-sen University in Shenzhen Shenzhen 518057China Department of Biomedical Sciences&Tung Biomedical Sciences Centre City University of Hong KongHong KongChina

Point-of-care testing(POCT)technology is highly desirable for clinical diagnosis,healthcare monitoring,food safety inspection,and environment surveillance,because it enables rapid detection anywhere,anytime,and by ***(ECL)has been widely used in chemo-/bio analysis due to its advantages such as high sensitivity,simplicity,rapidity and easy to control,and is now attracting increasing attention for POCT ***,to realize the accurate on-site quantitation,it is still challenging to develop portable devices which can precisely collect,analyze,transmit and display the ECL *** review will focus on how to develop a portable ECL device by summarizing recent examples and analyzing their key components part by *** the possible solutions to the existing challenges in the development and applications of portable ECL devices are summarized and discussed in detail,followed by offering future *** attempted to provide an appealing viewpoint to inspire interested researchers to comprehend and explore portable ECL sensing systems for practical applications and even commercialization.

关键词： Smartphone Screen-printed electrode Bipolar electrode Machine learning Aggregation-induced ECL Nanoscale ECL luminophores Microfluidics

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Plasmon-enhanced self-powered GaN/ZnTe core/shell nanopillar array photodetector

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Nano Research 2024年第6期17卷 5569-5577页

作者： Jianqi Dong Dongqi Zhang Yi Ma Daotong You Jinping Chen Bin Liu Xingfu Wang Zengliang Shi Chunxiang Xu State Key Laboratory of Digital medical engineering School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Jiangsu provincial Key Laboratory of advanced Photonic and Electronic Materials National Laboratory of Solid State MicrostructuresSchool of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Photonics technology Jinan UniversityGuangzhou 510632China guangdong engineering Research center of Optoelectronic Functional Materials and devices Institute of SemiconductorsSouth China Normal UniversityGuangzhou 510631China

Nanostructure photodetectors,as the core component of optoelectronic devices,are mainly focused on the precise preparation of mixed-component nano-heterostructures and the realization of zero power consumption ***,we successfully fabricated n-GaN/p-ZnTe core/shell nanopillar array and realized self-power ultraviolet/violet *** radial heterojunction nanodevice reveals high light-dark current ratio of 104 at 0 V bias,indicating effective carriers’*** more,by integrating plasmonic effect,the responsivity and detectivity of the Au nanoparticles decorated device are increased from 3.85 to 148.83 mA/W and 4.45×1011 to 2.33×1012 Jones under 325 nm UV light *** the rise and the fall time are decreased 1.3 times and 6.8 times under 520 nm visible light irradiation at 0 V *** high photocurrent gain is derived from that the oscillating high-energy hot electrons in Au nanoparticles spontaneously inject into the ZnTe conduction band to involve the photodetection *** work presents an effective route to prepare high-performance self-power photodetector and provides a promising blueprint to realize different functional photoelectronic devices based on core/shell nanostructure.

关键词： GaN/ZnTe core/shell nanopillar array self-power ultraviolet/visible photodetector plasmonic effect

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Super‑elastic Scintillating Fibers and Fabrics for Efficient and Visual Radiation Detection

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advanced Fiber Materials 2023年第4期5卷 1493-1504页

作者： Minghui Du Jin Wang Sijia Xu Hongwei Li Zhihao Zhang Yankun Qi Shichao Lv Jianrong Qiu Yurong Yan Shifeng Zhou State Key Laboratory of Luminescent Materials and devices School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China Institute of Photonics technology Jinan UniversityGuangzhou 510632China National engineering Research center of Novel Equipment for Polymer Processing School of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China Key Lab guangdong High Property&Functional Polymer Materials School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641China guangdong provincial Key Laboratory of Fiber Laser Materials and Applied Techniques Guangdong Engineering Technology Research and Development Center of Special Optical Fiber Materials and DevicesGuangzhou 510641China College of Optical Science and engineering State Key Laboratory of Modern Optical InstrumentationZhejiang UniversityHangzhou 310027China

The fabrication of advanced radiation detectors is an important subject due to the wide use of radiation sources in scientific instruments,medical services,security check,non-destructive inspection,and nuclear ***,the manufacture of flexible and stretchable radiation detectors remains a ***,we report the scalable fabrication of super-elastic scintillating fibers and fabrics for visual radiation detection by thermal drawing and melt-spinning methods using styrene-b-(ethylene-co-butylene)-b-styrene,and scintillating Gd_(2)O_(2)S:Tb(GOS).Microstructure evolution,rheological properties,and radiation-composite interaction are studied to reveal the excellent processability,elasticity,and radiation detection ability of the fabricated *** from the physical crosslinking structural features of the polymer matrix and the excellent radiation absorption capacities of GOS,the resulting fiber can sustain high strains of 765%with a high content of GOS dopants(2 wt.%)and has excellent X-ray detection performance with the limit down to 53 nGy_(air)s^(-1).Furthermore,stretchable fabrics are constructed,and their applications in various fields,such as radiation warning,and X-ray imaging,are *** work not only provides a new type of super-elastic scintillating fibers and fabrics for smart textiles but also demonstrates their potential applications in the nuclear field.

关键词： Elastic fiber Radiation detection Optical materials X-ray imaging

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Superparamagnetic iron oxide nanoparticle regulates microbiota-gut-inner ear axis for hearing protection

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National Science Review 2024年第6期11卷 273-284页

作者： Zhanhang Guo Yunhao Wu Bo Chen Mengdie Kong Peng Xie Yan Li Dongfang Liu Renjie Chai Ning Gu Jiangsu Key Laboratory for Biomaterials and devices School of Biological Science and Medical EngineeringSoutheast University medical Science and technology Innovation center Shandong First Medical University &Shandong Academy of Medical Sciences State Key Laboratory of Digital medical engineering Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Jiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast University Institute of Materials Science and devices School of Materials Science and Engineering Suzhou University of Science and Technology Nurturing center of Jiangsu Province for State Laboratory of AI Imaging &Interventional Radiology & Vascular Surgery Department of Radiology Medical School Zhongda Hospital Southeast University Co-Innovation center of Neuroregeneration Nantong University School of medical technology Institute of Engineering MedicineBeijing Institute of Technology Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of China Institute for Stem Cell and Regeneration Chinese Academy of Sciences Southeast university Shenzhen research institute Cardiovascular Disease Research center Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Medical School Nanjing University

Noise-induced hearing loss(NIHL) is a highly prevalent form of sensorineural hearing damage that has significant negative effects on individuals of all ages and there are no effective drugs approved by the US Food and Drug Administration. In this study, we unveil the potential of superparamagnetic iron oxide nanoparticle assembly(SPIOCA) to reshape the dysbiosis of gut microbiota for treating NIHL. This modulation inhibits intestinal inflammation and oxidative stress responses, protecting the integrity of the intestinal barrier. Consequently, it reduces the transportation of pathogens and inflammatory factors from the bloodstream to the cochlea. Additionally, gut microbiota-modulated SPIOCA-induced metabolic reprogramming in the gut–inner ear axis mainly depends on the regulation of the sphingolipid metabolic pathway, which further contributes to the restoration of hearing function. Our study confirms the role of the microbiota–gut–inner ear axis in NIHL and provides a novel alternative for the treatment of NIHL and other microbiota dysbiosis-related diseases.

关键词： superparamagnetic iron oxide nanoparticle hearing loss gut microbiota inflammation sphingolipid metabolism microbiota–gut–inner ear axis

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An in situ dressing material containing a multi-armed antibiotic for healing irregular wounds

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Aggregate 2024年第3期5卷 248-257页

作者： Ruihua Dong Mian Chen Yuexiao Jia Hao Tang Ziyin Xiong Yunze Long Xingyu Jiang Shenzhen Key Laboratory of Smart Healthcare engineering Guangdong Provincial Key Laboratory of Advanced BiomaterialsDepartment of Biomedical EngineeringSouthern University of Science and TechnologyShenzhenP.R.China School of Rehabilitation Sciences and engineering University of Health and Rehabilitation SciencesQingdaoP.R.China Collaborative Innovation center for Nanomaterials and devices College of PhysicsQingdao UniversityQingdaoP.R.China

Acute and infected wounds resulting from accidents,battleﬁeld trauma,or surgical interventions have become a global healthcare burden due to the complex bacterial infection ***,conventional gauze dressings present insufﬁcient contact with irregular wounds and lack antibacterial activity against multi-drug-resistant *** this study,we develop in situ nanoﬁbrous dressings tailored toﬁt wounds of various shapes and sizes while providing nanoscale comfort and excellent antibacterial *** approach involves the fabrication of these dressings using a handheld electrospinning device that allows for the direct depo-sition of nanoﬁber dressings onto speciﬁc irregular wound sites,resulting in perfect conformal wound closure without any mismatch in 2 *** nanoﬁbrous dressings are loaded with multi-armed antibiotics that exhibit outstanding antibacterial activ-ity against Staphylococcus aureus(***)and methicillin-resistant *** to conventional vancomycin,this in situ nanoﬁbrous dressing shows great antibacterial performance against up to 98%of multi-drug-resistant *** vitro and in vivo experiments demonstrate the ability of in situ nanoﬁbrous dressings to prevent multi-drug-resistant bacterial infection,greatly alleviate inﬂammation,and promote wound ***ﬁndings highlight the potential of these personalized nanoﬁbrous dressings for clinical applications,including emergency,accident,and surgical healthcare treatment.

关键词： deposited nanoﬁbrous dressing multi-armed antibiotics personalized healthcare portable electrospin-ning device

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In-situ generation of poly(quinolizine)s via catalyst-free polyannulations of activated diyne and pyridines

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Science China Chemistry 2022年第4期65卷 789-795页

作者： Benzhao He Jiachang Huang Jing Zhang Xinyue Liu Dong Wang Herman H.Y.Sung Yajun Liu Anjun Qin Jacky W.Y.Lam Ben Zhong Tang center for advanced Materials Research Science and Technology Experimental PlatformAdvanced Institute of Natural SciencesBeijing Normal University at ZhuhaiZhuhai 519085China Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstructionand Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional MaterialsThe Hong Kong University of Science&TechnologyKowloonHong KongChina center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518060China Department of Laboratory Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Luminescent Materials and devices Guangdong Provincial Key Laboratory of Luminescence from Molecular AggregatesCenter for Aggregation-Induced EmissionSouth China University of TechnologyGuangzhou 510640China HKUST-Shenzhen Research Institute Shenzhen 518057China Shenzhen Institute of Aggregate Science and technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China

The development of new polymerization routes to afford N-heterocyclic polymers is of vital importance and highly desired for various practical applications. Herein, a facile and efficient polyannulation reaction of dual-activated alkyne and pyridines was developed to construct novel N-heterocyclic poly(quinolizine)s. This polymerization can proceed smoothly under catalystfree conditions with 100% atom utilization to furnish poly(quinolizine)s with high molecular weights(up to 34,100) and welldefined structures in acceptable yields. The resulting polymers show good solubility, high thermal stability and strong red emission. Moreover, the prepared poly(quinolizine)s exhibit low cytotoxicity and can selectively label lysosomes in live *** the remarkable advantages of readily available raw materials, mild polymerization conditions, atom economy, and excellent product performance, this new and efficient polymerization tool will open up enormous opportunities for preparing functional N-heterocyclic polymers.

关键词： polyannulation activated alkyne N-heterocyclic polymers poly(quinolizine)s bioimaging

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High-performance polarization management devices based on thin-film lithium niobate

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Light(Science & Applications) 2022年第5期11卷 868-876页

作者： Zhongjin Lin Yanmei Lin Hao Li Mengyue Xu Mingbo He Wei Ke Heyun Tan Ya Han Zhaohui Li Dawei Wang X.Steve Yao Songnian Fu Siyuan Yu Xinlun Cai State Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-sen University510275 GuangzhouChina Department of Electrical and Computer engineering The University of British ColumbiaVancouverBC V6T 1Z4Canada Photonics Information Innovation center and Hebei provincial center for Optical Sensing Innovations College of Physics Science and TechnologyHebei University071002 BaodingChina Institute of advanced Photonics technology School of Information EngineeringGuangdong University of Technology510006 GuangzhouChina

High-speed polarization management is highly desirable for many applications,such as remote sensing,telecommunication,and medical ***,most of the approaches for polarization management rely on bulky optical components that are slow to respond,cumbersome to use,and sometimes with high drive ***,we overcome these limitations by harnessing photonic integrated circuits based on thin-film lithium niobate *** successfully realize a portfolio of thin-film lithium niobate devices for essential polarization management functionalities,including arbitrary polarization generation,fast polarization measurement,polarization scrambling,and automatic polarization *** present devices feature ultra-fast control speeds,low drive voltages,low optical losses and compact *** these devices,we achieve high fidelity polarization generation with a polarization extinction ratio up to 41.9 dB and fast polarization scrambling with a scrambling rate up to 65 Mrad s−1,both of which are best results in integrated *** also demonstrate the endless polarization state tracking operation in our *** demonstrated devices unlock a drastically new level of performance and scales in polarization management devices,leading to a paradigm shift in polarization management.

关键词： polarization lithium film

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Mussel-Inspired and Bioclickable Peptide Engineered Surface to Combat Thrombosis and Infection

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Research 2022年第3期2022卷 91-104页

作者： Xiaohui Mou Hongbo Zhang Hua Qiu Wentai Zhang Ying Wang Kaiqin Xiong Nan Huang Hélder A.Santos Zhilu Yang Affiliated Dongguan Hospital Southern Medical UniversityDongguanGuangdong 523059China guangdong provincial Key Laboratory of Shock and Microcirculation GuangzhouGuangdong 510080China Key Laboratory of advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Pharmaceutical Sciences Laboratory Åbo Akademi UniversityTurku Biosciences CenterUniversity of Turku andÅbo Akademi University20520 TurkuFinland State Key Laboratory of Molecular engineering of Polymers Fudan UniversityShanghai 200438China Department of Biomedical engineering and W.J.Kolff Institute for Biomedical engineering and Materials Science University Medical Center Groningen/University of GroningenAnt.Deusinglaan 19713 AV GroningenNetherlands Drug Research Program Division of Pharmaceutical Chemistry and TechnologyFaculty of PharmacyUniversity of HelsinkiFI-00014 HelsinkiFinland

Thrombosis and infections are the two major complications associated with extracorporeal circuits and indwelling medical devices,leading to significant mortality in *** address this issue,here,we report a biomimetic surface engineering strategy by the integration of mussel-inspired adhesive peptide,with bio-orthogonal click chemistry,to tailor the surface functionalities of tubing and *** by mussel adhesive foot protein,a bioclickable peptide mimic(DOPA)4-azidebased structure is designed and grafted on an aminated tubing robustly based on catechol-amine ***,the dibenzylcyclooctyne(DBCO)modified nitric oxide generating species of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid(DOTA)chelated copper ions and the DBCO-modified antimicrobial peptide(DBCO-AMP)are clicked onto the grafted surfaces via bio-orthogonal *** combination of the robustly grafted AMP and Cu-DOTA endows the modified tubing with durable antimicrobial properties and ability in long-term catalytically generating NO from endogenous snitrosothiols to resist adhesion/activation of platelets,thus preventing the formation of ***,this biomimetic surface engineering technology provides a promising solution for multicomponent surface functionalization and the surface bioengineering of biomedical devices with enhanced clinical performance.

关键词： DOTA generating Engine

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