Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles

作     者：Mengfei Hou Wandi Chen Junkai Zhao Deshen Dai Mo Yang Changqing Yi Mengfei Hou;Wandi Chen;Junkai Zhao;Deshen Dai;Mo Yang;Changqing Yi

作者机构：Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical DevicesSchool of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center For Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Department of Biomedical EngineeringThe Hong Kong Polytechnic UniversityHong KongChina 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第8期

页      面：4101-4106页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 1010[医学-医学技术（可授医学、理学学位）] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100215[医学-康复医学与理疗学] 10[医学] 0702[理学-物理学] 

基　　金：The financial support from Shenzhen Basic Research Program(No.JCYJ20210324140004013) Guangdong Provincial Key Laboratory of Sensing Technology and Biomedical Instruments(No.2020B1212060077) Guangdong Natural Science Foundation(No.2020A1515010661) 

主　　题：Porphyrins Fluorescence imaging Photodynamic therapy Theranostics 

摘      要：Fluorescence(FL)imaging guided photodynamic therapy(PDT)is becoming highly desirable for personalized therapy and precision *** this study,fluorescent polymer nanoparticles TCPP@PEI/PGA were facilely synthesized through electrostatic interaction-mediated self-assembly of porphyrins tetra(4-carboxyphenyl)porphine(TCPP)and polyethylenimine(PEI),and subsequent surface modification withγ-poly(glutamic acid)(γ-PGA).TCPP served a dual function as the FL imaging probe and the *** as-prepared TCPP@PEI/PGA nanoparticles showed excellent water-solubility and biocompatibility,while having outstanding capabilities of in vivo bioimaging and~1 O_(2) *** bioimaging of mice and effective killing of CT 26 cells as well as CT 26 tumor-bearing mice upon laser irradiation were successfully demonstrated when using TCPP@PEI/PGA as theranostic *** study provides a simple but robust method to design and synthesize porphyrin-based polymer nanoparticles for theranostics.