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Chinese Science Bulletin 2013年第3期58卷 291-298页

作者： SHEN YuanYuan WANG TianFu CHIN ChienTing DIAO XianFen CHEN SiPing guangdong key laboratory for biomedical measurements and ultrasound imaging National-Regional key Technology Engineering laboratory for Medical ultrasound

The interaction between microbubble and elastic microvessel wall has been hypothesized to be important in the mechanisms of therapeutic ultrasound *** this study,a 2D axisymmetric finite element numerical model is established to study the interaction between elastic microvessel wall and oscillating microbubble in low frequency ultrasound field using fluid solid interaction *** numerical results show that the bubble oscillation induces the vessel wall dilation and *** von Mises stress distribution over the microvessel wall is heterogeneous and the maximum value of the midpoint on the inner vessel wall could reach 0.23 MPa and 1.32 MPa under PNP 0.2 MPa and 0.5 MPa,*** the bubble collapses,the circumferential stress decreases rapidly and the transmural pressure increases ***,the circumferential stress becomes compressive with the maximum magnitude 1.83 MPa under PNP 0.5 MPa,larger than the maximum tension *** is possible that the rapid compression stress during bubble collapse plays important role in mechanical effect on microvessel wall endothelial lining disruption.

关键词：相互作用有限元法超声场微血管弹性微泡低频数值模型

Strategies for engineering advanced nanomedicines for gas therapy of cancer

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National Science Review 2020年第9期7卷 1485-1512页

作者： Yingshuai Wang Tian Yang Qianjun He guangdong Provincial key laboratory of biomedical measurements and ultrasound imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical Engineering Health Science CenterShenzhen University

As an emerging and promising treatment method, gas therapy has attracted more and more attention for treatment of inflammation-related diseases, especially cancer. However, therapeutic/therapy-assisted gases（NO, CO, H2S, H2, O2, SO2and CO2） and most of their prodrugs lack the abilities of active intratumoral accumulation and controlled gas release, resulting in limited cancer therapy efficacy and potential side effects. Therefore, development of nanomedicines to realize tumor-targeted and controlled release of therapeutic/therapy-assisted gases is greatly desired, and also the combination of other therapeutic modes with gas therapy by multifunctional nanocarrier platforms can augment cancer therapy efficacy and also reduce their side effects. The design of nanomedicines with these functions is vitally important, but challenging. In this review, we summarize a series of engineering strategies for construction of advanced gas-releasing nanomedicines from four aspects:（1） stimuli-responsive strategies for controlled gas release;（2） catalytic strategies for controlled gas release;（3） tumor-targeted gas delivery strategies;（4）multi-model combination strategies based on gas therapy. Moreover, we highlight current issues and gaps in knowledge, and envisage current trends and future prospects of advanced nanomedicines for gas therapy of cancer. This review aims to inspire and guide the engineering of advanced gas-releasing nanomedicines.

关键词： nanomedicine gas therapy drug delivery controlled release cancer treatment

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing key laboratory of Magnetic Resonance imaging and Brain Informatics BeijingChina key laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive Decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

Terpyridine-Grafted Nitrogen-Terminal Endowing Cyanine with Metal-Ion-Regulated Photophysical Properties for Cancer Theranostics

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Research 2023年第4期2023卷 117-130页

作者： Junfei Zhu Gang He Peng-Hang Chen Yajie Zhang Yafei Zhang Shan Lei Yu Zhang Meng Li Peng Huang Jing Lin Marshall laboratory of biomedical Engineering International Cancer CenterLaboratory of Evolutionary Theranostics(LET)Guangdong Key Laboratory for Biomedical Measurements and Ultrasound ImagingSchool of Biomedical EngineeringShenzhen University Medical SchoolShenzhen 518060China

Heptamethine cyanines(Cy7)are one of the most important dyes in bioimaging and phototherapy,but they often suffer from poor photostability or limited photothermal conversion ***,a facile molecular engineering approach to regulating the photophysical properties of Cy7 by metal ions is *** innovatively modifying the nitrogen with functional groups,a novel terpyridine-grafted nitrogen-terminated Cy7 scaffold(denoted as CydtPy)was synthesized and exhibited tunable photophysical properties when chelating with various metal ions(Mn^(2+),Fe^(2+),etc.).In comparison with metal-ion-free PEGylated CydtPy(LET-11),Mn^(2+)-chelated LET-11(namely,LET-11-Mn)exhibited the increased fluorescence emission intensity,and Fe^(2+)-chelated LET-11(namely,LET-11-Fe)showed the enhanced photostability with~2-fold increase in photothermal conversion *** simply switching the chelated metal ion species,LET-11-Mn or LET-11-Fe could be used for near-infrared fluorescence imaging,magnetic resonance imaging,or photoacoustic ***,LET-11-Fe displayed superior synergistic efficacy of photothermal therapy and chemodynamic therapy both in vitro and in *** work not only provides a new strategy for regulating the photophysical properties of cyanine dyes but also establishes a versatile nanoplatform for cancer theranostics.

关键词： versatile terminated cyanine

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State key laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Melanin/polydopamine-based nanomaterials for biomedical applications

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Science China Chemistry 2019年第2期62卷 162-188页

作者： Chao Qi Lian-Hua Fu Han Xu Tian-Fu Wang Jing Lin Peng Huang guangdong key laboratory for biomedical measurements and ultrasound imaging Carson International Cancer Center Laboratory of Evolutionary Theranostics School of Biomedical Engineering Health Science Center Shenzhen University key laboratory of Optoelectronic Devices and Systems of Ministry of Education and guangdong Province College of Optoelectronic Engineering Shenzhen University

The natural melanin is one kind of ubiquitous biological pigments, which is produced in melanosomes and widely distributed in living organisms. The synthetic melanin, often known as polydopamine(PDA), has similar chemical compositions and physical properties to natural melanin. In recent years, both natural melanin and PDA have aroused increased research interests in biomedical fields owing to their inherent biocompatibility, antioxidant activity, free-radical scavenging, metal ion chelation,strong near-infrared absorption and high photothermal conversion efficiency. Inspired by these fascinating properties, melanin and PDA have been widely used as building blocks for the construction of multifunctional nanoplatforms for various biomedical applications. This review focuses on the state-of-the-art progress in melanin/PDA-based nanomaterials, which covers from their preparation methods to biomedical applications including bioimaging, treatment, theranostics, antibacterial, UV/radiation protection, biosensor and tissue engineering. Moreover, the current trends and the future prospects of melanin/PDA-based nanomaterials are also discussed.

关键词： melanin polydopamine nanomaterials biomedical applications

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota

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Neural Regeneration Research 2022年第2期17卷 409-417页

作者： Yi-Tong Lin Qing-Qing Shi Lei Zhang Cai-Ping Yue Zhi-Jun He Xue-Xia Li Qian-Jun He Qiong Liu Xiu-Bo Du College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenGuangdong ProvinceChina guangdong Provincial key laboratory of biomedical measurements and ultrasound imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhenGuangdong ProvinceChina Shenzhen Bay laboratory ShenzhenGuangdong ProvinceChina

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic(3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China(approval No. AEWC-20140615-002) on June 15, 2014.

关键词： Alzheimer's disease amyloid-β anti-inflammation bioenergetics gut microbiota hydrogen therapy neurodegenerative disease neurofibrillary tangles

Conductivity reconstruction algorithms and numerical simulations for magneto–acousto–electrical tomography with piston transducer in scan mode

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Chinese Physics B 2014年第10期23卷 275-282页

作者：郭亮刘国强夏慧刘宇陆敏华 Institution of Electrical Engineering Chinese Academy of Sciences University of Chinese Academy of Sciences College of Control Theory and Engineering China University of PetroleumQingdao guangdong key laboratory for biomedical measurements and ultrasound imaging

Conductivities tomography with the interactions of magnetic field, electrical field, and ultrasound field is presented in this paper. We utilize a beam of ultrasound in scanning mode instead of the traditional ultrasound field generated by point source. Many formulae for the reconstruction of conductivities are derived from the voltage signals detected by two electrodes arranged somewhere on tissue＇s surface. In a forward problem, the numerical solutions of ultrasound fields generated by the piston transducer are calculated using the angular spectrum method and its Green＇s function is designed approximately in far fields. In an inverse problems, the magneto-acousto-electrical voltage signals are proved to satisfy the wave equations if the voltage signals are extended to the whole region from the boundary locations of transducers. Thus the time-reversal method is applied to reconstructing the curl of the reciprocal current density. In addition, a least square iteration method of recovering conductivities from reciprocal current densities is discussed.

关键词： magneto-acousto-electrical tomography Green's function conductivity reconstructing scanmode

Novel photo-theranostic GdB_(6) nanoparticles for fluorescence imaging and NIR-photothermal therapy

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Chinese Chemical Letters 2021年第11期32卷 3487-3490页

作者： Yuqi Chen Mengna Jiang Liwei Xiong Xianxian Yao Mingjian Fan Danyang Chen Qi Jiang Zhaokui Jin Qianjun He guangdong Provincial key laboratory of biomedical measurements and ultrasound imaging National-Regional Key Technology Engineering Laboratory for Medical UltrasoundMarshall Laboratory of Biomedical EngineeringSchool of Biomedical EngineeringHealth Science CenterShenzhen UniversityShenzhen 518060China Hubei key laboratory of Plasma Chemistry and Advanced Materials Wuhan Institute of TechnologyWuhan 430205China

The development of multifunctional theranostic nano-agents is an important resolution for personalized treatment of *** this work,we synthesized a new kind of gadolinium boride nanoparticles(GBN)by a microwave-assisted chemical etching method,and discovered their optical characteristics including fluorescence imaging and near-infrared(NIR)photothermal conversion *** greenishyellow fluorescence enabled for intracellular localization,while effective NIR-photothermal conversion supported photothermal therapy(PTT).In vitro and in vivo results indicated that GBN exhibited a superior antitumor performance and high *** study demonstrated a promising multifunctional theranostic nanoplatform for cancer treatment.

关键词： Gadolinium boride Nanomedicine Photothermal therapy Fluorescence imaging Theranostics

IMPACT OF DYNAMICAL HYDRATION SHELL AROUND HA PROTEIN ON NONLINEAR CONCENTRATION DEPENDENT T-RAYS ABSORPTION

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Journal of Innovative Optical Health Sciences 2013年第4期6卷 77-83页

作者： YIWEN SUN TIANFU WANG SIPING CHEN JIAN ZUO ZHENWEI ZHANG CUNLIN ZHANG National-Regional key Technology Engineering laboratory for Medical ultrasound guangdong key laboratory for biomedical measurements and ultrasound imaging Department of biomedical Engineering School of Medicine Shenzhen University Shenzhen 518060P.R.China Department of Physics Capital Normal University Beijing 100037P.R.China

T rays is sensitive to covalently cross linked proteins and can be used to probe unique dynamic properties of water surrounding a *** this paper,we demonstrate the unique abeorption properties of the dynamic hydnation shells deternined by hemagglutinin(HA)protein in ter-ahertz *** study the changes arising fom diferent concentrations in detail and show that nonlinear absorption coefficient is induced by the dynamic hydration *** binary and ternary component model were used to interpret the nonlinearity absorption behaviors and predict the thickness of the hydration shells around the HA protein in aquous phase.

关键词： T-rays absorption officient hemagglutinin hydration shell