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Design to enhance sensing performance of ZIF-8 crystals

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Progress in Natural Science:Materials International 2024年第2期34卷 240-250页

作者： Ya-Ru Li Xiuxiu Dong Shu-Yi Pan Lin Luo Hong-Tao Lei Zhen-Lin Xu guangdong Provincial Key Laboratory of food Quality and Safety College of Food Science South China Agricultural University Key Laboratory of Modern Agricultural Equipment and Technology (Jiangsu University) Ministry of Education School of Agricultural Engineering Jiangsu University

Metal-organic frameworks（MOFs） are a large class of crystalline porous materials that composed of organic ligands and metal ions,of which zeolitic imidazolate frameworks（ZIFs） are a broad *** most wellknown ZIF-like material is ZIF-8 crystals,which have been the subject of extensive research for ***-8 crystals have been synthesized under various conditions for application in the fields of sensing,drug delivery,and *** paper provides a brief introduction to the preparation methods,formation processes,and formation mechanisms of ZIF-8 crystals in different media,and then explains the effects of different precursor conditions(type of Zn2+,ratio of raw materials,and type of solvent) on ZIF-8 crystals in terms of formation ***,current reports on the application of ZIF-8-based chemiresistive gas sensors,electrochemical,fluorescent and colorimetric sensors are also ***,ZIF-8 crystals with good catalytic properties will be obtained based on rational design for promoting the application in different fields of the sensors.

关键词： Formation mechanism Regulation Sensing performance Synthesis method ZIF-8

Effectiveness of fecal DNA syndecan-2 methylation testing for detection of colorectal cancer in a high-risk Chinese population

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1361-1373页

作者： Wen-Feng Luo Yu-Ting Jiao Xiao-Ling Lin Ying Zhao Sheng-Bo Wang Jian Shen Jie Deng Yu-Feng Ye Ze-Ping Han Fang-Mei Xie Jin-Hua He Yu Wan Central Laboratory of Panyu Central Hospital Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Digestive Disease Center Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina Shunde vocational and Technical college Foshan 528300Guangdong ProvinceChina Medical Imaging Institute of Panyu Guangzhou Panyu Central HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND Colorectal cancer(CRC)is among the most prevalent and life-threatening malignancies ***-2 methylation(mSDC2)testing has emerged as a widely used biomarker for early detection of CRC in stool and serum ***(CRC)is among the most prevalent and life-threatening malignancies ***2 testing has emerged as a widely used biomarker for early detection of CRC in stool and serum *** To validate the effectiveness of fecal DNA mSDC2 testing in the detection of CRC among a high-risk Chinese population to provide evidence-based data for the development of diagnostic and/or screening guidelines for CRC in *** A high-risk Chinese cohort consisting of 1130 individuals aged 40-79 years was selected for evaluation via fecal mSDC2 *** and specificity for CRC,advanced adenoma(AA)and advanced colorectal neoplasia(ACN)were ***-risk factors for the incidence of colorectal lesions were determined and a logistic regression model was constructed to reflect the efficacy of the *** A total of 1035 high-risk individuals were included in this study according to established *** them,16 suffered from CRC(1.55%),65 from AA(6.28%)and 189 from non-AAs(18.26%);150 patients were diagnosed with polyps(14.49%).Diagnoses were established based upon colonoscopic and pathological *** of the mSDC2 test for CRC and AA were 87.50%and 40.00%,respectively;specificities were 95.61%for other *** predictive values of the mSDC2 test for CRC,AA and ACN were 16.09%,29.89%and 45.98%,respectively;the negative predictive value for CRC was 99.79%.After adjusting for other high-risk covariates,mSDC2 test positivity was found to be a significant risk factor for the occurrence of ACN(P<0.001).CONCLUSION Our findings confirmed that offering fecal mSDC2 testing and colonoscopy in combination for CRC screening is effective for earlier detection of malignant colorectal lesions in a high

关键词： Colorectal cancer Syndecan-2 DNA methylation Chinese population

Ononin inhibits triple-negative breast cancer lung metastasis by targeting the EGFR-mediated PI3K/Akt/mTOR pathway

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Science China Life Sciences 2024年第9期67卷 1849-1866页

作者： Kumar Ganesan Cong Xu Jianming Wu Bing Du Qingqing Liu Yue Sui Cailu Song Jinhui Zhang Hailin Tang Jianping Chen School of Chinese Medicine LKS Faculty of Medicine The University of Hong Kong School of Pharmacy Southwest Medical University Education Ministry Key Laboratory of Medical Electrophysiology Sichuan Key Medical Laboratory of New Drug Discovery and Druggability EvaluationLuzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica Southwest Medical University college of food Science South China Agricultural University State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center

The spreading of cancer cells from the primary tumor site to other parts of the body, known as metastasis, is the leading cause of cancer recurrence and mortality in patients with triple-negative breast cancer(TNBC). Overexpression of epidermal growth factor receptor(EGFR)is observed in approximately 70% of TNBC patients. EGFR is crucial for promoting tumor metastasis and associated with poor ***, it is vital to identify effective therapeutic strategies targeting EGFR inhibition. Ononin, an isoflavonoid found in various plants,such as clover and soybeans, has been shown to have anticancer properties in several cancers. In the present study, we aimed to investigate the effects of ononin on TNBC lung metastasis and the associated molecular pathways. We used various assays, including cell viability,colony formation, Transwell, wound healing, ELISA, Western blotting, and staining techniques, to achieve this objective. The results demonstrated that ononin effectively suppressed cellular proliferation and induced apoptosis, as evidenced by the cell viability assay, colony formation assay, and expression of apoptosis markers, and reduced the metastatic capabilities of TNBC cells. These effects were achieved through the direct suppression of cell adhesion, invasiveness and motility. Furthermore, in TNBC xenograft lung metastatic models, ononin treatment significantly reduced tumor growth and lung metastasis. Additionally, ononin reversed the epithelial-mesenchymal transition(EMT) by downregulating the expression of EMT markers and matrix metalloproteinases, as confirmed by Western blot analysis. Furthermore, ononin treatment reduced EGFR phosphorylation and suppressed the PI3K, Akt, and m TOR signaling pathways, which was further confirmed using EGFR agonists or inhibitors. Importantly, ononin treatment did not exert any toxic effects on liver or kidney function. In conclusion, our findings suggest that ononin is a safe and potentially therapeutic treatment

关键词： ononin TNBC breast cancer lung metastasis EGFR PI3k/Akt EMT therapeutic effect

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Goji berry-derived phenylpropionyl phenylethylamine derivatives protect against ethanol-induced hepatic damage

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food Science and Human Wellness 2024年

作者： Zhengqun Zhou Zhaodi Che Jiancong Mai Rui Zhang Zhihui Luo Yifang Li Kwokfai So Jia Xiao Xinsheng Yao Hao Gao GMH Institute of CNS Regeneration guangdong Medical Key Laboratory of Brain Function and Diseases Jinan University Clinical Medicine Research Institute and Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan University Institute of Traditional Chinese Medicine and Natural Products college of Pharmacy/guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative drug Development of Ministry of Education (MOE) of China Jinan University

Goji berry is a famous edible and medicinal substance around the world. In this research， 15 phenylpropionyl phenylethylamine derivatives (1-15)， including one new compound (1)， were separated and identified from goji berry. All isolates were elucidated via extensive NMR spectral analyses and chemical techniques. Six known isolates were first obtained from Lycium genus. Six isolates were effectively split into double chromatographic peaks accompanied by the basically identical areas， indicating they belong to racemates. The ORAC experiment indicated that all isolates displayed a capacity of scavenging free radicals， and most of them exhibited higher ORAC values than EGCG. In ethanol/palmitic acid (PA)-established in vitro hepatocyte injury model， four phenylpropionyl phenylethylamine derivatives (1， 2， 9， and 15) significantly alleviated hepatocyte injury， among which compound 1 exerted the strongest protective activity. Notably， the hepatoprotective effect of compound 1 was further confirmed in ethanol-established liver damage mouse model， reflected by the reduction of lipid accumulation and the attenuation of pathological alteration. Combined with the in vitro results， the in vivo observations suggested that compound 1 suppressed cell apoptosis and the outburst of inflammation. Our findings provided first-hand evidence proving that goji berry-derived phenylpropionyl phenylethylamine derivatives hold a potential in treating alcoholic liver disease.

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Microelectrode glucose biosensor based on nanoporous platinum/graphene oxide nanostructure for rapid glucose detection of tomato and cucumber fruits

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food Quality and Safety 2022年第1期6卷 45-55页

作者：巫彬芳徐海涛施玉峰姚志杰余家愉周华栗云鹏陈秋兰龙拥兵 college of Electronic Engineering South China Agricultural UniversityGuangzhouChina Lingnan Modern Agricultural Science and Technology guangdong Laboratory GuangzhouChina Department of Medical Devices Guangdong Food and Drug Vocational CollegeGuangzhouChina

A microelectrode glucose biosensor based on a three-dimensional hybrid nanoporous platinum/graphene oxide nanostructure was developed for rapid glucose detection of tomato and cucumber *** nanostructure was fabricated by a two-step modification method on a microelectrode for loading a larger amount of glucose *** nanoporous structure was prepared on the surface of the platinum microelectrode by electrochemical etching,and then graphene oxide was deposited on the prepared nanoporous electrode by electrochemical *** nanoporous platinum/graphene oxide nanostructure had the advantage of improving the effective surface area of the electrode and the loading quantity of glucose *** a result,the biosensor achieved a wide range of 0.1-20.0 mmol/L in glucose detection,which had the ability to accurately detect the glucose *** was found that the three-dimensional hybrid nanostructure on the electrode surface realized the rapid direct electrochemistry of glucose ***,the biosensor achieved high glucose detection sensitivity 11.64μA·L/(***^(2)),low detection limit(13μmol/L)and rapid response time(reaching 95%steady-state response within 3 s),when calibrating in glucose standard *** agricultural application,the as-prepared biosensor was employed to detect the glucose concentration of tomato and cucumber *** results showed that the relative deviation of this method was less than 5%when compared with that of high-performance liquid chromatography,implying high accuracy of the presented biosensor in glucose detection in plants.

关键词： Direct electrochemistry three-dimensional hybrid nanoporous platinum/graphene oxide nanostructure glucose biosensor glucose detection in plants

Remodel the perifollicular microenvironment via Minoxidil-loaded microneedle patch and cold atmospheric plasma for treating androgenetic alopecia

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Nano Research 2024年第7期17卷 6411-6419页

作者： Hao Chen Xianzhe Tang Yueye Huang Chen Chen Yuheng Yang Chaojie Hao Wenqi Xie Tingjing Huang Xiaofeng Cheng Qingnan Xu Shicong Huang Zhi Ye Xucong Lin Zhaowei Chen Zhitong Chen MOE Key Laboratory for Analytical Science of food Safety and Biology and New Cornerstone Science LaboratoryCollege of ChemistryFuzhou UniversityFuzhou 350108China Institute of Biomedical and Health Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Advanced Therapeutic Center National Innovation Center for Advanced Medical DevicesShenzhen 518000China Department of Chemistry University College LondonLondon WC1H 0AJUK Engineering Technology Research Center on Reagent and Instrument for Rapid Detection of Product Quality and food Safety in Fujian Province College of ChemistryFuzhou UniversityFuzhou 350108China Key Laboratory of Biomedical Imaging Science and System Chinese Academy of SciencesShenzhen 518055China

Androgenetic alopecia(AGA)is a chronic and progressive form of hair loss characterized by vascular degeneration in the perifollicular microenvironment,leading to cell apoptosis and eventual loss of hair follicles(HFs).Traditional therapeutic formulations,such as Minoxidil(MXD)tincture,have limitations in reshaping the perifollicular microenvironment and exhibit limited ***,we report a multi-synergistic therapeutic platform for high-performance hair regeneration *** platform combines microneedle(MN)patches loaded with MXD-encapsulated nanostructured lipid carriers(MXD-NLC-MNs)and cold atmospheric plasma(CAP).The MNs’mechanical strength enables efficient transdermal delivery of MXD to the targeted dermal papilla cells,promoting cell ***,in collaboration with MXD,the mechanical stimulation exerted by MN application synergistically upregulates the expression of vascular endothelial growth factor,leading to ***,the transient microchannels in the skin created by MNs facilitate the transdermal delivery of CAPgenerated nitric oxide(NO)to the sites of HF lesions,whereby the synergistic interaction between MXD and NO boosts perifollicular ***,the perifollicular microenvironment can be effectively reshaped to accelerate hair regeneration in AGA murine *** multi-synergistic combination therapy strategy would hold great promise for effectively treating AGA and promoting hair regrowth.

关键词： nanomedicine androgenetic alopecia microneedle cold atmospheric plasma drug delivery

Phosphatidylethanolamine functionalized biomimetic monolith for immobilized artificial membrane chromatography

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Journal of Pharmaceutical Analysis 2022年第2期12卷 332-338页

作者： Peijie Zhu Weijia Chen Qiqin Wang Huihui Wu Meng Ruan Hongwu Wang Zhengjin Jiang School of food&Pharmaceutical Engineering Zhaoqing UniversityZhaoqingGuangdong526061China Institute of Pharmaceutical Analysis College of PharmacyJinan UniversityGuangzhou510632China School of Pharmaceutical Engineering Guangdong Food and Drug Vocational CollegeGuangzhou510632China Department of Pharmacy and guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine&New drug Research Jinan UniversityGuangzhou510632China

In this research,a new phospholipid based monolith was fabricated by in situ co-polymerization of 1-dodecanoyl-2-(11-methacrylamidoundecanoyl)-sn-glycero-3-phosphoethanolamine and ethylene dimethacrylate to mimick bio-membrane *** physicochemical properties of this novel monolith that were achieved included column efficiency,stability,and ***,the biomimetic monolith showed outstanding separation capability for a series of intact proteins and small *** particular,it exhibited good potential as an alternative to the commercial immobilized artificial membrane(IAM)column(***2)for studying drug-membrane *** study not only enriched the types of IAM stationary phases,but also provided a simple model for the prediction of phosphatidylethanolamine related properties of drug candidates.

关键词： Phosphatidylethanolamine Biomimetic monolith IAM drug-membrane interaction

The Anti-glioma Effect of Luteolin Via Mir-384/PIWIL4 Pathway and Its Influencing Mechanism

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Chinese Journal of Biomedical Engineering(English Edition) 2022年第1期31卷 19-26页

作者： CHEN Xia LAI Man-xiang LIU Xiao-ai LAI Hui-li Department of Nursing Guangdong Food and Drug Vocational CollegeGuangdong Guangzhou 510520China

Objective:To explore the anti-glioma effect and influence of luteolin through mi R-384/PIWIL4 ***:30 cases of human glioblastoma multiform U251,U87,A172,SHG44 cells,and 30 cases of the normal glial cell NHA were treated with *** control group was detected by Western blot,and the level of PIWIL4 in the cytoplasm and nucleus of each cell line was *** expression levels of PIWIL4 m RNA and mi R-384 in each cell line were detected by ***:the glial cell NHA with normal PIWIL4 level in the cytoplasm was related to U251,U87,A172,and SHG44 human pleomorphic glioma *** m RNA expression levels of U251,U87,A172,and SHG44 human pleomorphic glioma cells were significantly higher than those of normal gliomas(P<0.05),and the mi R-384 expression levels of U251,U87,A172,and SHG44 human pleomorphic glioma cells were significantly higher than those of normal gliomas(P<0.05).With the continuous increase of luteolin concentration,glioma cells showed a significant increase in dependence(P<0.05).Conclusion:Luteolin could up-regulate mi R-384,inhibit PIWIL4,and regulate the biological activity of glioma cell proliferation and migration.

关键词： luteolin glioma cell cell proliferation cell migration

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Oyster Protein Hydrolysate Alleviates Cadmium Toxicity by Restoring Cadmium-Induced Intestinal Damage and Gut Microbiota Dysbiosis in Mice via Its Abundance of Methionine,Tyrosine,and Glutamine

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Biomedical and Environmental Sciences 2022年第7期35卷 669-673页

作者： WANG Jing Wen FANG Zhi Jia LI Yong Bin HUANG Lin Ru SUN Li Jun LIU Ying WANG Ya Ling LIAO Jian Meng college of food Science and Technology Guangdong Provincial Key Laboratory of Aquatic Product Processing and SafetyGuangdong Provincial Engineering Technology Research Center of Marine FoodKey Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education InstitutionGuangdong Ocean UniversityZhanjiang 524088GuangdongChina Institute for food and drug Control Zhanjiang 524088GuangdongChina

As a typical heavy metal contaminant in food,cadmium(Cd)easily enters the human food chain via crop production,and therefore,threatens human health[1].Intestinal absorption is the principal route for Cd entry into the body,and therefore,intestinal tissue become the primary target for Cd toxicity[2].Previous studies showed that acute Cd exposure damaged intestinal tight junctions,resulting in gut barrier destruction and alterations in gut microbiota[3].Thus,the effective prevention of Cd-induced intestinal damage has become a major research challenge.

关键词： prevention alterations cadmium

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