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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期 226-232页

作者： Rongrong Du Senmiao Xu state Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University university of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

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Reflection of Liberal Values in the Georgian Press in 1918-1921

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International Relations and Diplomacy 2016年第5期4卷 341-352页

作者： Manana Shamilishvili Mari Tsereteli IvaneJavakhishvili tbilisi state university Tbilisi Georgia

This study deals with the values and orientation of Georgian social and political publications in the times of the Georgian Democratic Republic （1918-1921）. It also shows how the press of that time reflected the idea of ＂Georgian Europeanism＂ based on liberal values that took shape as an anti-colonial concept in the journalism of the late 19th century. The opposed dominant ideological projects of that era comprised on the one hand, National Democratic and Socialist Federalist parties that aspired to preserve national identity and carry out changes and on the other hand, ruling Social Democrats （who initially neglected national identity, but later shared the idea）. This opposition was clearly reflected in the media discourse of that time, which implied the following rights based on the principles of classical liberalism： freedom of conscience and expression, rule of law, personal independence, and individual rights. Other elements were added to this list later. The issue of religious tolerance also became topical. Journalist texts of the period reflected and rationalised the values recognised in today＇s democratic and liberal communities. The research was carried out in the archives of the periodicals of the aforementioned period （newspapers Sakhalkho Sakme, Sakartvelo, Ertoba, and Sakartvelos Respublika） by means of systematising and classifying retrieved materials and making a substantive and varietal analysis of individual media texts.

关键词： Georgian journalism the Georgian Party Press in 1918-1921 the liberal values the idea of Georgian Europeanism

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu Xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma Xiaoping Gu Tianjiao Xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina state Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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Towards the continuum coupling in nuclear lattice effective field theory Ⅰ: A three-particle model

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Chinese Physics C 2020年第12期44卷 177-183页

作者： J.-J.Wu Ulf-GMeißner School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universität BonnD-53115 BonnGermany Institute for Advanced Simulation Institut für Kernphysikand Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JülichGermany tbilisi state university 0186 TbilisiGeorgia

Weakly bound states often occur in nuclear *** precisely understand their properties,the coupling to the continuum should be worked out *** the first step,we use a simple nuclear model in the continuum and on a lattice to investigate the influence of a third particle on a loosely bound state of a particle and a heavy *** approach is consistent with the Lüscher formalism.

关键词： nuclear lattice effective field theory continuum coupling Hamiltonian method

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Molecules “buckle up” to drive layered hybrid perovskites into single-crystal nanowires in water

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Science China Chemistry 2025年第1期 3-4页

作者： Seokhyoung Kim Department of Chemistry Michigan State University

Layered 2D metal halide perovskites (MHPs) are one of the most exciting candidates for next-generation light sources owing to their outstanding optoelectronic properties. These properties are readily tunable by controlling the halide composition, number of inorganic layers, and the chemistry of organic cations. Another key element that can substantially impact the materials’ functionalities is crystal morphology [1].

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A note on scalar meson dominance

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Chinese Physics C 2019年第10期43卷 46-49页

作者： Y.ünal Ulf-G.Meiβner Helmholtz-Institut für Strahlen-und Kernphysik and Bethe Center for Theoretical Physics Universitat BonnD-53115 BonnGermany Physics Department Canakkale Onsekiz Mart University17100 CanakkaleTurkey Institute for Advanced Simulation Institut für Kernphysik and Jülich Center for Hadron PhysicsForschungszentrum JülichD-52425 JülichGermany tbilisi state university 0186 TbilisiGeorgia

We consider chiral perturbation theory with an explicit broad σ-meson and study its contribution to the scalar form factors of the pion and the nucleon. Our goal is to learn more about resonance saturation in the sca... 详细信息

关键词： chiral Lagrangians scalar mesons resonance saturation

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Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang Ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-Fei Xu Ying Zeng Yun-Dong Wu Xiao-Jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences university of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory state Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University state Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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Phenomenon of Mutual Compensation of Radiation Donors and Acceptors and Creation of Radiation-Resistant Materials

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Journal of Electrical Engineering 2014年第4期2卷 187-192页

作者： Nodar Kekelidze Bela Kvirkvelia David Kekelidze Vugar Aliyev Elza Khutsishvili George Kekelidze Laboratory of Semiconductor Materials Ferdinand Tavadze Institute of Metallurgy and Materials Science Tbilisi 0160 Georgia Institute of Materials Research lvane Javakhishvili Tbilisi State University Tbilisi 0179 Georgia Department of Physics Georgian Technical University Tbilisi 0175 Georgia Laboratory of Crystal Pkysics Institute of Physics of Azerbaijan National Academy of Sciences Baku 1143 Azerbaijan BoTEUROSOLAR e.V. Bonn 53113 Germany

The phenomenon of mutual compensation of radiation donors and acceptors is discovered in IrtAs-InP solid solutions. This phenomenon is a result of opposite directed radiation processes, taking place in the irradiated InAs-InP solid solutions. The radiation creates donor type defects in the sublattice of InAs and electrons concentration increases. The contrary process occurs in the sublattice of InP. Radiation originates acceptor type defects and the carrier concentration decreases. The noted effect is going on in the all alloy composition. Exact mutual compensation of radiation donors and acceptors is achieved by selecting of the alloys definite composition. As a result, the main parameter of semiconductors-electrons concentration remains constant even under the hard radiation with fluences of Ф = 2 × 10^18 fast neutrons/cm^2. So there has been created radiation-resistant material.

关键词： InAs-InP radiation donors and acceptors radiation resistance.

Segment-Centric Geo-Competitive Environment of a Tourism Destination (A Case of Georgia)

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Journal of Tourism and Hospitality Management 2023年第1期11卷 19-30页

作者： Ioseb Khelashvili Ivane Javakhishvili tbilisi state university TbilisiGeorgia

This work aims to introduce a conceptual approach to determining the competitive environment for a particular tourist destination by considering popular outbound destinations of its leading *** approach we name as a concept of a segment-centered geo-competitive environment of a tourism destination(SGE-TD).The applied methodology includes consideration of the popularity of tourist destinations for each selected segment and the indicators of leading segments of the studied *** practical application of the proposed concept is examined in the case of Georgia as a tourist destination by selecting its leading segments and identifying their popular travel *** integrated consideration and application of the mentioned indicators define the competitive position of a destination(in this case Georgia)among the specified tourism destinations,considered as the geo-competitive *** research suggests an innovative version of the universal conceptual approach to identify the leading competing destinations for a specific studied *** fills the gap in similar studies where competing destinations for the analysis are selected based on specific research objectives,missing the universal conceptual approach in this regard.

关键词： tourism destination segment competitive environment Georgia segment-centric geo-competitive environment(SGE-TD)