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An in-depth understanding of the role and mechanisms of T cells in immune organ aging and age-related diseases

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Science China(Life Sciences) 2025年第2期68卷 328-353页

作者： Yudai Xu Zijian Wang Shumin Li Jun Su Lijuan Gao Junwen Ou Zhanyi Lin Oscar Junhong Luo Chanchan Xiao Guobing Chen department of Microbiology and Immunology School of MedicineInstitute of Geriatric ImmunologySchool of MedicineJinan UniversityGuangzhou 510632China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China Guangdong-Hong Kong-Macao Great Bay Area Geroscience Joint Laboratory School of MedicineJinan UniversityGuangzhou 510632China First Affiliated Hospital Jinan UniversityGuangzhou 510630China Anti Aging Medical Center Clifford HospitalGuangzhou 511495China Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences) Southern Medical UniversityGuangzhou 510080China department of Systems Biomedical Sciences School of MedicineJinan UniversityGuangzhou 510632China The Sixth Affiliated Hospital of Jinan University(Dongguan Eastern Central Hospital) Jinan UniversityDongguan 523000China Zhuhai Institute of Jinan University Jinan UniversityZhuhai 519070China

T cells play a critical and irreplaceable role in maintaining overall ***,their functions undergo alterations as individuals *** is of utmost importance to comprehend the specific characteristics of T-cell aging,as this knowledge is crucial for gaining deeper insights into the pathogenesis of aging-related diseases and developing effective therapeutic *** this review,we have thoroughly examined the existing studies on the characteristics of immune organ ***,we elucidated the changes and potential mechanisms that occur in T cells during the aging ***,we have discussed the latest research advancements pertaining to T-cell agingrelated *** findings provide a fresh perspective for the study of T cells in the context of aging.

关键词： T cell aging immune organ age-related diseases

Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool

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World Journal of Gastroenterology 2025年第9期31卷 135-145页

作者： Jia-Wei Yu Lin-Biao Xiang Xiao-Juan Dong Chen-Xi Yang Lei Wang Xiao-Yu Liu Yi-Hong Song Xian-Jie Bai Jing-Wen Xiao Lu Ren Qin-Hong Xu Gang-Hua Yang Yi Lv Qiang Lu National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina department of International Medical Center The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina department of geriatric Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Shortening the recipient warm ischemia time(rWIT)has been proven to be effective for improving the short-and long-term outcomes after liver transplantation(LT)and offsets the negative impact of an extended cold ischemia ***,few studies have been conducted to explore the prognostic effects of shortening the rWIT in transplantations using a liver graft from an extendedcriteria donor(ECD).AIM To investigate whether shortening the rWIT could improve the outcomes of ECD *** Rat ECD autologous orthotopic LT were performed with variable rWITs(0,10,20,and 30 minutes).Near-infrared fluorescence imaging(FI)was used for the real-time assessment of liver graft ischemia-reperfusion injury after the anhepatic *** was assessed,and liver function and histological analyses were performed on the third day after *** The FI curve growth rate and postoperative three-day survival rate significantly increased,and the liver function and Suzuki score of the liver grafts significantly improved when the rWIT was≤10 minutes(P<0.05).CONCLUSION The post-transplant outcomes were significantly better with a shorter rWIT(10 minutes or less)than with a longer rWIT,which could be a strategy for expanding the liver donor pool.

关键词： Extended criteria donor Recipient warm ischemia time Autologous orthotopic liver transplantation Near-infrared fluorescence imaging Outcome

What is the relationship between frailty and orthostatic hypotension in older adults?

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Journal of geriatric Cardiology 2019年第3期16卷 272-279页

作者： Suleyman Emre Kocyigit Pinar Soysal Esra Ates Bulut Ali Ekrem Aydin Ozge Dokuzlar Ahmet Turan Isik Unit for Aging Brain and Dementia Department of Geriatric MedicineFaculty of MedicineDokuz Eylul UniversityIzmirTurkey department of geriatric Medicine Bezmialem Vakif UniversityFaculty of MedicineIstanbulTurkey

Background Frailty and orthostatic hypotension (OH),which is common in older adults,is associated with morbidity and *** relationship between them remains *** aim of the study is to determine whether there is a relationship between frailty and *** A total of 496 patients who were admitted to the geriatric clinic and underwent comprehensive geriatric assessment were retrospectively *** a cross-sectional and observational study,OH was measured by the Head-up Tilt Table test at 1,3,and 5 min (respectively,OH1,OH3,and OH5) and the frailty was measured by the Fried’s frailty *** The mean age of all patients was 75.4 ± *** prevalence of females was 69.8%.When the frail people were compared with the pre-frail and the robust ones,the frailty was associated with *** was no relationship between the groups in terms of OH1 when the pre-frail group was compared with the robust ***3 were higher in the frail group than in the pre-frail group (P 0.05).Slowness and weakness were associated with OH1 (P < 0.05),whereas the other components of the Fried’s test were *** Frailty may be a risk factor for *** 1^st min measurements of OH should be routinely evaluated in frail older adults to prevent OH-related poor outcomes.

关键词： Frail Orthostatic hypotension Pre-frail Robust

Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate

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Journal of geriatric Cardiology 2017年第11期14卷 696-702页

作者： Xi WANG Fan WANG department of geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein （HDL）. Findings from a growing number of studies further indicate that sphingosine-l-phosphate （S1P） mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec- tion against atherosclerosis and ischemiaJreperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S 1 P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.

关键词： ApoM HDL-associated S1P Vascular function

Incidence,predictors and prognosis of acute kidney injury in acute ST-segment elevation myocardial infarction patients undergoing emergent coronary angiography/primary percutaneous coronary intervention

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Journal of geriatric Cardiology 2023年第2期20卷 139-149页

作者： Jing TAN Ying-Hua ZHANG Jin SI Ke-Ling XIAO Qi HUA Jing LI department of Cardiology Xuanwu HospitalCapital Medical UniversityBeijingChina department of geriatric Medicine Xuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Acute kidney injury(AKI) after coronary angiography(CAG) and primary percutaneous coronary intervention(PPCI) is frequently observed, and often interpreted as contrast induced-AKI. This study aimed to investigate the incidence, predictors and outcomes of AKI in acute ST-segment elevation myocardial infarction(STEMI) patients undergoing emergent CAG/PPCI using the control group of STEMI patients who were not exposed to contrast agents within the first 72 *** We performed a retrospective analysis of 1670 STEMI patients. Of them, 673 patients underwent emergent CAG/PPCI, and 997 patients treated with thrombolysis or no reperfusion therapy who were not exposed to contrast material during the first 72 h. AKI was defined as an increase of serum creatinine ≥ 44.2 mmol/L or ≥ 25% from baseline within 72 h. Patents were then followed up for the occurrence of all-cause mortality for 40 months(interquartile range: 24–55 months).RESULTS After propensity score matching, 505 pairs of patients were matched. Overall, the incidence of AKI was 27.4%, and AKI rates were not significantly different in patients with and without emergent CAG/PPCI procedure(27.5% vs. 27.3%, P = 0.944). Multivariate logistic regression analysis identified that the independent predictors of AKI were female, elevated interleukin-6 level,decreased lymphocyte count, left ventricular ejection fraction < 50% and use of diuretics in patients with emergent CAG/PPCI. Patients with AKI than those without AKI experienced higher incidence of acute heart failure with Killip class Ⅲ(9.4% vs. 3.3%, P =0.005;15.2% vs. 6.8%, P = 0.003, respectively) and mortality(5.8% vs. 1.4%, P = 0.014;12.3% vs. 4.6%, P = 0.002, respectively) in patients with and without emergent CAG/PPCI. Multivariate Cox regression analysis confirmed that AKI was independently associated with long-term mortality rate at 40 months follow-up in patients with and without emergent CAG/PPCI(HR = 1.867, 95% CI:1.086–3.210, P = 0.024;HR = 1.7

关键词： patients coronary infarction

Association of prealbumin with short-term and long-term outcomes in patients with acute ST-segment elevation myocardial infarction

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Journal of geriatric Cardiology 2024年第4期21卷 421-430页

作者： Jing TAN Jin SI Ke-Ling XIAO Ying-Hua ZHANG Qi HUA Jing LI department of Cardiology Xuanwu Hospital Capital Medical UniversityBeijingChina department of geriatric Medicine Xuanwu Hospital Capital Medical UniversityNational Clinical Research Center for Geriatric DiseasesBeijingChina

BACKGROUND Prealbumin is considered to be a useful indicator of nutritional status. Furthermore, it has been found to be associated with severities and prognosis of a range of diseases. However, limited data on the association of baseline prealbumin level with outcomes of patients with acute ST-segment elevation myocardial infarction(STEMI) are *** We analyzed 2313 patients admitted for acute STEMI between October 2013 and December 2020. In-hospital outcomes and mortality during the 49 months(interquartile range: 26–73 months) follow-up period were compared between patients with the low prealbumin level(< 170 mg/L) and those with the high prealbumin level(≥ 170 mg/L).RESULTS A total of 114 patients(4.9%) died during hospitalization. After propensity score matching, patients with the low prealbumin level than those with the high prealbumin level experienced higher incidences of heart failure with Killip class Ⅲ(9.9%vs. 4.4%, P = 0.034), cardiovascular death(8.4% vs. 3.4%, P = 0.035) and the composite of major adverse cardiovascular events(19.2%vs. 10.3%, P = 0.012). Multivariate logistic regression analysis identified that the low prealbumin level(< 170 mg/L) was an independent predictor of in-hospital major adverse cardiovascular events(odds ratio = 1.918, 95% CI: 1.250–2.942, P = 0.003). The cutoff value of prealbumin level for predicting in-hospital death was 170 mg/L(area under the curve = 0.703, 95% CI: 0.651–0.754, P< 0.001;sensitivity = 0.544, specificity = 0.794). However, after multivariate adjustment of possible confounders, baseline prealbumin level(170 mg/L) was no longer independently associated with 49-month cardiovascular death. After propensity score matching, Kaplan-Meier survival curves revealed consistent *** Decreased prealbumin level closely related to unfavorable short-term outcomes. However, after multivariate adjustment and controlling for baseline differences, baseline prealbumin level was not independently assoc

关键词： patients admitted infarction

Transforming Growth Factor-β1 Induces Transdifferentiation of Fibroblasts into Myofibroblasts in Hyp0Xic Pulmonary Vascular Remodeling

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Acta Biochimica et Biophysica Sinica 2006年第1期38卷 29-36页

作者： Yong-Liang JIANG Ai-Guo DAI Qi-Fang LI Rui-Cheng HU department of Respiratory Medicine,Hunan Institute of Gerontology,Hunan Province geriatric Hospital,Changsha 410001,China department of Respiratory Medicine Hunan Institute of Gerontology Hunan Province Geriatric Hospital Changsha 410001 China

The muscularization of non-muscular pulmonary arterioles is an important pathological featureof hypoxic pulmonary vascular ***,the origin of the cells involved in this process is stillnot well *** present study was undertaken to test the hypothesis that transforming growthfactor-β1 (TGF-β1) can induce transdifferentiation of fibroblasts into myofibroblasts,which might play akey role in the muscularization of non-muscular pulmonary *** was found that mean pulmonaryarterial pressure increased significantly after 7 d of *** artery remodeling index and rightventricular hypertrophy became evident after 14 d of *** distribution of nonmuscular,partiallymuscular,and muscular vessels was significantly different after 7 d of *** demonstrated that the expression of co-smooth muscle actin was increased in intra-acinar pulmonaryarteries with increasing hypoxic ***-β1 mRNA expression in pulmonary arterial walls was increasedsignificantly after 14 d of hypoxia,but showed no obvious changes after 3 or 7 d of *** pulmonarytunica adventitia and tunica media,TGF-β1 protein staining was poorly positive in control rats,but wasmarkedly enhanced after 3 d of hypoxia,reaching its peak after 7 d Of *** myofibroblast phenotypewas confirmed by electron microscopy,which revealed microfilaments and a well-developed rough endo-plasmic *** together,our results suggested that TGF-β1 induces transdifferentiation of fibro-blasts into myofibroblasts,which is important in hypoxic pulmonary vascular remodeling.

关键词： transforming growth factor-β1 fibroblast myofibroblast hypertension lung

Silencing of Bcl-2 gene expression by siRNA transfection in- hibits the protective effect of fluvastatin against cell apoptosis in human aortic endothelial cells

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Journal of geriatric Cardiology 2008年第1期5卷 33-38页

作者： Wenwen Zhong Yang Liu Jian Li Hui Tian department of geriatric Endocrinology Chinese PLA General HospitalBeijing 100853China Department of Geriatric EndocrinologyChinese PLA General HospitalBeijing 100853China Department of Geriatric EndocrinologyChinese PLA General HospitalBeijing 100853China Department of Geriatric EndocrinologyChinese PLA General HospitalBeijing 100853China

Objective To study the protective effect of fluvastatin,one of the HMG-CoA reductase inhibitors (statins),against oxygen radical-induced oxidative damages in human aortic endothelial cell,and the role of Bcl-2 in this *** Human aortic endothelial cells with or without Bcl-2 siRNA transfection were subjected to 1-100 nM of fluvastatin and 100 la hydrogen peroxide for 24 ***-2 mRNA and protein expression were measured by Taqman quantitative PCR and Western *** apoptosis was measured by normal and fluorescent microscopy and Cell Death Detection *** In the Bcl-2-expressed cells,fluvastatin significantly reversed hydrogen peroxide-induced microscopic apoptosis and apoptotic DNA fragmentation,which were accompanied by a markedly upregulation of Bcl-2 expression by ***,the endothelial protection by fluvastatin was completely lost in Bcl-2 siRNA transfected *** Fluvastatin protects human endothelial cells against oxygen radical-induced cell apoptosis in vitro,and this protection seemed to be mediated in a Bcl-2 dependent pathway.(J Geriatr Cardil 12008;5:33-38)

关键词： fluvastatin,Bcl-2,gene silencing,apoptosis

Interaction between systemic iron parameters and left ventricular structure and function in the preserved ejection fraction population:a two-sample bidirectional Mendelian randomization study

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Journal of geriatric Cardiology 2024年第1期21卷 64-80页

作者： Xiong-Bin MA Yong-Ming LIU Yan-Lin LV Lin QIAN The First Clinical Medical College of Lanzhou University LanzhouGansuChina geriatric Cardiovascular department and Gansu Clinical Research Center for geriatric Diseases First Hospital of Lanzhou UniversityGansuChina

BACKGROUND Left ventricular(LV)remodeling and diastolic function in people with heart failure(HF)are correlated with iron status;however,the causality is *** Mendelian randomization(MR)study investigated the bidirectional causal relationship between systemic iron parameters and LV structure and function in a preserved ejection fraction *** Transferrin saturation(TSAT),total iron binding capacity(TIBC),and serum iron and ferritin levels were extracted as instrumental variables for iron parameters from meta-analyses of public genome-wide association *** without myocardial infarction history,HF,or LV ejection fraction(LVEF)<50%(n=16,923)in the UK Biobank Cardiovascular Magnetic Resonance Imaging Study constituted the outcome *** dataset included LV end-diastolic volume,LV endsystolic volume,LV mass(LVM),and LVM-to-end-diastolic volume ratio(LVMVR).We used a two-sample bidirectional MR study with inverse variance weighting(IVW)as the primary analysis method and estimation methods using different algorithms to improve the robustness of the *** In the IVW analysis,one standard deviation(SD)increased in TSAT significantly correlated with decreased LVMVR(β=-0.1365;95%confidence interval[CI]:-0.2092 to-0.0638;P=0.0002)after Bonferroni ***,no significant relationships were observed between other iron and LV *** Bonferroni correction,reverse MR analysis showed that one SD increase in LVEF significantly correlated with decreased TSAT(β=-0.0699;95%CI:-0.1087 to-0.0311;P=0.0004).No heterogeneity or pleiotropic effects evidence was observed in the *** We demonstrated a causal relationship between TSAT and LV remodeling and function in a preserved ejection fraction population.

关键词： fraction function parameters