Vascular protection by high-density lipoprotein-associated sphingosine-1- phosphate

作     者：Xi WANG Fan WANG 

作者机构：Department of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2017年第14卷第11期

页      面：696-702页

核心收录：

学科分类：0710[理学-生物学] 071010[理学-生物化学与分子生物学] 081702[工学-化学工艺] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 

基　　金：国家自然科学基金 the Open Project Program of the State Key Laboratory of Proteomics (Academy of Military Medical Sciences 

主　　题：ApoM HDL-associated S1P Vascular function 

摘      要：Epidemiological studies and animal experiments have consistently demonstrated cardiovascular protection by high-density lipoprotein （HDL）. Findings from a growing number of studies further indicate that sphingosine-l-phosphate （S1P） mediates many of the beneficial effects of HDL on the cardiovascular system, including vasodilatation, angiogenesis, maintenance of endothelial barrier function, and protec- tion against atherosclerosis and ischemiaJreperfusion injury. In this review, we summarize the most recent literature investigating the effects of HDL-S 1 P on cardiovascular health and highlight potential opportunities for clinical translation of these findings.