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World Journal of Emergency Medicine 2024年第1期15卷 52-55页

作者： Miao Bian Zhihao Wang Yanling Chen Yue Sun Hongsen Ji Yutao Wang Li Pang department of Respiratory Qianwei Hospital of Jilin ProvinceChangchun 130012China department of geriatrics Jilin Provincial Geriatric Medicine Clinical Research Centerthe First Hospital of Jilin UniversityChangchun 130021China department of Emergency the First Hospital of Jilin UniversityChangchun 130021China The First Operating Room the First Hospital of Jilin UniversityChangchun 130021China

Sepsis is a lethal condition characterized by multiple organ dysfunction due to disrupted host responses to severe infections.[1]Aff ected patients often have a Sequential Organ Failure Assessment(SOFA)score≥2.[2]Patients with a SOFA score<2 and at least one of the following were considered as“suspected sepsis”:(1)quick SOFA(qSOFA)score≥2;(2)SOFA score=1;or(3)National Early Warning Score(NEWS)4-6.[3]Compared with studies on fluid resuscitation in sepsis patients,there are few studies on fluid management in patients with suspected ***,we conducted a retrospective cohort study to evaluate the relationship between fluid management and disease progression in suspected sepsis patients.

关键词： patients sepsis admitted

Optimization of colorectal cancer screening strategies: New insights

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World Journal of Gastroenterology 2024年第28期30卷 3361-3366页

作者： Magie Tamraz Najib Al Ghossaini Sally Temraz department of Nutrition and Public Health Holy Spirit University of KaslikJounieh 446Lebanon department of Internal Medicine Ain Wazein Medical VillageChouf 1503Lebanon department of Internal Medicine Division of Hematology/OncologyAmerican University of Beirut Medical CenterBeirut 11072020Lebanon

In this editorial,we discuss the article by Agatsuma et *** concentrate specifically on the current routinely used screening tests recommended by society guidelines and delve into the significance of early diagnosis of colorectal cancer(CRC)and its substantial impact on both incidence and mortality *** is highly recommended,and an early diagnosis stands out as the most crucial predictor of survival for CRC ***,it is essential to identify and address the barriers hindering adherence to screening measures,as these barriers can vary among different ***,we focus on screening strategy optimization by selecting high-risk *** with comorbidities who regularly visit hospitals have been diagnosed at an early stage,showing no significant difference compared to patients undergoing regular *** finding highlights the importance of extending screening measures to include patients with comorbidities who do not routinely visit the hospital.

关键词： Colorectal neoplasms Early diagnosis Barriers to adherence Cancer screening guidelines Screening tests

Evaluating the influence of a structured nursing protocol on targeted outcomes in rheumatoid arthritis patients

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Journal of Integrative Nursing 2024年第1期6卷 22-28页

作者： Mohammed Elsayed ZAKY Shimaa Magdi FARGHALY Osama Mohamed Elsayed RAMADAN Rehab M.ABDELKADER Mostafa SHABAN department of Medical Surgical Nursing Faculty of Nursing Cairo UniversityCairoEgypt department of Medical Surgical Nursing College of NursingJouf UniversitySakakaAljawfSaudi Arabia Faculty of Nursing Cairo University CairoEgypt department of geriatric Nursing Faculty of Nursing Cairo UniversityCairoEgypt

Objective:Rheumatoid arthritis(RA)requires comprehensive *** nursing protocols may enhance outcomes,but evidence is *** study evaluated the effect of a structured nursing protocol on RA *** and Methods:In this one-group pre-post study,30 Egyptian RA patients completed assessments before and after a 12-week nursing protocol comprising education,psychosocial support,and self-management *** included clinical evaluation of joint counts,erythrocyte sedimentation rate(ESR),and C-reactive protein(CRP)and patient-reported Arthritis Self-Efficacy Scale(ASES),Health Assessment Questionnaire(HAQ),Visual Analog Scale(VAS)for pain,and Hospital Anxiety and Depression Scale(HADS).Results:The study demonstrated significant improvements in both clinical-and patient-reported *** count decreased from 18.4±4.2 to 14.2±3.8(P<0.001),ESR from 30.1±6.8 mm/h to 25.5±6.8 mm/h(P<0.01),and CRP levels from 15.2±3.6 mg/L to 11.8±2.9 mg/L(P<0.01)***-reported outcomes showed a marked increase in ASES score from 140±25 to 170±30(P<0.001)and reductions in HAQ from 1.6±0.4 to 1.3±0.3(P<0.01),VAS pain score from 7.8±1.7 to 6.2±1.2(P<0.001),and HADS anxiety and depression scores from 11±3 to 8±2(P<0.05)and 10±2 to 7±1(P<0.05),***:A structured nursing protocol significantly improved clinical disease activity,physical functioning,pain,self-efficacy,and emotional well-being in RA patients.A multifaceted nursing intervention appears beneficial for optimizing RA outcomes.

关键词： Nursing care patient education quality of life rheumatoid arthritis self‑management

Successful treatment of Purpureocillium lilacinum pulmonary infection with isavuconazole: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1772-1777页

作者： Xue-Lin Yang Jun-Yu Zhang Jian-Min Ren department of Emergency Medicine Lishui Central HospitalLishui 323000Zhejiang ProvinceChina department of hematology Lishui Central HospitalLishui 323000Zhejiang ProvinceChina department of Clinical Laboratory The Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND Purpureocillium lilacinum(***)is a saprophytic fungus widespread in soil and *** a causative agent,it is very rarely detected in humans,most commonly in the *** SUMMARY In this article,we reported the case of a 72-year-old patient with chronic lymphocytic leukemia who was admitted with cough and *** tomography revealed an infection in the right lower *** lavage fluid culture and metagenomic next-generation sequencing were ultimately confirmed to have a pulmonary infection with *** was eventually discharged with good outcomes after treatment with *** Pulmonary infection with *** was exceedingly *** currently there are no definitive therapeutic agents,there are reports of high resistance to amphotericin B and fluconazole and good sensitivity to second-generation *** present report is the first known use of isavuconazole for pulmonary *** *** provides new evidence for the characterization and treatment of clinical *** lung infections.

关键词： Purpureocillium lilacinum Pulmonary infection Isavuconazole Case report

Seizure as the main presenting manifestation of three patients with acute glufosinate-ammonium poisoning

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期25卷 354-358页

作者： Ping WANG Congying SONG Xuan LU Yuanqiang LU department of Emergency Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 3100030 China Zhejiang Key Laboratory for Diagnosis and Treatment of Physic chemical and Aging related Injuries Hangzhou 310003China department of geriatric Medicine the First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China

Glufosinate-ammonium herbicides are the most widely used broad-spectrum,non-selective herbicides in the ***-ammonium is a structural analogue of glutamate(Glu)which can irreversibly inhibit the activity of glutamine synthetase(GS)and Glu decarboxylase in plants,thereby blocking the synthesis of glutamine(Gln)from Glu and ammonia(Hoerlein,1994).This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of *** humans,the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity(Watanabe and Sano,1998).

关键词： ammonium ammonia thereby

Identification of tumor-suppressor genes in lung squamous cell carcinoma through integrated bioinformatics analyses

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Oncology Research 2024年第1期32卷 187-197页

作者： HENG LI YOUMING LEI GAOFENG LI YUNCHAO HUANG The 2nd department of Thoracic Surgery The Third Affiliated Hospital of Kunming Medical UniversityYunnan Tumor HospitalKunming650118China The 1st department of Thoracic Surgery The Third Affiliated Hospital of Kunming Medical UniversityYunnan Tumor HospitalKunming650118China department of geriatric Thoracic Surgery The First Affiliated Hospital of Kunming Medical UniversityKunming650032China

Lung cancer is a prevalent malignancy,and fatalities of the disease exceed 400,000 cases *** squamous cell carcinoma(LUSC)has been recognized as the most common pathological form of lung *** comprehensive understanding of molecular features related to LUSC progression has great significance in LUSC prognosis assessment and clinical *** this study,we aim to identify a panel of signature genes closely associated with LUSC,which can provide novel insights into the progression of *** expression profiles were retrieved from public resources including gene expression omnibus(GEO)and the cancer genome atlas(TCGA)*** expressed genes(DEGs)between LUSC specimens and normal lung tissues were identified by bioinformatics analyses.A total of 66 DEGs were identified based on two cohorts of *** plugin of Cytoscape software was utilized for the further analyses of the top 10 candidate hub genes including OGN,ABI3BP,MAMDC2,FGF7,FAM107A,SPARCL1,DCN,COL14A1,and MFAP4 and CHRDL1,which showed significant downregulation in *** LUSC cell lines were used to validate the functions of CHRDL1 and FAM107A through overexpression ***,our data revealed novel candidate tumor-suppressor genes in LUSC,suggesting previously unappreciated mechanisms in the progression of LUSC.

关键词： LUSC DEGs WGCNA PPI network Tumor-suppressor

Simple procedure for assessing diffuse subarachnoid hemorrhage successfully created using filament perforation method in mice

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Animal Models and Experimental Medicine 2024年第1期7卷 77-81页

作者： Tatsushi Mutoh Ryota Tochinai Hiroaki Aono Masayoshi Kuwahara Yasuyuki Taki Tatsuya Ishikawa department of Surgical Neurology Research Institute for Brain and Blood VesselsAkita Cerebrospinal and Cardiovascular CenterAkitaJapan department of Aging Research and geriatric Medicine Institute of DevelopmentAging and CancerTohoku UniversitySendaiJapan department of Veterinary Pathophysiology and Animal Health Graduate School of Agriculture and Life SciencesThe University of TokyoTokyoJapan

The murine model of subarachnoid hemorrhage(SAH)is a valuable experimental tool for investigating molecular and cellular mechanisms,and the endovascular filament perforation technique can be used to simulate prominent pathophysiological features observed after human SAH;however,current validation methods for assessing an appropriate SAH model are ***,we introduce a simple procedure for se-lecting a mouse model of diffuse *** was induced in 24 mice using a standard filament perforation *** confirming survival at 24 h,SAH was scored 0-1 based on T2*-weighted images on whole-brain magnetic resonance imaging(MRI)and visual surveillance of the cisterna magna(CM)through the dura *** CM-based SAH grading correlated well with a reference parameter defined by extracted brain(r^(2)=0.53,p<0.0001).The receiver operating characteristic curve revealed a sensi-tivity of 85%and a specificity of 91%for detecting diffuse SAH,with a similar area under the curve(0.89±0.06[standard error of the mean])as the MRI-based grading(0.72±0.10,p=0.12).Our data suggest that confirming an SAH clot in the CM is a valuable way to select a clinically relevant diffuse SAH model that can be used in future experimental studies.

关键词： cisterna magna clot distribution filament perforation mouse model subarachnoid hemorrhage

SOX11 as a potential prognostic biomarker in hepatocellular carcinoma linked to immune infiltration and ferroptosis

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Chinese Journal of Cancer Research 2024年第4期36卷 378-397页

作者： Hongyu Chen Qiangguo Ao Yueling Wang Yue Qian Qingli Cheng Wei Zhang department of Nephrology the Second Medical Center of PLA General HospitalNational Clinical Research Center for Geriatric DiseasesBeijing 100853China Clinical Laboratory the First Affiliated Hospital of Henan UniversityKaifeng 475000China Cell Biology department Wuxi School of MedicineJiangnan UniversityWuxi 214122China department of Pathogen Biology Guizhou Nursing Vocational CollegeGuiyang 550000China

Objective:SOX11 is expressed in numerous malignancies,including hepatocellular carcinomas(HCC),but its oncogenic function has not been ***,we performed a comprehensive bioinformatics analysis of the Liver Hepatocellular Carcinoma(LIHC)dataset to investigate the function of SOX11 in ***:SOX11 expression data from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)were validated by immunohistochemistry(IHC).Co-expression,differential expression,and functional analyses utilized TCGA-LIHC,Timer 2.0,Metascape,GTEx,and LinkedOmics *** with immune infiltration,ferroptosis,and immune checkpoint genes were *** changes were explored via *** regression,receiver operating characteristic curve(ROC),Kaplan-Meier analysis,and nomogram modeling evaluated associations with HCC clinicopathological ***11’s impact on proliferation and migration was studied in HepG2 and HuH7 cell ***:SOX11 was significantly elevated in HCC tumors compared to ***11-associated genes exhibited differential expression in pathways involving extracellular membrane ion *** associations were found between SOX11 levels,immune infiltration,ferroptosis,and immune checkpoint genes in HCC ***11 levels correlated with HCC stage,histologic grade,and tumor status,and independently predicted overall and disease-specific ***11 expression effectively distinguished between tumor and normal liver *** correlations highlighted a significant relationship between SOX11 and ferroptosis-associated *** SOX11 levels in HepG2 and HuH7 cells resulted in reduced proliferation and ***:SOX11 was found to represent a promising biomarker within HCC diagnosis and prognosis together with being a possible drug-target.

关键词： SOX11 biomarker HCC prognosis genetic alterations tumor-immune infiltration ferroptosis

Not to be and how not to be:the questions of Tregs controlled by RIPK1

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Cellular & Molecular Immunology 2024年第2期21卷 205-206页

作者： Zhengcai Peng Huiyuan Zhang Hongbo Hu Center for Immunology and hematology Department of Biotherapy and Cancer Center and State Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu610041China Chongqing International Institute for Immunology Chongqing401338China

Millions of cells undergo daily cell death,a process essential for maintaining physiological homeostasis and *** forms of cell death,such as apoptosis,necroptosis,ferroptosis and pyroptosis,have been extensively studied for their distinct biological functions[1,2].Generally,programmed cell death,like apoptosis,is considered physiological and results in little to no inflammatory response.

关键词： death homeostasis pathogenesis

EBV-associated lymphoproliferative disease post-CAR-T cell therapy

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Frontiers of Medicine 2024年第2期18卷 394-398页

作者： Shiyuan Zhang Xiaoxi Zhou Shangkun Zhang Na Wang Tongcun Zhang Donghua Zhang Qilin Ao Yang Cao Liang Huang department of hematology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Immunotherapy Research Center for Hematologic Diseases of Hubei Province Wuhan430030China Institute of Biology and Medicine College of Life and Health SciencesWuhan University of Science and TechnologyWuhan430081China department of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China State Key Laboratory of Experimental hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Tianjin Institutes of Health Science Tianjin301600China

Epstein–Barr virus(EBV)-associated lymphoproliferative diseases(EBV-LPDs)are common complications that occur after solid organ transplantation or allogeneic hematopoietic stem-cell transplantation(HSCT).However,their occurrence and treatment post-chimeric antigen receptor-modified T(CAR-T)cell therapy has not been *** patients had been diagnosed with EBV-positive aggressive B-cell lymphoma and experienced relapses after multiple lines of *** receiving CAR-T cell therapy in tandem with autologous HSCT,the patients achieved complete ***,with a median time of 38.5 months after CAR-T cell therapy,B-cell-derived EBV-LPDs were diagnosed,and they were relieved through the administration of immune checkpoint inhibitor or B-cell-depleting ***,our report suggests that EBV-LPDs may represent a long-term adverse event after CAR-T cell therapy,especially in patients who previously had EBV-positive disorders,and they can be resolved by immune normalization strategy or B-cell depleting therapy.

关键词： EBV-associated lymphoproliferative disease chimeric antigen receptor T-cell autologous stem cell transplantation immune checkpoint inhibitor