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Journal of Integrative Agriculture 2024年第6期23卷 2144-2148页

作者： Yanjing Liu Qingqing Yu Xiangyu Zhou Wenxin Li Xinwen He Yan Wang Guohua Deng Jianzhong Shi Guobin Tian Xianying Zeng Hualan Chen College of Veterinary Medicine Gansu Agricultural UniversityLanzhou 730070China State Key Laboratory for Animal disease control and prevention Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry DiseasesMinistry of Agriculture and Rural Affairs/Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China National Poultry Laboratory Animal Resource center Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150009China Harbin Weike Biotechnology Co. Ltd.Harbin 150009China

H9N2 virus has been widely distributed in wild birds and poultry around the world since its first emergence in the United States of America in 1966(Gu et al.2017;Carnaccini and Perez 2020).The virus appeared in chickens in China in the early 1990s,and over the last two decades has gradually become the dominant epidemic subtype(Sun and Liu 2015;Bi et al.2020).Although H9N2 virus infection alone cannot cause severe disease or death in poultry,H9N2 virus-infected birds experience a degree of egg production drop and can be easily infected by other pathogens,thus causing economic losses for poultry industry.

关键词： H9N2 poultry policy

Progressing our knowledge of enterovirus:Epidemiology,diagnosis,prevention,control,and beyond

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Biosafety and Health 2024年第1期6卷 3-4页

作者： Jing Lu Zexin Tao Yong Zhang Guangdong provincial Institution of Public Health Guangdong Provincial Center for Disease Control and PreventionGuangzhou 511430China Shandong center for disease control and prevention Jinan 250014China National Key Laboratory of Inteigent Tracking and Forecasting for Infectious diseases(NITFID) National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China National Polio Laboratory WHO WPRO Regional Polio Reference LaboratoryNational Health Commission Key Laboratory for BiosafetyNational Health Commssion Key Laboratory for Medical VirologyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

We are thrilled to present this dedicated issue spotlighting enterovirus infections and health in Biosafety and *** articles presented in this issue span the broad spectrum of current research in this vital field,providing insights into the epidemiology,diagnostic procedures,and pathogenesis of enterovirus ***,a genus of RNA viruses encompassing polioviruses,coxsackieviruses,and echoviruses,play a crucial role in public health.

关键词： prevention diagnosis epidemiology

Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

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World Journal of Pediatrics 2024年第1期20卷 92-96页

作者： Wei Li Bing-Han Wang Bao-Hai Chen Yi Sun Lin Li Wen-Qing Xiang Ahmed Faisal Ali Lin-Xuan Su Hai-Yan Mao Hong-Qiang Shen Qiang Shu Department of Clinical Laboratory Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Department of Information center Children's HospitalZhejiang University School of MedicineHangzhouChina Zhejiang provincial center for disease control and prevention HangzhouChina Department of Thoracic&Cardiovascular Surgery Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina

Since the outbreak of coronavirus disease 2019(COVID-19),the entire world has been affected by the epidemic[1,2].On November 9,2021,a variant of the novel coronavirus B.1.1.529 was detected for the first time from case samples in South *** Omicron strain spread and mutated significantly *** variant has the characteristics of escape immunity,which can induce relatively extreme disease and reduce the neutralization of antibodies in vaccinators,and is more likely to be reinfected[3,4].The clinical presentation of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)in children has mild symptoms and a lower risk of hospitalization and death.

关键词： respiratory immunity acute

An SEIHR model with age group and social contact for analysis of Fuzhou COVID-19 large wave

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Infectious disease Modelling 2024年第3期9卷 728-743页

作者： Xiaomin Lan Guangmin Chen Ruiyang Zhou Kuicheng Zheng Shaojian Cai Fengying Wei Zhen Jin Xuerong Mao School of Mathematics and Statistics Fuzhou UniversityFuzhou350116FujianChina Fujian provincial center for disease control and prevention Fuzhou350012FujianChina center for Applied Mathematics of Fujian Province Fuzhou350116FujianChina Key Laboratory of Operations Research and control of Universities in Fujian Fuzhou UniversityFuzhou350116FujianChina Complex Models Research center Shanxi UniversityTaiyuan030006ShanxiChina Department of Mathematics and Statistics University of StrathclydeGlasgowG11XHUK

The main epidemiological features such as basic reproduction number,effective reproduction number and sensitivity analysis were extensively discussed for multi-age groups SEIHR model in this ***,by using of the next generation matrix method,basic reproduction number R0 of the total population was estimated as 1.57 using parameter values of four age groups of Fuzhou COVID-19 large *** age group k,the values of R_(0k)(age group k to age group k),the values of R_(o)^(k)(an infected of age group k to the total population)and the values of R_(o)^(k)>R_(0k)>R_(o)^(k)(an infected of the total population to age group k)were also estimated,in which the explorations of the impacts of age groups revealed that the relationship was ***,the fluctuating tendencies of effective reproduction number Rt were demonstrated by using two approaches(the surveillance data and the SEIHR model)for Fuzhou COVID-19 large wave,during which high-risk group(G4 group)mainly contributed the infection scale due to high susceptibility to infection and high risks to basic ***,the sensitivity analysis using two approaches(the sensitivity index and the PRCC values)revealed that susceptibility to infection of age groups played the vital roles,while the numerical simulation showed that infection scale varied with the changes of social contacts of age *** results of this study claimed that the high-risk group out of the total population was concerned by the local government with the highest susceptibility to infection against *** This study verified that the partition structure of age groups of the total population,the susceptibility to infection of age groups,the social contacts among age groups were the important contributors of infection *** less social contacts and adequate hospital beds for high-risk group were profitable to control the spread of *** avoid the emergence of medical runs against new variant in the future,the polic

关键词： COVID-19 model Age group Omicron BA.5.2 variant Contact matrixSocial contact

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin Wang Qian Liu Hai-tao Yu Jia-zhao Xie Jun-ning Zhao Zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-Zhi Wang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine Department of Liyuan Hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is *** this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s *** investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate *** resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in *** AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like ***,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

Viromes of Haemaphysalis longicornis reveal different viral abundance and diversity in free and engorged ticks

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Virologica Sinica 2024年第2期39卷 194-204页

作者： Jian Xiao Xuan Yao Xuhua Guan Jinfeng Xiong Yaohui Fang Jingyuan Zhang You Zhang Abulimiti Moming Zhengyuan Su Jiayin Jin Yingying Ge Jun Wang Zhaojun Fan Shuang Tang Shu Shen Fei Deng Key Laboratory of Virology and Biosafety and National Virus Resource center Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Hubei provincial center for disease control and prevention Wuhan430070China University of Chinese Academy of Sciences Beijing101408China Hubei Jiangxia Laboratory Wuhan430200China Xinjiang Key Laboratory of Vector-borne Infectious diseases Urumqi830002China Current address:Department of Medical Laboratory The Second Affiliated HospitalHainan Medical UniversityHaikou57000China

Haemaphysalis longicornis ticks,commonly found in East Asia,can transmit various pathogenic viruses,includingthe severe fever with thrombocytopenia syndrome virus(SFTSV)that has caused febrile diseases among humansin Hubei ***,understanding of the viromes of *** was limited,and the prevalence ofviruses among *** ticks in Hubei was not well *** study investigates the viromes of bothengorged(fed)and free(unfed)*** ticks across three mountainous regions in Hubei Province from 2019to ***-sequencing analysis identified viral sequences that were related to 39 reference viruses belonging tounclassified viruses and seven RNA viral families,namely Chuviridae,Nairoviridae,Orthomyxoviridae,Parvoviridae,Phenuiviridae,Rhabdoviridae,and *** abundance and diversity in these ticks were analysed,andphylogenetic characteristics of the Henan tick virus(HNTV),Dabieshan tick virus(DBSTV),Okutama tick virus(OKTV),and Jingmen tick virus(JMTV)were elucidated based on their full genomic *** demonstrated that DBSTV was the most common virus found in individual *** ticks(12.59%),followed by HNTV(0.35%),whereas JMTV and OKTV were not *** results improve our understanding of *** tick viromes in central China and highlight the role of tick feeding status and geographyin shaping the viral *** findings of new viral strains and their potential impact on public health raisethe need to strengthen surveillance efforts for comprehensively assessing their spillover potentials.

关键词： Ticks Virome Haemaphysalis longicornis Phylogenetic analysis Viral abundance and diversity

Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave:a single-center cohort study

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第6期25卷 529-540页

作者： Duo LV Xishao XIE Qinyun YANG Zhimin CHEN Guangjun LIU Wenhan PENG Rending WANG Hongfeng HUANG Jianghua CHEN Jianyong WU Department of Clinical Pharmacy the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Zhejiang provincial Key Laboratory for Drug Evaluation and Clinical Research Hangzhou 310003China Kidney disease center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory of Kidney disease prevention and control Technology Zhejiang ProvinceHangzhou 310003China Institute of Nephrology Zhejiang UniversityHangzhou 310003China Zhejiang Clinical Research center of Kidney and Urinary System disease Hangzhou 310003China The Third Grade Laboratory under the National State Administration of Traditional Chinese MedicineHangzhou 310003China Information center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background:Following the short-term outbreak of coronavirus disease 2019(COVID-19)in December 2022 in China,clinical data on kidney transplant recipients(KTRs)with COVID-19 are ***:We conducted a single-center retrospective study to describe the clinical features,complications,and mortality rates of hospitalized KTRs infected with COVID-19 between Dec.16,2022 and Jan.31,*** patients were followed up until Mar.31,***:A total of 324 KTRs with COVID-19 were *** median age was 49 *** median time between the onset of symptoms and admission was 13 ***,azvudine,and nirmatrelvir/ritonavir were administered to 67(20.7%),11(3.4%),and 148(45.7%)patients,***-nine(9.0%)patients were treated with more than one antiviral ***-eight(14.8%)patients were treated with tocilizumab and 53(16.4%)patients received baricitinib *** acute kidney injury(AKI)occurred in 81(25.0%)patients and 39(12.0%)patients were admitted to intensive care *** infections were observed in 55(17.0%)***(15.4%)patients lost their *** 28-d mortality rate of patients was 9.0%and 42(13.0%)patients died by the end of *** Cox regression analysis identified that cerebrovascular disease,AKI incidence,interleukin(IL)-6 level of>6.8 pg/mL,daily dose of corticosteroids of>50 mg,and fungal infection were all associated with an increased risk of death for hospitalized ***:Our findings demonstrate that hospitalized KTRs with COVID-19 are at high risk of *** administration of immunomodulators or the late application of antiviral drugs does not improve patient survival,while higher doses of corticosteroids may increase the death risk.

关键词： Coronavirus disease 2019(COVID-19) Kidney transplant Hospitalization Mortality

Analysis of Lavandulyl Flavonoids from Sophora flavescens with Antiinflammatory Activity Based on Molecular Network Technology

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Medicinal Plant 2024年第2期15卷 1-5,14页

作者： Yan LIN Bo TU Shanggao LIAO Minghui HE Guizhou provincial Higher Education Institutions Genuine Medicinal Materials Chronic disease prevention and control Engineering Research center College of PharmacyGuizhou Medical UniversityGuiyang 550025China

[Objectives]This study was conducted to screen lavandulyl flavonoids with anti-inflammatory activity from Sophora flavescens.[Methods]35 compounds were screened from traditional Chinese medicine *** using the nitric oxide(NO)anti-inflammatory activity model.[Results]Five components,8(xanthohumol),13(kurarinol),27(4-methoxysalicylic acid),28(b-resorcic acid)and 30(b-resorcic acid),exhibited significant anti-inflammatory activity,with IC 50 values of 5.99,4.76,6.96,3.41 and 5.22μM,***,8(xanthohumol)and 13(kurarinol)were typical lavandulyl flavonoids in ***,which were worth further ***,UPLC-Q-Exactive and GNPS molecular networking technique were used for rapid analysis of lavandulyl flavonoids from ***.A total of 15 components were identified.[Conclusions]This work lays a theoretical foundation for further separation and analysis of lavandulyl flavonoids with anti-inflammatory activity from ***.

关键词： Sophora flavescens Molecular network Anti-inflammatory activity Lavandulyl flavonoids

Treatment of lumbar disc herniation with robot combined with unilateral biportal endoscopic technology:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3235-3242页

作者： Yan-Dong Liu Duo-Fang Xu Qiang Deng Yan-Jun Zhang Tie-Feng Guo Ran-Dong Peng Jun-Jie Li Graduate School Gansu University of Traditional Chinese MedicineLanzhou 730030Gansu ProvinceChina Spinal disease Treatment center Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina Department of Spinal Orthopedics II Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina Department of Osteomyelitis Gansu Provincial Hospital of Traditional Chinese MedicineLanzhou 730050Gansu ProvinceChina

BACKGROUND This reported procedure combines the orthopedic surgical robot with the unilateral biportal endoscopy-lumbar interbody fusion(UBE-LIF),utilizing the UBE's wide viewing field and operating space to perform minimally invasive decompressive fusion of the lesioned segment,and the orthopedic surgical robot's intelligence and precision to perform percutaneous pedicle screw *** advancement of this procedure lies in the superposition of advantages and offsetting disadvantages of the two new technologies,and the maximum effect of treatment is achieved with maximum minimization of invasiveness and precision under the monitoring of imaging instruments to maximize the benefit of patients,and this review reports a case of multiple-segment lumbar decompression and fusion surgery for lumbar disc herniation via robot-assisted UBE for *** SUMMARY A 44-year-old patient presented to our *** various clinical data,we diagnosed the patient with lumbar disc herniation with radiculopathy,lumbar spondylolisthesis,and lumbar spinal *** developed a surgical plan of"UBE decompression+UBE-LIF+orthopedic surgery robot-assisted percutaneous pedicle screw implantation for internal fixation".The results were *** We present an extremely rare case of multiple-segment lumbar decompression and fusion surgery for lumbar disc herniation via robot-assisted UBE and achieved good ***,the technique is worthy of clinical promotion.

关键词： Orthopedic robot Unilateral biportal endoscopy Unilateral biportal endoscopic lumbar interbody fusion Lumbar disc herniation Decompression fusion Case report

Update understanding on diagnosis and histopathological examination of atrophic gastritis:A review

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4080-4091页

作者： Xiu-Zhen Ma Ni Zhou Xiu Luo Si-Qi Guo Ping Mai The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Gansu Provincial People's HospitalLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Xi'an International Medical CenterXi’an 710000Shaanxi ProvinceChina The First School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Chronic atrophic gastritis(CAG)is a complex syndrome in which long-term chronic inflammatory stimulation causes gland atrophy in the gastric mucosa,reducing the stomach's ability to secrete gastric juice and pepsin,and interfering with its normal physiological *** pathogenic factors contribute to CAG incidence,the most common being Helicobacter pylori infection and the immune reactions resulting from gastric ***,CAG has a broad spectrum of clinical manifestations,including gastroenterology and extraintestinal symptoms and signs,such as hematology,neurology,and ***,the initial CAG evaluation should involve the examination of clinical and serological indicators,as well as diagnosis confirmation via gastroscopy and histopathology if *** on the severity and scope of atrophy affecting the gastric mucosa,a histologic staging system(Operative Link for Gastritis Assessment or Operative Link on Gastritis intestinal metaplasia)could also be ***,chronic gastritis has a higher risk of progressing to gastric cancer(GC).In this regard,early diagnosis,treatment,and regular testing could reduce the risk of GC in CAG ***,the optimal interval for endoscopic monitoring in CAG patients remains uncertain,and it should ideally be tailored based on individual risk evaluations and shared decision-making *** there have been many reports on CAG,the precise etiology and histopathological features of the disease,as well as the diagnosis of CAG patients,are yet to be fully ***,this review offers a detailed account of CAG,including its key clinical aspects,aiming to enhance the overall understanding of the disease.

关键词： Atrophic gastritis Helicobacter pylori infection Autoimmune gastritis Diagnosis Operative link for gastritis assessment staging Gastric cancer risk