检索结果-南通市图书馆

Novel insights on oral squamous cell carcinoma management using long non-coding RNAs

Oncology Research 2024年第10期32卷 1589-1612页

作者： SUBHAYAN SUR dIMPLE dAVRAY SOUMYA BASU SUPRIYA KHEUR JAYANTA KUMAR PAL SHUCHI NAGAR AVINASH SANAP BHIMAPPA MRUdAGI SAMIR GUPTA Cancer and Translational Research Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethTathawadePune411033India Bioinformatics Centre Dr.D.Y.Patil Biotechnology and Bioinformatics InstituteDr.D.Y.Patil VidyapeethPune411033India department of Oral Pathology and Microbiology Dr.D.Y.Patil Dental College&HospitalDr.D.Y.Patil VidyapeethPune411018India department of Surgical Oncology Dr.D.Y.Patil Medical CollegeHospital&Research CentreDr.D.Y.Patil VidyapeethPune411018India

Oral squamous cell carcinoma(OSCC)is one of the most prevalent forms of head and neck squamous cell carcinomas(HNSCC)with a poor overall survival rate(about 50%),particularly in cases of ***-based cancer biomarkers are a relatively advanced concept,and non-coding RNAs currently have shown promising roles in the detection and treatment of various *** review underlines the function of long non-coding RNAs(lncRNAs)in the OSCC and its subsequent clinical ***,a class of non-coding RNAs,are larger than 200 nucleotides and resemble mRNA in numerous ***,unlike mRNA,lncRNA regulates multiple druggable and non-druggable signaling molecules through simultaneous interaction with dNA,RNA,proteins,or microRNAs depending on concentration and localization in *** of oncogenic lncRNAs and downregulation of tumor suppressor lncRNAs are evident in OSCC tissues and body fluids such as blood and saliva indicating their potential as valuable *** inhibition of candidate oncogenic lncRNAs or overexpression of tumor suppressor lncRNAs showed potential therapeutic roles in in-vivo animal *** types of lncRNAs that are expressed differentially in OSCC tissue and bodily fluids have been systematically documented with specificity and *** review thoroughly discusses the biological functions of such lncRNAs in OSCC cell survival,proliferation,invasion,migration,metastasis,angiogenesis,metabolism,epigenetic modification,tumor immune microenvironment,and drug ***,we addressed the diagnostic and therapeutic importance of lncRNAs in OSCC pre-clinical and clinical systems,providing details on ongoing research and outlining potential future directions for advancements in this *** essence,this review could be a valuable resource by offering comprehensive and current insights into lncRNAs in OSCC for researchers in fundamental and clinical domains.

关键词： Oral squamous cell carcinoma(OSCC) Head and neck cancer Non-coding RNA Long non-coding RNA(lncRNA) Cancer diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

diabetes and pulmonary infection:how hyperglycaemia shapes the immune system

引用

Signal Transduction and Targeted Therapy 2024年第4期9卷 1245-1246页

作者： Christian Herder Michael Roden Nicolas Venteclef Institute for Clinical diabetology German Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf40225DüsseldorfGermany German Center for diabetes Research(dZd) Partner Düsseldorf85764München-NeuherbergGermany department of Endocrinology and diabetology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University Düsseldorf40225DüsseldorfGermany Institut Necker-Enfants Malades(INEM) UniversitéParis CitéINSERM UMR-S1151CNRS UMR-S8253ParisFrance

In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory *** analyses revealed a central role of lung dendritic cells(dC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.

关键词： impaired lung respiratory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Epidemicity indices and reproduction numbers from infectious disease data in connected human populations

引用

Infectious disease Modelling 2024年第3期9卷 875-891页

作者： Cristiano Trevisin Lorenzo Mari Marino Gatto Andrea Rinaldo Laboratory of Ecohydrology École Polytechnique Fédérale de LausanneStation 2Lausanne1015Switzerland dipartimento di Elettronica Informazione e BioingegneriaPolitecnico di MilanoVia Ponzio 34/5Milano20133Italy dipartimento di Ingegneria Civile Edile e Ambientale(ICEA)Universitàdi PadovaStation 2Padova35131Italy

We focus on distinctive data-driven measures of the fate of ongoing *** relevance of our pursuit is suggested by recent results proving that the short-term temporal evolution of infection spread is described by an epidemicity index related to the maximum instantaneous growth rate of new infections,echoing concepts and tools developed to study the reactivity of *** epidemicity indices can showcase the dynamics of infections,together with commonly employed effective reproduction numbers,especially when the latter assume values less than *** particular,epidemicity evaluates the short-term reactivity to perturbations of a disease-free ***,we show that sufficient epidemicity thresholds to prevent transient epidemic outbreaks in a spatially connected setting can be estimated by generalizing existing analogues derived when spatial effects are *** specifically account for the discrete nature,in both space and time,of surveillance data of the type typically employed to estimate effective reproduction numbers that formed the bulk of the communication of the state of the COVId-19 pandemic and its *** analyzing the effects of spatial heterogeneity on the considered prognostic indicators,we perform a short-and long-term analysis on the COVId-19 pandemic in Italy,showing that endemic conditions were maintained throughout the duration of our simulation despite stringent control *** method provides a portfolio of prognostic indices that are essential to pinpoint the ongoing pandemic in both a qualitative and quantitative manner,as our results *** base our conclusions on extended investigations of the effects of spatial fragmentation of communities of different sizes owing to connectivity by human mobility and contact scenarios,within real geographic contexts and synthetic setups designed to test our framework.

关键词： COVId-19 Ecological reactivity Epidemicity Reproduction numbersLeslie matrix Metapopulation Mobility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Robust Machine Learning Mapping of sEMG Signals to Future Actuator Commands in Biomechatronic devices

引用

Journal of Bionic Engineering 2024年第1期21卷 270-287页

作者： Ali Nasr Sydney Bell Rachel L.Whittaker Clark R.dickerson John McPhee Systems design Engineering University of WaterlooWaterloo N2L 3G1Canada Kinesiology and Health Sciences University of WaterlooWaterloo N2L3G3Canada

A machine learning model for regression of interrupted Surface Electromyography(sEMG)signals to future control-oriented signals(e.g.,robot’s joint angle and assistive torque)of an active biomechatronic device for high-level myoelectric-based hierarchical control is proposed.A Recurrent Neural Network(RNN)was trained using output data,initially obtained from offline optimization of the biomechatronic(human–robot)device and shifted by the prediction *** input of the RNN consisted of interrupted sEMG signals(to mimic signal disconnections)and previous kinematic signals of the assistive *** RNN with a 0.1-s prediction horizon could predict the control-oriented joint angle and assistive torque with 92%and 86.5%regression accuracy,respectively,for the test *** proposed approach permits a fast,predictive,and direct estimation of control-oriented signals instead of an iterative process that optimizes assistive torque in the inverse dynamic simulation of a multibody human–robot *** with these interrupted input signals significantly improves the regression accuracy in the case of sEMG signal *** Robust Predictive Control-oriented Machine Learning(Robust-MuscleNET)model can support volitional high-level myoelectric-based control of biomechatronic devices,such as exoskeletons,prostheses,and assistive/resistive *** work should study the application to prosthesis control as well as the repeatability of the high-level controller with electrode *** low-level hierarchical controller that manages the human–robot interaction,the assistance/resistance strategy,and the actuator coordination should also be studied.

关键词： Myoelectric-based control-Surface electromyography Machine learning Multibody system dynamics Exoskeleton Bionic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental measurement and numerical modeling of deformation behavior of breast cancer cells passing through constricted microfluidic channels

引用

Microsystems & Nanoengineering 2024年第1期10卷 129-147页

作者： Pouyan Keshavarz Motamed Hesam Abouali Mahla Poudineh Nima Maftoon department of Systems design Engineering University of WaterlooWaterlooON N2L 3G1Canada Center for Bioengineering and Biotechnology University of WaterlooWaterlooON N2L 3G1Canada department of Electrical and Computer Engineering University of WaterlooWaterlooON N2L 3G1Canada

during the multistep process of metastasis,cancer cells encounter various mechanical forces which make them deform *** accurate in-silico models,capable of simulating the interactions between the mechanical forces and highly deformable cancer cells,can pave the way for the development of novel diagnostic and predictive methods for metastatic ***-network models of cancer cell,empowered by our recently proposed identification approach,promises a versatile numerical tool for developing experimentally validated models that can simulate complex interactions at cellular *** this numerical tool,we presented spring-network models of breast cancer cells that can accurately replicate the experimental data of deformation behavior of the cells flowing in a fluidic domain and passing narrow constrictions comparable to ***,using high-speed imaging,we experimentally studied the deformability of breast cancer cell lines with varying metastatic potential(MCF-7(less invasive),SKBR-3(medium-high invasive),and MdA-MB-231(highly invasive)in terms of their entry time to a constricted microfluidic *** observed that MdA-MB-231,that has the highest metastatic potential,is the most deformable cell among the ***,by focusing on this cell line,experimental measurements were expanded to two more constricted microchannel *** experimental deformability data in three constricted microchannel sizes for various cell sizes,enabled accurate identification of the unknown parameters of the spring-network model of the breast cancer cell line(MdA-MB-231).Our results show that the identifed parameters depend on the cell size,suggesting the need for a systematic procedure for identifying the size-dependent parameters of spring-network models of *** the numerical results show,the presented cell models can simulate the entry process of the cell into constricted channels with very good agreements with the measured experimen

关键词： strict passing numerical

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

durable hierarchical phosphorus‐doped biphase MoS_(2)electrocatalysts with enhanced H^(*)adsorption

引用

Carbon Energy 2024年第4期6卷 104-114页

作者： Yongteng Qian Jianmin Yu Zhiyi Lyu Qianwen Zhang Tae Hyeong Lee Huan Pang dae Joon Kang College of Pharmacy Jinhua PolytechnicJinhuaZhejiangChina department of Physics Sungkyunkwan UniversitySuwonGyeonggi‐doRepublic of Korea International Collaborative Laboratory of 2d Materials for Optoelectronic Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhenGuangdongChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhouJiangsuChina

Phase engineering is an efficient strategy for enhancing the kinetics of electrocatalytic ***,phase engineering was employed to prepare high‐performance phosphorous‐doped biphase(1T/2H)MoS_(2)(P‐BMS)nanoflakes for hydrogen evolution reaction(HER).The doping of MoS_(2)with P atoms modifies its electronic structure and optimizes its electrocatalytic reaction kinetics,which significantly enhances its electrical conductivity and structural stability,which are verified by various characterization tools,including X‐ray photoelectron spectroscopy,high‐resolution transmission electron microscopy,X‐ray absorption near‐edge spectroscopy,and extended X‐ray absorption fine ***,the hierarchically formed flakes of P‐BMS provide numerous catalytic surface‐active sites,which remarkably enhance its HER *** optimized P‐BMS electrocatalysts exhibit low overpotentials(60 and 72 mV at 10 mA cm^(−2))in H_(2)SO_(4)(0.5 M)and KOH(1.0 M),*** mechanism of improving the HER activity of the material was systematically studied using density functional theory calculations and various electrochemical characterization *** study has shown that phase engineering is a promising strategy for enhancing the H*adsorption of metal sulfides.

关键词： 1T/2H MoS_(2) density functional theory electrocatalysts phase engineering phosphorous doping

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interlayer exciton dynamics of transition metal dichalcogenide heterostructures under electric fields

引用

Nano Research 2024年第5期17卷 4555-4572页

作者： Jian Tang Yue Zheng Ke Jiang Qi You Zhentian Yin Zihao Xie Henan Li Cheng Han Xiaoxian Zhang Yumeng Shi International Collaborative Laboratory of 2d Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China College of Electronics and Information Engineering Shenzhen UniversityShenzhen 518060China Key Laboratory of Luminescence and Optical Information Ministry of EducationInstitute of Optoelectronic TechnologyBeijing Jiaotong UniversityBeijing 100044China

Stacking single layers of atoms on top of each other provides a fundamental way to achieve novel material systems and engineer their physical properties,which offers opportunities for exploring fundamental physics and realizing next-generation optoelectronic *** the two-dimensional(2d)-stacked systems,transition metal dichalcogenide(TMdC)heterostructures are particularly attractive because they host tightly-bonded interlayer excitons which possess various novel and appealing *** interlayer excitons have drawn significant research attention and hold high potential for the application in unique optoelectronic devices,such as polarization-and wavelength-tunable single photon emitters,valley Hall transistors,and possible high-temperature *** development of these devices requires a comprehensive understanding of the fundamental properties of these interlayer excitons and the impact of electric fields on their *** this review,we summarize the recent advances on the understanding of interlayer exciton dynamics under electric fields in TMdC *** put emphasis on the electrical modulation of interlayer excitons’emission,the valley Hall transport of charge carriers after the separation of interlayer excitons by an electric field,and the correlation physics of interlayer excitons and charges under electrical doping and *** and perspectives are finally discussed for the application of TMdC heterostructures in future optoelectronics.

关键词： interlayer exciton transition metal dichalcogenide(TMdC)heterostructures circular polarization valley Hall effect strong coupling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of inorganic and organic pollutants from a Belgian wastewater treatment plant on adjacent surface and groundwaters

引用

Frontiers of Environmental Science & Engineering 2024年第4期18卷 75-90页

作者： Mingyue Luo Yiqi Su delphine Jenny Vandeputte Yuwei Jia Guanlei Li Willy Baeyens Marijke Huysmans Marc Elskens Yue Gao Analytical Environmental and Geo-Chemistry Department(AMGC)Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium Hydrology and Hydraulic Engineering(HYdR) Vrije Universiteit Brussel(VUB)Pleinlaan 21050 BrusselsBelgium

Under the pressure of global droughts and water shortage,it is essential to evolve toward a sustainable and robust water *** possible avenue is the maximum reuse of treated wastewater,but the quality of which determines its ***,inorganic(Cd,Pb,Cr,Ni,Cu,and As)and organic(xenoestrogens and polycyclic aromatic contaminants,PACs)contaminants were monthly monitored in an effluent of the wastewater treatment plant(WWTP),the surrounding surface waters and the local groundwater in *** and particulate concentrations of inorganic contaminants in these water bodies were *** addition,diffusive Gradients in Thin-films(dGT)was used in situ to obtain bioavailable metal *** the WWTP effluent and surface waters,only Ni exceeds the Annual Average-Environmental Quality Standard(AA-EQS),while in the groundwater,dissolved As was the predominant ***,in the surface and effluent waters the highest lability degrees were observed for Cd and *** concentrations of these metal species in the effluent water were lower than in the other water ***-organic pollutants,xenoestrogens and PACs were analyzed by dual Estrogen and Aryl hydrocarbon Receptor-Chemical Activated LUciferase gene eXpression(ER&AhR-CALUX)*** the annual averaged(AA)bioequivalent concentration of E2(0.18 ng/L)is below the AA-EQS standard(0.4 ng/L),and the bioequivalent concentration of benzo[a]pyrene never exceeded the maximum admissible concentration(MAC),the reclamation and reuse of treated wastewater for groundwater replenishment and agricultural irrigation should pose no environmental problems,at least in a short-term.

关键词： Metal contaminants dGT Labile metal fractions ERE/AhR-CALUX BEQ Xenoestrogens and polycyclic aromatic contaminants

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CFd-dEM analysis of particle polydispersity on the performance of fluidised bed reactor during silane pyrolysis Author links open overlay panel

引用

Particuology 2024年第8期91卷 72-87页

作者： Akshayveer Vijay M.Shinde MS2discovery Interdisciplinary Research Institute Wilfrid Laurier UniversityWaterlooOntarioN2L3C5Canada department of Chemical Engineering Indian Institute of Technology(BHU)Varanasi221005India

A CFd-dEM model is developed for chemical vapour deposition of silane in a fluidized bed reactor to investigate the effect of polydispersity on local phase dynamics,mass and heat transport,as well as the rate of Si *** gas-phase fines formation and heterogeneous deposition on the seed particle,as well as the scavenging effect for Si particle growth,are *** method is first validated against the experimentally measured Si deposition rate,percentage of fine production and minimum fluidisation ***,the properties,primarily particle intermixing,fluidisation behaviour and bubble dynamics along with the deposition process,are analyzed for several polydisperse beds under various operating *** effect of polydispersity of the bed on a fraction of the bubble size,dense phase expansion and interchange coefficient between various phases is thoroughly investigated to establish a correlation with reactor *** results show that broad-Gaussian particle size distribution(PSd)exhibits excellent improvement in fluidisation behaviour,resulting in a high deposition rate,and minimum formation of Si fines.

关键词： CFd-dEM method Chemical vapour deposition(CVd) Particle size distribution Silicon Gas-solid fluidized bed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Preparation,characterization and antioxidant activity analysis of three Maillard glycosylated bone collagen hydrolysates from chicken,porcine and bovine

引用

Food Science and Human Wellness 2024年第4期13卷 2002-2013页

作者： Liwei Qi Hongru Zhang Yujie Guo Hong Liu Chunhui Zhang Key Laboratory of Agro-Products Processing Ministry of Agriculture and Rural AffairsInstitute of Food Science and TechnologyChinese Academy of Agricultural SciencesBeijing 100193China Laboratory of Biomass and Green Technologies University of Liege-Gembloux Agro-Bio TechPassage des déportés 2Gembloux B-5030Belgium

Bone collagen hydrolysates(peptides)derived from byproduct of animal product processing have been used to produce commercially valuable products due to their potential antioxidant *** glycosylated reaction is considered as a promising method to enhance the antioxidant activity of ***,this research aims at investigating the Maillard glycosylation activity and antioxidant activity of bone collagen hydrolysates from different *** this study,3 glycosylated bone collagen hydrolysates were prepared and characterized,and cytotoxicity and antioxidant activity were analyzed and *** free amino groups loss,browning intensity,and fluorescence intensity of G-Cbcp(glycosylated chicken bone collagen hydrolysates(peptides))were the heaviest,followed by G-Pbcp(glycosylated porcine bone collagen hydrolysates(peptides))and G-Bbcp(glycosylated bovine bone collagen hydrolysates(peptides)).The results of amino acid analysis showed that amino acid composition of different bone collagen hydrolysates was significantly different and the amino acid decreased to different degrees after Maillard glycosylated reaction,which may lead to differences in Maillard glycosylated reaction ***,the 3 glycosylated hydrolysates showed no significant *** results showed that glycosylation process significantly increased the antioxidant activity of bone collagen hydrolysates,and G-Cbcp showed the strongest antioxidant activity,followed by G-Pbcp and ***,compared with the bone collagen hydrolysates,3 glycosylated hydrolysates showed significant characteristic and structural changes,and higher antioxidant activity.

关键词： Bone collagen hydrolysates Glycosylation reaction Antioxidant activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：