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Major gastrointestinal bleeding and antithrombotics: Characteristics and management

World Journal of gastroenterology 2020年第36期26卷 5463-5473页

作者： Jacques Bouget Damien Viglino Quentin Yvetot Emmanuel Oger EA 7449 REPERES Pharmacoepidemiology and Health Services ResearchUniv RennesRennes 35000France Emergency Department and Mobile Intensive Care Unit-HP2 Laboratory INSERM U1042 University Grenoble AlpsLa Tronche 38700France Emergency Department CHU RennesRennes 3500France EA 7449 REPERES Universitéde Rennes 1Rennes 35000France

BACKgROUND There are few reports on major gastrointestinal(gI)bleeding among patients receiving an *** To describe clinical characteristics,bleeding locations,management and inhospital mortality related to these *** Over a three-year period,we prospectively identified 1080 consecutive adult patients admitted in two tertiary care hospitals between January 1,2013 and December 31,2015 for major gI bleeding while receiving an *** bleeding events were medically *** characteristics,causative lesions,management and fatalities were *** distribution of antithrombotics prescribed was compared across the bleeding lesions *** Of 576 patients had symptoms of upper gI bleeding and 504 symptoms of lower gI *** cause was identified for 383(35.5%)***-duodenal ulcer was the first causative lesion in the upper tract(209 out of 408)and colonic diverticulum the first causative lesion in the lower tract(120 out of 289).There was a larger proportion of direct oral anticoagulant use among patients with lower gI than among those with upper gI lesion locations(P=0.03).There was an independent association between gastro-duodenal ulcer and antithrombotic use(P=0.03),taking account of confounders and proton pump inhibitor *** wise comparisons pointed to a difference between vitamin K antagonist,direct oral anticoagulants,and antiplatelet agents in monotherapy vs dual antiplatelet *** We showed a higher rate of bleeding lesion identification and suggested a different pattern of antithrombotic exposure between upper and lower gI lesion locations and between gastro-duodenal ulcer and other identified upper gI causes of *** was similar across antithrombotics and in-hospital mortality was low(5.95%).

关键词： Real-world setting Emergency Bleeding Mortality Antithrombotics Management

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Electron spectroscopies and their use for materials characterization

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Nuclear Science and Techniques 2003年第1期14卷 28-48页

作者： Didier SBILLEAU Bat.11C France Laboratoire PALMS UMR CNRS-Universite 6627 Universite de rennes-1 35042 rennes-Cedex

We present here a general overview of electron spectroscopies from a practical point of view. The most frequently used ones are described and the type of structural information they can provide on materials is explained in relation to the physical processes on which they are based. Furthermore, we explore critically and in detail various tools that have been developed to allow a systematic solving of structures by these spectroscopies.

关键词： Electron spectroscopy Materials characterization Surface analysis

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Chitinozoans from the Fenxiang Formation (Early Ordovician) of Yichang,Hubei Province,China

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Acta geologica Sinica(English Edition) 2008年第2期82卷 287-294页

作者： CHEN Xiaohong Florentin PARIS ZHANg Miao Yichang Institute of geology and Mineral Resources Hubei 443003 China geosciences-rennes UMR6-118 du CNRS Universite de Rennes I 35042 Rennes Cedex France

Chitinozoans collected from upper Tremadocian to lower Floian strata of Chenjiahe section, Yichang, western Hubei, China comprise six species belonging respectively to the genera Euconochitina including a new species, Euconochitina fenxiangensis, Lagenochitina and Bursachitina, together with Desmochitina sp. and Eremochitina sp. The chitinozoan succession across the interval is correlated with relevant conodont and chitinozoan biozones and two new regional chitinozoan biozones, the Lagenochitina destombesi Biozone and the Euconochitina symmetrica Biozone are proposed based on their stratigraphic ranges in the Fenxiang to Honghuayuan formations in the Chenjiahe section.

关键词： Early Ordovician Chitinozoa systematics biozonation western Hubei China

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Comment on“Hypothermic machine perfusion in liver transplantation-a randomized trial”

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 364-366页

作者： Fabien Robin Heithem Jeddou Department of Hepatobiliary and Digestive Surgery University HospitalRennes 1 UniversityRennesFrance INSERM U1242 Chemistry Oncogenesis Stress SignalingRennes 1 UniversityRennesFrance

We read with great interest the article by van Rijn et *** in March 2021,in The New England Journal of Medicine(1).In this multicenter,randomized controlled trial,the authors investigated the efficacy of dual hypothermic oxygenated perfusion(D-HOPE)versus static cold storage(SCS)in grafts from donors after cardiac death(DCD)to decrease the rate of non-anastomotic biliary stenosis(NAS)within the first 6 post-transplant months.

关键词： randomized therm perfusion

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Epitaxial growth of gd_(0.67)Ca_(0.33)MnO_3 Thin Films by Laser Ablation

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Journal of Rare Earths 2004年第6期22卷 739-742页

作者：马衍伟 guilloux Viry M Barahona P Pea O Moure C Applied Superconductivity Laboratory Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100080 China Chimie du Solide et Inorganique Moléculaire UMR 6511 CNRS - Université de Rennes 1 Institut de Chimie de Rennes 35042 Rennes France Chimie du Solide et Inorganique Moléculaire UMR 6511 CNRS - Université de Rennes 1 Institut de Chimie de Rennes 35042 Rennes France Instituto de Ceramica y Vidrio CSIC Campus de Cantoblanco 28049 Madrid Spain

gd_(0.67)Ca_(0.33)MnO_3(gCMO)thin films grown by laser ablation on SrTiO_3(100)(STO)substrates was studied. Films are highly crystallized, very well epitaxial and single-phased. The ordering magnetic temperature(T_c)of the films is much higher than the value of bulk samples of similar composition. It is found that the gCMO film exhibits a reversal of its magnetization at low temperature when cooled under a magnetic field. The negative magnetization is a consequence of the rapid increase(～1/T)with decreasing temperature of the magnetization of a sublattice aligned antiparallel to the local field, relative to the magnetic contribution of a second sublattice which is aligned parallel to the applied field.

关键词： pulsed laser deposition gd_(0.67)Ca_(0.33)MnO_3 thin films magnetic properties

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In vitro study of human endothelial progenitor cells behaviour on nitrided Ni-free Ti–27Nb alloy

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Progress in Natural Science:Materials International 2019年第4期29卷 466-471页

作者： Raluca Ion Yvan Bédouin Thierry gloriant gladiola Andruseac Doina-Margareta gordin Anisoara Cimpean University of Bucharest Department of Biochemistry and Molecular Biology Univ rennes INSA Rennes CNRS ISCR (Institut des Sciences Chimiques de Rennes) CHU de rennes P?le d'Odontologie et de Chirurgie Buccale Department of Biomedical Science Faculty of Medical Bioengineering “Grigore T.Popa” University of Medicine and Pharmacy

A superelastic Ni-free Ti-27 Nb alloy has been synthesized and gas nitrided at high temperature to investigate its suitability for vascular implant *** cellular responses of human endothelial progenitor cells(EPCs)to both bare and nitrided Ti-27 Nb alloy have been analyzed using Live/Dead staining,MTT assay,fluorescence microscopy and ELISA technique,as well as NiTi alloy for ***/Dead staining and MTT assay were performed to assess the cellular viability and proliferation,while fluorescence microscopy was used to analyze cell adhesion,cell morphology,and the expression of endothelial cell markers(VE-cadherin and von Willebrand factor).Secretion of the pro-inflammatory chemokine MCP(monocyte chemoattractant protein)-1 by the cells grown in contact with the analyzed materials was further verified using the enzyme-linked immunosorbent *** results obtained revealed that adhesion,spreading,viability,proliferation rate and phenotypic markers expression of EPCs were similar on the surfaces of Ti-27 Nb and NiTi *** exposed to nitrided Ti-27 Nb surface exhibited significantly decreased inflammatory response,which may be beneficial for reducing in-stent restenosis incidence.

关键词： Titanium alloy Nitriding Endothelial progenitor cells Biocompatibility Inflammatory response

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Characterization of the Omni-Processor Sewage Sludge Ash for Reuse as Construction Material

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Fluid Dynamics & Materials Processing 2022年第6期18卷 1581-1593页

作者： Prince Momar gueye Siham Kamali-Bernard Dame Keinde Fabrice Bernard Vincent Sambou LE3PI of E S P-UCAD DakarSenegal LgCgM of INSA of rennes RennesFrance

Omni Processors(OP)are machines which use sludge as a fuel to generate electricity and clean water,but create ash at the same *** the present study,fly ash and bottom ash are investigated as materials for potential reuse in the construction ***,the granular size,density and Blaine finesse are ***,the chemical composition and microstructure are obtained by means of X-ray fluorescence and Scanning Electron Microscopy-Energy Dispersive Spectroscopy(SEM-EDS),***,ashes reactivity is determined by two chemical methods(modified Chapelle test,bound water content R3)and a mechanical method(pozzolanic activity index).The characterization results indicate two material types:fly ash similar to cement and bottom ash similar to fine ***’s why the mortars mechanical strength with fly ash 0%-30%is better than that with bottom ash at the same *** ash slightly decreases the mechanical strength of mortars while bottom ash induces a much more significant decrease.

关键词： Characterization Omni-processor fly Ash bottom ash

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Biodegradation by bioaugmentation of dairy wastewater by fungal consortium on a bioreactor lab-scale and on a pilot-scale

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Journal of Environmental Sciences 2013年第9期25卷 1906-1912页

作者： Hayet Djelal Abdeltif Amrane Trades School of the Environment Campus de Ker Lann35170 Bruz France European University of Brittany 5 Laennec Boulevard Rennes France University of rennes 1 ENSCR CNRS UMR 6226 Avenue du General LeclercCS 50837 35708 Rennes Cedex 7 France

A fungal consortium including Aspergillus niger, Mucor hiemalis and galactomyces geotrichum was tested for the treatment of dairy wastewater. The bio-augmentation method was tested at lab-scale （4 L）, at pilot scale （110 L） and at an industrial scale in Wastewater Treatment Plants （WWTP）. The positive impact of fungal addition was confirmed when fungi was beforehand accelerated by pre-culture on whey （5 g/L lactose） or on the dairy effluent. Indeed, chemical oxygen demand （COD） removal yields increased from 55% to 75% for model medium, diluted milk. While after inoculation of an industrial biological tank from a dairy factory with the fungal consortium accelerated by pre-cultivation in a 1000 L pilot plant, the outlet COD values decreased from values above the standard one （100 mg/L） to values in the range of 50-70 mg/L. In addition, there was a clear impact of fungal addition on the ＇hard＇ or non-biodegradable COD owing to the significant reduction of the increase of the COD on BOD 5 ratio between the inlet and the outlet of the biological tank of WWTP. It was in the range of 451%-1111% before adding fungal consortium, and in the range of 257%-153% after bio-augmentation with fungi. An inoculated bioreactor with fungal consortium was developed at lab-scale and demonstrated successfully at pilot scale in WWTP.

关键词： dairy wastewater biodegradation bioaugmentation fungi wastewater treatment

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Liver transplantation for perihilar cholangiocarcinoma is not a provocative idea

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 232-234页

作者： Alexandre Chebaro Heithem Jeddou Service de Chirurgie Hépatobiliaire et Digestive CHU RennesUniv RennesRennesFrance Inserm EHESPIrset(Institut de recherche en santéenvironnement et travail)-UMR_S 1085Univ RennesRennesFrance

This is a multicenter benchmarking study on liver transplantation(LT)for perihilar cholangiocarcinoma(PHC)after neoadjuvant chemoradiotherapy(1).The study comprises of 134 patients from 2014 to 2018 among whom the majority had underlying primary sclerosing cholangitis(PSC).Dropout rate was available from 4 out of 17 centers and was 28%,primarily for oncological reasons(tumor progression and lymph node invasion).All patients followed neo-adjuvant chemoradiotherapy according to the Mayo(88%)or Mayo-like *** grafts originated from brain-dead donors in 61.3%of cases and from living donors in 29.7%of cases.

关键词： Liver invasion patients

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Soil properties, grassland management, and landscape diversity drive the assembly of earthworm communities in temperate grasslands

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Pedosphere 2021年第3期31卷 375-383页

作者： Kevin HOEFFNER Mathieu SANTONJA CécileMONARD Lou BARBE Mathilde LEMOINg Daniel CLUZEAU University of rennes CNRSECOBIO UMR 6553Rennes F-35000France INRAE AGROCAMPUS OUEST UMR SASRennes F-35000France Aix Marseille Université Avignon UniversitéCNRSIRDIMBEMarseille F-13397France

Earthworms are widespread soil organisms that contribute to a wide range of ecosystem *** such,it is important to improve our knowledge,still scanty,of the factors that drive the assembly of earthworm *** aim of the present study was to conjointly evaluate the effects on the assembly of earthworm communities of i)soil properties(texture,organic matter content,and pH),ii)grassland management(grassland age,livestock unit,and type of fertilization),iii)landscape diversity(richness,diversity of surrounding habitats,and grassland plant diversity),and iv)presence of *** study was conducted in temperate grasslands of Brittany,*** were sampled in 24 grasslands and,in three of these grasslands,they were sampled near a hedgerow or near a ditch(control without a hedgerow).Soil properties explained the larger portion of the variation in the earthworm community parameters compared to grassland management or landscape *** increase in soil organic matter content and pH were the most favorable factors for earthworm abundance and biomass,in particular for endogeic *** grassland management,the increase in the livestock unit was the most damaging factor for earthworm communities,in particular for the anecic earthworm biomass and endogeic species ***,landscape diversity negatively affected the total earthworm abundance and epigeic earthworm biomass,but it was related to an increase in the epi-anecic *** a finer scale,we also demonstrated that the presence of hedgerows surrounding grasslands enhanced earthworm species richness,especially within the epigeic and anecic ecological *** study highlights that the earthworm ecological categories respond specifically to environmental filters;further studies need to be conducted to elucidate the factors that drive the assembly of earthworm communities at this ecological category *** recommend that policymakers should act on landscape man

关键词： ecological categoryfield marginhedgerowlivestock unitsoil organic mattersoil PHtrampling

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