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Stimulating effect of thyroid hormones in peripheral nerve regeneration:research history and future direction toward clinical therapy

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Neural Regeneration Research 2018年第4期13卷 599-608页

作者： I.Barakat-Walter R.Kraftsik department of fundamental Neurosciences Faculty of Biology and MedicineUniversity of Lausanne

Injury to peripheral nerves is often observed in the clinic and severe injuries may cause loss of motor and sensory functions.Despite extensive investigation,testing various surgical repair techniques and neurotrophic molecules,at present,a satisfactory method to ensuring successful recovery does not exist.For successful molecular therapy in nerve regeneration,it is essential to improve the intrinsic ability of neurons to survive and to increase the speed of axonal outgrowth.Also to induce Schwann cell phenotypical changes to prepare the local environment favorable for axonal regeneration and myelination.Therefore,any molecule that regulates gene expression of both neurons and Schwann cells could play a crucial role in peripheral nerve regeneration.Clinical and experimental studies have reported that thyroid hormones are essential for the normal development and function of the nervous system,so they could be candidates for nervous system regeneration.This review provides an overview of studies devoted to testing the effect of thyroid hormones on peripheral nerve regeneration.Also it emphasizes the importance of combining biodegradable tubes with local administration of triiodothyronine for future clinical therapy of human severe injured nerves.We highlight that the local and single administration of triiodothyronine within biodegradable nerve guide improves significantly the regeneration of severed peripheral nerves,and accelerates functional recovering.This technique provides a serious step towards future clinical application of triiodothyronine in human severe injured nerves.The possible regulatory mechanism by which triiodothyronine stimulates peripheral nerve regeneration is a rapid action on both axotomized neurons and Schwann cells.

关键词： peripheral nerve regeneration thyroid hormones thyroid hormone nuclear receptors biodegradable nerve growth guides axotomized neuron survival microsurgery reinnervation of denervated muscles compound muscle action potential

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Scaling Theory of Polyelectrolyte Nanogels

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Communications in Theoretical Physics 2017年第8期67卷 250-254页

作者：瞿立建 department of fundamental Science Institute of Disaster Prevention

The present paper develops the scaling theory of polyelectrolyte nanogels in dilute and semidilute solutions.The dependencies of the nanogel dimension on branching topology, charge fraction, subchain length, segment number,solution concentration are obtained. For a single polyelectrolyte nanogel in salt free solution, the nanogel may be swelled by the Coulombic repulsion(the so-called polyelectrolyte regime) or the osmotic counterion pressure(the so-called osmotic regime). Characteristics and boundaries between different regimes of a single polyelectrolyte nanogel are summarized.In dilute solution, the nanogels in polyelectrolyte regime will distribute orderly with the increase of concentration. While the nanogels in osmotic regime will always distribute randomly. Different concentration dependencies of the size of a nanogel in polyelectrolyte regime and in osmotic regime are also explored.

关键词：标度理论聚电解质凝胶电解质渗透纳米尺寸溶液浓度拓扑结构电荷分数凝胶特性

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Spin-current pump in silicene

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Chinese Physics B 2018年第5期27卷 500-503页

作者： John Tombe Jada Marcellino 王美娟汪萨克汪军 department of Physics Southeast University department of fundamental Courses Jinling Institute of Technology

We report a theoretical study of pumped spin currents in a silicene-based pump device, where two time-dependent staggered potentials are introduced through the perpendicular electric fields and a magnetic insulator is considered in between the two pumping potentials to magnetize the Dirac electrons. It is shown that giant spin currents can be generated in the pump device because the pumping can be optimal for each transport mode, the pumping current is quantized. By controlling the relevant parameters of the device, both pure spin currents and fully spin-polarized currents can be obtained.Our results may shed a new light on the generation of pumped spin currents in Dirac-electron systems.

关键词： spin currents charge pump quantization silicene

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Characterization of retinal ganglion cell damage at single axon bundle level in mice by visible-light optical coherence tomography fibergraphy

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Neural Regeneration Research 2023年第1期18卷 135-136页

作者： Xiaorong Liu Hao F.Zhang department of Biology Department of PsychologyProgram in Fundamental NeuroscienceUniversity of VirginiaCharlottesvilleVAUSA department of Biomedical Engineering Northwestern UniversityEvanstonILUSA

Retinal ganglion cells(RGCs)receive synaptic inputs through their dendritic trees in the inner plexiform layer(IPL)and convey the visual information via their axons which form the optic nerve to the brain(Sanes and Masland,2015).In glaucoma,RGCs and their axons degenerate and die,leading to irreversible vision loss and eventually blindness if left untreated(Quigley,2016).

关键词： bundle visible eventually

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Cross-regulation between CDK and MAPK control cellular fate

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Quantitative Biology 2021年第3期9卷 341-359页

作者： Eric Durandau Serge Peiet department of fundamental Microbiology University of LausanneCH-1015 LausanneSwitzerland

Background:Commitment to a new cell cycle is controlled by a number of cellular signals.Mitogen-activated protein kinase(MAPK)pathways,which transduce multiple extracellular cues,have been shown to be interconnected with the cell cycle and can modulate its progression.Methods:In budding yeast,we have introduced fluorescent biosensors that monitor in real time the signaling activity of the MAPKs Fus3 and Kssl and the cyclin-dependent kinase(CDK)in individual cells.We have quantified in hundreds of live single cells the interplay between the MAPKs regulating the mating response and the CDK controlling cell cycle progression.Results:Different patterns of MAPK activity dynamics could be identified by clustering cells based on their CDK activity,denoting the tight relationship between these two cellular signals.Our data suggest that beyond the already well-established mechanisms of regulation between the MAPK and the CDK,additional mechanisms remain to be identified.Conclusion:A tight interplay between MAPK pathways and the cell cycle is essential to control cellular proliferation and cell fate decisions.

关键词： MAPK signaling cell cycle yeast mating single cell analysis fluorescent biosensors

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Attitudes towards pain management in hospitalized cancer patients and their influencing factors

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Chinese Journal of Cancer Research 2017年第1期29卷 75-85页

作者： Fangli Lou Shaomei Shang department of fundamental Nursing Peking University School of Nursing Beijing 100191 China

Objective： To investigate patients＇ attitudes towards cancer pain management and analyze the factors influencing these attitudes.Methods： The self-developed Demographic and Disease-Related Information Questionnaires, Pain Management Barriers Questionnaire-Taiwan form（BQT）, and Pain Knowledge Questionnaire were administered to 363 pairs of hospitalized cancer patients and their caregivers from the oncology departments of 7 hospitals in Beijing, China.Results： The average patient score for attitudes towards pain management was 2.96±0.49. The dimension scores indicated good attitudes in three areas（scores 〈2.5）, ＂Desire to be good＂（2.22±1.04）, ＂Fatalism＂（2.08±0.81） and＂Religious fatalism＂（1.86±1.00）, and poor attitudes in six areas（scores ≥2.5）, ＂Tolerance＂（3.83±0.96）, ＂Use of analgesics as needed（p.r.n.）＂（3.73±1.01）, ＂Addiction＂（3.44±1.05）, ＂Disease progression＂（3.28±1.26）, ＂Distraction of physicians＂（3.16±1.07） and ＂Side effects＂（2.99±0.68）. Two factors were entered into the regression equation：the caregivers＇ attitudes towards cancer pain management and the patients＇ pain knowledge. These two factors explained 23.2% of the total variance in the patients＇ average scores for their attitudes towards cancer pain management.Conclusions： The patients＇ attitudes towards cancer pain management were poor and could be influenced by the caregivers＇ attitudes and the patients＇ pain knowledge, and thus need to be improved.

关键词： Cancer patients cancer pain attitudes towards cancer pain management

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Polaron effects in cylindrical GaAs/Al_xGa_(1-x)As core-shell nanowires

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Chinese Physics B 2017年第9期26卷 415-420页

作者：孙慧刘炳灿田强 department of Physics Beijing Normal University department of fundamental Courses Academy of Armored Forces Engineering

By the fractal dimension method, the polaron properties in cylindrical GaAs/AlxGa1-xAs core-shell nanowire are explored. In this study, the polaron effects in GaAs/AlxGa1-xAs core-shell nanowire at different values of shell width and aluminum concentration are discussed. The polaron binding energy, polaron mass shift and fractal dimension parameter are numerically worked out each as a function of core radius. The calculation results show that the binding energy and mass shift of the polaron first increase and then decrease as the core radius increases, forming their corresponding maximum values for different aluminum concentrations at a given shell width. Polaron problems in the cylindrical GaAs/AlxGa1-xAs core-shell nanowire are solved simply by using the fractal dimension method to avoid complex and lengthy calculations.

关键词： core-shell nanowire core radius polaron effects fractal dimension

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The Fourier Transform Infrared Spectra of the Key Organs Derived from Kidney(Shen)-Yang Deficiency Syndrome Mice

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Chinese Journal of Integrative Medicine 2014年第11期20卷 829-834页

作者：李炜弘李启杰李宛真刘伟伟曾英姿张天娥张先庚孙素琴王米渠丁维俊 department of fundamental Medicine Chengdu University of Traditional Chinese Medicine

Objective：To explore an approach to rapidly and accurately identify the compounds as biomarkers of Chinese medicine（CM）syndromes.Method：The Fourier transform infrared（FT-IR）spectrometry was applied to investigate the characteristic components of a mice model of Kidney（Shen）-yang deficiency syndrome（KDS）,and the remedial effect of a typical CM formula Shenqi Pill（肾气丸）.Thirty-six females and 18 males of Balb/c mice were randomly divided into KDS,Shenqi or control group.The females and males of the same group freely were mated for 96 h,and the males were taken out and only the female mice were raised.Females of the KDS group were threatened by a ferocious cat every other day for 14 d.After delivery,the KDS,or gestational threatened,offspring were raised at standard condition for 11 weeks.Then 10 male offspring were randomly selected,anaesthetized and their representative organs,i.***.testes,kidneys,lungs and feet were collected,for the FT-IR scan.Mice of the Shenqi group were intragastric administered Shenqi Pill;while mice in the KDS and control groups were given the same volume of saline.Results：The attenuated birth outcomes of the KDS group were displayed.The remarkable FT-IR differences of all organs between KDS mice and healthy control were mainly at 1,735-1,745 cm-1（indicating the increased levels of lipids）and at 1,640-1,647 cm-1and 1,539-1,544 cm-1（displaying the decreased proteins）.No statistic FT-IR difference between Shenqi and control mice was observed.Conclusion：In accordance with major traits of KDS,prenatal stress extensively impaired the building up of proteins and resulting in the excessive lipid storage,and FT-IR could effectively identify the biomarkers of KDS.

关键词： Fourier-transform infrared prenatal stress Chinese medicine Kidney（Shen）-yang deficiency syndrome

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Optimized Hybrid Block Adams Method for Solving First Order Ordinary Differential Equations

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Computers, Materials & Continua 2022年第8期72卷 2947-2961页

作者： Hira Soomro Nooraini Zainuddin Hanita Daud Joshua Sunday department of fundamental and Applied Sciences Universiti Teknologi PETRONAS32610Seri IskandarPerakMalaysia department of Mathematics University of Jos930003JosNigeria

Multistep integration methods are being extensively used in the simulations of high dimensional systems due to their lower computational cost.The block methods were developed with the intent of obtaining numerical results on numerous points at a time and improving computational efficiency.Hybrid block methods for instance are specifically used in numerical integration of initial value problems.In this paper,an optimized hybrid block Adams block method is designed for the solutions of linear and nonlinear first-order initial value problems in ordinary differential equations(ODEs).In deriving themethod,the Lagrange interpolation polynomial was employed based on some data points to replace the differential equation function and it was integrated over a specified interval.Furthermore,the convergence properties along with the region of stability of the method were examined.It was concluded that the newly derived method is convergent,consistent,and zero-stable.The method was also found to be A-stable implying that it covers the whole of the left/negative half plane.From the numerical computations of absolute errors carried out using the newly derived method,it was found that the method performed better than the ones with which we compared our results with.Themethod also showed its superiority over the existing methods in terms of stability and convergence.

关键词： Initial value problem(IVPs) linear multi-step method block interpolation hybrid Adams-Moulton method

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NORMA:The Network Makeup Artist—A Web Tool for Network Annotation Visualization

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 578-586页

作者： Mikaela Koutrouli Evangelos Karatzas Katerina Papanikolopoulou Georgios A.Pavlopoulos Institute for fundamental Biomedical Research BSRC“Alexander Fleming”Vari 16672Greece department of Informatics and Telecommunications University of AthensAthens 15703Greece

The Network Makeup Artist(NORMA) is a web tool for interactive network annotation visualization and topological analysis, able to handle multiple networks and annotations simultaneously. Precalculated annotations(e.g., Gene Ontology, Pathway enrichment, community detection,or clustering results) can be uploaded and visualized in a network, either as colored pie-chart nodes or as color-filled areas in a 2D/3D Venn-diagram-like style. In the case where no annotation exists,algorithms for automated community detection are offered. Users can adjust the network views using standard layout algorithms or allow NORMA to slightly modify them for visually better group separation. Once a network view is set, users can interactively select and highlight any group of interest in order to generate publication-ready figures. Briefy, with NORMA, users can encode three types of information simultaneously. These are 1) the network, 2) the communities or annotations of interest, and 3) node categories or expression values. Finally, NORMA offers basic topological analysis and direct topological comparison across any of the selected networks. NORMA service is available at http://norma.***.info, whereas the code is available at https://***/Pavlopoulos Lab/NORMA.

关键词： Network annotation Visualization Topological analysis Community detection Functional enrichment visualization

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