NORMA:The Network Makeup Artist—A Web Tool for Network Annotation Visualization

作     者：Mikaela Koutrouli Evangelos Karatzas Katerina Papanikolopoulou Georgios A.Pavlopoulos Mikaela Koutrouli;Evangelos Karatzas;Katerina Papanikolopoulou;Georgios A.Pavlopoulos

作者机构：Institute for Fundamental Biomedical ResearchBSRC“Alexander Fleming”Vari 16672Greece Department of Informatics and TelecommunicationsUniversity of AthensAthens 15703Greece 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2022年第20卷第3期

页      面：578-586页

核心收录：

学科分类：0710[理学-生物学] 0711[理学-系统科学] 07[理学] 070104[理学-应用数学] 0701[理学-数学] 

基　　金：supported by the Operational Program Competitiveness,Entrepreneurship,Innovation,NSRF 2014-2020 (Grant No.MIS 5002562,co-financed by Greece and the European Union (European Regional Development Fund) supported by the Hellenic Foundation for Research and Innovation (HFRI) under the"First Call for HFRI Research Projects to support Faculty members and Researchers and the procurement of high-cost research equipment grant"(Grant No.1855-BOLOGNA) supported by the Action Strengthening Human Resources Education and Lifelong Learning,2014-2020,co-funded by the European Social Fund (ESF) and the Greek State (Grant No.MIS 5000432) supported by a grant from the Stavros Niarchos Foundation to the Biomedical Sciences Research Center"Alexander Fleming",as part of the initiative of the Foundation to support the Greek research center ecosystem 

主　　题：Network annotation Visualization Topological analysis Community detection Functional enrichment visualization 

摘      要：The Network Makeup Artist(NORMA) is a web tool for interactive network annotation visualization and topological analysis, able to handle multiple networks and annotations simultaneously. Precalculated annotations(e.g., Gene Ontology, Pathway enrichment, community detection,or clustering results) can be uploaded and visualized in a network, either as colored pie-chart nodes or as color-filled areas in a 2D/3D Venn-diagram-like style. In the case where no annotation exists,algorithms for automated community detection are offered. Users can adjust the network views using standard layout algorithms or allow NORMA to slightly modify them for visually better group separation. Once a network view is set, users can interactively select and highlight any group of interest in order to generate publication-ready figures. Briefy, with NORMA, users can encode three types of information simultaneously. These are 1) the network, 2) the communities or annotations of interest, and 3) node categories or expression values. Finally, NORMA offers basic topological analysis and direct topological comparison across any of the selected networks. NORMA service is available at http://norma.***.info, whereas the code is available at https://***/Pavlopoulos Lab/NORMA.