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Pretreatment inflammatory indices predict Bevacizumab response in recurrent Glioma

cancer Drug Resistance 2020年第3期3卷 623-635页

作者： Alicia Martínez-González Raquel cabrera Marta Lloret Pedro c.Lara department de Matemáticas Universidad de Castilla-La ManchaETSI IndustrialesAvdaCiudad Real 13071Spain. Oncología Radioterápica Hospital Universitario de Gran canaria Dr negrin Barranco de la Ballena s/nLas Palmas de Gran CanariaLas Palmas 35010Spain. Facultad de ciencias de la Salud Universidad de Las Palmas de Gran CanariaPaseo de Blas Cabrera Felipes/nLas Palmas de Gran CanariaLas Palmas 35016Spain. fundación canaria del instituto canario de investigación del cáncer Avda de la Trinidad 61 Torre Agustín Arevalo 7 planta La LagunaSanta Cruz de Tenerife 38204Spain. San Roque University Hospitals Dolores de la Rocha5Las Palmas de Gran CanariaLas Palmas 35001Spain. Fernando Pessoa canarias University Dolores dela Rocha 14Las Palmas de Gran CanariaLas Palmas 35016Spain.

Aim:It remains unclear what the best therapeutic option for recurrent glioma patients after Stupp treatment ***(BVZ)is commonly administered in progression,but it appears that only some patients *** would be useful to find biomarkers that determine beforehand who these patients ***:The protocol included 31 high-risk progressing glioma patients after Stupp treatment who received BVZ 5-10 mg/kg every 14 days and temozolomide(3-19 cycles,150-200 mg five days each 28-day cycle)during a mean of eight cycles of BVZ or until tumor progression or unacceptable *** analyzed the clinical outcome values of inflammatory indices measured before BVZ ***:Lymphocyte level before BVZ administration was the best independent predictor of overall survival(HR=0.34;95%cI:0.145-0.81;P=0.015).The area under the receiver operating characteristic(ROc)curve was 0.823,with 1.645 being the optimal cut-off value,and 0.80 and 0.85 the sensitivity and specificity values,*** and non-responder survival curves were also significantly different,considering the first and second tertiles as cut-off *** number of BVZ cycles was not related to *** neutrophil platelet levels,platelet-to-lymphocyte ratio(PLR),and neutrophil-to-lymphocyte ratio(nLR)did not have independent predictive *** variables were not correlated with each ***,patients with high nLR and PLR simultaneously(double positive PLR-nLR)showed a worse clinical outcome than the rest(P=0.043).conclusion:Pretreatment lymphocyte levels and double positive PLR-nLR could be used as non-invasive hematological prognostic markers for recurrent gliomas treated with bevacizumab.A close relationship emerged between inflammation and angiogenesis.

关键词： Recurrent glioma bevacizumab predictive biomarker inflammatory indices lymphocytes

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computer vision based eyewear selector

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Journal of Zhejiang University-Science c(computers and Electronics) 2010年第2期11卷 79-91页

作者： Oscar DénIZ Modesto cASTRILLón Javier LOREnZO Luis AnTón Mario HERnAndeZ Gloria BUEnO instituto Universitario de Sistemas Inteligentes y Aplicaciones numéricas en Ingeniería Universidad de Las Palmas deGran CanariaEdificio Central del Parque Científico-Tecnológico 35017 Las Palmas E.T.S. Ingenieros Industriales Universidad de Castilla-La Mancha Campus UniversitarioAvda. Camilo José Cela

The widespread availability of portable computing power and inexpensive digital cameras are opening up new possibilities for retailers in some markets. One example is in optical shops,where a number of systems exist that facilitate eyeglassess election. These systems are now more necessary as the market is saturated with an increasingly complex array of lenses,frames,coatings,tints,photochromic and polarizing treatments,etc. Research challenges encompass computer Vision,Multimedia andHuman-computer Interaction. cost factors are also of importance for widespread product acceptance. This paper describes alow-cost system that allows the user to visualize different glasses models in live video. The user can also move the glasses toadjust its position on the face. The system,which runs at 9.5 frames/s on general-purpose hardware,has a homeostatic modulethat keeps image parameters controlled. This is achieved by using a camera with motorized zoom,iris,white balance,etc. Thisfeature can be specially useful in environments with changing illumination and shadows,like in an optical shop. The system alsoincludes a face and eye detection module and a glasses management module.

关键词： Face detection. Eve detection Perceptual user interfaces Human-computer interaction

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Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RIcA registry

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Journal of Geriatric cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel Manuel Méndez-Bailón JoséPérez-Silvestre JoséMaría Fernández-Rodríguez Beatriz cuesta García Adrián Argüelles-curto Álvaro González-Franco Alicia conde-Martel Sara carrascosa-García Marta Sánchez-Marteles JoséManuel cerqueiro-González noel Lorenzo-Villalba Manuel Montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de Medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de Medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de Medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de Medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de Medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de Medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de Médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de Medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BAcKGROUnD Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIOnEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced nT-proBnP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(AcEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RIcA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and november 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%cI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%cI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%cI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%cI:0.325-1.612).cOncLUSIOn Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with AcEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission

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High Blood Pressure Effects on the Brain Barriers and choroid Plexus Secretion

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neuroscience & Medicine 2012年第1期3卷 60-64页

作者： Ibrahim González-Marrero Leandro castaneyra-Ruiz Juan M.González-Toledo Agustín castaneyra-Ruiz Héctor de Paz-carmona Lidia Ruiz-Mayor Agustín castaneyra-Perdomo Emilia M.carmona-calero departamento de Anatomía Facultad de MedicinaUniversidad de La LagunaTenerifeSpain departamento de Biotecnología Instituto de Investigación y Ciencias de Puerto del RosarioFuerteventuraSpain

High blood pressure produces ventricular dilation, variations in circumventricular organs and changes in the cerebrospinal fluid compositions. On the other hand, chronic hypertension in spontaneously hypertensive rats can cause changes in the integrity of the brain barriers: blood-cerebrospinal fluid barrier and blood brain barrier. The permeability of the brain barriers can be studied by using transthyretin and S-100β. In the present work we study the integrity of the brain barrier and the choroid plexus function variations in arterial hypertension. control rats and spontaneously hypertensive rats were used and the choroid plexus were processed by immunohistochemistry with anti-transthyretin and anti-vasopressin. Western blot was also performed in cerebrospinal fluid, serum and choroid plexus using anti-S-100β, anti-transthyretin. The accumulation of transthyretin immunoreactive was bigger in spontaneously hypertensive rats with respect to the control. Vasopressin was also higher in spontaneously hypertensive rats with respect to the control. Western blot showed that transthyretin tetramer was higher in the spontaneously hypertensive rats than in the control rats. The expression of transthyretin monomer was lower in hypertensive rats than the control in the cerebrospinal fluid, the transthyretin monomer reaction in the blood was stronger in hypertensive than in control rats. Western blot for the S-100 β showed an increase in blood and cerebrospinal fluid of hypertensive rats. The high blood pressure produces a disruption of the blood brain barrier and blood to cerebrospinal fluid barrier that allows extravasations from the cerebrospinal fluid to the blood and from the blood to the cerebrospinal fluid.

关键词： Brain Barriers choroid Plexus Arterial Hypertension

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Acceptance of living liver donation among medical students: A multicenter stratified study from Spain

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World Journal of Gastroenterology 2016年第25期22卷 5800-5813页

作者： Antonio Ríos Ana Isabel López-navas Ana Isabel López-López Francisco Javier Gómez Jorge Iriarte Rafael Herruzo Gerardo Blanco Francisco Javier Llorca Angel Asunsolo Pilar Sánchez-Gallegos Pedro Ramón Gutiérrez Ana Fernández María Teresa de Jesús Laura Martínez-Alarcón Alberto Lana Lorena Fuentes Juan Ramón Hernández Julio Virseda José Yelamos José Antonio Bondía Antonio Miguel Hernández Marco Antonio Ayala Pablo Ramírez Pascual Parrilla International collaborative Donor Project ('Proyecto colaborativo Internacional Donante' 30007 Casillas Murcia Spain department of Surgery Paediatrics Obstetrics and Gynaecology University of Murcia Avenida de las Fuerzas Armadas 30800 Espinardo Murcia Spain Transplant Unit Surgery Service IMIB - Virgen de la Arrixaca University Hospital Carretera Madrid-Cartagena s/n 30120 El Palmar Murcia Spain Regional Transplant centre Consejeria de Sanidad y Consumo de la Region de Murcia 30008 Ronda de Levante Murcia Spain Hospital clinico Universitario Virgen de la Arrixaca Departamento de Cirugia General y del Aparato Digestivo Unidad de Trasplantes 30007 Casillas Murcia Spain department of Psychology Universidad Catolica San Antonio (UCAM) Avenida de los Jeronimos 30107 Guadalupe Murcia Spain department of Urology San Juan University Hospital of Alicante 03010 Calle Pintor Baeza Alicante Spain Universidad de Granada Avenida del Hospicio s/n 18010 Granada Spain Universidad de navarra Campus Universitario 31080 Pamplona Navarra Spain Universidad Autonoma de Madrid Ciudad Universitaria de cantoblanco 28049 Madrid Spain Servicio de cirugia HBP y Trasplante Hepatico Complejo Hospitalario Universitario de Badajoz Hospital Infanta Cristina Avenida Elvas s/n 06006 Badajoz Spain Universidad de cantabria Avenida los Castros s/n 39005 Santander Cantabria Spain departamento de cirugia Ciencias Medicas y Sociales Facultad de Medicina y Ciencias de la Salud Universidad de Alcala Campus Cientifico-Tecnologico Plaza de San Diego s/n 28801 Alcala de Henares Madrid Spain Facultad de Medicina Universidad de Malaga 29071 Avenida de Cervantes Malaga Spain Servicio de Urologia (complejo Hospitalario Universitario de canarias CHUC) y Departamento de Cirugia (Universidad de La Laguna ULL) Calle Molinos de Agua s/n 38207 San Cristobal de La Laguna Santa Cruz de Tenerife Spain departamento de ciencias Biomedicas Basicas Facultad de Ciencias Biomedicas Universidad Europea de

AIM: To analyze the attitude of Spanish medical students toward living liver donation (LLD) and to establish which factors have an influence on this ***: Study type: A sociological, interdisciplinary, multicenter and observational study. Study population: Medical students enrolled in Spain (n = 34000) in the university academic year 2010-2011. Sample size: A sample of 9598 students stratified by geographical area and academic year. Instrument used to measure attitude: A validated questionnaire (PcID-DVH RIOS) was self-administered and completed anonymously. Data collection procedure: Randomly selected medical schools. The questionnaire was applied to each academic year at compulsory sessions. Statistical analysis: Student´s t test, χ2 test and logistic regression ***: The completion rate was 95.7% (n = 9275). 89% (n = 8258) were in favor of related LLD, and 32% (n = 2937) supported unrelated LLD. The following variables were associated with having a more favorable attitude: (1) age (P = 0.008); (2) sex (P < 0.001); (3) academic year (P < 0.001); (4) geographical area (P = 0.013); (5) believing in the possibility of needing a transplant oneself in the future (P < 0.001); (6) attitude toward deceased donation (P < 0.001); (7) attitude toward living kidney donation (P < 0.001); (8) acceptance of a donated liver segment from a family member if one were needed (P < 0.001); (9) having discussed the subject with one’s family (P < 0.001) and friends (P < 0.001); (10) a partner’s opinion about the subject (P < 0.001); (11) carrying out activities of an altruistic nature; and (12) fear of the possible mutilation of the body after donation (P < 0.001).cOncLUSIOn: Spanish medical students have a favorable attitude toward LLD.

关键词： Attitude Living liver donation Medical students Transplantation Organ donation Psychosocial variables Spain

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Review on the management of cardiovascular risk factors in the elderly

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Journal of Geriatric cardiology 2022年第11期19卷 894-927页

作者： Magali González-colaço Harmand María del Mar García-Sanz Antònia Agustí Pablo césar Prada-Arrondo Alberto Domínguez-Rodríguez Beatriz Grandal-Leirós David Peña-Otero natalia negrín-Mena Jesús Javier López-Hernández Pablo Díez-Villanueva department of Internal Medicine-Geriatric Medicine Hospital Universitario Nuestra Señora de CandelariaSanta Cruz de TenerifeSpain Universidad Europea de canarias Faculty of Health SciencesLa OrotavaSpain clinical Pharmacology department Hospital Universitario Marqués de ValdecillaSantanderSpain clinical Pharmacology department.Hospital Vall d'Hebron BarcelonaSpain cardiac Surgery department Hospital Universitario de CanariasLa LagunaTenerifeSpain cardiology department Hospital Universitario de CanariasLa LagunaTenerifeSpain Ortogeriatric department.Hospital Universitario de canarias La LagunaTenerifeSpain Subdepartment of Health care Hospital Universitario Marqués de ValdecillaServicio Cántabro de SaludSantanderSpain instituto de investigación Sanitaria Gregorio Marañón(liSGM)y Valdecilla(IDIVAL) Spain Hospital Universitario de canarias Sistema Canario de SaludTenerifeSpain Primary care Management Servicio Cántabro de SaludSpain cardiology department Hospital de la PrincesaMadridSpain

cardiovascular risk factors(cVRF)are very prevalent in the elderly population and in addition to predisposing to cardiovascular disease they are related to functional decline,which limits the quality of life in this *** objective of this work is to offer a review of the current evidence in the management of cVRF in the elderly *** search strategy was executed in PubMed,*** and Embase,to search for clinical trials,observational cohort or cross-sectional studies,reviews,and clinical practice guidelines focused or including elderly *** results provided were refined after reading the title and abstract,as well as elimination of duplicates,and were finally identified and assessed following the GRAde methodology.A total of 136 studies were obtained for all predefined risk factors,such as sedentary lifestyle,smoking,obesity and metabolic syndrome,hypertension,diabetes mellitus,dyslipidemia and *** described the results of the studies identified and assessed according to their methodological quality in different recommendation sections:diagnostic and prevention,intervention,or treatment in the elderly *** the main limitation to the results of this review,there is the lack of quality studies whose target population is elderly *** issue limits the recommendations that can be made in this *** to this reason,comprehensive geriatric assessment seems the best tool currently available to implement the most appropriate treatment plans based on the baseline situation and comorbidity of each elderly patient.

关键词： prevention elderly finally

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Effects of Intake of Milk Enriched with <i>Aloe vera</i>on Patients with Gastrointestinal Reflux Disease

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Food and nutrition Sciences 2014年第10期5卷 936-942页

作者： Marta Sangil-Monroy Lluís Serra-Majem José M. Marrero Monroy Adriana Ortiz Andrellucchi Almudena Sánchez-Villegas Jorge Doreste Paul Knipschild department of Gastroenterology Hospital Universitario Insular de Gran Canaria Servicio Canario de Salud Las Palmas de Gran Canaria Spain nutrition Research Group Research Institute of Biomedical and Health Sciences University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Spain nutrition Research Group Research Institute of Biomedical and Health Sciences University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Spain ciber de Fisiopatología de la Obesidad y nutrición (cIBER OBn) Instituto de Salud Carlos III Madrid Spain nutrition Research Group Research Institute of Biomedical and Health Sciences University of Las Palmas de Gran Canaria Las Palmas de Gran Canaria Spain ciber de Fisiopatología de la Obesidad y nutrición (cIBER OBn) Instituto de Salud Carlos III Madrid Spain Service of Preventive Medicine Hospital Universitario Insular de Gran Canaria Servicio Canario de Salud Las Palmas de Gran Canaria Spain

Background: Aloe vera has been used by many civilizations throughout history due to the numerous properties attributed. Gastro oesophageal reflux disease is a common disorder with consequences for the patient’s health related quality of life. Aims: The purpose of this study was to assess the benefits of the Aloe vera in 80 patients with gastro oesophageal reflux. Methods: This is probably the first randomised and double-blind trail ever performed on this subject. The study included eight weeks of treatment with milk enriched with Aloe vera or placebo. Data of diet (frequency questionnaire), symptoms (gastrointestinal symptom rating scale) and quality of life (quality of life in reflux and disease) were obtained. Results: So far, there has been hardly any proof that Aloe vera decreases symptoms of reflux disease;on the contrary, a lower percentage of remission of pain is observed among the Aloe vera group. As long as its effectiveness has not been proven properly, the use of Aloe vera in reflux disease cannot be recommend. conclusion: Aloe vera does not have a beneficial effect on reflux disease under the study conditions.

关键词： Aloe vera Alternative Treatment Gastrointestinal Reflux (See MESH) clinical Trial

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Effectiveness and safety of first-generation protease inhibitors in clinical practice:Hepatitis c virus patients with advanced fibrosis

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javier Salmeron carmen Vinaixa Ruben Berenguer Juan Manuel Pascasio Juan Jose Sanchez Ruano Miguel angel Serra Ana Gila Moises Diago Manuel Romero-Gomez Jose Maria navarro Milagros Testillano conrado Fernandez Dolores Espinosa Isabel carmona Jose Antonio Pons Francisco Jorquera Francisco Javier Rodriguez Ramon Perez Jose Luis Montero Rafael Granados Miguel Fernandez Ana Belen Martin Paloma Munoz de Rueda Rosa Quiles cIBERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Unit for clinical Management of Digestive Diseases Complejo Hospitalario Universitario de Granada instituto de investigacion Biosanitaria de Granada University Hospital Politecnico La Fe Unit for clinical Management of Digestive Diseases University Hospital Virgen Del Rocio Hospital Toledo University clinic Hospital of Valencia University General Hospital of Valencia Unit for clinical Management of Digestive Diseases University Hospital Nuestra Senora de Valme department of Gastroenterology and Hepatology Agencia Sanitaria costa del Sol University Hospital cruces Gastroenterology Unit University Hospital Fundacion Alcorcon University Hospital Virgen Macarena University Hospital Virgen de la Arrixaca Hospital of Leon University General Hospital Reina Sofia department Gastroenterology and Hepatology University Hospital Central de Asturias University Hospital Reina Sofia University Hospital de Gran canaria Dr. negrin Hospital San Pedro de Alcantara

AIM:To evaluates the effectiveness and safety of the first generation,nS3/4A protease inhibitors(PIs) in clinical practice against chronic c virus,especially in patients with advanced fibrosis. METHODS:Prospective study and non-experimental analysis of a multicentre cohort of 38 Spanish hospitals that includes patients with chronic hepatitis c genotype 1,treatment-na?ve(Tn) or treatment-experienced(TE),who underwent triple therapy with the first generation nS3/4A protease inhibitors,boceprevir(BOc) and telaprevir(TVR),in combination with pegylated interferon and ribavirin. The patients were treatment in routine practice settings. Data on the study population and on adverse clinical and virologic effects were compiled during the treatment period and during follow ***:One thousand and fifty seven patients were included,405(38%) were treated with BOc and 652(62%) with TVR. Of this total,30%(n = 319) were Tn and the remaining were TE:28%(n = 298) relapsers,12%(n = 123) partial responders(PR),25%(n = 260) null-responders(nR) and for 5%(n = 57) with prior response unknown. The rate of sustained virologic response(SVR) by intention-to-treatment(ITT) was greater in those treated with TVR(65%) than in those treated with BOc(52%)(P ntention-to-treatment(m ITT) no were found significant differences. By degree of fibrosis,56% of patients were F4 and the highest SVR rates were recorded in the non-F4 patients,both Tn and TE. In the analysis by groups,the Tn patients treated with TVR by ITT showed a higher SVR(P = 0.005). However,by m ITT there were no significant differences between BOc and TVR. In the multivariate analysis by m ITT,the significant SVR factors were relapsers,IL28 B cc and non-F4; the type of treatment(BOc or TVR) was not significant. The lowest SVR values were presented by the F4-nR patients,treated with BOc(46%) or with TVR(45%). 28% of the patients interrupted the treatment,mainly by non-viral response(51%):this outcome was

关键词： Hepatitis c Boceprevir Telaprevir First-generation protease inhibitors Advanced fibrosis

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degradation and detoxification of Banana Postharvest Treatment Water Using Advanced Oxidation Techniques

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Green and Sustainable chemistry 2011年第3期1卷 39-46页

作者： Dunia E.Santiago Elisenda Pulido Melian cristina Fernandez Rodriguez Jose A.Ortega Mendez Sebastian O.Perez-Baez Jose M.Dona-Rodriguez Grupo de Photocatalisis y Espectroscopia Aplicada al Medioambiente-FEAM(Unidad Asociada al instituto de ciencia de Materiales de Sevilla C.S.I.C.)CIDIA-Depto.de QuimicaEdificio del Parque Cientifico TecnologicoUniversidad De Las Palmas De Gran CanariaLas PalmasSpain

The elimination and detoxification of water contaminated with the principal commercial fungi-cides—thia- bendazole (Textar 60 T) and imazalil sulphate (Fruitgard IS 7.5)—used in the postharvest treatment of bananas was successfully achieved through the use of advanced oxidation processes (AOPs). The techniques tested were heterogeneous photocatalysis with TiO2 and TiO2-activated carbon (TiO2-cA) and Fenton and photo-Fenton processes. The evolution of fungicide concentration during degradation was studied together with mineralization and toxicity levels. When treated with any of the methods under study, the water meets the conditions stipulated by the legislation currently in force for its reuse in irrigation. However, this study proposes that the Fenton process is the best option for treatment of this type of water due to the efficiency of its reactions and its low economic cost.

关键词： Thiabendazole Imazalil Sulphate Photocatalysis Fenton Photo-Fenton Banana Postharvest

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Earth-Moon Barycentre Excursions and Anomalous Quaternary Sea Level Highstands

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International Journal of Geosciences 2022年第8期13卷 627-656页

作者： Joaquin Meco consuelo Sendino Alejandro Lomoschitz Antonio núñez María José Huertas Juan F. Betancort departamento de Biología Facultad de Ciencias del Mar Universidad de Las Palmas de Gran Canaria (ULPGC) Las Palmas de Gran Canaria Spain department of Earth Sciences Natural History Museum London United Kingdom instituto de Oceanografía y cambio Global IOCAG Universidad de Las Palmas de Gran Canaria ULPGC Las Palmas de Gran Canaria Spain department of Electrical and Electronics Engineering Universidad de Las Palmas de Gran Canaria ULPGC Las Palmas de Gran Canaria Spain departamento de Mineralogía y Petrología Facultad de Ciencias Geológicas Universidad Complutense de Madrid (UCM) Madrid Spain

Plate tectonics is driven by Earth-Moon barycentre shifts in the lower mantle. The eastern canary Islands have geographic and geological conditions derived from the movements of the central American plates. Some features of these islands are influenced by the rotation of the Earth from west to east in the evolution of the marine currents that surround them and the opening of the north Atlantic to the north Pole with little dependence of the glacial isostatic adjustment (GIA). In addition, their position with respect to the Tropic of cancer and the African continent affect the north-south and east-west climatic change dynamics and their tectonic stability respectively. Dated lavas contain marine and aeolian deposits and some of the Pleistocene marine deposits indicate higher sea level in cooler circumstances, which is anomalous. Relating those marine deposits produced during the warmest interglacial, the last interglacial and the Holocene with their equivalents in the Southern Hemisphere, they reflect shifts in the barycentre. Thanks to Holocene radiocarbon, topographic and day length data and alkenone temperature, we describe a mechanism by which the oscillation of the Moon’s inclination (and declination) reaches extreme values (14ºand 34ºabout 4.9ºmore than current values) approximately every 1450 years. These values occur when there is a harmonic distortion in surface areas of the Earth’s crust as response associated with oscillations in the displacements of the barycentre of the Earth-Moon system. As the declination influences the movement of oceanic waters, there is also a relationship with the Bond Events of the north Atlantic, of unknown cause until now.

关键词： Earth-Moon Barycentre Lunar declination Sea-Level canary Islands neogene Quaternary

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