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Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang John Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

Effects of carbon sources and temperature on the formation and structural characteristics of food-related Staphylococcus epidermidis biofilms

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food science and Human Wellness 2020年第4期9卷 370-376页

作者： Mingming Zou Donghong Liu College of Biosystems Engineering and food science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhou 310058China fuli institute of food science Zhejiang UniversityHangzhou 310058China Ningbo Research institute Zhejiang UniversityNingbo 315100China

Biofilms are a constant concern in the food industry;understanding the effect of environmental conditions on biofilm formation is essential to develop effective control ***,this study was conducted to investigate biofilms formation by Staphylococcus epidermidis under various *** were cultured in nutrient broth containing different carbon source concentrations(0–10 mg/mL)on polystyrene surfaces for 32 h of incubation at 37℃or 55℃,with quantification and enumeration at 8,16,24 and 32 *** developed biofilms under all tested conditions;achieved the highest yield of biofilm biomass at 2.5 mg/mL for all carbon sources at 37℃.The highest efficiency of extracellular polymeric substance(EPS)molecule production occurred under glucose availability in the growth environment,with a higher yield of biomass and a significantly smaller number of metabolically active cells than under other tested conditions.A condensed ball-shaped structure was observed under the lactose ***,biofilms in the presence of maltose showed mainly opaque thick rich colonies,while a compact multilayered-shaped structure was exhibited under both glucose and sucrose *** results contribute to a better understanding of the biofilm formation by *** in order to reduce contamination and recontamination in the food industry.

关键词： Staphylococcus epidermidis Carbon sources Temperature Bacterial biofilm Community structure

A rapid method for extraction,purification and structure analysis of chondroitin sulfate from six marine tissues

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food Quality and Safety 2023年第1期7卷 20-29页

作者： Yuying Wang Shokouh Ahmadi Chengxiao Yu Laiming Zhang Xinxin Hu Xingqian Ye Shiguo Chen College of Biosystems Engineering and food science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhouChina Zhejiang University Zhongyuan institute ZhengzhouChina Shandong(Linyi)institute of Modern Agriculture Zhejiang UniversityLinliChina fuli institute of food science Zhejiang UniversityHangzhouChina Ningbo Research institute Zhejiang UniversityHangzhouChina

This study was designed to establish a strategy for the extraction,purification,and structure analysis of chondroitin sulfate(cs)in milligram *** acidic polysaccharides were extracted from six kinds of marine animals by enzymatic hydrolysis and hexadecylpyridinium chloride precipitation and purified by Q Sepharose Fast Flow strong anion exchange *** purification of each crude polysaccharide was completed within 1 *** structure of the polysaccharides,*** chemical characterization,functional group,molecular weight and monosaccharide composition,were analyzed by colorimetry,nuclear magnetic resonace and high-performance liquid chromatogrpahy,*** polysaccharides were identified as *** oligosaccharide profile produced by enzyme hydrolysis of polysaccharides was determined by strong anion-exchange high-performance liquid *** method can be widely applied to the extraction and characterization of chondroitin sulfate from unknown raw materials,screening high-quality sources of functional polysaccharides,and laying a good foundation for thefollowing studyof the structure-function relationshipof polysaccharides.

关键词： Chondroitin sulfate marinepolysaccharide disaccharide analysis

Optimization of ultrasonic-assisted freezing of Penaeus chinensis by response surface methodology

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food Quality and Safety 2021年第2期5卷 143-151页

作者： Yubin Ying Yingchun Xiang Jialin Liu Xin Chen Lingping Hu Yujin Li Yaqin Hu College of Biosystems Engineering and food science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingIntegrated Research Base of Southern Fruit and Vegetable Preservation TechnologyZhejiang International Scientific and Technological Cooperation Base of Health Food Manufacturing and Quality ControlNingbo Research InstituteFuli Institute of Food ScienceZhejiang UniversityHangzhouChina College of food science and Technology Hainan Tropical Ocean UniversitySanyaChina College of food science and Engineering Ocean University of ChinaQingdaoChina

Objectives:Optimization of ultrasonic-assisted freezing of Penaeus chinensis by response surface methodology was studied in order to(1)obtain frozen Penaeus chinensis of high quality and(2)provide practical guidance for the application of ultrasonic-assisted freezing in Penaeus *** and Methods:Three independent and major variables were selected,including initial ultrasonic temperature(℃),ultrasonic power(W)and ultrasonic time(s on/2 s off).On the basis of one-factor experiments,17 groups of experiments were established by response surface methodology according to Box-Behnken *** multiple regression analysis the experimental data were fitted into a second-order polynomial equation,which was tested by proper statistical ***:The optimal ultrasonic conditions were as follows:initial ultrasonic temperature 0℃,ultrasonic power 180 W,ultrasonic time 5 son/2 s *** the optimization conditions,the time of passing through maximum ice crystal generation zone was 105.500 s,which was very close to the predictive passage time of 101.541 ***:Initial ultrasonic temperature,ultrasonic time and ultrasonic power played an important role in the process of ultrasonic-assisted freezing of Penaeus *** surface methodology was used to optimize the three factors in ultrasonic-assisted freezing,which could greatly shorten the time of passing through the maximum ice crystal generation zone and maintain the tissue structure of Penaeus chinensis well.

关键词： Ultrasonic-assisted freezing Penaeus chinensis response surface methodology time of passing through the maximum ice crystal generation zone optimization

Identification of carbohydrate in Polygonatum sibiricum:fructo-oligosaccharide was a major component

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food Quality and Safety 2023年第3期7卷 439-446页

作者： Jiabei Xia Cenrong Zhang Kai Zhu Xingyu Mei Huan Cheng Shiguo Chen Xingqian Ye Jianle Chen Ningbo Innovation Center Zhejiang UniversityNingboChina College of Biosystems Engineering and food science National–Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agri-Food ProcessingFuli Institute of Food ScienceZhejiang Engineering Laboratory of Food Technology and EquipmentZhejiang UniversityHangzhouChina Zhejiang University Zhongyuan institute ZhengzhouChina School of Biological and Chemical Engineering NingboTech UniversityNingboChina

Polygonatum sibiricum,famous for its physiological activities,is a popular Chinese food and a traditional Chinese herb containing many carbohydrates as the main ***,except for most reported polysaccharides,other detailed compositions of carbohydrates are still not *** verify the controversial existence of starch and investigate other components,especially oligosaccharides,we used iodine–potassium iodide colorimetric detection and enzymatic hydrolysis to determine ***,oligosaccharides were analyzed by thin-layer chromatography,gel permeation chromatography,high-performance anion exchange chromatography with pulsed amperometric detection,and hydrophilic interaction chromatography–electrospray tandem mass *** results showed that the rhizome of *** lacked starch,and fructooligosaccharides were the main component,accounting for approximately 28.95%.Oligosaccharides with degrees of polymerization above 10 were the most abundant *** study clearly illustrated the unknown carbohydrate components of the Polygonatum rhizome,promoting its functional value with new evidence.

关键词： Polygonatum sibiricum starch determination fructo-oligosaccharides HPAEC-PAD HILIC-ESI-MS/MS

Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed Linlin Ma Griffith institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

通过受控晶体应变揭示PtCo双金属固体溶液中增强的氧还原活性（英文）

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science China Materials 2025年第01期 180-188页

作者：贺宁吴胜强俞文松金方润谢文俊鲁欣欣赵晓续陈仲欣涂文广唐叔贤 School of science and Engineering The Chinese University of Hong Kong School of Materials science and Engineering Peking University School of Materials science and Engineering Huaqiao University Petro China Shenzhen New Energy Research institute institute of Materials science and Devices Suzhou University of Science and Technology

开发用于氧还原反应（ORR）的低成本、高活性铂（Pt）基电催化剂对于燃料电池的广泛应用至关重要.一种有效的方法在于将Pt与非贵过渡金属合金化,以调节Pt表面的物理化学状态.然而,由于合金化过程中成分、晶体类型和表面结构的复杂性,在...

开发用于氧还原反应（ORR）的低成本、高活性铂（Pt）基电催化剂对于燃料电池的广泛应用至关重要.一种有效的方法在于将Pt与非贵过渡金属合金化,以调节Pt表面的物理化学状态.然而,由于合金化过程中成分、晶体类型和表面结构的复杂性,在理解结构-性能关系方面仍然存在巨大挑战.在本研究中,我们使用液相合成方法合成了一系列不同比例的PtCo双金属固溶体.通过利用固溶体的特性,所得的PtCo双金属合金保持了面心立方晶体结构,最大限度地减少了合金化过程中引入的复杂性,有利于活性机理分析.此外,在受控合金成分和晶体结构下,我们研究了氧还原反应的电催化活性对铂催化剂表面应变的依赖性.据此设计的S-PtCo-SNPs阴极赋予了质子交换膜燃料电池（PEMFC）(2.08 W cm-2,4 A cm-2)和锌-空气电池（ZAB）(143.1m W cm-2,214.5m A cm-2)出色的性能.

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Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei Xiong Center of Materials science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment