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Journal of Genetics and Genomics 2022年第3期49卷 267-267页

作者： Xiaoxue Li Tingdong Hu Jiying Liu Bin Fang Xue Geng Qiang Xiong Lining Zhang Yong Jin Xiaorui Liu Lin Li Ying Wang Rongfeng Li Xiaochun Bai Haiyuan Yang Yifan Dai Jiangsu key laboratory of Xenotransplantation Nanjing Medical UniversityNanjing 211166China key laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjing 211166China Department of Cell Biology Guangdong Provincial Key Laboratory of Bone and Joint Degenerative DiseasesSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China State key laboratory of reproductive Medicine Nanjing Medical UniversityNanjing 211166China Shenzhen Xenotransplantation Medical Engineering research and Development Center Institute of Translational MedicineShenzhen Second People's HospitalFirst Affiliated Hospital of Shenzhen UniversityShenzhen 518035China

This erratum clarifies information in the article“A Bama miniature pig model of monoallelic TSC1 mutation for human tuberous sclerosis complex”by Li et al.(2020).In the“Acknowledgment”section,the statement that“This work was supported by grants from the National Natural Science Foundation of China(31701283,81970164)”should say“This work was supported by grants from the National Natural Science Foundation of China(81874144,81970164)”.

关键词： statement mono TSC1

Strain Hardening Associated with Dislocation,Deformation Twinning,and Dynamic Strain Aging in Fe–20Mn–1.3C–(3Cu) TWIP Steels

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Acta Metallurgica Sinica(English Letters) 2014年第4期27卷 601-608页

作者： Lingyan Zhao Dingyi Zhu Longlong Liu Zhenming Hu Mingjie Wang College of Materials Science and Engineering Fuzhou University fujian San Ming Iron & Steel Group Co. Ltd. College of Materials Science and Engineering Fujian University of Technology

The effects of Cu on stacking fault energy,dislocation slip,mechanical twinning,and strain hardening in Fe–20Mn–1.3C twinning-induced plasticity（TWIP） steels were systematically *** stacking fault energy was raised with an average slope of 2 mJ/m2 per 1 wt% *** Fe–20Mn–1.3C–3Cu steel exhibited superior tensile properties,with the ultimate tensile strength reached at 2.27 GPa and elongation up to 96.9% owing to the high strain hardening that *** examine the mechanism of this high strain hardening,dislocation density determination by XRD was *** dislocation density increased with the increasing strain,and the addition of Cu resulted in a decrease in the dislocation density.A comparison of the strain-hardening behavior of Fe–20Mn–1.3C and Fe–20Mn–1.3C–3Cu TWIP steels was made in terms of modified Crussard–Jaoul（C–J） analysis and microstructural *** at low strains,the contributions of all the relevant deformation mechanisms—slip,twinning,and dynamic strain aging—were quantitatively *** analysis revealed that the dislocation storage was the leading factor to the increase of the strain hardening,while dynamic strain aging was a minor contributor to strain ***,which interacted with the matrix,acted as an effective barrier to dislocation motion.

关键词： Twinning-induced plasticity(TWIP) Strain hardening Mechanical twinning Dislocation density Dynamic strain aging

Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China:a nation-wide study

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Science China(Life Sciences) 2022年第9期65卷 1855-1865页

作者： Jianping Li Nan Zhang Ziyi Zhou Xiao Huang Weiyi Fang Hongbing Yan Jiyan Chen Weimin Wang Dingcheng Xiang Xi Su Bo Yu Yan Wang Yawei Xu Lefeng Wang Chunjie Li Kai Huang Xiaobin Wang Yong Huo Junbo Ge Department of Cardiology Peking University First HospitalBeijing 100044China key laboratory of Precision Nutrition and Food Quality Ministry of EducationDepartment of Nutrition and HealthCollege of Food Sciences and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Institute of Biomedicine Anhui Medical UniversityHefei 230032China Department of Cardiovascular Medicine Second Affiliated Hospital of Nanchang UniversityNanchang 330008China Department of Cardiology Huadong Hospital Affiliated to Fudan UniversityShanghai 200050China Department of Cardiology Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China Department of Cardiology Guangdong Provincial People’s HospitalGuangzhou 510080China Department of Cardiology Peking University People’s HospitalBeijing 100044China Department of Cardiology General Hospital of Southern Theatre CommandGuangzhou 510010China Department of Cardiology Wuhan ASIA Heart HospitalWuhan 430010China Department of Cardiology The 2nd Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Cardiology Xiamen Cardiovascular Hospital Xiamen UniversityXiamen 361004China Department of Cardiology Shanghai Tenth People’s HospitalShanghai 200072China Department of Cardiology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100069China Department of Emergency Tianjin Chest HospitalTianjin 300074China Department of Cardiology Union Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore 21218USA Department of Cardiology Zhongshan HospitalFudan UniversityShanghai 200032China

Lockdown and re-opening may become cyclical due to the recurrent waves of the COVID-19 *** studies have examined temporal trends and determinants of in-hospital mortality among patients with ST-segment elevation myocardial infarction(STEMI),a life-threatening condition that requires emergency medical *** nation-wide data before,during and after the Wuhan lockdown,we aimed to depict temporal patterns and major determinants of STEMI in-hospital mortality in China across five time periods of the COVID-19 *** analyzed the data of 283,661 STEMI patients who were admitted to 4,487 chest-pain-centers across China,from January 1,2019 to May 31,*** with the period before the lockdown,STEMI in-hospital mortality increased by 25%(OR 1.25,95%CI 1.16–1.34)during Early Lockdown,by 12%(OR 1.12,95%CI 1.03–1.22)during Later Lockdown,by 35%(OR 1.35,95%CI 1.21–1.50)during Early Lift,and returned to pre-COVID risk(OR 1.04,95%CI 0.95–1.14)during Later *** each time-period,we observed a clear mortality gradient by timing and types of revascularization *** conclusion,the COVID-19 epidemic had a significant adverse impact on STEMI in-hospital mortality,with bimodal peaks during early lockdown and early lift periods and clear mortality gradients by timing and types of revascularization procedure,independent of the time periods.

关键词： COVID-19 STEMI mortality lockdown re-opening

Standard:Human intestinal organoids

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Cell Regeneration 2023年第1期12卷 199-203页

作者： Yalong Wang Hanqing Lin Lianzheng Zhao Fan Hong Jie Hao Zhen Zhang Weiqi Sheng Linhong Song Chu‑Xia Deng Bing Zhao Jiani Cao Lei Wang Liu Wang Lingmin Liang Wenli Kelly Chen Chunping Yu Zhijian Sun Yingying Yang Changlin Wang Yong Zhang Qiyuan Li Ka Li Aijin Ma Tongbiao Zhao Guoqiang Hua Ye-Guang Chen The State key laboratory of Membrane Biology Tsinghua‑Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Guangzhou laboratory Guangzhou 510005China Guangzhou Institutes of Biomedicine and health Chinese Academy of SciencesGuangzhou 510530China Guangzhou Hua Yi Regeneration Technology Co. LtdHuangpu DistrictGuangzhou 510700China D1Med Technology(Shanghai)Inc Shanghai 201802China State key laboratory of Stem Cell and reproductive Biology Institute for Stem Cell and RegenerationInstitute of ZoologyNational Stem Cell Resource CenterChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute of Clinical Science Zhongshan HospitalFudan UniversityShanghai 200433China Department of Radiation Oncology and Cancer Institute Fudan University Shanghai Cancer Center Fudan UniversityShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai key laboratory of Radiation Oncology Shanghai 200032China Department of Pathology Fudan University Shanghai Cancer CenterShanghai 200032China Sichuan Academy of Medical Sciences&Sichuan provincial People’s Hospital Chengdu 610072China Cancer Centre Faculty of Health SciencesUniversity of MacaoMacao 999078SARChina State key laboratory of Genetic Engineering School of Life SciencesFudan UniversityShanghai 200438China China Innovation Center of Roche Li Shi Zhen RoadPudongShanghai 201203China Eli Lilly and Company PudongShanghai 201203China K2 Oncology Co. LtdKeChuang StreetBeijing 100176China Qilu Pharmaceutical Co. LtdJinan 250104China China National Institute of Standardization Beijing 100191China Chinese Society for Stem Cell research Shanghai 200032China HHLIFE Co. IncShenzhen 518040China China National GeneBank Shenzhen 518000China Beijing Technology and Business University Beijing 100048China School of Bas

Organoids have attracted great interest for disease modelling,drug discovery and development,and tissue growth and homeostasis ***,lack of standards for quality control has become a prominent obstacle to limit their translation into clinic and other applications.“Human intestinal organoids”is the first guideline on human intestinal organoids in China,jointly drafted and agreed by the experts from the Chinese Society for Cell Biology and its branch society:the Chinese Society for Stem Cell *** standard specifies terms and definitions,technical requirements,test methods,inspection rules for human intestinal organoids,which is applicable to quality control during the process of manufacturing and testing of human intestinal *** was originally released by the Chinese Society for Cell Biology on 24 September *** hope that the publication of this standard will guide institutional establishment,acceptance and execution of proper practical protocols and accelerate the international standardization of human intestinal organoids for applications.

关键词： Human jointly branch

Melatonin antagonizes ovarian aging via YTHDF2-MAPK-NF-κB pathway

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Genes & Diseases 2022年第2期9卷 494-509页

作者： Ruigong Zhu Xian Ji Xuan Wu Jiajing Chen Xuesong Li Hong Jiang Haiping Fu Hui Wang Zhe Lin Xin Tang Shixiu Sun Qingguo Li Bingjian Wang Hongshan Chen key laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166PR China Department of Cardiothoracic Surgery The Second Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210003PR China key laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingJiangsu 211166PR China Department of Cardiology Huai'an First People's Hospital Affiliated with Nanjing Medical UniversityHuai'anJiangsu 223399PR China

Cellular senescence is closely associated with age-related *** aging,a special type of organ senescence,is the pathophysiological foundation of the diseases of the reproductive *** is characterized by the loss of integrity of the surface epithelium and a gradual decrease in the number of human ovarian surface epithelial cells(HOSEpiCs).To contribute to the research on delaying ovarian aging,we aimed to investigate the novel epigenetic mechanism of melatonin in protecting *** discovered that melatonin has antagonistic effects against the oncogene-induced senescence(OIS)of ***,the oncogene Ras decreased the expression of YTHDF2,which is the reader of RNA-m6A,by stimulating the generation of reactive oxygen species(ROS).Moreover,we found that the suppression of YTHDF2 increased the expression of MAP2K4 and MAP4K4 by enhancing the stability of the transcription of their mRNAs,thereby upregulating the expression of the senescence-associated secretory phenotype(SASP)through the activation of the MAP2K4 and MAP4K4-dependent nuclear factor-κB(NF-κB)signaling *** further determined that melatonin has antagonistic effects against the OIS of HOSEpiCs by inhibiting the ROS-YTHDF2-MAPK-NF-κB *** findings provide key insights into the potential avenues for preventing and treating ovarian aging.

关键词： Gene expression Inflammation Melatonin Senescence YTHDF2

Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats

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World Journal of Gastroenterology 2019年第40期25卷 6077-6093页

作者： Yang Bai Ying-Biao Chen Xin-Tong Qiu Yan-Bing Chen Li-Tian Ma Ying-Qi Li Hong-Ke Sun Ming-Ming Zhang Ting Zhang Tao Chen Bo-Yuan Fan Hui Li Yun-Qing Li Department of Anatomy Histology and Embryology&K.K.Leung Brain Research CentreFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Anatomy Fujian Health CollegeFuzhou 350101Fujian ProvinceChina Department of Cardiology The Second Affiliated Hospital of Xian Jiaotong UniversityXian Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Joint laboratory of Neuroscience at Hainan Medical University and Fourth Military Medical University Hainan Medical UniversityHaikou 571199Hainan ProvinceChina

BACKGROUND Central sensitization plays a pivotal role in the maintenance of chronic pain induced by chronic pancreatitis(CP).We hypothesized that the nucleus tractus solitarius(NTS),a primary central site that integrates pancreatic afferents apart from the thoracic spinal dorsal horn,plays a key role in the pathogenesis of visceral hypersensitivity in a rat model of *** To investigate the role of the NTS in the visceral hypersensitivity induced by chronic *** CP was induced by the intraductal injection of trinitrobenzene sulfonic acid(TNBS)in *** hyperalgesia was assessed by referred somatic pain via von Frey filament *** activation of the NTS was indicated by immunohistochemical staining for *** synaptic transmission within the NTS was assessed by electrophysiological *** of vesicular glutamate transporters(VGluTs),N-methyl-D-aspartate receptor subtype 2B(NR2B),andα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subtype 1(GluR1)was analyzed by *** insertion of NR2B and GluR1 was evaluated by electron *** regulatory role of the NTS in visceral hypersensitivity was detected via pharmacological approach and chemogenetics in CP *** TNBS treatment significantly increased the number of Fos-expressing neurons within the caudal *** excitatory synaptic transmission was substantially potentiated within the caudal NTS in CP rats(frequency:5.87±1.12 Hz in CP rats vs 2.55±0.44 Hz in sham rats,P<0.01;amplitude:19.60±1.39 pA in CP rats vs 14.71±1.07 pA in sham rats;P<0.01).CP rats showed upregulated expression of VGluT2,and increased phosphorylation and postsynaptic trafficking of NR2B and GluR1 within the caudal *** excitatory synaptic transmission via the AMPAR antagonist CNQX and the NMDAR antagonist AP-5 microinjection reversed visceral hypersensitivity in CP rats(abdominal withdraw threshold:7.00±1.02 g in CNQX group,8.00±0.81 g in AP-5 group and

关键词： Rat Chronic pancreatitis Visceral hypersensitivity Nucleus tractus solitarius Excitatory synaptic transmission

A Dual-Chaining Watermark Scheme for Data Integrity Protection in Internet of Things

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Computers, Materials & Continua 2019年第3期58卷 679-695页

作者： Baowei Wang Weiwen Kong Wei Li Neal NXiong Jiangsu Engineering Centre of Network Monitoring Jiangsu Collaborative Innovation Center on Atmospheric Environment and Equipment TechnologySchool of Computer and SoftwareNanjing University of Information Science&TechnologyNanjing210044China Engineering research Center of Electronic Information and Control from fujian provincial Education Department Fuzhou350108China Department of Mathematics and Computer Science Northeastern State UniversityOklahomaUSA.

Chaining watermark is an effective way to verify the integrity of streaming data in wireless network environment,especially in resource-constrained sensor networks,such as the perception layer of Internet of Things ***,in all existing single chaining watermark schemes,how to ensure the synchronization between the data sender and the receiver is still an unsolved *** the synchronization points are attacked by the adversary,existing data integrity authentication schemes are difficult to work properly,and the false negative rate might be up to 50 *** the additional fixed group delimiters not only increase the data size,but are also easily detected by *** this paper,we propose an effective dual-chaining watermark scheme,called DCW,for data integrity protection in smart campus IoT *** proposed DCW scheme has the following three characteristics:(1)In order to authenticate the integrity of the data,fragile watermarks are generated and embedded into the data in a chaining way using dynamic grouping;(2)Instead of additional fixed group delimiters,chained watermark delimiters are proposed to synchronize the both transmission sides in case of the synchronization points are tampered;(3)To achieve lossless integrity authentication,a reversible watermarking technique is *** experimental results and security analysis can prove that the proposed DCW scheme is able to effectively authenticate the integrity of the data with free distortion at low cost in our smart meteorological Internet of Things system.

关键词： Dual-chaining reversible watermark integrity authentication Internet of things.

Synergistic and antagonistic interactions between potassium and magnesium in higher plants

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The Crop Journal 2021年第2期9卷 249-256页

作者： Kailiu Xie Ismail Cakmak Shiyu Wang Fusuo Zhang Shiwei Guo Jiangsu provincial key Lab of Solid Organic Waste Utilization Jiangsu Collaborative Innovation Center of Solid Organic WastesEducational Ministry Engineering Center of Resource-saving FertilizersNanjing Agricultural UniversityNanjing 210095JiangsuChina School of Land Resources and Environment Jiangxi Agricultural UniversityNanchang 330045JiangxiChina Faculty of Engineering and Natural Sciences Sabanci University34956 IstanbulTurkey International Magnesium Institute College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Resources and Environmental Sciences China Agricultural UniversityBeijing 100193China

Magnesium(Mg)affects various critical physiological and biochemical processes in higher plants,and its deficiency impedes plant growth and *** potassium(K)-induced Mg deficiency in agricultural production is widespread,the specific relationship of K with Mg and especially its competitive nature is poorly *** review summarizes current knowledge on the interactions between K and Mg with respect to their root uptake,root-to-shoot translocation and distribution in *** synergistic effects on certain physiological functions are also *** antagonistic effect of K on Mg is stronger than that of Mg on K in root absorption and transport within plants,indicating that the balanced use of K and Mg fertilizers is necessary for sustaining high plant-available Mg and alleviating K-induced Mg deficiency,especially in plant species with high K demand or in highavailable-K *** relationship between Mg and K in plant tissues may be antagonistic or synergistic depending on plant species,cell type,leaf age,source-and sink *** are synergistic effects of K and Mg on photosynthesis,carbohydrate transport and allocation,nitrogen metabolism,and turgor *** of optimal K/Mg ratios for soils and plant tissues is desirable for maintaining proper nutritional status in plants,leading to a physiological state supporting crop *** research should concentrate on identifying the physiological and molecular mechanisms underlying the interactions between K and Mg in a given physiological function.

关键词： Antagonism Functional replacement Magnesium Potassium Synergy

Expression of inhibin α,matrix metalloproteinase-2 and tissue inhibitors of metalloproteinase-1 in luteinized granulosa cells:comparison between women with and without endometriosis

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生殖医学杂志 2012年第B12期21卷 61-69页

作者：谭容容刘丽鹏浦丹华崔毓桂江世文刘嘉茵吴洁 State key laboratory of reproductive Medicine Department of Obstetrics & Gynecologythe First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Department of Biomedical Sciences Mercer University School of MedicineSavannahGA 31405USA State key laboratory of reproductive Medicine

Objective:To assess the differences in expression of inhibin a,MMP-2 and TIMP-1 in luteinized granulosa cells from women with and without endometriosis undergoing in vitro fertilization(IVF),and determine whether inhibin a,MMP-2 and TIMP-1 expressions correlate with the follicle development in patients with endometriosis. Methods:Thirty six infertile patients with stageⅢandⅣendometriosis patients(group A) and 35 tubal infertile and/or male factor patients(group B) attending to the clinic of Jiangsu provincial Hospital Human reproductive Center during May 2011 and December 2011 were included in this prospective *** patients with the number of mature oocyte≤4 were considered as poor *** to this,the two groups were further divided into four subgroups:Al group(23 endometriosis patients with normal response),A2 group(13 endometriosis patients with poor response),Bl group(23 controls with normal response) and B2 group(12 controls with poor response).Fasting blood samples were collected on the first day of ovarian stimulation and on the day of hCG administration,and follicle fluid were collected on the day of oocytes *** concentrations of follicle stimulating hormone(FSH),Luteinizing hormone(LH) and estradiol(E_2) were measured by *** was collected from follicle fluid by Percoll method,and Stepone real-time polymerase chain reaction(PCR) was used to analysis the expression level of inhibinα,MMP-2 and TIMP-1. Results;The expression of inhibinαin endometriosis group and poor responders in control group were significantly lower than those of the normal responders in control group,in which the alternation of inhibinαexpression was not correlated to the variables of follicle ***,MMP-2 levels were lower and TIMP-1 levels were higher in both endometriosis and tubal/male infertility poor responders compared to normal ovarian ***,the correlation between MMP-2 or TIMP-1 expression and variables of fol

关键词：子宫内膜异位症基质金属蛋白酶-2 颗粒细胞抑制素卵巢聚合酶链反应 TIMP-1 抑制剂

Birth seasonality and pattern in black-and-white snub-nosed monkeys （Rhinopithecus bieti） at Mt. Lasha, Yunnan

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Zoological research 2014年第6期35卷 474-484页

作者： Jin-Fa LI Yu-Chao HE Zhi-Pang HUANG Shuang-Jin WANG Zuo-Fu XIANG Juan-Jun ZHAO Wen XIAO Liang-Wei CUI key laboratory of Forest Disaster Warning and Control in Yunnan Province Southwest Forestry University Kunming Yunnan 650224 China Bureau of Yunling provincial Nature Reserve Lanping Yunnan 671400 China College of Life Science and Technology Central South University of Forestry and Technology Changsha Hunan 410004 China Institute of Eastern-Himalaya Biodiversity research Dali University Dali Yunnan 671003 China

Seasonal variation in environmental factors is vital to the regulation of seasonal reproduction in primates. Consequently, long-term systematic data is necessary to clarify the birth seasonality and pattern of primates in highly seasonal environments. This study indicated that black-and-white snub-nosed monkeys （Rhinopithecus bieti） at Mt. Lasha exhibited strict birth seasonality with a pulse model. Infants were born with a certain degree of synchronization. Birth distribution showed three birth peaks, and the birth pattern showed a ＂V＂ style in even-numbered years and a gradual increase in odd-numbered years. The beginning date, end date and median birth date were earlier in even-numbered years than those in odd-numbered years. The higher latitude of their habitats, earlier birth date, shorter birth period, fewer birth peaks and stronger birth synchrony might be adaptations for strongly seasonal variation in climate and food resources. After the summer solstice when daylight length began to gradually shorten, R. bieti at Mt. Lasha started to breed during the period with the highest environmental temperature and food availability, which implied that photoperiod may be the proximate factor triggering the onset of estrus and mating. It appears that R. bieti coincided conception and mid-lactation with the peak in staple foods, and weaning with the peak in high quality of foods. Thus, food availability was the ultimate factor regulating reproductive seasonality, and photoperiod was the proximate factor fine-turning the coordination between seasonal breeding and food availability.

关键词： Rhinopithecus bieti Birth seasonality Birth pattern Birth synchrony