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Industry Distribution Characteristics of Benzene-Induced Leukemia—7 PLADs,China,2005–2019

China CDC weekly 2022年第17期4卷 358-363,I0002页

作者： Jinzhe Li Yuan Zhao Xiurong Cheng Lei Han Xue Wang Qiang Jia Shang Gao Peiyu Xu Zihuan Wang Jin Li Xinglin Fang Jiabin Chen Baoli Zhu Meibian Zhang Caihong Xing key laboratory of Chemical Safety and Health National Institute for Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijingChina Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsuChina Shandong Academy of Occupational Health and Occupational Medicine Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandongChina Occupational and Radiation Health Institute Sichuan Center for Disease Control and PreventionChengduSichuanChina Department of Nutrition Food Safety and ToxicologyWest China School of Public HealthSichuan UniversityChengduSichuanChina Beijing Center for Disease Prevention and Control Beijing Research Center for Preventive MedicineBeijingChina fujian Center for Prevention and Control of Occupational Diseases and Chemical Poisoning FuzhouFujianChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiangChina Guangdong Provincial key laboratory of Occupational Disease Prevention and Treatment GuangzhouGuangdongChina

Summary What is already known about this topic?In the ***-induced leukemia(BIL)mainly occurred in shoemaking and painting *** the industry distribution of benzene-induced leukemia may have changed over *** is added by this report?BlL cases mainly occurred in the manufacturing industry from 2005-2019,especially in private enterprises and small/medium-sized *** industry with the largest number of new cases of BIL was the general and special equipment *** number of leukemia cases in emerging industries such as computer/electronic product manufacturing was found to be *** are the implications for public health practice?Strengthening supervision and regulation of manufacturing,especially of small/medium-sized enterprises and emerging manufacturing industry,may be effective in reducing BIL.

关键词： enterprises sized industry

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Anti-tumor and reversing MDR effects of conglobatin a macrolide dilactone compound

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中国药理学与毒理学杂志 2019年第10期 894-894页

作者： ZHANG Zi-qiang LIU Ling-xue MA Chun-ling XU Jian-hua School of Pharmacy Fujian Provincial Key Laboratory of Natural Medicine Pharmacology Fujian Medical University

OBJECTIVE To investigate macrolide dilactone compound conglobatin anti-tumor, reversing multi-drug resistance（MDR） effects and their mechanisms of action in vitro and in vivo. METHODS MTT assay was used to assess the proliferation-inhibiting effect of conglobatin alone or combination with lapatinib, and used to detected the reversal MDR effect of conglobatin on ABCB1 or ABCG2 overexpressing cells. Flow cytometry was used to examined the effects of conglobatin induced cell apoptosis and intracellular accumulation of doxorubicin（DOX, adriamycin, adr）/Rhodamine 123（Rho 123）, efflux of doxorubicin. Chemproteomics, computational docking,immunoprecipitation and Western blotting were taken to investigate the antitumor mechanism of *** antitumor activity and reversal MDR effect of conglobatin in vivo were evaluated with xenograftes *** Conglobatin significantly inhibited the proliferation of hepatocellular carcinoma cell QGY7703 and breast cancer cell SKBR3（the IC50 values ranging from12 to 19 μmol·L-1 at 48 h exposure）, and induced apoptosis in a dose-dependent manner. Its inducing apoptosis was associated with down-regulating the expression of antiapoptotic protein Bcl-2 and up-regulating the expression of pro-apoptotic protein Bax, and then promoting the cleavage of caspase and PARP. The combination of conglobatin and lapatinib showed synergistic effects on inhibiting cell proliferation, inducing cell apoptosis, which was associate with its reducing the total and activated HER3 levels in HER2+breast cancer cells. Conglobatin 100 mg·kg-1 significantly reduced the tumor volume of QGY7703 and SKBR3 and conglobatin combining with lapatinib 100 mg·kg-1 significantly enhanced the anti-tumor effect in vivo. Further research found that conglobatin could directly bind to the N-terminal of Hsp90 then disturb forming a complex of Hsp90, Cdc37 and clients, and dissociate clients from Hsp90 subsequently induce proteasome-dependent degradation of the clients such

关键词： conglobatin Hsp90 inhibitor anti-tumor effect

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The Distribution and Concentration Monitoring of Benzene Industries—Six PLADs,China,2020

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China CDC weekly 2021年第43期3卷 897-900页

作者： Xue Wang Jin Zhou Lei Han Xiurong Cheng Hua Shao Qiang Jia Peiyu Xu Jing Liu Jie Ren Jin Li Fei Li Baoli Zhu Meibian Zhang Caihong Xing key laboratory of Chemical Safety and Health National Institute for Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijingChina Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsuChina Shandong Academy of Occupational Health and Occupational Medicine Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandongChina Department of Nutrition Food Safety and ToxicologyWest China School of Public HealthSichuan UniversityChengduSichuanChina Tianjin Centers for Disease Control and Prevention TianjinChina fujian Center for Prevention and Control of Occupational Diseases and Chemical Poisoning FuzhouFujianChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiangChina.

Summary What is already known about this topic?Benzene is classified as a Class I human carcinogen by the International Agency for Research on ***-term exposure to benzene increases the risk of chronic benzene poisoni... 详细信息

关键词： benzene Benzene exposure

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Paraquat and MPTP induce alterations in the expression profiles of long noncoding RNAs in the substantia nigra of mice:Role of the transcription factor Nrf2

Paraquat and MPTP induce alterations in the expression profi...

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2016中国毒理学会神经毒理专业委员会学术年会

作者： Lijin Wang Hongyu Yang Qingqing Wang Qiaohui Zhang Zhangjing Wang Qunwei Zhang Siying Wu Huangyuan Li Department of Preventive Medicine Fujian Provincial Key Laboratory of Environment factors and CancerSchool of Public HealthFujian Medical University Department of Endemic Disease Prevention and Control Fujian Center For Disease Control & Prevention

Parkinson’s disease(PD) is a common age-related degenerative disease of the central nervous system caused by hereditary,pesticides,metals,and polychlorinated ***(PQ),a widely used herbicide,causes *** noncoding RNAs(lncRNAs) are nonprotein-coding transcripts,expressed in the brain and play irreplaceable roles in neurodegenerative ***2 is an important genetic transcription regulator in oxidative *** aimed to discover novel PQ or MPTP-Nrf2-related lncRNAs and explore their associations with ***,a IncRNA array was used to identify 17157 lncRNAs and 13707 mRNAs on a Mouse LncRNA Expression Microarray(fold change ≥2,p-value<0.05).Then,several lncRNAs were double-checked using real-time quantitative reverse transcription PCR(qRT-PCR) and fluorescence in situ ***-noncoding analysis and qRT-PCR were applied to discover the functions of lncRNAs and predict the targeted *** vivo,PQ and1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP) exposure changed the IncRNA expression profiles,probably related to their neurotoxic *** changes in their IncRNA expression were distinct but *** changed the IncRNA expression profiling in the substantia nigra(SN) through an interaction with Nrf2,thus changing the NR27648/Zc3hl4/Cybb and NR30777/Zfp326/Cpne5 mRNA ***,MPTP changed the IncRNA expression profiling in SN through an interaction with ***2 may be involved in the development of neurodegeneration induced by PQ and MPTP via interactions of lncRNAs as the molecular *** findings,for the first time,indicate the potential roles of lncRNAs in the development of PD by PQ or MPTP and provide positive insights into future mechanism studies.

关键词： Paraquat 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Neurodegeneration LncRNA Nrf2 Epigenetic toxicology

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Ganoderma Lucidum polysaccharide peptides protect kidney from renal ischemia reperfusion injury via counteracting oxidative stress

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中国药理学与毒理学杂志 2015年第S1期29卷 72-73页

作者： Dan-danZHONG Hong-kaiWANG MingLIU Ying-liJIA MingHUANG HongZHOU Shu-qianLIN Zhi-binLIN Bao-xueYANG State key laboratory of Natural and Biomimetic Drugs Department of Pharmacology School of Basic Medical Sciences Peking University Beijing China Fuzhou Institute of Green Valley Bio-Pharm Technology Fuzhou China Juncao Technology Research Institute fujian Agriculture and Forestry University Fuzhou China

OBJECTIVE Ganoderma lucidum polysaccharide peptides(GLPP)have an anti-oxidant *** oxidative stress implicates in the pathogenesis of renal ischemia-reperfusion injury(RIRI).The objective of this study was to determine whether GLPP could attenuate RIRI via counteracting the oxidative *** Mice subjected to uninephrectomy with the right kidney ischemia for 35 min and reperfusion for 24 hwere used to explore the protective activity of GLPP against *** GLPP-treated group,100mg·kg-1·d-1 of GLPP were intraperitoneally injected for 7dbefore the *** vitro,NRK-52 Ecells subjected to hypoxia-reoxygenation(H/R)and tunicamycin were used to explore the protective effect of GLPP against oxidative *** mechanisms in which GLPP protected kidney from RIRI were studied using a series of physiological and molecular biological *** Kidneys undergone ischemia-reperfusion showed renal dysfunction and characteristic morphological changes including cellular necrosis,brush border loss,cast formation,vacuolization and tubular dilatation while these damages were significantly attenuated by GLPP *** abnormal levels of MPO,MDA and SOD caused by renal ischemia-reperfusion were significantly reversed by GLPP *** apoptotic cells were found in the renal ischemia-reperfusion group than the sham group whereas GLPP reduced apoptotic cells in the ischemia-reperfusion mice by21.75%(P<0.01).The GLPPs(25-1μg·mL)alleviated H/R induced cell viability loss by 20.12%(P<0.01)andΔφm dissipation by 27.3%(P<0.01)in vitro as well and its pretreatment dramatically reduced H/R and tunicamycin induced cell *** Our study found that GLPP had a protective effect on RIRI via its anti-oxidative capacity,which suggests that GLPP may be developed as a candidate drug for preventing acute kidney injury.

关键词： Ganoderma lucidum polysaccharide peptides acute ki

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Industry Distribution Characteristics of Benzene-ExposedWorkers with Cytopenia - Four Provinces, China, 2020

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China CDC weekly 2022年第51期4卷 1143-1147页

作者： Dongning Hua Xue Wang Lei Han Jin Zhou Xiurong Cheng Boshen Wang Juan Zhang Jinzhe Li Peiyu Xu Shang Gao Lifang Zhou Fei Li Xinglin Fang Jin Li Zihuan Wang Jing Liu Jie Ren Baoli Zhu Meibian Zhang Caihong Xing key laboratory of Chemical Safety and Health National Institute for Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijing MunicipalityChina Jiangsu Provincial Center for Disease Control and Prevention Nanjing CityJiangsu ProvinceChina key laboratory of Environmental Medicine Engineering of Ministry of Education School of Public HealthSoutheast UniversityNanjing CityJiangsu ProvinceChina Department of Nutrition Food Safety and ToxicologyWest China School of Public HealthSichuan UniversityChengdu CitySichuan ProvinceChina Occupational and Radiation Health Institute Sichuan Center for Disease Control and PreventionChengdu CitySichuan ProvinceChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouZhejiangChina fujian Center for Prevention and Control of Occupational Diseases and Chemical Poisoning Fuzhou CityFujian ProvinceChina Beijing Center for Disease Prevention and Control Beijing Research Center for Preventive MedicineBeijing MunicipalityChina Tianjin Centers for Disease Control and Prevention Tianjin MunicipalityChina.

What is already known about this topic?Benzene is harmful to the hematopoietic system and can cause ***,benzene is still being used in various industries including furniture,rubber,plastic products,and metal product *** is added by this report?The white blood cell count of workers in general equipment,special equipment,chemical raw materials,and chemical products manufacturing decreased *** enterprises in which benzene concentration exceeded the occupational exposure limit were small enterprises and private *** are the implications for public health practice?Regular health examinations are necessary for benzeneexposed *** addition,the monitoring of benzene concentration in small enterprises and private enterprises should be strengthened.

关键词： enterprises rubber strengthened

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Specific biotests to assess eco-toxicity of biodegradable polymer materials in soil

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Journal of Environmental Sciences 2021年第7期33卷 150-162页

作者： Haiyan Chen Fei Wang Huilun Chen HongDa Fang Weiying Feng Yuan Wei FanFan Wang HaiLei Su YiDong Mi Min Zhou XinRu Li Serena Doni Andrea Corti State key laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental ScienceBeijing 10012China School of Energy&Environmental Engineering University of Science and Technology BeijingBeijing 100083China Water Treatment Engineering Research Center of Jimei University Fujian 361021China School of Space and Environment Beihang UniversityBeijing 100191China Beijing Advanced Innovation Center for Big Data-Based Precision Medicine Beihang UniversityBeijing 100191China Eco-toxicology laboratory National Research Council(CNR)-Institute of Ecosystem Study(ISE)Via Moruzzi 1Pisa 56124Italy INSTM Unit Department of Chemistry and Industrial ChemistryUniversity of Pisavia Risorgimento 3556126Italy BIOlabvia Vecchia Livornese 1291 Loc.S.Piero a Grado(Pi)Pisa 56122Italy

Eco-toxicity investigation of polymer materials was considered extremely necessary for their potential menace,which was widely use as mulching materials in *** this study,polyethylene(PE),polystyrene(PS)and synthetic biomaterials-Ecoflex and cellulose were applying into soil cultivated with two potential indicator plants species:oat(A v ena sati v a)and red radish(Raphanus sativum).Variety of chemical,biochemical parameters and enzyme activity in soil were proved as effective approach to evaluate polymers phytotoxicity in plant-soil *** F-value of biomass,pH,heavy metal and electoral conductivity of Raphanus behaved significant different from *** analysis results indicated biodegradation was fast in PE than PS,besides,heavy metals were dramatically decrease in the end implied the plant absorption may help decrease heavy metal *** increase value at T2 of Dehydrogenase activity(0.84 higher than average value for Avena&0.91 higher for Raphanus),Metabolic Index(3.12 higher than average value for Avena&3.81 higher for Raphanus)means during soil enzyme activity was promoted by biodegradation for its heterotrophic organisms’energy transportation was *** analysis was carried on Biplot PC1(24.2%of the total variance),PC2(23.2%of the total variance),versus PC3(22.8%of the total variance),which indicated phosphatase activity and metabolic index was significant correlated,and high correlation of ammonium and protease ***,the effects were more evident in Raphanus treatments than in Avena,suggesting the higher sensitivity of Raphanus to polymers treatment,which indicate biodegradation of polymers in Raphanus treatment has produced intermediate phytotoxic compounds.

关键词： Avena sativa Raphanus sativum Polymer materials Biodegradation Eco-toxicity Phytotoxicity

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低剂量BPA对人胚胎干细胞向乳腺上皮细胞定向分化的影响(英文)

低剂量BPA对人胚胎干细胞向乳腺上皮细胞定向分化的影响(英文)

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作者：杨淋清 Lingfeng Luo Weidong Ji Chunmei Gong Desheng Wu Haiyan Huang Qingcheng Liu Bo Xia Gonghua Hu Wenjuan Zhang Qian Zhang Jianjun Liu Wenchang Zhang Zhixiong Zhuang School of Public Health Sun Yat-sen University key laboratory of Modern toxicology Medical Key Laboratory of Health ToxicologyShenzhen Center for Disease Control and Prevention key laboratory of Environment and Health.fujian Medical University Department of Urology Minimally Invasive Surgery Center.The first Affiliated Hospital of Guangzhou Medical CollegeGuangdong Provincial Key Laboratory of Urology

it has been previously reported that Bisphenol A(BPA) can disturb the development of mammary structure and increase the risk of breast cancer in experimental *** this study,an in vitro model of human embryonic stem cell(hESC) differentiation into mammary epithelial cells was applied to investigate the effect of low dose BPA on the early stages of mammogenesis.A newly established hESC line was directionally differentiated into mammary epithelial cells by a well-established three-dimensional(3D)culture *** differentiated mammary epithelial cells were characterized by immunofluorescence and western blotting assay,and were called induced differentiated mammary epithelial cells(iDMECs)based on these *** hESCs were treated with low doses of BPA range 10-10 M during the differentiation process,with DMSO as the solvent control and 17-β-estrodiol(E2) as the estrogen-positive *** results showed that low dose BPA and E2 could influence the mammosphere area of iDMECs and upregulate the expression level of Oct4 and Nanog proteins,while only BPA could downregulate the expression of E-cadherin *** together,this study provides some insights into the effects of low dose BPA on the early differentiation stage of mammary epithelial cells and suggests an easier canceration status of iDMECs under the effect of low dose BPA during its early differentiation stage.

关键词： Human embryonic stem cells Mammary epithelial cells Bisphenol A

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Effects of deltamethrin on the activation or expression of Nrf2 and on the GCS-HS protein level in primary astrocytes with laser scanning confocal microscope

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Journal of Nanjing Medical University 2006年第1期20卷 1-7页

作者： Huangyuan Li Nian Shi Yufang Zhong Linlin Liu Doctor of Medicine Department of Occupational and Environmental Hygiene School of Public Health Fujian Medical University Fuzhou 350004 China Department of Health toxicology MOE Key lab of environment and health School of Public Health Tongji Medical College HuazJmng Unive.rsity ofScience and Technology Wuhan 430030 China

Objective： To examine the effects of deltamethrin（DM） and tBHQ on the activation of Nrt2 and expression of GCS-HS in primary astrocytes. Methods： Rat primary astrocytes were treated with DM （10μmol/L） and tBHQ （40μmol/L）, for 1 and 6 h respectively. Results： Analysis using immunofluorescent confocal microscopy revealed that tBHQ treatment led to a dramatic increase in the level of Nrt2. The ratio of cytoplasmic Nrt2 protein to nuclear Nrt2 protein was markedly reduced in astrocytes by either tBHQ or DM treatment. The level of Nrf2 was reduced by combined tBHQ with DM treatment for 1 h, but treatment the ratio of cytoplasmic Nrf2 protein to nuclear Nrf2 protein was increased compared with that of the tBHQ only. The expression of GCS-HS in astrocytes was not altered by DM or tBHQ or both in astrocytes. Conclusion： These findings demonstrated for the first time that Nrf2 was activated by pesticides and antioxidants in astrocytes, implicating a tote of Nrf2 in response to pesticide neurotoxicity ingla.

关键词： deltamethrin NF-E2 related factor 2 gmmm-glutamylcysteine synthetase LSCM astrocyte

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Inhibition of PKC represses the prolongation of QRS complex in EAM rat model

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中国药理学与毒理学杂志 2019年第10期 807-807页

作者： ZHONG Chun-lian JIA Lee Institute of Oceanography Minjiang University Cancer Metastasis Alert and Prevention Center College of Chemistry fujian Provincial key laboratory of Cancer Metastasis Chemoprevention and Chemotherapy Fuzhou University

OBJECTIVE To test the hypothesis,using experimental autoimmune myocarditis(EAM) rat model, that unexplained cases of malignant ventricular arrhythmias were caused by protein kinase C(PKC) activation. METHODS Using EAM rats model and isolated heart infusion technic, the effect of PKC on the QRS complex and molecular mechanism will be clarified. RESULTS In isolated hearts of normal rats, PKC agonist PMA induced prolongation of QRS complex. Mechanistically, activation of PKC increases phosphorylation and changes distribution of Cx43, and causes prolongation of QRS *** contrast, administration of PKC inhibitor with Ro-32-0432 in EAM rat after the most severe inflammation period still significantly al eviated the prolongation of QRS *** Pharmacological inhibition of PKC ameliorates the prolongation of QRS complex in EAM rat, provide a potential therapeutic strategy for arrhythmias induced by myocarditis.

关键词： PKC Cx43 QRS complex EAM ion channels

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