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Interplays of liver fibrosis-associated microrNAs:Molecular mechanisms and implications in diagnosis and therapy

Genes & diseases 2023年第4期10卷 1457-1469页

作者： Hong Li Tingli Liu Yongchun Yang William C.Cho robin J.Flynn Majid Fasihi Harandi Houhui Song Xuenong Luo Yadong Zheng State Key Laboratory of Veterinary Etiological Biology Key Laboratory of Veterinary Parasitology of Gansu ProvinceLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhouGansu 730046China Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province Zhejiang Provincial Engineering Laboratory for Animal Health Inspection&Internet TechnologyZhejiang International Science and Technology Cooperation Base for Veterinary Medicine and Health ManagementChina-Australia Joint Laboratory for Animal Health Big Data AnalyticsCollege of Animal Science and Technology&College of Veterinary Medicine of Zhejiang A&F UniversityHangzhouZhejiang 311300China department of Clinical Oncology Queen Elizabeth HospitalHong Kong SAR 999077China department of Infection Biology Institute of Infection and Global HealthUniversity of LiverpoolLiverpool L35RFUK Graduate Studies Office Department of ResearchInnovation and Graduate StudiesWaterford Institute of TechnologyX91 K0EKIreland research center for Hydatid disease in Iran Kerman University of Medical SciencesKerman ***Iran

microrNAs(mirNAs)are a class of non-coding functional small rNA composed of 21e23 nucleotides,having multiple associations with liver ***-associated mirNAs are roughly classified into pro-fibrosis or anti-fibrosis *** former is capable of activating hepatic stellate cells(HSCs)by modulating pro-fibrotic signaling pathways,mainly including TGF-b/SMAd,WNT/b-catenin,and Hedgehog;the latter is responsible for maintenance of the quiescent phenotype of normal HSCs,phenotypic reversion of activated HSCs(aHSCs),inhibition of HSCs proliferation and suppression of the extracellular matrix-associated gene ***,several mirNAs are involved in regulation of liver fibrosis via alternative mechanisms,such as interacting between hepatocytes and other liver cells via exosomes and increasing autophagy of ***,understanding the role of these mirNAs may provide new avenues for the development of novel interventions against hepatic fibrosis.

关键词： diagnosis Hepatic stellate cell Liver fibrosis mirNA Therapy

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细胞外SQSTM1通过胰岛素受体信号介导小鼠细菌性脓毒症死亡

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中华烧伤杂志 2021年第6期37卷 581-581页

作者：曾茁(译) 彭毅志(审校) Zhou B Liu J Zeng L The Third Affiliated Hospital Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation Guangzhou Medical University Guangzhou China State Key Laboratory of Trauma Burns and Combined Injury Institute of Surgery Research Daping Hospital Army Medical University Chongqing China department of Pediatrics The Third Xiangya Hospital Central South University Changsha China Laboratory of Emergency Medicine North Shore University Hospital and the Feinstein Institute for Medical Research Manhasset USA department of Surgery University of Pittsburgh Pittsburgh USA Equipe Labellisée par la Ligue Contre le Cancer Université de Paris Sorbonne Université Institut National de la Santé et de la Recherche Médicale U1138 Centre de Recherche des Cordeliers Paris France Metabolomics and cell Biology Platforms Gustave Roussy Cancer Campus Villejuif France Pôle de Biologie Hôpital Européen Georges Pompidou Assistance Publique-Hôpitaux de Paris Paris France Suzhou Institute for Systems Medicine Chinese Academy of Sciences Suzhou China department of Women’s and Children’s Health Karolinska University Hospital Stockholm Sweden Life Sciences Institute and department of Molecular Cellular and Developmental Biology University of Michigan Ann Arbor USA department of Surgery UT Southwestern Medical Center Dallas USA

宿主对感染的反应失调导致脓毒症成为全世界ICU最常见的死亡原因。本文研究了脓毒症中SQSTM1/p62——一种自噬受体,其可作为先天性免疫调节剂的作用。作者指出LPS引起gasdermin d依赖性焦亡,使巨噬细胞和单核细胞被动释放SQSTM1;而跨膜... 详细信息

宿主对感染的反应失调导致脓毒症成为全世界ICU最常见的死亡原因。本文研究了脓毒症中SQSTM1/p62——一种自噬受体,其可作为先天性免疫调节剂的作用。作者指出LPS引起gasdermin d依赖性焦亡,使巨噬细胞和单核细胞被动释放SQSTM1;而跨膜蛋白173依赖的TANK结合激酶1激活导致SQSTM1丝氨酸403磷酸化,随后巨噬细胞和单核细胞分泌SQSTM1。此外,细胞外SQSTM1与胰岛素受体结合.

关键词：胰岛素受体巨噬细胞免疫调节剂脓毒症 SQS 单核细胞死亡原因跨膜蛋白

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ME0X1: a novel druggable target that orchestrates the activation of fibroblasts in cardiac fibrosis

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Signal Transduction and Targeted Therapy 2022年第1期7卷 19-21页

作者： david Schumacher Fabian Peisker rafael Kramann nstitute of Experimental Medicine and Systems Biology University Hospital AachenRWTH Aachen UniversityAachenGermany department of Anesthesiology University Hospital AachenRWTH Aachen UniversityAachenGermany department of Internal Medicine Erasmus Medical CenterErasmus UniversityRotterdamThe Netherlands department of Nephrology and Clinical Immunology University Hospital AachenRWTH Aachen UniversityAachenGermany

Sin gle-cell genomic tech no logy has bee n used to ide ntify MEOX1 as a potential cell-specific,druggable target in cardiac *** this effect,a Iandmark study was recently published in Nature by Alexanian and colleagues.^(1) Fibrosis is a comm on resp onse to chronic repetitive injury to vital organs and considered an important therapeutic target to slow dow n,in hi bit,or reverse progressio n of orga n *** there is broad interest in developing novel antifibrotic therapeutics,currently,only nintedanib and pirfenidone have been approved to treat fibrosis for one disease entity;idiopathic pulmonary fibrosis.^(2)

关键词： cardiac organs drug

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Scavenger receptor Class B type 1(Sr-B1)and the modifiable risk factors of stroke

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Chinese Neurosurgical Journal 2020年第1期6卷 35-44页

作者： Lenahan Cameron Huang Lei Travis Zachary d. Zhang John H. Burrell College of Osteopathic Medicine Las CrucesNM 88003USA center for Neuroscience research School of MedicineLoma Linda UniversityLoma LindaCA 92324USA department of Neurosurgery School of MedicineLoma Linda UniversityLoma LindaCA 92350USA department of Physiology&Pharmacology School of MedicineLoma Linda UniversityLoma LindaCA 92350USA department of Earth and Biological Sciences School of MedicineLoma Linda UniversityLoma LindaCA 92350USA department of Anesthesiology School of MedicineLoma Linda UniversityLoma LindaCA 92324USA

Stroke is a devastating disease that occurs when a blood vessel in the brain is either blocked or ruptured,consequently leading to deficits in neurological *** consistently ranked as one of the top causes of mortality,and with the mean age of incidence decreasing,there is renewed interest to seek novel therapeutic *** Scavenger receptor Class B type 1(Sr-B1)is a multifunctional protein found on the surface of a variety of *** has found that that Sr-B1 primarily functions in an anti-inflammatory and antiatherosclerotic *** this review,we discuss the characteristics of Sr-B1 and focus on its potential correlation with the modifiable risk factors of ***-B1 likely has an impact on stroke through its interaction with smoking,diabetes mellitus,diet,physical inactivity,obesity,hypercholesterolemia,atherosclerosis,coronary heart disease,hypertension,and sickle cell disease,all of which are critical risk factors in the pathogenesis of stroke.

关键词： Scavenger receptor Class B type 1 Sr-B1 Atherosclerosis Coronary heart disease diabetes mellitus Sickle cell Obesity Physical inactivity Hypercholesterolemia Hypertension

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Magnetic Hysteresis Property of Barium Hexaferrite Using d-Fructose as a fuel

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材料科学与工程：中英文版 2010年第9期4卷 88-92页

作者： S. Kanagesan S. Jesurani r. Velmurugan C. Kumar T. Kalaivani center for Material Science and Nano devices department of Physics SRM University Kattankulathur 603203 Tamil Nadu India department of Physics Jeyaraj Annapackium College for Women Periyakulam 625601 Tamil Nadu India

Barium hexaferrite (BaFe12O19) has traditionally been used in permanent magnets and more recently used for high density magnetic recording. Fine particles of barium hexaferrite (BaFe12O19) powder have been synthesized by sol-gel based combustion technique. In this technique, barium and iron nitrates were used as the source nitrates and d-Fructose was used as the fuel. The phase formation, functional groups, thermal properties, particle morphology and magnetic hysteresis behavior were analyzed by X-ray diffraction (Xrd), Fourier transform infrared spectroscopy (FTIr), thermo gravimetric/differential thermal analysis (TG-dTA), high resolution scanning electron microscope (Hr-SEM) and vibrating sample magnetometer (VSM). Fine crystalline particles were obtained from calcinations of precursor relatively at 900 °C. The crystalline diffraction pattern shows the corresponding major angles were 32.14°, 34.1196°, 30.3207°, 37.0953°, 55.0400°, 56.5423°, and 63.0425° respectively. Hr-SEM studies reveal that the diameters of the few particles were roughly about 90 to 120 nm. The calcined powder shows specific saturation magnetization (Ms), was 55.016 A·m2/kg, remanence magnetization (Mr) was 33.1286 A·m2/kg, coercive force (Hc) was 3851.4 Gauss and squereness ratio was 0.6022. Few particles were nano meters in diameter.

关键词：钡铁氧体 BaFe12O19 燃料晶体果糖傅立叶变换红外光谱扫描电子显微镜振动样品磁强计

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CHOP THEr APY INdUCEd MITOCHONdrIAL rEdOX STATE ALTErATION IN NON-HOdGKIN'S LYMPHOMA XENOGrAFTS

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Journal of Innovative Optical Health Sciences 2013年第2期6卷 29-35页

作者： H.N.XU H.ZHAO T.A.MIr S.C.LEE M.FENG r.CHOE J.d.GLICKSON L.Z.LI department of radiology University of Pennsylvania PhiladelphiaPAUSA Britton Chance Laboratory of redox Imaging Johnson research Foundation department of Biochemistry and Biophysics University of Pennsylvania PhiladelphiaPAUSA Biostatistics and data Management Core The Children's Hospital of Philadelphia(CHOP) PhiladelphiaPAUSA department of Biomedical Engineering University of rochester RochesterNYUSA Abramson Cancer center University of Pennsylvania PhiladelphiaPAUSA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPAUSA

We are interested in investigating whether cancer therapy may alter the mitochondrial redox state in cancer cells to inhibit their growth and *** redox state can be imaged by the redox scanner that collects the fuorescence signals from both the oxidized-fAavoproteins(Fp)and the reduced form of nicotinamide adenine dinucleotide(NAdH)in snap frozen tissues and has been previously employed to study tumor aggressiveness and treatment ***,with the redox scanner we investigated the effects of chemotherapy on mouse xenografts of a human diffuse large *** lymphoma cell line(dLCL2).The mice were treated with CHOP therapy,i.e,cyclophosphamide(C)+hydroxydoxorubicin(H)+Oncovin(O)+prednisone(P)with CHO administration on day 1 and prednisone administration on days *** Fp content of the treated group was significantly decreased(p=0.033)on day 5,and the mitochondrial redox state of the treated group was slightly more reduced than that of the control group(p=0.048).The decrease of the Fp heterogeneity(measured by the mean st andard deviation)had a border-line statistical significance(p=0.071).The result suggests that the mitochondrial metabolism of lymphoma cells was slightly suppressed and the lymphomas became less aggressive after the CHOP therapy.

关键词： NA dH flavoprotein dLCL2 therapeutic effect tumor metabolism

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Carbon-emcoating architecture boosts lithium storage of Nb_(2)O_(5)

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Science China Materials 2021年第5期64卷 1071-1086页

作者： Qing Ji Zhuijun Xu Xiangwen Gao Ya-Jun Cheng Xiaoyan Wang Xiuxia Zuo George Z.Chen Binjie Hu Jin Zhu Peter G.Bruce Yonggao Xia Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China The University of Nottingham Ningbo China Ningbo 315100China University of Chinese Academy of Sciences Beijing 100049China department of Materials University of OxfordParks RdOX13PHOxfordUnited Kingdom Materials Science and Engineering Program and Texas Materials Institute University of Texas at AustinAustinTX 78712USA University of Nottingham University ParkNottingham NG72RDUnited Kingdom The Henry royce Institute Parks RoadOxford OX13PHUnited Kingdom The Faraday Institution Quad OneBecquerel AvenueHarwell CampusDidcot OX11 OR1United Kingdom center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

Intercalation transition metal oxides (ITMO)have attracted great attention as lithium-ion battery negative electrodes due to high operation safety,high capacity and rapid ion ***,the intrinsic low electron conductivity plagues the lifetime and cell performance of the ITMO negative *** we design a new carbon-emcoating architecture through single CO_(2)activation treatment as demonstrated by the Nb_(2)O_(5)/C *** structure engineering of the carbon-emcoating Nb_(2)O_(5)/C nanohybrid is achieved in terms of porosity,composition,and crystallographic *** carbon-embedding Nb_(2)O_(5)/C nanohybrids show superior cycling and rate performance compared with the conventional carbon coating,with reversible capacity of 387 m A h g(-1)at 0.2 C and 92%of capacity retained after 500cycles at 1 *** electrochemical mass spectrometry(dEMS) indicates that the carbon emcoated Nb_(2)O_(5)nanohybrids present less gas evolution than commercial lithium titanate oxide during *** unique carbon-emcoating technique can be universally applied to other ITMO negative electrodes to achieve high electrochemical performance.

关键词： niobium pentoxide/carbon nanohybrids mesoporous CO_(2)activation emcoating lithium-ion battery negative electrode

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ACS Nano：科学家利用来自尿液的生物标志物进行早期癌症筛查

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现代生物医学进展 2017年第11期17卷 I0003-I0003页

作者： Hyun-Kyung Woo[†]‡ Vijaya Sunkara[†]‡ Juhee Park[⊥] Tae-Hyeong Kim[⊥] Ja-ryoung Han[†] Chi-Ju Kim[†][⊥] Hyun-Il Choi[§] Yoon-Keun Kim[§][∥] Yoon-Kyoung Cho[*][†][⊥] [†] department of Biomedical Engineering School of Life Sciences Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea[§] Department of Life Sciences Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea[∥] Institute of MD Healthcare Seoul 03923 Republic of Korea[⊥] Center for Soft and Living Matter Institute for Basic Science (IBS) Ulsan 44919 Republic of Korea

日前。来自韩国蔚山国家科学技术研究所的研究人员通过研究开发出了一种新技术，该技术能够有效在尿液或血液中有效鉴别出促进癌症发生的物质，相关研究刊登于国际杂志ACS Nano上。

关键词： Nano ACS 生物标志物癌症尿液科学家筛查早期

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Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法

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现代生物医学进展 2017年第22期17卷 I0002-I0002页

作者： Yu, Pengchun Wilhelm, Kerstin dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua de Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael Yale Univ Sch Med Yale Cardiovasc Res Ctr 333 Cedar St New Haven CT 06511 USA Max Plank Inst Heart & Lung res Angiogenesis & Metab Lab D-61231 Bad Nauheim Germany Yale Univ Sch Med Dept Internal Med Endocrinol Sect 333 Cedar St New Haven CT 06520 USA Yale Univ Sch Med Dept Cellular & Mol Physiol 333 Cedar St New Haven CT 06520 USA WuXi NextCOdE Genom Computat Stat & Bioinformat Grp Adv Artificial Intelligence Res Lab Cambridge MA 02142 USA VIB KU Leuven Switch Lab B-3000 Leuven Belgium dana Farber Canc Inst Ctr Mol Oncol Pathol Boston MA 02215 USA Gwangju Inst Sci & Technol Sch Life Sci Gwangju 61005 South Korea WuXi NextCOdE Genom Genom Lab 288 Fute Zhong Rd Shanghai 200131 Peoples R China Univ Illinois Coll Med Dept Biochem & Mol Genet Chicago IL 60607 USA Katholieke Univ Leuven Dept Oncol Lab Angiogenesis & Neurovasc Link B-3000 Leuven Belgium VIB Vesalius Res Ctr Lab Angiogenesis & Neurovasc Link B-3000 Leuven Belgium Paris Cardiovasc res Ctr U970 56 Rue Leblanc F-75015 Paris France Yale Univ Sch Med Dept Cell Biol 333 Cedar St New Haven CT 06520 USA

最近，一项刊登在国际杂志Nature上的研究报告中，来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。

关键词：心血管疾病疗法癌症治疗开发控制生长血管发育

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Observation and modeling of vertical carbon dioxide distribution in a heavily polluted suburban environment

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Atmospheric and Oceanic Science Letters 2020年第4期13卷 371-379页

作者： BAO Zhongxiu HAN Pengfei ZENG Ning LIU di CAI Qixiang WANG Yinghong TANG Guiqian ZHENG Ke YAO Bo College of Atmospheric Sciences Chengdu University of Information TechnologyChengduChina State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina department of Atmospheric and Oceanic Science and Earth System Science Interdisciplinary CenterUniversity of MarylandCollege ParkMarylandUSA State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjingChina Meteorological Observation Centre of China Meteorological Administration BeijingChina

The vertical distribution of carbon dioxide(CO2)is important for the calibration and validation of transport models and remote sensing *** to the large mass and volume of traditional instruments as well as supporting systems,in-situ measurements of the CO2 vertical profile within the boundary layer are *** study used a miniaturized CO2 monitoring instrument based on a low-cost non-dispersive infrared(NdIr)sensor to measure the CO2 vertical profile and meteorological parameters of the lower troposphere(0–1000 m)in southwestern Shijiazhuang,Hebei Province,*** sensors were onboard a tethered balloon with two processes:the ascending process and the descending *** results showed that the overall trend of CO2 concentration decreased with *** conditions and CO2 emission sources caused fluctuations in CO2 *** CO2 concentration varied from morning to afternoon due mainly to the faster spread of air mass during daytime,with strong convections and the accumulation of emissions at *** low-cost sensor produced results consistent with the traditional gas chromatography *** Weather research and Forecasting model could not capture the CO2 profiles well due mainly to the bad performances in boundary layer height and the potential outdated fossil fuel emissions around the experimental *** experiment is the first successful attempt to observe the CO2 vertical distribution in the lower troposphere by using lowcost NdIr *** results help us to understand the vertical structure of CO2 in the boundary layer,and provide data for calibrating and validating transport models.

关键词： Low cost sensor co2 vertical profile tethered balloon meteorological conditions non-dispersive infrared(NdIr)

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