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An Outbreak of Poisoning from Penicillium cyclopium Contaminated Dried Persimmon

Biomedical and Environmental Sciences 1992年第2期5卷 115-124页

作者： HE SHUNZHONG, JIU YIQUAN, BIAN HUARONG, HUANG JIANPING,YE SHUSEN, LAN ZHEN, AND XIN YOUCHUANsanitary and anti-epidemic station of Shuang Liu county, Chengdu, Sichuan Province sanitary and anti-epidemic station of Chengdu City, Sichuan province College forHealth Administration Staffs of Sichuan Province Institute of FoodSafety Control and Inspection, Sichuan Province sanitary and anti-epidemic station of Shuang Liu county Chengdu.

It is the first report of an outbreak of 114 food-poisoning cases due to consumption of Penicillium cyclopium contaminated dried persimmon. Gastralgia, diarrhea, dizziness and general malaise are chief symptoms of the poisoning, with incubation period of 2-6 hrs generally and a short disease period (generally recovered within 2-3 days). No entero-pathogenic organism, pathogenic coccus and Campylobacter jejuni were detected. Surface fungi counts were 49,000/g, 21.3 times of that discovered in the marketed dried persimmon. Penicillium cyclopium Westling was the dominant fungus isolated. Mouse toxicity tests were carried out with the crude extracts of the fungus culture. Diarrhea, tremor and convulsion were observed before death. During autopsy, necrosis and hemorrhagic foci were observed in G.I. tract after intra-peritoneal injection and intubation. In histo-pathological examination, different degree of necrosis and scaling of gastro-intestinal mucous membrane, lymphocyte infiltration, and necrosis of liver cells and renal tubule epithelial cells could be seen.

关键词： acid ATP

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H2 strain attenuated live hepatitis A vaccines:protective efficacy in a hepatitis A outbreak

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World Journal of Gastroenterology 2000年第6期6卷 829-832页

作者： Yu Liang Zhao Zong Da Meng Zhi Yi Xu Jun Jie Guo Shao Ai Chai Cheng Gang Duo Xuan Yi Wang Jin Feng Yao Hong Bin Liu Shun Xiang Qi Hui Bin Zhu Department of Virology Hebei Provincial Sanitary and Antiepidemic StationBaoding 071000Hebei ProvinceChina Department of Epidemiology Shanghai Medical University.Shanghai 200032China fucheng county sanitary and anti-epidemic station Zhejiang Academy of Medical Sciences Hangzhou

AIM:To investigate the protective efficacy of H2 strain attenuated live hepatitis A vaccines (H2-strain vaccines) in hepatitis A (HA) ***:With the permission of their parents, 5551 pre-school and grade 1-3 primary school children were inoculated with 1 dose (10(6.5) TCID(50)) of H2 strain vaccines in a nonrandomized, controlled trial conducted in fucheng county, Hebei Province in May *** 6485 children in the same grades and compatible in gender and age were enrolled as controls. Epidemiological and serological survey was conducted to evaluate the protective efficacy of the vaccines. ELISA was used to detect serum IgM ***:HA outbreak started in early May 1998, peaked in the middle of the same month, and lasted about 80 days. Overall 302 HA cases were found, 192(63.58%) were 5-9 years old. One vaccinee and 25 control cases were found to have hepatitis A, which account for 0.28% (1/356) and 5.92% (25/422) of all vaccinees and controls in the 14 villages, respectively. The protective efficacy of vaccines was 95.27% (95% CI: 85.83%-104.72%). In subjects tested for anti-HAV IgM from 13 villages, 1(0.40%) overt and 11(4.06%) asymptomatic HAV cases were found in 271 vaccinees but 21(6.69%) of overt and asymptomatic ones were found in 314 ***:H2 strain vaccines were excellent in preventing overt hepatitis A,but not so effective in preventing asymptomatic hepatitis A virus infection.A booster dose might be needed to get permanent reliable immunity.

关键词： hepatitis A/prevention and control vaccines, attenuated vaccines, inactivated viral hepatitis vaccines disease outbreaks protective efficacy

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A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns

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World Journal of Gastroenterology 2000年第3期6卷 381-383页

作者： Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao Virology Department of Hebei Provincial sanitary and anti-epidemic station Baoding 071000Hebei ProvinceChina Department of Hepatitis Zhengding county Sanitary and Anti-Epidemic StationZhengding 070800ShijiazhuangHebei ProvinceChina Department of Hepatitis Institute of VirologyChinese Academy of Preventive MedicineBeijing 100052China

AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B *** In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 *** serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA *** annual HBsAgpositive conversion rate was counted by life-table ***①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year *** valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year *** a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic *** with the baselinebefore immunization,the protective rates were97.19% and 95.32% *** The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers.

关键词： hepatitis B vaccine HBsAg vaccination rural newborn cohort study

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SCANNING ELECTRON MICROSCOPIC OBSERVATIONS ON LATE SPOROGONIC STAGES OF DEVELOPMENT OF PLASMODIUM FALCIPARUM

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Chinese Medical Journal 1987年第7期

作者：陈佩惠郑璇张穗刘祥焜吴洪张贵宁 Department of Parasitology Capital Institute of Medicine Guizhou Provincial Institute of Parasitic Disease sanitary and anti-epidemic station of Qian Xi Nan county Guizhou

Five batches of Anopheles dirus, after taking blood meal from 3 Plasmodium falciparum infected patients were dissected 10-17 days later. 46 midgut specimens of these infected mosquitoes were examined with the scanning electron microscope (SEM). The surface features of early and late stage oocysts were similar to those described for other species of P. but those of the sporoblast and sporozoite appeared somewhat different from those described by us earlier for P. yoelii yoelii, P. cynomolgi and P. vivax. It seems that the SME morphological charac-teristics, especially those of sporoblasts and sporo-zoites can be utilized in differentiating these Plasmodium species.

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