An Outbreak of Poisoning from Penicillium cyclopium Contaminated Dried Persimmon

作     者：HE SHUNZHONG, JIU YIQUAN, BIAN HUARONG, HUANG JIANPING,YE SHUSEN, LAN ZHEN, AND XIN YOUCHUANSanitary and Anti-epidemic Station of Shuang Liu County, Chengdu, Sichuan Province Sanitary and Anti-epidemic Station of Chengdu City, Sichuan province College forHealth Administration Staffs of Sichuan Province Institute of FoodSafety Control and Inspection, Sichuan Province 

作者机构：Sanitary and Anti-epidemic Station of Shuang Liu County Chengdu. 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：1992年第5卷第2期

页      面：115-124页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：acid ATP 

摘      要：It is the first report of an outbreak of 114 food-poisoning cases due to consumption of Penicillium cyclopium contaminated dried persimmon. Gastralgia, diarrhea, dizziness and general malaise are chief symptoms of the poisoning, with incubation period of 2-6 hrs generally and a short disease period (generally recovered within 2-3 days). No entero-pathogenic organism, pathogenic coccus and Campylobacter jejuni were detected. Surface fungi counts were 49,000/g, 21.3 times of that discovered in the marketed dried persimmon. Penicillium cyclopium Westling was the dominant fungus isolated. Mouse toxicity tests were carried out with the crude extracts of the fungus culture. Diarrhea, tremor and convulsion were observed before death. During autopsy, necrosis and hemorrhagic foci were observed in G.I. tract after intra-peritoneal injection and intubation. In histo-pathological examination, different degree of necrosis and scaling of gastro-intestinal mucous membrane, lymphocyte infiltration, and necrosis of liver cells and renal tubule epithelial cells could be seen.