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Acute lung injury in mechanically ventilated patients with epidermal necrolysis:an exposed-unexposed retrospective cohort study

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Burns & Trauma 2020年第1期8卷 30-33页

作者： S.Lalevée J.Catano S.Ingen-Housz-Oro M.Surenaud J.Tran Van Nhieu F.Schlemmer I.Bendib A.Mekontso-dessap S.Hue N.de Prost service de dermatologie AP-HPhoital Henri MondorCréteilFrance UniversitéParis Est Créteil INSERM U955IMRBF-94010 CréteilFrance service de Médecine Intensive Réanimation Hoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France EA7379 EpidermE UPECCréteilFrance Centre de référence des dermatoses bulleuses toxiques et toxidermies graves TOXIBUL CréteilFrance service d’Anatomopathologie AP-HPhoital Henri MondorCréteilFrance Unitéde Pneumologie Service de Médecine Intensive RéanimationHoitaux Universitaires Henri MondorAssistance Publique-Hoitaux de ParisCréteil Cedex 94010France Groupe de Recherche Clinique CARMAS Facultéde Santéde CréteilUniversitéParis Est CréteilCréteil Cedex 94010France AP-HP Département d’Hématologie et d’Immunologie biologiquesGroupe hospitalouniversitaire Chenevier MondorAssistance Publique-Hoitaux de Paris F-94010 CréteilFrance

To the Editor,During the acute phase of epidermal necrolysis(EN,including Stevens-Johnson syndrome and toxic epidermal necrolysis),mucosal lesions involving the tracheo-bronchial tract have been reported[1,2]and approximately one in four EN patients develop acute respiratory failure and require endotracheal intubation and mechanical ventilation(MV)support[3].Asymptomatic respiratory sequelae may be detected on pulmonary function tests after the acute phase in as much as 50%of EN patients,possibly related to pulmonary lesions that occurred at the acute phase[4].

关键词： acute patients respiratory

An Atypical Ovarian and Peritoneal Pelvic Tuberculosis Complicated by Toxidermia

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Case Reports in Clinical Medicine 2023年第8期12卷 261-269页

作者： Ndeye Amy Sarr Daouda Thioub Agbogbenkou Tevi Déla Lawson Khalifa Ababacar Mansour Fall Haby Dione Kane Sylvie Audrey Diop service des Maladies infectieuses et tropicales de l’hô pital Abdoul Aziz Sy Dabakh de Tivaouane Tivaouane Sénégal service gynécologie et obstétrique de l’hô pital Abdoul Aziz sy Dabakh de Tivaouane Tivaouane Sénégal service dermatologie de l’hô pital Abdoul Aziz sy Dabakh de Tivaouane Tivaouane Sénégal

Background: Ovarian tuberculosis is a rare form of tuberculosis. Its clinical presentation mimics an ovarian tumor, leading to misdiagnosis. Proper treatment with anti-tuberculosis drugs can lead to a cure for the disease but can sometimes cause adverse effects that compromise therapeutic management. Observation: We report a 71-year-old female Senegalese patient who presented with a chronic abdominopelvic mass with an elevated Cancer Antigen 125 (CA125) level, raising the suspicion of an ovarian tumor. She underwent an exploratory laparotomy and the anatomopathological study confirmed the diagnosis of ovarian and peritoneal tuberculosis. After starting treatment with anti-tuberculosis drugs, she developed toxidermia in the form of generalized urticaria. Discontinuation of the four-drug therapy and separate reintroduction of anti-tuberculosis drugs led to the incrimination of rifampicin. Progress was then favorable on Isoniazid (H) pyrazinamide (Z) and Ethambutol (E). Conclusion: Ovarian tuberculosis should be suspected in the presence of an abdominopelvic mass in a woman living in an endemic area. The occurrence of adverse reactions to anti-tuberculosis treatment is not uncommon, hence the importance of regular monitoring.

关键词： Ovarian Peritoneal Tuberculosis Toxidermia Senegalese

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女性阴部巨大皮脂腺异常增生(法语)

世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 39-40页

作者： Masmoudi A. Bouassida S. Ayadi L. 李晓莉 service de dermatologie EPS Hedi Chaker 3029 Sfax Tunisia

Background. Sebaceous gland hyperplasia is an epithelial tumour with sebaceous differentiation. Genital involvement is rare. In this paper, we report a new case of sebaceous gland hyperplasia of the vulva. Case report. A 27 year-old woman presentedmultiple polypoid lesions of the lower third of left labium majus. The lesions were soft to the touch, measured 5 cm in length and were painless. The cutaneous biopsy confirmed the diagnosis of sebaceous gland hyperplasia of the vulva. Surgical excision was performed in two separate procedures and was successful. Discussion. This case was unusual in terms of the site, the clinical appearance and the weeping seen due to the high concentration of hyperplasic sebaceous glands.

关键词：异常增生大阴唇上皮性肿瘤息肉状生殖器部位损害部位女阴

在HIV感染的患者中使用可生物降解的物质改善面部皮下脂肪萎缩(法国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 15-16页

作者： Carbonnel E Claudy A 刘安 service de dermatologie Hopital Edouard Herriot 69437 Lyon France

Introduction. Facial lipoatrophy in HIV-infected patients undertri-therapy occurs frequently and alters their quality of life. No systemic treatment is capable of curing this problem. Patients and methods. Eighty-one patients were included in an open, prospective, compassionate study. A strict intradermal injection of a biodegradable, polyacrylamide cationic copolymer was administered in several sessions. Results. In all the patients, the correction of the facial lipoatrophy was considered satisfactory and stable over a period of 6 months using comparative photographic cliches. The thickness of the dermal skin, assessed by sonography, was doubled. No local or systemic side effect was reported. Conclusion. Our study shows that is it possible to durably correct the facial lipoatrophy of HIV-infected patients under tri-therapy by using a biodegradable implant.

关键词：皮下脂肪萎缩 HIV感染生物降解三联疗法埋植剂超声波检测法生活质量永久地

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铈诱导的肉芽肿性皮炎(法语)

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 33-34页

作者： Boye T. Terrier J.-P. Coillot C. F. Carsuzaa 焦婷 service de dermatologie HIA Sainte-Anne 83800 Toulon Naval

Background. The presence of inorganic foreign bodies in granulomatous cutaneous lesions is not infrequent. In this paper, we describe the first case of cerium-induced cutaneous granulomatous dermatitis. Case report. A 57-year-old woman seriously burned four years ago presented with papulonodular lesions affecting only the burned areas treated with topical cerium nitrate-silver sulfadiazine cream (Flammacé rium ). Biopsies revealed sarcoidal granuloma associated with exogenous particles. Electron probe X-ray microanalysis demonstrated a high cerium content. Screening for systemic sarcoidosis was negative. The patient was treated with hydroxychloroquine. After four months of follow-up, clinical and histological evidence of decreased infiltrate was noted. Discussion. Cerium nitratesilver sulfadiazine cream (Flammacé rium ) is widely used for the topical treatment of burns. The main effect of cerium is to create superficial calcification, which decreases wound colonization and prevents the formation of granulation tissue (no hypertrophic scar formation) in bur-ns. Prior to our case, no cutaneous side-effects of cerium had been encountered. Inoculation of foreign matter may or may not induce granuloma formation or sarcoidosis in different subjects, according to their immunologic status. The favorable outcome in this case could in fact be due to a change in the pattern of cytokinin production (TH1→ TH2) rather than the effects of hydroxychloroquine therapy.

关键词：肉芽肿性系统性结节病硝酸铈浅表性钙化烧伤部位严重烧伤磺胺嘧啶银乳膏丘疹结节硫酸羟氯喹

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原发于皮肤的骨外Ewing肉瘤(法语)

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 27-28页

作者： Kourda M. Chatti S. Sfia M. 李晓莉 service de dermatologie Hopital de Nabeul avenue Habib Thameur Nabeul 8000Tunisia

Background. Cutaneous extraskeletal Ewing s sarcoma is rare, being seen principally in children. We report a case of cutaneous sarcoma in the sole of the foot in a child. Case report. A 9-yearold child with no medical history of note was presenting a skin tumor for 3months on the heel of the right foot. This tumor was burgeoning and painful and measured 3.5cm in diameter; it was ulcerative at the surface and covered with a crust. Histological and immunohistochemical examinations confirmed the diagnosis of Ewing s sarcoma. Staging examinations proved negative and the patient underwent polychemotherapy, resulting in complete regression of the tumor. Comments. Until 1998, 37 cases of cutaneous and subcutaneous Ewing s sarcoma were reported, being seen in 21 girls and 16 boys. Mean age at diagnosis was 15 years and mean tumor size was 3 cm (range: 1 to 12 cm). The tumors were observed throughout the body, being seen in the sole of the foot in 2 cases. Confirmation of the diagnosis was made by histological examination (malignant proliferation of small round cells in the dermis), immunohistochemical examination (CD99+ ) and cytogenetic analysis (translocation between chromosomes 22 and 11). The prognosis for cutaneous Ewing s sarcoma appears more favorable than that of Ewing s sarcoma in bone. Of the 37 patients treated, 7 had metastases and 2 presented relapse. Treatment for cutaneous Ewing s sarcoma, though not codified, consists of polychemotherapy associated with surgery and/or radiotherapy.

关键词： Ewing 骨外肿瘤平均直径联合化疗免疫组化检查足后跟组织学检查小圆细胞特殊病史组织

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Well综合征显示有真性红细胞增多

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 31-32页

作者： Chamaillard M. Beylot-Barry M. Cogrel O. 田中伟 service de dermatologie Hopital Haut-Leveque avenue de Magellan 33600 Pessac France

Background. Wells syndrome is an eosinophilic dermatosis that is mainly reported in association with infections or insect bites, and more rarely during haematological disorders. Case report. A 32 year-old woman presented several recurrent episodes of massive swelling and erythema papulo-nodular inflammatory plaques on the butoocks that spontaneously resolved. The biopsy revealed marked infiltration of the dermis with eosinophils suggesting Wells syndrome. Examination found an isolated hepatosplenomegaly with true polycythemia and a myeloproliferative disorder. The diagnosis of Vaquez disease was made. Discussion. Wells syndrome is a distinctive disease entity with a wide polymorphism of clinical and histological features, unspecific, and varying depending on the age of the lesions. Various triggering factors are involved, but this syndrome may also reveal hematological disorders. Cutaneous manifestations often occur before the hematological diagnosis, but are frequently misdiagnosed. Only two other cases of Wells syndrome associated with Vaquez disease have been reported. Our case report underlined the importance of systematic research for an hemopathy in Wells syndrome, especially in young patients.

关键词：真性红细胞增多 Well 血液系统疾病嗜酸性细胞虫咬红斑丘疹肝脾大骨髓增生结节样触发因子

皮肤黏膜巴西芽生菌病:法国奎亚那确诊的首例病例(法国)

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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 29-30页

作者： Sarazin F. Sainte-Marie D. demar M. P.Couppie 刘燕 'service de dermatologie Centre Hospitalier de Cayenne BP 6006 Cayenne Cedex French Guiana

Introduction. Paracoccidio-domycosisis a deep mycosis due to a dimorphic fungus: Paracoccidioides brasiliensis. The principle endemic country is Brazil. We describe the first case of paracoccidio-domycosis, in its cutaneous-mucosal form, diagnosed in French Guiana. Observation. A 20 year-old Brazilian man, having mover to French Guiana a few months earlier, presented with multiple disseminated cutaneous lesions, predominating on the face, and composed of multiple nodules and two ulcerations. The clinical examination also revealed voluminous superficial lymph nodes and ulcerations of the pharynx and larynx. Direct examination, anatomopathology and culture of cutaneous biopsies revealed specific images of Paracoccidioides brasiliensis. HIV serology was negative. Treatment combining cotrimoxazole and itraconazole eliminated the lesions in one month. Discussion. Because the patient had just moved to Guiana, this observation probably corresponded to an imported disease. The principle differential diagnosis was leishmaniosis.

关键词：巴西芽生菌病皮肤黏膜亚那播散型双相型真菌皮损消退依曲康唑多形性利什曼病病理解剖学

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婴儿和新生儿发疹性假性血管瘤(法语)

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 25-26页

作者： Guillot B. Chraibi H. Girard C. 李晓莉 service de dermatologie Hopital Saint-Eloi CHU de Montpellier 34295 Montpellier Cedex 5

Introduction. Eruptive pseudoangiomatosis was first described in children in the form of an acute non-pruritic macular or popular rash that fades on application of a glass test and resolves within several days. Viral aetiology is suspected but has never been demonstrated to date. Observations. We discuss seven cases of infants presenting this disease: 5 boys and 2 girls aged8 days to 16months. The rash presented typical clinical features in all cases and affected the face and limbs in 6 of the 7 subjects. In one child, involvement of the face and back was observed with sparing of the limbs. The rash occurred after an episode of rhinolaryngeal infection in 3 cases and after gastrointestinal infection in 1 case. Spontaneous resolution was seen within 3 to 10 days in 6 patients although a longer course lasting over 9 months was observed in one infant. In another patient, the rash appeared after surgery for mesoblastic nephroma. In one child, a similar rash was seen in both parents. Screening for infectious agents was negative for the two children from whom samples were obtained. Discussion. This series of paediatric cases of eruptive pseudoangiomatosis is characterised by the very young age of one of the children, coexistence of the condition with a renal tumour in another child, the familial nature of the rash in a third child and unusually long disease duration in the final child. However, this series did not allow identification of the causative infectious agent or agents. Probably, as with other syndromes such as Giannotti-Crosti syndrome or “ gloves and socks"” syndrome, eruptive pseudoangiomatosis forms a clinical picture common to a non-specific viral infection.

关键词：假性血管瘤发疹肾瘤胚叶细胞肾脏肿瘤临床综合征病毒感染胃肠道感染数日特异性