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Genes & Diseases 2024年第5期11卷 91-93页

作者： Linzi Wei Qian Yu Xueying Yang department of Thoracic surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China

Lung cancer(LC)is a prevalent and fatal malignancy,with high incidence and mortality rates.1 ATP binding cassette(ABC)transporters,a superfamily of integral membrane proteins,use ATP hydrolysis to facilitate substrate transport across cellular membranes.2 The pivotal role of ABC transporters in tumorigenesis was initially established by Mochida,3 who demonstrated that the loss of ABCB1 suppresses intestinal polyp formation and tumor progression in *** investigations have reported correlations between ABC transporters and the tumor microenvironment and cancer immunotherapy response,suggesting their modulatory effects on tumor progression and immunotherapy.

关键词： mortality adenocarcinoma Lung

Upregulated lncRNA PRNT promotes progression and oxaliplatin resistance of colorectal cancer cells by regulating HIPK2 transcription

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1564-1577页

作者： Sai-Nan Li Shan Yang Hao-Qi Wang Tian-Li Hui Meng Cheng Xi Zhang Bao-Kun Li Gui-Ying Wang The First department of surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina The Second department of surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina department of General surgery The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most common cancer and a significant cause of cancer-related mortality *** to chemotherapy,especially during CRC treatment,leads to reduced effectiveness of drugs and poor patient *** noncoding RNAs(lncRNAs)have been implicated in various pathophysiological processes of tumor cells,including chemotherapy resistance,yet the roles of many lncRNAs in CRC remain *** To identify and analyze the lncRNAs involved in oxaliplatin resistance in CRC and to understand the underlying molecular mechanisms influencing this *** Gene Expression Omnibus datasets GSE42387 and GSE30011 were reanalyzed to identify lncRNAs and mRNAs associated with oxaliplatin *** bioinformatics tools were employed to elucidate molecular *** expression levels of lncRNAs and mRNAs were assessed via quantitative reverse transcription-polymerase chain *** assays,including MTT,wound healing,and Transwell,were conducted to investigate the functional implications of lncRNA *** between lncRNAs and trans-cription factors were examined using RIP and luciferase reporter assays,while Western blotting was used to confirm downstream ***,a xenograft mouse model was utilized to study the in vivo effects of lncRNAs on chemotherapy *** LncRNA prion protein testis specific(PRNT)was found to be upregulated in oxaliplatin-resistant CRC cell lines and negatively correlated with homeodomain interacting protein kinase 2(HIPK2)*** was demonstrated to sponge transcription factor zinc finger protein 184(ZNF184),which in turn could regulate HIPK2 *** expression of PRNT influenced CRC cell sensitivity to oxaliplatin,with overexpression leading to decreased sensitivity and decreased expression reducing *** RIP and luciferase reporter assays indicated that ZNF184 and HIPK2 are targets of *** PRNT/ZNF184

关键词： Colorectal cancer Oxaliplatin resistance Prion protein testis specific Zinc finger protein 184 Homeodomain interacting protein kinase 2

Colon cancer-associated transcript 1 ( CCAT1): A potential novel target in cancer therapy

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中华医学杂志(英文版) 2024年第17期137卷 2128-2130页

作者： Ma Jinjie Pei Junpeng Zhang Xueping Bai Xiao Ding Siqi Dai Dongqiu department of Gastrointestinal surgery The Fourth Affiliated Hospital of China Medical University Shenyang Liaoning China Cancer Center The Fourth Affiliated Hospital of China Medical University Shenyang Liaoning China

Effects of oral probiotics on inflammation and intestinal function in adult patients after appendectomy:Randomized controlled trial

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World Journal of Gastrointestinal surgery 2024年第5期16卷 1371-1376页

作者： Ke Lan Ke-Rui Zeng Fu-Rui Zhong Sheng-Jin Tu Jin-Long Luo Shi-Long Shu Xue-Feng Peng Hua Yang Kai Lu department of General surgery Zigong Fourth People's HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal *** probiotics are one of the postoperative treatments for rapid ***,there is a lack of prospective studies on this topic after *** To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following *** This was a prospective,randomized trial.A total of 60 emergency patients were randomly divided into a control group(n=30)and a probiotic group(n=30).Patients in the control group started to drink some water the first day after surgery,and those in the probiotic group were given water supplemented with Bacillus licheniformis capsules for 5 consecutive days *** indices of inflammation and postoperative conditions were recorded,and the data were analyzed with RStudio 4.3.2 *** A total of 60 participants were *** with those in the control group,the C-reactive protein(CRP),interleukin 6 and procalcitonin(PCT)levels were significantly lower in the probiotic group at 2 d after surgery(P=2.224e-05,P=0.037,and P=0.002,respectively,all Psurgery,with CRP and PCT levels remaining significantly lower in the probiotic group(P=0.001 and P=0.043,both P<0.05).Furthermore,probiotics0.028,both P<0.05).CONCLUSION Postoperative oral administration of probiotics may modulate the gut microbiota,benefit the recovery of the early inflammatory response,and subsequently enhance recovery after appendectomy.

关键词： Probiotics Gut microbiota Appendectomy Inflammatory markers Intestinal function Enhanced recovery after surgery Postsurgical infections

IGF2BPs as novel m^(6)A readers:Diverse roles in regulating cancer cell biological functions,hypoxia adaptation,metabolism,and immunosuppressive tumor microenvironment

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Genes & Diseases 2024年第2期11卷 890-920页

作者： Meiqi Duan Haiyang Liu Shasha Xu Zhi Yang Fusheng Zhang Guang Wang Yutian Wang Shan Zhao Xiaofeng Jiang department of General surgery The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China department of Gastroendoscopy The Fourth Affiliated Hospital of China Medical UniversityShenyangLiaoning 110032China department of Rheumatology and Immunology The First Affiliated Hospital of China Medical UniversityShenyangLiaoning 110002China

m^(6)A methylation is the most frequent modification of mRNA in eukaryotes and plays a crucial role in cancer progression by regulating biological ***-like growth factor 2 mRNA-binding proteins(IGF2BP)are newly identified m^(6)A‘readers’.They belong to a family of RNA-binding proteins,which bind to the m^(6)A sites on different RNA sequences and stabilize them to promote cancer *** this review,we summarize the mechanisms by which different upstream factors regulate IGF2BP in *** current literature analyzed here reveals that the IGF2BP family proteins promote cancer cell proliferation,survival,and chemoresistance,inhibit apoptosis,and are also associated with cancer glycolysis,angiogenesis,and the immune response in the tumor ***,with the discovery of their role as‘readers’of m^(6)A and the characteristic re-expression of IGF2BPs in cancers,it is important to elucidate their mechanism of action in the immunosuppressive tumor *** also describe in detail the regulatory and interaction network of the IGF2BP family in downstream target RNAs and discuss their potential clinical applications as diagnostic and prognostic markers,as well as recent advances in IGF2BP biology and associated therapeutic value.

关键词： Cancer IGF2BP Immunosuppressive TME m^(6)A Molecular mechanism Therapy

Nomogram model including LATS2 expression was constructed to predict the prognosis of advanced gastric cancer after surgery

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World Journal of Gastrointestinal surgery 2024年第2期16卷 518-528页

作者： Nan Sun Bi-Bo Tan Yong Li department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hubei ProvinceChina Third department of General surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Gastric cancer is a leading cause of cancer-related deaths *** assessments are typically based on the tumor-node-metastasis(TNM)staging system,which does not account for the molecular heterogeneity of this ***2,a tumor suppressor gene involved in the Hippo signaling pathway,has been identified as a potential prognostic biomarker in gastric *** To construct and validate a nomogram model that includes LATS2 expression to predict the survival prognosis of advanced gastric cancer patients following ra-dical surgery,and compare its predictive performance with traditional TNM *** A retrospective analysis of 245 advanced gastric cancer patients from the fourth Hospital of Hebei Medical University was *** patients were divided into a training group(171 patients)and a validation group(74 patients)to deve-lop and test our prognostic *** performance of the model was determined using C-indices,receiver operating characteristic curves,calibration plots,and decision *** The model demonstrated a high predictive accuracy with C-indices of 0.829 in the training set and 0.862 in the validation *** under the curve values for three-year and five-year survival prediction were significantly robust,suggesting an excellent discrimination *** plots confirmed the high concordance between the predictions and actual survival *** We developed a nomogram model incorporating LATS2 expression,which significantly outperformed conven-tional TNM staging in predicting the prognosis of advanced gastric cancer patients *** model may serve as a valuable tool for individualized patient management,allowing for more accurate stratification and im-proved clinical *** validation in larger patient cohorts will be necessary to establish its generaliza-bility and clinical utility.

关键词： Gastric cancer LATS2 Column line graph Prognosis Advanced gastric cancer survival Molecular biomarkers Predictive analytics in oncology Survival analysis

New perspectives in prognostication of hepatocellular carcinoma:The role and clinical implications of transient receptor potential family genes

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2862-2864页

作者： Shi-Hao Guan Wen-Jing Hu Xin-Yu Wang Yue-Xia Gu De-Hua Zhou department of Plastic surgery Qingpu Branch of Zhongshan Hospital Affiliated to Fudan UniversityShanghai 201700China department of Nursing Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of Gastrointestinal surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

The study titled“Transient receptor potential-related risk model predicts prognosis of hepatocellular carcinoma patients”is a significant contribution to hepatocellular carcinoma(HCC)research,highlighting the role of transient receptor potential(TRP)family genes in the disease’s progression and *** data from The Cancer Genome Atlas database,it establishes a new risk assessment model,emphasizing the interaction of TRP genes with tumor proliferation pathways,key metabolic reactions like retinol metabolism,and the tumor immune ***,the overexpression of the TRPC1 gene in HCC correlates with poorer patient survival outcomes,suggesting its potential as a prognostic biomarker and a target for personalized therapy,particularly in strategies combining immunotherapy and anti-TRP agents.

关键词： Hepatocellular carcinoma Transient receptor potential channels TRPC1 gene Tumor immune microenvironment Cancer prognosis Bioinformatics in cancer research

Development and validation of a machine learning-based early prediction model for massive intraoperative bleeding in patients with primary hepatic malignancies

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 90-101页

作者： Jin Li Yu-Ming Jia Zhi-Lei Zhang Cheng-Yu Liu Zhan-Wu Jiang Zhi-Wei Hao Li Peng department of Hepatological surgery The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina department of General surgery II Baoding First Central HospitalBaoding 071000Hebei ProvinceChina

BACKGROUND Surgical resection remains the primary treatment for hepatic malignancies,and intraoperative bleeding is associated with a significantly increased risk of ***,accurate prediction of intraoperative bleeding risk in patients with hepatic malignancies is essential to preventing bleeding in advance and providing safer and more effective *** To develop a predictive model for intraoperative bleeding in primary hepatic malignancy patients for improving surgical planning and *** The retrospective analysis enrolled patients diagnosed with primary hepatic malignancies who underwent surgery at the Hepatobiliary surgery department of the fourth Hospital of Hebei Medical University between 2010 and *** regression analysis was performed to identify potential risk factors for intraoperative bleeding.A prediction model was developed using Python programming language,and its accuracy was evaluated using receiver operating characteristic(ROC)curve *** Among 406 primary liver cancer patients,16.0%(65/406)suffered massive intraoperative *** regression analysis identified four variables as associated with intraoperative bleeding in these patients:ascites[odds ratio(OR):22.839;P<0.05],history of alcohol consumption(OR:2.950;P<0.015),TNM staging(OR:2.441;P<0.001),and albumin-bilirubin score(OR:2.361;P<0.001).These variables were used to construct the prediction *** 406 patients were randomly assigned to a training set(70%)and a prediction set(30%).The area under the ROC curve values for the model’s ability to predict intraoperative bleeding were 0.844 in the training set and 0.80 in the prediction *** The developed and validated model predicts significant intraoperative blood loss in primary hepatic malignancies using four preoperative clinical factors by considering four preoperative clinical factors:ascites,history of alcohol consumption,TNM staging,and albumin-bilirubin ***

关键词： Primary liver cancer Intraoperative bleeding Machine learning Model

Gastric cancer immunotherapy:A scientometric and clinical trial review

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World Journal of Gastroenterology 2024年第2期30卷 196-198页

作者： Qian-Cheng Du Xin-Yu Wang Hua Yu Thoracic surgery Shanghai Xuhui Central HospitalShanghai 200031China Thyroid Breast and Vascular SurgeryShanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China department of General surgery Shanghai Fourth People’s Hospital Affiliated to Tongji University School of MedicineShanghai 200434China

This letter is intended to arouse your interest in a recent review of comprehensive scientometrics and clinical trials on immunotherapy for gastric cancer(GC).Our study reviews recent advances in immunotherapy in the field of GC and highlights its new prospects as a treatment for *** research reveals China’s leadership in this field,as well as new therapeutic strategies such as immune checkpoint inhibitors,cellular immunotherapy,and *** combined findings highlight the potential of immunotherapy to improve survival and quality of life in patients with stomach *** believe that this study will provide important guidance for the future direction of the GC treatment field.

关键词： Gastric cancer Immunotherapy Bibliometrics Comment Therapeutic strategies

Effects of psychological intervention on negative emotions and psychological resilience in breast cancer patients after radical mastectomy

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World Journal of Psychiatry 2024年第1期14卷 8-14页

作者： Jing Wang Dong-Xue Kang Ai-Jun Zhang Bing-Rui Li department of surgery The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina Operating Room The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina department of Central Sterile Supply The Fourth Affiliated Hospital of China Medical UniversityShenyang 110033Liaoning ProvinceChina

Breast cancer(BC)is the most common malignant tumor in women,and the treatment process not only results in physical pain but also significant psychological distress in *** intervention(PI)has been recognized as an important approach in treating postoperative psychological disorders in BC *** has been proven that PI has a significant therapeutic effect on postoperative psychological disorders,improving patients'negative emotions,enhancing their psychological resilience,and effectively enhancing their quality of life and treatment compliance.

关键词： Breast cancer Psychological intervention Negative emotions Psychological resilience Radical surgery