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Development of a health education intervention strategy using an implementation research method to control taeniasis and cysticercosis in Burkina Faso

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Infectious Diseases of Poverty 2017年第1期6卷 833-847页

作者： Helena Ngowi Ivan Ozbolt Athanase Millogo Veronique Dermauw Telesphore Some Paul Spicer Lori L.Jervis Rasmane Ganaba Sarah Gabriel Pierre Dorny Helene Carabin Department of Veterinary Medicine and Public Health Sokoine University of AgricultureP.O.Box 3021MorogoroTanzania Department of Anthropology University of OklahomaNormanOKUSA Language Department Citizen Potawatomi NationShawneeOKUSA Sourou Sanou University Teaching Hospital Bobo-DioulassoBurkina Faso Department of Biomedical Sciences Institute of Tropical MedicineAntwerpBelgium Agriculutral and research Training Agency for Africa(AFRICSante) Bobo-DioulassoBurkina Faso Department of Anthropology and Center for Applied Social research University of OklahomaOklahoma CityOKUSA Department of Biostatistics and Epidemiology College of Public HealthOklahoma University Health Sciences CenterOklahoma CityOKUSA

Background:Taeniasis and cysticercosis are two diseases caused by Taenia solium,a parasite transmitted between humans and pigs,leading to considerable economic loss and *** of the parasite is linked to environmental and behavioural factors such as inadequate sanitation and hygiene,poor pig management,and consumption of infected *** study used implementation research method to design a health education intervention strategy for reducing *** infections in Burkina Faso,a country endemic for the ***:Eighteen group discussions were conducted with 8-18 participants each in three *** addition,structured interviews were conducted among 4777 participants and 2244 pig owners,who were selected through cluster random sampling in 60 villages of three provinces of Burkina *** approaches assessed knowledge and practices related to *** information obtained was used to develop a community-adapted health education intervention strategy to control taeniasis and cysticercosis in Burkina ***:The group discussions revealed that participants had a poor quality of life due to the diseases as well as inadequate access to latrines,safe water,and healthcare *** addition,it was found that pig production was an important economic activity,especially for ***,financial and knowledge constraints were important limitations to improved pig management and latrine *** survey data also showed that open defecation and drinking unboiled water were common behaviours,enhanced by a lack of knowledge regarding the transmission of the parasite,perceived financial barriers to the implementation of control measures,lack of public sensitization,as well as a lack of self-efficacy towards control of the ***,the perceived financial benefits of controlling porcine cysticercosis could be emphasized by an education program that discourages open defecation and encourages drinking safe water

关键词： Taenia solium control plan Taeniasis Cysticercosis PHAST Burkina Faso

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Diminazene aceturate modified nanocomposite for improved efficacy in acute trypanosome infection

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Journal of Acute Disease 2018年第1期7卷 36-42页

作者： Oluwatosin Kudirat Shittu Shaba Yisa Aaron Mariam Damilola Oladuntoye Bashir Lawal Department of Biochemistry Tropical Disease/Nanotechnology Research UnitFederal University of TechnologyP.M.B.65MinnaNigeria

Objective: To investigate the improved antitrypanocidal activity and toxicity of diminazene aceturate modified Nano drug in experimental rats. Methods: Aqueous leaf extract of Hyptis suaveolens was used to reduce gold tetrachloride to its nanoparticle size and this was characterized and formulates with naturally synthesized polyhydroxybutyrateas a Nano carrier. A total of thirty (30) albino rats were group into 6 (A-F) of 5 rats each & infected intraperitoneally with 0.2 mL of the inoculum containing about 1×103 Trypanosoma brucei brucei parasites per 0.2 mL of blood. groups A and B were treated with 3 and 6 minutes released orange PHB, groups C and D were treated with 15 and 30 minutes released mango PHB formulated tablet while groups E and F were negative (untreated) and standard drug (Dininazene aceturare) respectively. Results: The free drug and modified orange synthesized polyhydroxy butyrate shows antitrypanocidal activities by reducing the replicating rate of the parasite as compared to infect untreated. While the modified- mango synthesized shows increasing order of replication. There were significant increases in all the haematological parameter evaluated in the infected treated groups compared to infect untreated. But no significant difference (Pgroups whereas, the modified orange synthesized shows significant decrease in other enzymes activities evaluated when compared with the free drug, mango synthesized and the infected untreated groups. Conclusion: Orange synthesized modified diminazene aceturate show efficacy as free drug with limited toxicity that can enhance the therapeutic.

关键词： Nano carrier Hyptissuaveolens Polyhydroxybutyrate Diminazeneaceturate Trypanosomiasis Toxicity

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parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina)infected with SIVmac239

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Zoological research 2018年第1期39卷 42-51页

作者： tian-zhang song ming-xu zhang yu-jie xia yu xiao wei pang yong-tang zheng Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China University of Chinese Academy of Sciences Bejing 100049China Kunming Primate research Center Kunming Institute of ZoologyChinese Academy of SciencesKunming Yunnan 650223China

parasites can increase infection rates and pathogenicity in immunocompromised human immunodeficiency virus （HIV） patients. However, in vitro studies and epidemiological investigations also suggest that parasites might escape immunocompromised hosts during HIV infection Due to the lack of direct evidence from animal experiments, the effects of immunocompromised hosts parasitic infections on remain unclear. Here we detected 14 different parasites in six northern pig-tailed macaques （NPMs） before or at the 50th week of simian immunodeficiency virus （SIV） infection by ELISA. The NPMs all carried parasites before viral injection. At the 50th week after viral injection, the individuals with negative results in parasitic detection （i.e., 08247 and 08287） were characterized as the parasites Exit （PE） group, with the other individuals （i.e., 09203, 09211, 10205, and 10225） characterized as the parasites Remain （PR） group. Compared with the PR group, the NPMs in the PE group showed higher viral loads, lower CD4＋ T cells counts, and lower CD4/CD8 rates. Additionally, the PE group had higher immune activation and immune exhaustion of both CD4~ and CD8~ T cells. Pathological observation showed greater injury to the liver, cecum, colon, spleen, and mesenteric lymph nodes in the PE group This study showed more seriously compromised immunity in the PE group, strongly indicating that parasites might exit an immunocompromised host.

关键词： AIDS Immunocompromised Northernpig-tailed macaque parasite SIVmac239

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Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds

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BIOCELL 2021年第6期45卷 1601-1610页

作者： FAZLUR RAHMAN SHAMS TABREZ RAHAT ALI SAJJADUL KADIR AKAND MOHAMMED AALAIDAROUS MOHAMMED ALSAWEED BADER MOHAMMED ALSHEHRI SAEED BANAWAS ABDUR RUB ABDUL AZIZ BIN DUKHYIL Infection and Immunity Laboratory(414) Department of BiotechnologyJamia Millia Islamia-A Central UniversityNew Delhi110025India Department of Medical Laboratory Sciences College of Applied Medical SciencesMajmaah UniversityAl Majmaah11952Saudi Arabia Health and Basic Sciences research Center Majmaah UniversityAl Majmaah11952Saudi Arabia

Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus *** is transmitted by the bite of female phlebotomies sand *** main clinical manifestations of leishmaniasis include cutaneous,visceral,and mucocutaneous *** leishmaniasis(VL)caused by Leishmania donovani,is an infection of reticuloendothelial system and fatal if ***,a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent in plants,yeast,and protozoa,*** which is absent in human being,is an important constituent of parasite *** C-24 reductase(LdSR)enzyme catalyzes the final step in the ergosterol biosynthesis *** inhibition of biosynthesis of ergosterol may lead to decreased cell viability and ***,we performed the molecular docking-based virtual screening of a library of natural ligands against LdSR to identify a potential inhibitor to fight ***,prenyletin,flavan-3-ol,resveratrol,and gingerol showed the top binding affinity towards *** upon ADME properties and bioactivity score,gingerol showed the best lead-likeness and drug-likeness ***,we further annotated its leishmanicidal *** found that gingerol inhibited the growth and proliferation of promastigotes as well as intra-macrophagic *** exerted its antileishmanial action through the induction of reactive oxygen species(ROS)in concentration-dependent *** induced ROS led to ***,this study described that gingerol would act as possible inhibitor to LdSR.

关键词： Leishmania Gingerol Sterol C-24 reductase Molecular docking ROS

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Preliminary Study of Anthelmintic Potential of Terminalia catappa Fresh Leaves Following Short-Term Daily Feeding on Goats

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Journal of Agricultural Science and Technology(A) 2011年第8期1卷 1275-1279页

作者： L. M. Azrul A. Rawaidah A. W. M. Effendy Department of Agrotechnology Faculty of Agrotechnology and Food Science Universiti Malaysia Terengganu Kuala Terengganu Terengganu 21030 Malaysia Institute of Marine Biotechnology Universiti Malaysia Terengganu Kuala Terengganu Terengganu 21030 Malaysia Department of Biological Seiences Faculty of Science and Technology Universiti Malaysia Terengganu Kuala Terengganu Terengganu 21030 Malaysia

The anthelmintic resistance was developed in many species of gastrointestinal nematodes and occurred worldwide. This phenomenon had reduced the effectiveness of anthelmintics which based on drugs. This situation has led to the scientific study on natural anthelmintic that based on traditional usage of local plants. In this study, local plant named Ketapang (Terminalia catappa) that traditionally used to treat helminth infection was chose as experimental plant. Eighteen mix Katjang goats were equally divided into three groups, where two groups were treated with mature and immature T. catappa leaves respectively, while the third group was untreated. Leaves were daily feeding in raw to the goats for four weeks. Normal goat’s pellet was fed to the goats according to scheduled time-feeding; morning and afternoon, and water was given ad libitum. Fecal samples were collected every two days during the experimental period and subjected to modified Mc Master fecal egg count. Results for this short-term preliminary anthelmintic trial had showed significant percentage of helminth eggs reduction in goats. The reduction in goats treated with mature leaves was at 72% and 63% for the goats treated with immature leaves. Control goats did not showed significant reduction in terms of the parasite worm eggs. In conclusion, the ethnoveterinary data about this local plant was scientifically proven and can be widely promoted to the local livestock’s owner as an alternative approach for parasitic helminths control in goats.

关键词：驱虫药山羊短期寄生虫感染饲养日报新鲜科学研究

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Effect of Plasmodium yoelii YM Infection on Vaccination with 19 kDa Carboxylterminus of the Merozoite Surface Protein 1 (MSP1_(19))

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Journal of Microbiology and Immunology 2004年第4期2卷 265-271页

作者：徐沪济 Jiraprapa WIPASA 刘雪琴 Anthony STOWERS 杨晓平 Michael F GOOD Department of Rheumatology and Immunology Changzheng Hospital Second Military Medical University Shanghai 200003 China Division of Infection and Immunity Institute of Immunology Second Military Medical University 200043 China The Cooperative Research Center for Vaccine Technology The Queens- land Institute of Medical Research P.O. Royal Brisbane Hospital Queens- land 4029 Australia The Cooperative research Center for Vaccine Technology The Queens- land Institute of Medical Research P.O. Royal Brisbane Hospital Queens- land 4029 Australia The Laboratory of Parasitic Diseases National Institute of Allergy and Infectious Diseases The National Institutes of Health Bethesda MD 20892 USA Department of Rheumatology and Immunology Changzheng Hospital Second Military Medical University Shanghai 200003 China Division of Infection and Immunity Institute of Immunology Second Military Medical University 200043 China

We have previously demonstrated the ability of malaria parasites to interfere with specific immune responses. CD4 T cells specific to parasite antigens, but not CD4 T cells specific to an irrelevant antigen, ovalbumin (OVA), are de- leted via apoptosis during malaria infection. It is of interest, therefore, to investigate the immune responses that developed following vaccination with the 19 kDa carboxylterminus of the merozoite surface protein 1 (MSP119) in mice that had previ- ously experienced malaria infection. In this study, pre-exposure of mice to Plasmodium yoelii elicited native anti-MSP119 an- tibody responses, which could be boosted by vaccination with recombinant MSP119 . likewise, infection of MSP119-primed mice with Plasmodium yoelii ( P . yoelii) led to an increase of anti-MSP119 antibodies. MSP119 vaccination of malaria pre- exposed mice or immunization by infection/cure of MSP119-primed mice enabled the mice to survive challenge infection, with the former group having slightly lower parasitaemia. The data suggest that exposure to malaria infection primes a natural im- mune response which can be boosted by vaccination. This information is relevant to the development of a vaccine for use in individuals living in malaria-endemic areas.

关键词：疟疾寄生虫感染特异性免疫反应 CD4 T细胞疫苗接种裂殖子表面蛋白1

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Efficacy of Gold Nanoparticles against Nephrotoxicity Induced by Schistosoma mansoni Infection in Mice

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Biomedical and Environmental Sciences 2016年第11期29卷 773-781页

作者： Mohamed A Dkhil Mona F Khalil2 Amira A Bauom Marwa SM Dia Saleh A1-Qura Department of Zoology College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Zoology and Entomology Faculty of ScienceHelwan UniversityCairo 11795Egypt Department of Laboratory Sciences College of Science&ArtsA1-RassQassim UniversityAL-Qaseam 51921Saudi Arabia Molecular Drug Evaluation Department National Organization for Drug Control&Research(NODCAR)Giza 12553Egypt

Objective In this study, the ameliorative effects of gold nanoparticles （gold NP） on the renal tissue damage in Schistosoma mansoni （S. mansoni）-infected mice was investigated. Methods High-resolution transmission electron microscopy was used for the characterization of NP. The gold NP at concentrations of 250, 500, and 1000 μg/kg body weight were inoculated into 5. mansoni-infected mice. Results The parasite caused alterations in the histological architecture. Furthermore, it induced a significant reduction in the renal glutathione levels; however, the levels of nitric oxide and malondialdehyde were significantly elevated. The parasite also managed to downregulate KIM-I, NGAL, MCP-1, and TGF-8 mRNA expression in infected animals. Notably, gold NP treatment in mice reduced the extent of histological impairment and renal oxidative damage. Gold NP were able to regulate gene expression impaired by 5. Mansoni infection. Conclusion The curative effect of gold NP against renal toxicity in 5. mansoni-infected mice is associated with their role as free radical scavengers.

关键词： Gold nanoparticles Schistosomiasis Renal damage Gene expression Histopathology Oxidative stress

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Fungal plant relationships by direct sequencing in Foliar epiphytes

Fungal plant relationships by direct sequencing in Foliar ep...

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中国菌物学会2015年学术年会

作者： Xiangyu Zeng Tingchi Wen Putarak Chomnunti Saranyaphat Boonmee Kevin D.Hyde The Engineering and research Center of Southwest Bio-Pharmaceutical Resource Ministry of EducationGuizhou University Centre of Excellence in Fungal research Mae Fah Luang University School of Science Mae Fah Luang University Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of Sciences

Foliar epiphytes are a polyphyletic group mostly found on the surface of leaves with worldwide distribution. Many species of foliar epiphytes are obligate parasites which can reduce yield and quality of crops by absorbing plant nutrients, while some species indirectly affect plants by covering the host surface and thus reducing photosynthesis. The classification and phylogeny of foliar epiphytes are presently poorly known worldwide, for most of foliar epiphyte species are obligate parasites and are difficult or normally could not be cultured. In the meanwhile, directly sequence from mycelium or ascomata also have a problem with contamination and other problems. So far, we have introduced 3 new taxa, which are Ceramothyrium longivolcaniforme sp. nov., Irenopsis walsurae sp. nov. and Lembosia xyliae sp. nov.. And provided new sequences of Meliola clerodendricola, Meliola tamarindi and one Asterina species. The main objective of this study is to figure out the phylogeny and evolutionary relationships of foliar epiphytes by direct sequencing and further to gain knowledge of fungi–plant relationships.

关键词： Epifoliar parasite Phylogeny

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Feral Cats: Parasitic Reservoirs in Our Zoos?

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Open Journal of Veterinary Medicine 2020年第8期10卷 126-138页

作者： Thalyta Ananias Lima Paula Andrea Borges Salgado Carolina Romeiro Fernandes Chagas Patrícia Locosque Ramos Edson Aparecido Adriano Irys Hany Lima Gonzalez Department of Biological Science S&#227 o Paulo Federal University (UNIFESP) Diadema Brazil Applied research Department S&#227 o Paulo Zoological Park Foundation S&#227 o Paulo Brazil

Up until the recent past, zoos served limited function, primarily existing for entertainment value. Today’s zoos, however, are serving many roles, chief among them: species conservation of captive animals. The biggest zoo in Brazil, S?o Paulo Zoological Park Foundation, has among its 2000 animals and many species of wild cats. The presence of domestic cats living freely in zoos is common and can be a source of spreading disease. The aim of this study was to verify the variety and prevalence of parasites found in the feces of felids (feral and wild) living in the S?o Paulo Zoo. The results of this parasitological analysis have been obtained from the laboratory of clinical analysis and correspond to the 4-year period beginning January/2009 and ending December/2012. Eight species of parasites were identified in the feces of captive wild cats and three in the feces of feral cats. For those captives, Toxocara cati (7.95%) had the highest prevalence, followed by Toxascaris leonina (7.58%), Isospora sp. (2.03%), Hymenolepis nana (0.92%), Eimeria sp., Giardia sp. and Blastocystis sp. (0.37% each) and Ascaris sp. (0.18%). Among the feral cats, we found Toxocara cati (59.26%), Giardia sp. (22.22%) and Isospora sp. (11.11%). For the captive group, we also distinguished natives from exotic species, finding native species to be more frequently parasitized than the exotic ones. Key to our findings, though, was the fact that a few parasite species were found among all groups of felids, specifically (Toxocara cati, Giardia sp. and Isospora sp). Further research is needed, however,

关键词： Enteroparasites Felids Felis catus Toxocara cati Wild Animals

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Effect of Supplemental Sericea Lespedeza Pellets on Internal parasite Infection and Nutritional Status of Grazing Goats

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Journal of Agricultural Science and Technology(A) 2017年第5期7卷 334-344页

作者： Tiffani Hamilton Thomas Tenill Dill Sandeep Kommuru: Aqiyla Rivers Jorge Mosjidis James Miller Chris Drake Irene Mueller-Harvey Joan Burke Agricultural research Station Fort Valley State University Fort Valley GA 31030 USA Department of Agronomy and Soils Auburn University Auburn AL 36849 USA Department of Pathobiological Sciences Louisiana State University Baton Rouge LA 70803 USA School of Agriculture Policy and Development University of Reading Reading RG6 6AT UK United States Department of Agriculture Agricultural Research Service Booneville AR 72927 USA

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