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Effects of albendazole,artesunate,praziquantel and miltefosine,on Opisthorchis viverrini cercariae and mature metacercariae

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 120-126页

作者： Phornphitcha Pechdee Monticha Chaiyasaeng Chanisala Sereewong Jukkrid Chaiyos Apiporn Suwannatrai Sutee Wongmaneeprateep Smarn Tesana food-borne parasite research group Department of ParasitologyFaculty of MedicineKhon Kaen University Department of Fisheries Faculty of AgricultureKhon Kaen University

Objective:To explore larvicidal effects of anthelmintic drugs on Opisthorchis viverrini(***) for alternative approach to interrupting its cycle for developing a field-based control ***:The larvicidal activities of albendazole(A1),artesunate(Ar),praziquantel(Pzq) and miltefosine(Mf) on *** cercariae and mature metacercariae were *** concentrations(LC_(50) and LC_(95)) of these drugs were *** metacercariae previously exposed to various concentrations of the drugs were administered to *** were harvested 30 d post infection and worm recovery rates ***,Ar,Pzq and Mf produced morphological degeneration and induced shedding tails of cercariae after 24 h ***:The LC_(50) and LC_(95) of Al,Ar,Pzq and Mf on cercariae were 0.720 and 1.139,0.350 and 0.861,0.017 and 0.693,and 0.530 and 1.134 ppm,***_(50) and LC_(95) of Ar on mature metacercariae were 303.643 and 446.237 ppm and of Mf were 289.711 and 631.781 ppm,respectively but no lethal effect in Pzq-and Al-treated groups(up to 1 ppt).No worms were found in hamsters administered Pzq-treated *** adult worms from Al-treated metacercariae were significantly bigger in size compared to the control group(Pgroup(P<0.05).Conclusions:The larvicidal effects of these drugs were high efficacy to *** cercariae but lesser efficacy to *** should be further studied with the eventual aim of developing a field-based control program.

关键词： Albendazole Artesunate Praziquantel Miltefosine Opisthorchis viverrini Cercariae

Effects of physicochemical factors on development and survival of Opisthorchis viverrini uterine eggs

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Asian Pacific Journal of Tropical Biomedicine 2018年第9期8卷 431-435页

作者： Chanisala Sereewong Monticha Chaiyasaeng Naiyana Senasri Jukkrid Chaiyos Smarn Tesana food-borne parasite research group Department of Parasitology Faculty of Medicine Khon Kaen University Department of Fisheries Faculty of Natural Resources Rajamangala University of Technology Isan Sakonnakhon Campus

Objective: To investigate the maturity development of miracidia in uterine eggs from four portions of the Opisthorchis viverrini uterus and environmental factors possibly affected in maturation and infectivity of distal part uterine ***: Uteri of adult worms were divided into 4 equal *** of eggs was determined under light *** embryonated eggs were used to evaluate the effects of physicochemical factors: temperature, salinity, acidity, ultraviolet A, B, *** success was evaluated by feeding treated eggs to intermediate host snails and determining by using a PCR ***: Eggs obtained from the uterus closest to the ovary(regions 1 and 2) failed to develop in *** from region 4 of the uterus(close to the genital pore) were used to study effects of physicochemical *** highest survival and infection success was in groups of eggs kept at 30 ℃(95.20%).The calculated period of loss infection success(LI_(50) and LI_(95)) on miracidia in distal uterine eggs by exposure to UV-A, UV-B and UV-C were 73 and 1 523 d; 8 and 20 d; 1 and 2 d, *** concentrations(LC_(50) and LC_(95)) of salinity, HCl and NaOH on miracidia in distal uterine eggs were 45.43 and 120.09 ppt, 0.01 and 0.25 M; 0.01 and 0.11 M, respectively, after 24 h ***: Opisthorchis viverrini eggs display a high tolerance to environmental conditions, especially after snail host eating for infection.

关键词： Opisthorchis viverrini Physicochemical Development Survival Uterine eggs

Chemical constituents and pharmacological effects of Lonicerae japonicae

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Asian Journal of Traditional Medicines 2024年第1期19卷 34-45页

作者： Yunpeng Yang Dan Tian Yibo Wang Yi’an Shi Yuntian Xing Yu Chen School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China Shenyang Hoper group Co. LtdShenyang 110122China National Health Commission Key Laboratory of Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control TechnologyJiangsu Provincial Medical Key LaboratoryJiangsu Institute of Parasitic DiseasesWuxi 214064China

Lonicera japonica,also known as honeysuckle,is an evergreen shrub in the family of *** consulting Sciencedirect databases and Web of Science databases,79 related articles were found,of which 22 were related to chemical composition and pharmacological *** articles show that *** has a wide range of pharmacological activities,including antiviral,anti-tumor,and antioxidant *** activities have important applications in the pharmaceutical,food,and fragrance *** review focuses on the chemical composition and pharmacological effects of ***,which is of great significance to the development of new drugs and therapeutic methods.

关键词： Lonicerae japonicae chemical composition pharmacological activity

Epidemiological characteristics of Plasmodium malariae malaria in China:a malaria that should not be neglected post elimination

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Infectious Diseases of Poverty 2023年第6期12卷 51-60页

作者： Li Zhang Bo‑Yu Yi Shui‑Sen Zhou Zhi‑Gui Xia Jian‑Hai Yin National Institute of Parasitic Diseases Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research)NHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Center for Tropical DiseasesNational Center for International Research On Tropical DiseasesShanghai 200025China

Background Plasmodium malariae was always neglected compared *** *** the present study,we aimed to describe the epidemiology of reported cases infected *** in the past decade to raise awareness of the potential threat of this malaria parasite in *** Individual data of malaria cases infected *** reported in China in the past decade were collected via the China Information System for Disease Control and Prevention and Parasitic Diseases Information Reporting Management System,to explore their epidemiological *** Chi-square tests or Fisher’s Exact Test was used in the statistical *** From 2013 to 2022,a total of *** cases were reported in China,and mainly concentrated in 20-59 years old group(P<0.001),and there was no significant trend in the number of cases reported per ***,four kinds *** cases were classified,including 567 imported cases from 41 countries in 8 regions and distributed in 27 provinces(autonomous regions,municipalities)in China,six indigenous cases in a small outbreak in Hainan,seven recurrent cases in Guangdong and Shanghai,and one induced case in Shanghai,*** addition,only 379 cases(65.2%)were diagnosed as malaria on the first visit(P<0.001),and 413 cases(71.1%)were further confirmed *** cases(P=0.002).Meanwhile,most cases sought healthcare first in the health facilities at the county and prefectural levels,but only 76.7%(161/210)and 73.7%(146/198)cases were diagnosed as malaria,and the accuracy of confirmed diagnosis as malaria cases infected *** was only 77.2%(156/202)and 69.9%(167/239)in these health facilities *** Even though malaria cases infected *** didn’t account for a high proportion of reported malaria cases nationwide,the threat posed by widely distributed imported cases,a small number of indigenous cases,recurrent cases and induced case cannot be ignored in Chi

关键词： Plasmodium malariae Imported case Recurrence Induced case Reestablishment China

Macromolecular inhibitors of malarial cysteine proteases —An invited review

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Journal of Biomedical Science and Engineering 2013年第9期6卷 885-895页

作者： Kailash C. Pandey Host-parasite Interaction Biology group Protein-Protein Interaction Unit National Institute of Malaria Research (ICMR) Sector-8 Dwarka India

There are evidences indicating that cysteine proteases play an essential role in malaria parasites;therefore, an obvious area of investigation is the inhibition of these enzymes to treat malaria. Small cysteine protease inhibitors of malaria are well studied, but macromolecular nature of inhibitor is a new field to explore. In malarial cysteine proteases, there are macromolecular endogenous inhibitors playing important roles in regulation of the cysteine protease activity of parasite and host. Recent studies suggested that there are known and characterized endogenous inhibitors like falstatin present in P. falciparum, PbICP (inhibitor of cysteine protease in P. berghei), PyICP (inhibitor of cysteine protease in P. yoelli), and other macromolecular inhibitors which are the prodomain of enzyme itself regulating the activity of the mature enzyme. All the known macromolecular endogenous inhibitors are using specific loop-like structure to interact with malarial cysteine proteases. The majority of macromolecular inhibitors are competitive in nature, and block access to the active site of their target protease, but do not bind in a strictly substrate-like manner. They rather interact with the protease subsites and catalytic residues in a non-catalytically competent manner. In future, designing inhibitors based on these protein-protein interactions will be a new approach in the field of malaria. Since macromolecular inhibitors can gain potency through the burial of a large surface area and specificity through contacts with secondary binding sites critical for inhibition, and could be less prone to drug resistant mutation.

关键词： Malaria Cysteine Protease Hemoglobinase Macromolecular Inhibitor Protein-Protein Interaction

Molecular phylogeny of Anopheles hyrcanus group(Diptera:Culicidae)based on mtDNA COI

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Infectious Diseases of Poverty 2017年第1期6卷 522-531页

作者： Yuan Fang Wen-Qi Shi Yi Zhang National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborating Centre for Tropical DiseasesNational Center for International Research on Tropical DiseasesMinistry of Science and TechnologyKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025China

Background:The Anopheles hyrcanus group,which includes at least 25 species,is widely distributed in the Oriental and Palearctic *** group members have been incriminated as vectors of malaria and other mosquito-borne *** is difficult to identify Hyrcanus group members by morphological ***,molecular phylogeny has been proposed as an important complementary method to traditional morphological ***:Based on the GenBank database and our original study data,we used 466 mitochondrial DNA COI sequences belonging to 18 species to reconstruct the molecular phylogeny of the Hyrcanus group across its worldwide geographic ***:The results are as follows.1)The average conspecific K2P divergence was 0.008(range 0.002-0.017),whereas sequence divergence between congroup species averaged 0.064(range 0.026-0.108).2)The topology of COI tree of the Hyrcanus group was generally consistent with classical morphological taxonomy in terms of species classification,but disagreed in subgroup *** the COI tree,the group was divided into at least three main *** first cluster contained ***;the second was composed of the Nigerrimus Subgroup and ***;and the third cluster was comprised of the Lesteri Subgroup and other unassociated species.3)Phylogenetic analysis of COI indicated that ancient hybridizations probably occurred among the three closely related species,***,***,and ***.4)The results supported *** as a probable synonym of ***,and it was possible that *** and *** were the same species,as evident from their extremely low interspecific genetic divergence(0.020 and 0.007,respectively)and their phylogenetic ***:In summary,we reconstructed the molecular phylogeny and analysed genetic divergence of the Hyrcanus group using mitochondrial COI *** results suggest that in the future of malaria surveillance,we should not only pay much attent

关键词： Mosquito DNA barcoding Genetic distance Malaria

Impact of single annual treatment and four-monthly treatment for hookworm and Ascaris lumbricoides,and factors associated with residual infection among Kenyan school children

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Infectious Diseases of Poverty 2017年第1期6卷 249-260页

作者： Stella Kepha Charles S.Mwandawiro Roy M.Anderson Rachel L.Pullan Fred Nuwaha Jorge Cano Sammy M.Njenga Maurice R.Odiere Elizabeth Allen Simon J.Brooker Birgit Nikolay School of Public Health Makerere University College of Health SciencesKampalaUganda Eastern and Southern Africa Centre of International parasite Control Kenya Medical Research Institute(KEMRI)NairobiKenya London Centre for Neglected Tropical Disease research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK London School of Hygiene and Tropical Medicine LondonUK Centre for Global Health research KEMRIKisumuKenya KEMRI-Wellcome Trust research Programme NairobiKenya

Background:School-based deworming is widely implemented in various countries to reduce the burden of soil-transmitted helminths(STHs),however,the frequency of drug administration varies in different *** this study,we compared the impact of a single annual treatment and 4-monthly treatment over a follow-up among Kenyan school children,and investigated the factors associated with residual ***:We performed a secondary analysis of data from a randomized trial investigating whether deworming for STHs alters risk of acquiring *** received either a single treatment or 4-monthly albendazole treatments were followed longitudinally from February 2014 to October *** relative impact of treatment and factors associated with residual infections were investigated using mixed-effects regression *** to infection was assessed based on Spearman’s rank and Kendall’s Tau correlation ***:In the 4-monthly treatment group,the proportion of children infected with hookworm decreased from 59.9 to 5.7%,while Ascaris lumbricoides infections dropped from 55.7 to 6.2%.In the single treatment group,hookworm infections decreased over the same time period from 58.7 to 18.3%(12.6%absolute difference in reduction,95%CI:8.9-16.3%),and *** from 56.7 to 23.3%(17.1%absolute difference in reduction,95%CI:13.1-21.1%).There was strong evidence for predisposition to both STH *** hookworm infection among children on 4-monthly treatment were associated with male sex and baseline nutritional status,whereas *** infection was associated with individual and school-level infection at baseline,latrine cleanliness at ***:This study found that 4-monthly treatment w more effective than single annual *** treatments led to dramatic reductions in the intensities of STHs,but did not completely clear infections among school children in Kenya,a presumed reflection of reinfection in a setti

关键词： School-based deworming Soil-transmitted helminths Albendazole School children Kenya

Priorities for research and control of cestode zoonoses in Asia

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Infectious Diseases of Poverty 2013年第1期2卷 126-136页

作者： Ning Xiao Jia-Wen Yao Wei Ding Patrick Giraudoux Philip S Craig Akira Ito National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborative Center for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China Department of ChronoEnvironment University of Franche-Comté/CNRS and Institut Universitaire de FranceBesançonFrance Cestode Zoonoses research group School of Environment and Life SciencesUniversity of SalfordManchesterUK Department of Parasitology Asahikawa Medical UniversityAsahikawa 078-8510Japan

Globally,cestode zoonoses cause serious public health problems,particularly in *** all neglected zoonotic diseases,cestode zoonoses account for over 75%of global disability adjusted life years(DALYs)*** international symposium on cestode zoonoses research and control was held in Shanghai,China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these *** brought together 96 scientists from the Asian region and beyond to exchange ideas,report on progress,make a gap analysis,and distill prioritizing settings with a focus on the Asian *** objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission,and human mortality and morbidity caused by the three major cestode zoonoses(cystic echinococcosis,alveolar echinococcosis,and cysticercosis);to critically assess the potential to control these diseases;to establish a research and validation agenda on existing and new approaches;and to report on novel tools for the study and control of cestode zoonoses.

关键词： Neglected diseases Cestode zoonoses Asia Priority Gap research Control

Urgent needs in fostering neglected tropical diseases(NTDs)laboratory capacity in WHO Western Pacific Region:results from the external quality assessment on NTDs diagnosis in 2012-2015

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Infectious Diseases of Poverty 2017年第1期6卷 955-962页

作者： Yan Lu Glenda Gonzales Shao-Hong Chen Hao Li Yu-Chun Cai Yan-Hong Chu Lin Ai Mu-Xin Chen Hai-Ning Chen Jia-Xu Chen National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Center for Tropical Diseases207 Ruijin Er RdShanghai 200025People’s Republic of China Malaria Other Vector borne and Parasitic Diseases(MVP)unitthe World Health Organization Regional Office for the Western PacificP.O.Box 29321000 ManilaPhilippines National Institute of Parasitic Diseases Chinese Center for Diseases Control and Prevention207 Ruijin Er RdShanghai 200025China

Background:Neglected tropical diseases(NTDs)are a heterogeneous group of mainly chronic,debilitating and often stigmatizing diseases that largely affects low-income and politically marginalized populations,causing a large burden of public health,social and economies in the NTDs endemic *** are caused by infections with a range of pathogen,including bacteria,parasites,protozoa and *** accurate diagnosis of NTDs is important for reducing morbidity,preventing mortality and for monitoring of control *** Quality Assessment(EQA),a component of laboratory quality assurance,aims to assess the performance of participating laboratories in detecting parasitic *** aim of this paper is to report the findings and put forward the recommendations on capacity build from the EQA results of participating NTDs laboratories in selected countries in the WHO Western Pacific Region from 2012 to ***:Reference or public health laboratories at national level working on NTDs in 6 countries participated in EQAs organized by the National Institute of Parasitic Diseases(NIPD)of Chinese Center for Disease Control and Prevention(CDC)based in Shanghai,*** representatives of each participating laboratory were invited to NIPD to detect NTDs’parasitic infections using the same prepared samples for serological tests(IHA and ELISA)and helminth eggs’morphological tests(Direct smear and Kato-Katz).All of the results were scored and analyzed by using SPSS statistics 19.0 ***:The percentage of participants who had EQA score≥60 during 2012-2015 for direct smear test were 80.00%(2012),71.43%(2013),100%(2014)and 75.00%(2015),whereas for Kato-Katz test were 80.00%(2012),57.14%(2013),100%(2014)and 37.50%(2015),*** detection rate of helminth eggs varied in different species,with Ascaris lumbricoides being the highest at 94.07%in *** laboratories did very well with ELISA tests as shown by the high scores in all four years e

关键词： Neglected tropical diseases Diagnosis External quality assessment Western Pacific Region