Effects of albendazole,artesunate,praziquantel and miltefosine,on Opisthorchis viverrini cercariae and mature metacercariae

作     者：Phornphitcha Pechdee Monticha Chaiyasaeng Chanisala Sereewong Jukkrid Chaiyos Apiporn Suwannatrai Sutee Wongmaneeprateep Smarn Tesana 

作者机构：Food-Borne Parasite Research GroupDepartment of ParasitologyFaculty of MedicineKhon Kaen University Department of FisheriesFaculty of AgricultureKhon Kaen University 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2017年第10卷第2期

页      面：120-126页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：The Higher Education Research Promotion and National Research University Project of Thailand Office of the Higher Education Commission though the Health Cluster(SHePGMS) Khon Kaen University to student Miss Phornphitcha Pechdee and advisor Assoc.Prof.Dr.Smarn Tesana for financial support of this work 

主　　题：Albendazole Artesunate Praziquantel Miltefosine Opisthorchis viverrini Cercariae 

摘      要：Objective:To explore larvicidal effects of anthelmintic drugs on Opisthorchis viverrini(***) for alternative approach to interrupting its cycle for developing a field-based control ***:The larvicidal activities of albendazole(A1),artesunate(Ar),praziquantel(Pzq) and miltefosine(Mf) on *** cercariae and mature metacercariae were *** concentrations(LC_(50) and LC_(95)) of these drugs were *** metacercariae previously exposed to various concentrations of the drugs were administered to *** were harvested 30 d post infection and worm recovery rates ***,Ar,Pzq and Mf produced morphological degeneration and induced shedding tails of cercariae after 24 h ***:The LC_(50) and LC_(95) of Al,Ar,Pzq and Mf on cercariae were 0.720 and 1.139,0.350 and 0.861,0.017 and 0.693,and 0.530 and 1.134 ppm,***_(50) and LC_(95) of Ar on mature metacercariae were 303.643 and 446.237 ppm and of Mf were 289.711 and 631.781 ppm,respectively but no lethal effect in Pzq-and Al-treated groups(up to 1 ppt).No worms were found in hamsters administered Pzq-treated *** adult worms from Al-treated metacercariae were significantly bigger in size compared to the control group(P0.05).Fecundity and body width were greater in adults from Mf-treated metacercariae compared to the control group(P0.05).Conclusions:The larvicidal effects of these drugs were high efficacy to *** cercariae but lesser efficacy to *** should be further studied with the eventual aim of developing a field-based control program.