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Journal of Ocean University of China 2019年第5期18卷 1174-1184页

作者： MAO Lei WANG Yiming WANG Meiling DAI Yufeng WANG Jingfeng XUE Changhu College of food science and Engineering Ocean University of China

The present study investigated the anti-osteoporosis function and the mechanism of sialoglycoproteins isolated from the eggs of Gadus morhua(Gm-SGP)on ovariectomized(OVX)*** 3 months of Gm-SGP treatment,OVX-induced bone loss was suppressed and uncoupling bone turnover was balanced,as indicated by systemic biomarkers of bone metabolism;no uterine estrogenicity was ***,rats administered with Gm-SGP exhibited increased bone mineral density and biomechanical strength and significant restoration of the trabecular microarchitecture compared with rats in the control ***-SGP significantly decreased bone resorption-related indicators in *** of the associated mechanisms revealed that Gm-SGP significantly increases the OPG/RANKL ratio at the mRNA and protein *** research suggested that Gm-SGP inhibits the mRNA and protein expressions of important transcription factors of the MAPK and NF-κB signaling *** also attenuates the activation of related transduction signaling pathways by inhibiting phosphorylation of JNK,ERK,p38,and NF-κB,and ultimately suppresses the induction of c-Fos and ***,these results demonstrate that Gm-SGP inhibits bone resorption by suppressing osteoclastogenesis-related MAPK and NF-κB pathways,thereby improving osteoporosis.

关键词： Sialoglycoprotein osteoporosis MAPKs NF-κB bone resorption

Solubility of red palm oil in supercritical carbon dioxide： Measurement and modelling

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Chinese Journal of Chemical Engineering 2018年第5期26卷 964-969页

作者： Wan Jun Lee Chin Ping Tan Rabiha Sulaiman Gun Hean Chong Department of food Technology Faculty of Food Science and Technology Universiti Putra Malaysia 43400 Serdang Selangor Malaysia Supercritical Fluid Centre (SFC) Faculty of Food Science and Technology Universiti Putra Malaysia 43400 Serdang Selangor Malaysia

The solubility of red palm oil （RPO） in supercritical carbon dioxide （scCO2） was determined using a dynamic method at 8.5-25 MPa and, 313.15-333.15 K and at a fixed scCO2 flow rate of 2.9 g. mn -1 using a full factorial design. The solubility was determined under low pressures and temperatures as a preliminary study for RPO par- ticle formation using scCO2. The solubility of RPO was 0.5-11.3 mg. （g CO2） -1 and was significantly affected by the pressure and temperature. RPO solubility increased with pressure and decreased with temperature. The Adachi-Lu model showed the best-fit for RPO solubility data with an average relative deviation of 14% with a high coefficient of determination, R2 of 0.9667, whereas the Peng-Robinson equation of state thermodynamic model recorded deviations of 17%-30%.

关键词： Solubility Supercritical carbon dioxide Mathematical modelling Thermodynamics Palm oil

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease

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Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1117-1122页

作者： Prashamsa Koirala Su Hui Seong Hyun Ah Jung Jae Sue Choi Department of food and Life science Pukyong National University Department of food science and Human Nutrition Chonbuk National University

Objective: To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against b-site amyloid precursor protein cleaving enzyme 1(BACE1), which serve as a rate limiting step in amyloid beta(Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity ***: A systematic study of 70% ethanolic P. lobata root extract was employed to identify its BACE1 inhibitory potential. Further, BACE1 inhibitory potential of two lupane terpenoids, yielded from ethanolic extract, was assessed. In order to determine their inhibition mode, Lineweaver–Burk plots and Michaelis–Menten model for BACE1 was performed. Auto Dock 4.2 program in addition determined the molecular interaction of BACE1 with isolated ***: Considering the inhibitory potential of 70% ethanolic extract of P. lobata against BACE1(IC_(50)= 80.35 mg/mL), lupeol and lupenone were subsequently isolated and exhibited notable or moderate BACE1 inhibitory activity with IC_(50) values of 5.12 and 62.98 mmol/L, respectively, as compared to the positive control quercetin(IC_(50)= 21.28 mmol/L). The enzyme kinetics study enabled us to identify both compounds as competitive inhibitors, where lupeol displayed a very potent inhibition against BACE1 with low inhibition constant(Ki) value of 1.43 mmol/L, signifying greater binding *** order to understand the binding mechanism and structure–activity relationship of two triterpene-based BACE1 inhibitors, we employed computer aided docking studies which evidently revealed that hydroxyl group of lupeol formed two hydrogen bonds with the ASP32(catalytic aspartic residue) and SER35 residues of BACE1 with the binding energy of(-8.2 kcal/mol), while the ketone group of lupenone did not form any hydrogen bonds with BACE1 giving evidence for less binding affinity. These results in turn have predicted the dep

关键词： Pueraria lobata BACE1 Lupeol Lupenone Molecular docking Kinetics

Measurement and analysis of soil nitrogen and organic matter content using near-infrared spectroscopy techniques

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Journal of Zhejiang University-science B(Biomedicine & Biotechnology) 2005年第11期6卷 1081-1086页

作者：何勇宋海燕 PEREIRA Annia García GóMEZ Antihus Hernández School of Biosystems Engineering and food science Zhejiang University

Near infrared reflectance （N1R） spectroscopy is as a rapid, convenient and simple nondestructive technique useful for quantifying several soil properties. This method was used to estimate nitrogen （N） and organic matter （OM） content in a soil of Zhejiang Province, Hangzhou County. A total of 125 soil samples were taken from the field. Ninety-five samples spectra were used during the calibration and cross validation stage. Thirty samples spectra were used to predict N and OM concentration. NIR spectra of these samples were correlated using partial least square regression. The regression coefficients between measured and predicted values of N and OM was 0.92 and 0.93, and SEP （standard error of prediction） were 3.28 and 0.06, respectively, which showed that NIR method had potential to accurately predict these constituents in this soil. The results showed that NIR spectroscopy could be a good tool for precision farming application.

关键词： NIR spectroscopy Partial least square Precision farming Soil spatial variability Nitrogen Organic matter

Occurrence of retained placenta is preceded by an inflammatory state and alterations of energy metabolism in transition dairy cows

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Journal of Animal science and Biotechnology 2016年第3期7卷 423-435页

作者： Elda Dervishi Guanshi Zhang Dagnachew Hailemariam Suzana M.Dunn Burim N.Ametaj Department of Agricultural food and Nutritional ScienceUniversity of Alberta

Background： Failure to expel fetal membranes within 24 h of calving is a pathological condition defined as retained placenta（RP）. The objective of this investigation was to evaluate whether there are alterations in several selected serum variables related to innate immunity and carbohydrate and lipid metabolism that precede occurrence of RP in transition Holstein dairy ***： One hundred multiparous Holstein dairy cows were involved in the study. Blood samples were collected from the coccygeal vein during the-8 to ＋4 wks around parturition, once per week before the morning *** healthy control cows（CON） and 6 cows with RP were selected and serum samples at-8,-4, time of diagnosis of disease, and ＋4 wks relative to parturition were used for analyses. All samples were analyzed for lactate, nonesterified fatty acids（NEFA）, β-hydroxybutyrate（BHBA）, interleukin-1（IL-1）, interleukin-6（IL-6）, tumor necrosis factor（TNF）, haptoglobin（Hp）, and serum amyloid A（SAA）.Results： Cows with RP had greater concentrations of serum lactate, IL-1, IL-6, TNF, and SAA in comparison with CON cows. Intriguingly, elevated concentrations of all five variables were observed at-8 and-4 wks before the occurrence of RP compared to healthy cows. Cows with RP also had lower DMI and milk production vs CON animals; however milk composition was not affected by ***： Cows with RP showed an activated innate immunity 8 wks prior to diagnosis of disease. Overall results suggest that serum IL-1, IL- 6, and TNF, and lactate can be used as screening biomarkers to indicate cows that might have health issues during the transition period.

关键词： Innate immunity Retained placenta Serum metabolites Transition dairy cows

A Review of the Development of Properties and Structures Based on Konjac Glucomannan as Functional Materials

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Chinese Journal of Structural Chemistry 2017年第2期36卷 346-360页

作者：袁毅王林庞杰洪馨穆若郡王维海谢丙清 College of food science Fujian Agriculture and Forestry University

In recent years, konjac glucomannan（KGM） has gained considerable attention due to its non-toxic, harmless, excellent biocompatibility, biodegradability, good water imbibition as well as gel properties. KGM and its derivatives have been widely used in food science, chemical, pharmaceutical, and material areas. In this review, we will focus on the most recent advances in the structures and properties of KGM. We will first describe the influence of different modification methods on the structures and properties of KGM. Then we will review the results obtained with KGM as functional materials in different studies in the fields of hydrogels, aerogels, nanoparticles, membrane materials, microspheres and microcapsule to provide theoretical basis for the further study.

关键词： glucomannan carboxyl viscosity pharmaceutical biodegradable chains solubility polymerization esters hydrogel

Advanced analytical determination of volatile organic compounds (VOC) and other major contaminants in water samples using GC-Ion Trap MS

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Journal of Environmental sciences 2001年第1期13卷 25-36页

作者： B M Koroma K X Wang D D Jinya Laboratory of Socioeconomic science of food Production Nagoya University Japan.

The GC-Ion Trap MS is recently one of the most efficient instrumental analysis recommended for understanding the chemistry of volatile organic compounds, not only in water but even in the food chain and other environmental media (air and soil). Results of the experiment conducted on water samples from Kuguri and Yatsutani sampling stations showed considerably higher levels of organic enrichment (COD = 10 mg/L and 11 mg/L respectively). Total concentrations of Pb (0.072 mg/L and 0.093 mg/L) and Cd (0.004 mg/L and 0.011 mg/L) on the other hand, invariably exceeded the maximum allowable concentrations for human health and the living environment (Pb = 0.005 mg/L; Cd = 0.001 mg/L respectively). And the toxicity levels for these contaminants at LC50 showed critical impact on rainbow trout (hypersensitive species) at 0.14 mg/L for Pb and 0.007 mg/L for Cd in 96 hours respectively. Although these major contaminants including phenol and 3-, 4-cresol, showed relatively higher toxicity impact in the experimental media, it would remain contentious to justify any associated potential dangers without regular routine water monitoring, at least for a period of one year. Nevertheless, the data could serve as a benchmark through which other phenomena can easily be investigated.

关键词： www Advanced analytical determination of volatile organic compounds and other major contaminants in water samples using GC-Ion Trap MS VOC EB GC

Hovenia acerba *** and seeds extracts ameliorate alcoholic liver injury by activating the Nrf2/HO-1 signalling pathway in LO2 cells and mice

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food Bioscience 2023年第1期51卷 235-247页

作者： Rui-fei Cheng Meng-ke Sun Qi-rui Hu Zeyuan Deng Bing Zhang Hongyan Li State Key Laboratory of food science and Technology College of Food ScienceNanchang UniversityNanchangJiangxi330047China

Hovenia acerba Lindl.(HA)was formerly used as a treatment for alcohol *** explore the mechanism of hepatoprotective effect of HA,the chemical components of Hovenia acerba *** extract(HAPE)and Hovenia acerba *** extract(HASE)were compared by ***,the alcohol damage model of human normal hepatocytes(LO2)and male Kunming mice were used to measure their effects on alcoholic liver *** showed that HASE had 32 kinds of phenolic compounds,and the main components were caffeic acid,vitexin-2′′-O-glucoside,ferulic acid hexoside,quercetin and its glycosides;HAPE had 24 kinds of phenolic compounds,and the main components were caffeic acid,kaempferol and *** phenolic content of HASE(151.73±12.66 mg gallic acid equivalent per gram of dry weight)(mg GAE/g DW)was higher than that of HAPE(17.89±1.59 mg GAE/g DW).HASE and HAPE could increase the LO2 cell viability in the alcohol damage ***,the levels of triacylglycerol(TG),total cholesterol(TC),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)were decreased,the activities of superoxide dismutase(SOD)and catalase(CAT)were increased,and the concentration of malondialdehyde(MDA)was decreased in both HASE and HAPE treated cell and mice *** also showed that the concentration of reduced glutathione(GSH)and the activity of glutathione peroxidase(GSH-Px)were increased in *** and HAPE raised the mRNA expressions of nuclear factor erythroid-2 related factor 2(Nrf2)and activated antioxidant-related genes:heme oxygenase-1(HO-1),NADPH quinone acceptor oxidoreductase 1(NQO1),and glutamate-cysteine ligase modifier subunit(GCLM),and enhanced the expression of Nrf2 and HO-1 *** and HAPE could also increase antioxidant activity by enhancing Nrf2-mediated inducible expression of HO-1 to protect hepatocytes from ***,HASE showed better liver protective effect than *** study demonstrated the protective benefits o

关键词： Hovenia acerba Lindl.peduncles extract(HAPE) Hovenia acerba Lindl.seeds extract(HASE) Alcoholic liver disease(ALD) Oxidative stress

Engineering the thermostability of D-lyxose isomerase from Caldanaerobius polysaccharolyticus via multiple computer-aided rational design for efficient synthesis of D-mannose

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Synthetic and Systems Biotechnology 2023年第2期8卷 323-330页

作者： Hao Wu Ming Yi Xiaoyi Wu Yating Ding Minghui Pu Li Wen Yunhui Cheng Wenli Zhang Wanmeng Mu School of food science and Bioengineering Changsha University of Science&TechnologyChangsha410114China State Key Laboratory of food science and Technology Jiangnan UniversityWuxi214122China

D-Mannose is an attractive functional sugar that exhibits many physiological benefits on human *** demand for low-calorie sugars and sweeteners in foods are increasingly available on the *** sugar isomerases,such as D-lyxose isomerase(D-LIase),can achieve an isomerization reaction between D-mannose and ***,the weak thermostability of D-LIase limits its efficient conversion from D-fructose to ***,few studies are available that have investigated the molecular modification of D-LIase to improve its thermal *** this study,computer-aided tools including FireProt,PROSS,and Consensus Finder were employed to jointly design D-LIase mutants with improved thermostability for the first ***,the obtained five-point mutant M5(N21G/E78P/V58Y/C119Y/K170P)showed high thermal stability and cat-alytic *** half-life of M5 at 65◦C was 10.22 fold,and the catalytic efficiency towards 600 g/L of D-fructose was 2.6 times to that of the wild type enzyme,*** dynamics simulation and intramolecular forces analysis revealed a thermostability mechanism of highly rigidity conformation,newly formed hydrogen bonds andπ-cation interaction between and within protein domains,and redistributed surface electrostatic charges for the mutant *** research provided a promising D-LIase mutant for the industrial production of D-mannose from D-fructose.

关键词： D-lyxose isomerase Thermostability D-mannose Molecular modification

Photoinactivation of bacteriophage MS2,Tulane virus and Vibrio parahaemolyticus in oysters by microencapsulated rose bengal

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food Quality and Safety 2022年第3期6卷 396-403页

作者： Mohamad Eshaghi Gorji Dan Li Department of food science&Technology Faculty of ScienceNational University of SingaporeSingapore

Bivalve molluscan shellfish such as oysters are important vectors for the transmission of foodborne pathogens including both viruses and *** provides a cold-sterilization option against the contamination as excited photosensitizers could transfer electronic energy to oxygen molecules producing reactive oxygen species such as singlet oxygen,leading to oxidative damage and death of the ***,the efficacy of photoinactivation is very often compromised by the presence of food matrix due to the nonselective reactions of short-lived singlet oxygen with organic matter other than the target *** order to address this issue,we encapsulated a food-grade photosensitizer rose bengal(RB)in alginate *** extra coating of chitosan effectively prevented the release of RB from the microbeads in seawater,and more importantly,enhanced the selectivity of the photoinactivation via the electrostatic interactions between cationic chitosan and anionic charge of the virus particles(bacteriophage MS2 and Tulane virus)and the Gram-negative bacteria Vibrio parahaemolyticus(V parahaemolyticus).The treatment of oysters with microencapsulated RB resulted in significantly higher reductions of MS2 phage,Tulane virus and V parahaemolyticus than free RB and non-RB carrying microbeads(Pfoodborne pathogen contamination.

关键词： Bacteriophage MS2 Tulane virus Vibrio parahaemolyticus photosensitizer encapsulation oyster