Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways

作     者：MAO Lei WANG Yiming WANG Meiling DAI Yufeng WANG Jingfeng XUE Changhu 

作者机构：College of Food Science and Engineering Ocean University of China 

出 版 物：《Journal of Ocean University of China》 (中国海洋大学学报（英文版）)

年 卷 期：2019年第18卷第5期

页      面：1174-1184页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China (No. 31371876) 

主　　题：Sialoglycoprotein osteoporosis MAPKs NF-κB bone resorption 

摘      要：The present study investigated the anti-osteoporosis function and the mechanism of sialoglycoproteins isolated from the eggs of Gadus morhua(Gm-SGP)on ovariectomized(OVX)*** 3 months of Gm-SGP treatment,OVX-induced bone loss was suppressed and uncoupling bone turnover was balanced,as indicated by systemic biomarkers of bone metabolism;no uterine estrogenicity was ***,rats administered with Gm-SGP exhibited increased bone mineral density and biomechanical strength and significant restoration of the trabecular microarchitecture compared with rats in the control ***-SGP significantly decreased bone resorption-related indicators in *** of the associated mechanisms revealed that Gm-SGP significantly increases the OPG/RANKL ratio at the mRNA and protein *** research suggested that Gm-SGP inhibits the mRNA and protein expressions of important transcription factors of the MAPK and NF-κB signaling *** also attenuates the activation of related transduction signaling pathways by inhibiting phosphorylation of JNK,ERK,p38,and NF-κB,and ultimately suppresses the induction of c-Fos and ***,these results demonstrate that Gm-SGP inhibits bone resorption by suppressing osteoclastogenesis-related MAPK and NF-κB pathways,thereby improving osteoporosis.