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The potential mechanism of Isodon suzhouensis against COVID-19 via EGFR/TLR4 pathways

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food Science and Human Wellness 2024年

作者： Hong Duan Wei Wang Shu Li Han Li Ghulam Jilany Khan Fawang Liu Kefeng Zhai Lili Li Zhaojun Wei General Clinical research center Anhui Wanbei Coal-Electricity Group General Hospital Department of Pharmacology and Therapeutics Faculty of Pharmacy University of Central Punjab College of Biological and food Engineering Anhui Polytechnic University School of Biological and food Engineering Engineering research center for Development and High Value Utilization of Genuine Medicinal Materials in North Anhui Province Suzhou University School of food and Biological Engineering Hefei University of Technology

Corona Virus Disease 2019 (COVID-19) has brought the new challenges to scientific research. Isodon suzhouensis has good anti-inflammatory and antioxidant stress effects， which is considered as a potential treatment for COVID-19. The possibility for the treatment of COVID-19 with suzhouensis and its potential mechanism of action were explored by employing molecular docking and network pharmacology. Network pharmacology and molecular docking were used to screen drug targets， and Lipopolysaccharide (LPS) induced RAW264.7 and NR8383 cells inflammation model was used for experimental verification. Collectively a total of 209 possible linkages against 18 chemical components from suzhouensis and 1194 COVID-19 related targets were selected. Among these， 164 common targets were obtained from the intersection of suzhouensis and COVID-19. GO and KEGG enriched 582 function targets and 87 target proteins pathways， respectively. The results from molecular docking studies revealed that rutin， vitexin， isoquercitrin and quercetin had significant binding ability with SARS-CoV-23CLpro and ACE2. In vitro studies showed that Isodon suzhouensis extract (ISE) may inhibit the activation of PI3K/Akt pathway and the expression level of downstream pro-inflammatory factors by inhibiting the activation of EGFR in RAW264.7 cells induced by LPS. In addition， ISE was able to inhibit the activation of TLR4/NF-κB signaling pathway in NR8383 cells exposed to LPS. Overall， the network pharmacology and in vitro studies conclude that active components from suzhouensis have strong therapeutic potential against COVID-19 through multi-target， multi-pathway dimensions and can be a promising candidate against COVID-19.

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Chiral Phenol-2NO Ligand Cooperation with Achiral Organic Base in the Zn(II)-Catalyzed Asymmetric Alkylation Reaction of Indoles

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Chinese Journal of Chemistry 2024年第13期42卷 1474-1480页

作者： Ke-Lan Xu Yu-Heng Wang Xi-Rui Wang Pan Hu Bo-Wen Pan Wen-Jing Zhang Zi-Yue Chen Ying Zhou Xiong-Li Liu National&Local Joint Engineering research center for the Exploitation of Homology Resources of Southwest Medicine and food Guizhou UniversityGuiyangGuizhou 550025China College of Pharmaceutical Sciences Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550025China Green Catalysis center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China

The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric ***,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that incorporate the advantages of both the phenol skeleton and pyrroloimidazolone-based N-oxide moiety,from readily available L-prolinamides in operationally simple two steps and up to 44%overall *** importantly,using an achiral quinoline derivative as an additive,the newly developed Phenol-2NO ligand could serve as the anioic ligand upon deprotonative activation to coordinate to Zn(II)to form a highly enantioselective catalyst for the asymmetric Michael-type Friedel-Crafts alkylation reaction of indoles with 2,*** yields(up to 90%)and high enantioselectivities(up to 99%ee)are obtained for a wide range of substrates under mild *** and DFT calculations revealed the reaction mechanism and the origins of the *** also represented the first activation of phenol-type ligand/metal complex by an achiral organic base as the additive in asymmetric catalysis.

关键词： Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis Alkylation Synthesis design Heterocycles

A texture-modified dessert with high nutritional value designed for people with dysphagia:effect of refrigeration and frozen storage

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food Science and Human Wellness 2024年第1期13卷 462-471页

作者： María Cartagena Larisa Giura Diana Ansorena Iciar Astiasaran Department of Nutrition Food Science and PhysiologyFaculty of Pharmacy and NutritionUniversidad de NavarraC/Irunlarrea s/nPamplona 31008Spain center for Nutrition research University of Navarrac/Irunlarrea 1Pamplona 31008Spain Instituto de Investigación Sanitaria de Navarra IDISNAPamplona 31008Spain National Centre for food Technology and Safety(CNTA)—Technology and Knowledge for food Sector Competitiveness NavarreCrta-Na 134-km 53San Adrian 31570Spain

Dysphagia is commonly associated with malnutrition and an increased choking *** overcome these complications,food designed for people with dysphagia should have an appropriate texture and a high nutritional *** this study,six formulations of a strawberry dessert enriched in protein(calcium caseinate)and fiber(wheat dextrin or inulin)were developed using different hydrocolloids(xanthan gum,carboxymethyl cellulose or modified starch)to provide desirable texture and *** value was calculated and total phenolic content and antioxidant activity of the samples were ***-extrusion test,rheological measurements and sensory analysis were performed in refrigerated and frozen samples to characterize their textural and viscoelastic *** high content in protein(14.7 g/100 g)and fiber(7.9-8.7 g/100 g)made possible to use the claims“high protein”and“high fiber”.Phytochemicals supplied by strawberries contributed to the antioxidant properties of the *** tangent ranged 0.28-0.35 for all the formulations,indicating a weak gel behavior,which could be considered safe to *** formulations with dextrin in combination with carboxymethyl cellulose or xanthan gum seemed to be less susceptible to structural changes during frozen *** work provides insights for the development of a nutrient-dense dessert that meets the requirements of people with dysphagia.

关键词： Malnutrition Texture-modified-food Hydrocolloids Viscoelastic properties food texture

Tuning mechanical and electrical performances of B_(4)C-TiB_(2)ceramics in a two-step spark plasma sintering process

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Journal of Advanced Ceramics 2024年第4期13卷 518-528页

作者： Jun Zhao Xingshuo Zhang Zongning Ma Dong Wang Xing Jin Songlin Ran Advanced Ceramics research center School of Materials Science and EngineeringAnhui University of TechnologyMaanshan 243002China Anhui Engineering research center for High Efficiency Intelligent Photovoltaic Module Chaohu UniversityHefei 238024China

B_(4)C–TiB_(2)is an advanced electrically conductive ceramic with excellent mechanical and electrical discharge machinable *** is challenging and rewarding to achieve highly conductive and hard B_(4)C–TiB_(2)composites at a minimum content of conductive TiB2 that has inferior hardness but double specific gravity of the B_(4)C matrix.A novel strategy was used to construct conductive networks in B_(4)C‒15 vol%TiB2 composite ceramics with B_(4)C,TiC,and amorphous B as raw materials by a two-step spark plasma sintering *** influences of particle size matching between B_(4)C and TiC on the conducting of the strategy and the microstructure were discussed based on the selective matrix grain growth *** mechanical and electrical properties were also systematically *** B_(4)C–15 vol%TiB2 composite ceramic prepared from 10.29µm B_(4)C and 0.05µm TiC powders exhibited a perfect three-dimensional interconnected conductive network with a maximum electrical conductivity of 4.25×10^(4)S/m,together with excellent mechanical properties including flexural strength,Vickers hardness,and fracture toughness of 691±58 MPa,30.30±0.61 GPa,and 5.75±0.32 MPa·m^(1/2),respectively,while the composite obtained from 3.12µm B_(4)C and 0.8µm TiC powders had the best mechanical properties including flexural strength,Vickers hardness,and fracture toughness of 827±35 MPa,32.01±0.51 GPa,and 6.45±0.22 MPa·m^(1/2),together with a decent electrical conductivity of 0.65×10^(4)S/m.

关键词： B_(4)C-TiB_(2) mechanical properties electrical conductivity conductive network

Insights into the Impact of Bifidobacterium bifidum， B. breve， and B. longum on the Immune Response Against Salmonella Infection in Neonatal Rats

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food Science and Human Wellness 2024年

作者： Chunxiu Lin Yugui Lin Min Guo Rui Xiao Shunhe Wang Yonghua Zhou Jianxin Zhao Hao Zhang Wei Chen Gang Wang State Key Laboratory of food Science and Resources Jiangnan University School of food Science and Technology Jiangnan University Microbiology Laboratory Zhongshan Bo'ai Hospital Southern Medical University Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology Jiangsu Institute of Parasitic Diseases National Engineering research center for Functional food Jiangnan University (Yangzhou) Institute of food Biotechnology Jiangnan University Wuxi Translational Medicine research center and Jiangsu Translational Medicine research Institute Wuxi Branch

Infants exhibit diminished susceptibility to external infections， a phenomenon closely linked to the pervasive presence of the bifidobacterial community within their intestinal tract. Nonetheless， a significant knowledge gap remains concerning the distinct species of bifidobacteria initiating anti-infection immune responses during the early developmental stages. In this study， the impact of early intervention with Bifidobacterium bifidum (B. bifidum)， B. breve， and B. longum on neonatal rats infected with Salmonella enterica serovar Typhimurium (S. typhimurium) SL1344 were compared. The study encompasses various immunity levels， including gut immunity， central immunity (thymus)， peripheral immunity (spleen)， and brain immunity. Following Salmonella infection， significant alterations in neonatal rats were observed in growth and developmental levels， immune markers， cytokine levels， balance of T lymphocyte subpopulations， intestinal barrier function， and blood-brain barrier integrity. Compared with B. breve and B. longum， B. bifidum demonstrated more pronounced efficacy in regulating these physiological processes. By conducting multi-level analyses of gut microbiota， bifidobacterial community， colonic content metabolomics， and serum metabolomics， the significance of B. bifidum's role is underscored， and the immune-enhancing function of messenger metabolites is unveiled. Among these metabolites， γ-L-Glutamyl-L-glutamic acid and Orotic acid were found to be shared by all three species， while Hippuric acid and 1a，1b-dihomo Prostaglandin F2α were unique to B. bifidum， and DL-Arginine was specific to B. longum. Overall， this study has provided novel insights into the intervention and immunomodulation by Bifidobacterium in early-life infections， emphasizing the significant role of B. bifidum.

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Effects of low molecular weight polysaccharide from Sargassum thunbergii against palmitic acid-induced intracellular lipid accumulation in 3T3-L1 adipocyte and HepG2 cells

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food Science and Human Wellness 2024年第4期13卷 2244-2252页

作者： Hyo-Geun Lee D.P.Nagahawatta M.J.M.S.Kurera Kyung-Mo Song Yun-Sang Choi You-Jin Jeon Min-Cheol Kang Department of Marine Life Sciences Jeju National UniversityJeju 63243Republic of Korea Department of Biotechnology Faculty of Agriculture and Plantation ManagementWayamba University of Sri LankaMakanduraGonawila(NWP)60170Sri Lanka research Group of food Processing Korea Food Research Institute245Wanju 55365Republic of Korea

Low molecular weight polysaccharides can be isolated from Sargassum thunbergii(LMPST)and in vitro experiments were conducted to evaluate the inhibitory effects on *** natures of LMPST were attained from *** and appraised their LMPST on palmitic acid(PA)induced lipid accretion in Hep G2,and 3T3-L1 *** treatment lessened lipid deposition and intracellular free fatty acid and triglyceride intensities in PA-treated above mentioned *** mechanistic study publicized that LMPST2 significantly suppressed adipogenesis and stimulated the PA-treated 3T3-L1 cells occupied in the lipolysis ***,in PA-treated Hep G2 cells,the free fatty acid oxidation was significantly increased by *** these constructive properties of LMPST2 from ***,is a potential candidate for diminishing the intracellular lipids,and for a therapeutic agent in those conditions.

关键词： Sargassum thunbergii Low molecular weight polysaccharide Lipid accumulation Obesity Liver steatosis

Eugenol targeting CrtM inhibits the biosynthesis of staphyloxanthin in Staphylococcus aureus

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food Science and Human Wellness 2024年第3期13卷 1368-1377页

作者： Jiang Chang Bo Chen Zeqian Du Bowen Zhao Jiahui Li Ziyi Li Kannappan Arunachalam Ting Shi Dongqing Wei Chunlei Shi MOST-USDA Joint research center for food Safety School of Agriculture and BiologyState Key Laboratory of Microbial MetabolismShanghai Jiao Tong UniversityShanghai 200240China School of Life Sciences and Biotechnology Shanghai Jiao Tong UniversityShanghai 200240China

Staphylococcus aureus is a serious foodborne pathogen threatening food safety and public *** the emergence of methicillin-resistant Staphylococcus aureus(MRSA)increased the difficulty of *** *** is a crucial virulence factor of *** staphyloxanthin production could help the host immune system counteract the invading *** *** this study,we first screened for staphyloxanthin inhibitors using a virtual screening *** outcome of the virtual screening method resulted in the identification of eugenol(300μg/mL),which significantly inhibits the staphyloxanthin production in *** ATCC 29213,*** Newman,MRSA ATCC 43300 and MRSA ATCC BAA1717by 84.2%,63.5%,68.1%,and 79.5%,*** outcome of the growth curve assay,field-emission scanning electron,and confocal laser scanning microscopy analyses confirmed that eugenol at the test concentration did not affect the morphology and growth of ***,the survival rate of *** ATCC 29213 and MRSA ATCC 43300 under H_(2)O_(2) pressure decreased to 51.9%and 45.5%in the presence of eugenol,*** quantitative RT-PCR and molecular simulation studies revealed that eugenol targets staphyloxanthin biosynthesis by downregulating the transcription of the crtM gene and inhibiting the activity of the CrtM *** together,we first determined that eugenol was a prominent compound for staphyloxanthin inhibitor to combat *** especially MRSA infections.

关键词： Staphylococcus aureus Staphyloxanthin Eugenol Virtual screening 4 4’-Diapophytoene synthase(CrtM)

Proteomic studies of the effects of processing techniques on properties of abalone muscles: A comprehensive review

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food Science and Human Wellness 2024年

作者： Yan Tian Shuyi You Yi Zhang Baodong Zheng Hongliang Zeng College of food Science Fujian Agriculture and Forestry University Engineering research center of Fujian-Taiwan Special Marine food Processing and Nutrition Ministry of Education Key Laboratory of Marine Biotechnology of Fujian Province Institute of Oceanology Fujian Agriculture and Forestry University Fuzhou Ocean research Institute

Background: With the increasing per capita demand for animal protein， there is a growing interest in the abundant abalone protein resources. Abalone proteins are known for their nutritional and functional properties that contribute to flavor and texture. Scope and approach: We systematically constructed the relationship between abalone protein， processing， and proteomics. This paper reviews the nutritional properties of abalone proteins and evaluates the effects of different thermal processing techniques， non-thermal processing， and freezing on abalone proteins. In addition， we synthesize published abalone proteomics studies and the use of proteomics technology to better elucidate the quality changes of abalone and its products， and as a technical basis for the study of blue food marker proteins. It is important direction to clearly explain the protein composition and meat quality mechanism of abalone in the processing and storage by *** findings and conclusions: During various types of thermal processing， non-thermal processing， and freezing of abalone， the various chemical forces between protein molecules are disrupted， which in turn leads to different degrees of denaturation， aggregation， and gelation， which may have an impact on the organoleptic properties， bioavailability， and digestibility of abalone muscle. Proteomics is used in abalone biology studies to understand developmental biology， physiology， disease/stress， and species identification and can also be a powerful tool to characterize processing methods on abalone quality properties.

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Insight into the spoilage heterogeneity of meat-borne bacteria isolates with high-producing collagenase

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food Science and Human Wellness 2024年第3期13卷 1402-1409页

作者： Haodong Wang Liangting Shao Jinhao Zhang Xinglian Xu Jianjun Li Huhu Wang Jiangsu Collaborative Innovation center of Meat Production and Processing Quality and Safety ControlCollege of Food Science and TechnologyNanjing Agricultural UniversityNanjing 210095China Yantai XiWang Meat food Co. Ltd.Yantai 264000China

Chilled chicken is inevitably contaminated by microorganisms during slaughtering and processing,resulting in *** parts of chilled chicken,especially wings,feet,and other skin-on products,are abundant in collagen,which may be the primary target for degradation by spoilage *** this work,a total of 17 isolates of spoilage bacteria that could secrete both collagenase and lipase were determined by raw-chicken juice agar(RJA)method,and the results showed that 7 strains of Serratia,Aeromonas,and Pseudomonas could significantly decompose the collagen *** gelatin zymography showed that Serratia liquefaciens(F5)and(G7)had apparent degradation bands around 50 kDa,and Aeromonas veronii(G8)and Aeromonas salmonicida(H8)had a band around.65 and 95 kDa,*** lipase and collagenase activities were detected isolate-by-isolate,with F5 showing the highest collagenase *** spoilage ability on meat in situ,F5 performed strongest in spoilage ability,indicated by the total viable counts,total volatile basic nitrogen content,sensory scores,lipase,and collagenase *** study provides a theoretical basis for spoilage heterogeneity of strains with high-producing collagenase in meat.

关键词： Bacteria Chilled chicken Heterogeneity Collagenase Spoilage