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Environmental enrichment in combination with Bifidobacterium breve HNXY26M4 intervention amplifies neuroprotective benefits in a mouse model of Alzheimer's disease by modulating glutamine metabolism of the gut microbiome

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food Science and Human Wellness 2024年第2期13卷 982-992页

作者： Guangsu Zhu Min Guo Jianxin Zhao Hao Zhang Gang Wang Wei Chen State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and technology Jiangnan UniversityWuxi 214122China (Yangzhou)Institute of food Biotechnology Jiangnan UniversityYangzhou 225004China National Engineering Center of Functional food Jiangnan UniversityWuxi 214122China

The gut microbiota-brain axis has emerged as a novel target for Alzheimer's disease(AD),a neurodegenerative disease characterised by behavioural and cognitive ***,most previous microbiome-based intervention studies have focused on single factors and yielded only modest cognitive ***,we proposed a multidomain intervention strategy that combined Bifidobacterium breve treatment with environmental enrichment(EE)*** this study,we found that compared with EE or *** treatment alone,*** intervention combined with EE amplified its neuroprotective effects on AD mice,as reflected by improved cognition,inhibited neuroinflammation and enhanced synaptic ***,using microbiome and metabolome profiling,we found that the combination of *** and EE treatment restored AD-related gut microbiota dysbiosis and reversed microbial metabolite ***,by integrating behavioural and neurological data with metabolomic profiles,we revealed that the underlying mechanism may involve the modulation of microbiota-derived glutamine metabolism via gut-brain ***,combined *** intervention with EE treatment can alleviate AD-related cognitive impairment and improve brain function by regulating glutamine metabolism of the gut *** findings provide a promising multidomain intervention strategy,with a combination of dietary microbiome-based and lifestyle-targeted interventions,to promote brain function and delay the progression of AD.

关键词： Alzheimer’s disease Bifidobacterium breve Environmental enrichment Glutamine metabolism Microbiota-gut-brain axis

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Constructing porous ZnFC-PA/PSF composite spheres for highly efficient Cs^(+) removal

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Journal of Environmental Sciences 2024年第9期143卷 126-137页

作者： Senjian Han Chao Gao Wenfeng Yan Yafei Guo Shiqiang Wang Tianlong Deng College of Marine and Environmental Sciences Tianjin University of Science and TechnologyTianjin 300457China Key Laboratory of Marine Resource Chemistry and food technology Ministry of EducationTianjin 300457China

Radioisotope leaking from nuclear waste has become an intractable problem due to its gamma radiation and strong water *** this work,a novel porous ZnFC-PA/PSF composite sphere was fabricated by immobilization of ferrocyanides modified zinc phytate into polysulfone(PSF)substrate for the treatment of Cs-contaminated *** maximum adsorption capacity of ZnFC-PA/PSF was 305.38 mg/g,and the removal efficiency of Cs+was reached 94.27%within 2 *** ZnFC-PA/PSF presented favorable stability with negligible dissolution loss of Zn^(2+)and Fe^(2+)(<2%).The ZnFC-PA/PSF achieved high-selectivity towards Cs+(K_(d)=2.24×10^(4)mL/g)even in actual geothermal *** adsorption mechanism was inferred to be the ion-exchange between Cs^(+)and K^(+).What’s more,ZnFC-PA/PSF worked well in the fixed-bed adsorption(E=91.92%),indicating the application potential for the hazardous Cs^(+)removal from wastewater.

关键词： Adsorption Cesium Metal ferrocyanide Composite adsorbent

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Reduction of the oxidative damage to H_(2)O_(2)-induced HepG2 cells via the Nrf2 signalling pathway by plant flavonoids Quercetin and Hyperoside

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food Science and Human Wellness 2024年第4期13卷 1864-1876页

作者： Meijing Zhang Gaoshuai Zhang Xiangxing Meng Xinxin Wang Jiao Xie Shaoshu Wang Biao Wang Jilite Wang Suwen Liu Qun Huang Xu Yang Jing Li Hao Wang State Key Laboratory of food Nutrition and Safety Tianjin University of Science and Technology(TUST)Tianjin 300457China Key Laboratory of Environmental Pollution Monitoring and Disease Control Ministry of EducationGuizhou Medical UniversityGuiyang 550025China College of Chemical Engineering and Materials Science Tianjin University of Science and Technology(TUST)Tianjin 300457China Department of Agriculture Hetao CollegeBayannur 015000China College of food Science&technology Hebei Normal University of Science and TechnologyQinhuangdao 066004China National Center of Supervision and Inspection for Processed food Quality Tianjin Institute for Food Safety Inspection TechnologyTianjin 300457China

Hyperoside and quercetin are similar in molecular *** this study,the antioxidant regulatory targets of hyperoside and quercetin are mainly in the nuclear factor(erythroid-2-derived)-related factor 2(Nrf2)pathway predicted by network *** the antioxidant effect and mechanism of hyperoside and quercetin were measured and compared in H_(2)O_(2)-induced Hep G2 cells and Caenorhabditis *** findings indicated that quercetin was more effective than hyperoside in reducing oxidative damage,which was proved by improved cell viability,decreased reactive oxygen species(ROS)production,decreased cellular apoptosis,and alleviated mitochondrial *** addition,quercetin was more efficient than hyperoside in enhancing the expression of Nrf2-associated m RNAs,increasing the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and catalase(CAT),and reducing the cellular malondialdehyde(MDA)*** was superior to hyperoside in prolonging the lifespan of worms,decreasing the accumulation of lipofuscin,inhibiting ROS production,and increasing the proportion of skn-1 in the *** the Nrf2 inhibitor ML385,we verified that quercetin and hyperoside primarily protected the cells against oxidative damage via the Nrf2 signalling ***,molecular docking and dynamics simulations demonstrated that the quercetin-Kelch-like ECH-associated protein 1(Keap1)complex was more stable than the hyperoside-Keap1 *** stable structure of the complex might hinder the binding of Nrf2 and Keap1 to release Nrf2 and facilitate its entry into the nucleus to play an antioxidant ***,quercetin had a better antioxidant than hyperoside.

关键词： Hyperoside Quercetin HepG2 cell Oxidative damage Nrf2 signalling pathway

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Hydrogel-supported poly(L-lactic acid) and polystyrene microsphere-based three-dimensional culture systems for in vitro cell expansion

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Frontiers of Materials Science 2024年第2期18卷 129-137页

作者： Huaying Hao Lihong Sun Jiaxuan Chen Jun Liang State Key Laboratory of food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China College of Light Industry Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China College of food Science and Engineering Tianjin University of Science&TechnologyTianjin 300457China

The in vitro expansion of stem cells is important for their application in different life science fields such as cellular tissue and organ *** objective of this paper was to achieve static cell culture in vitro through peptide hydrogel-supported microspheres(MSs).The peptides,with their gel-forming properties,microstructures,and mechanical strengths characterized,were found to have good support for the MSs and to be *** internal structures of poly(L-lactic acid)microspheres(PLLA-MSs)and polystyrene microspheres(PS-MSs)made in thelaboratory were observed and statistically analyzed in terms of particle size and pore size,following which the co-cultured MSs with cells were found to have good cell *** addition,three-dimensional(3D)culturing of cells was performed on the peptide and microcarrier composite scaffolds to measure cell viability and cell *** results showed that the peptides could be stimulated by the culture medium to self-assembly form a 3D fiber network *** the peptide-Ms composite scaffold-based cell culture system,further enhancement of the cell culture effect was *** peptide-Ms composite scaffolds have great potential for the application in 3D cell culture and in vitro cellexpansion.

关键词： microcarrier microsphere peptide hydrogel cell scaffold three-dimensional culture cell expansion

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Epicatechin attenuates lead(Pb)-induced cognitive impairment in mice:regulation on Nrf2 signaling pathway,and interference on the interaction between Pb with albumin

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food Science and Human Wellness 2024年第2期13卷 1065-1078页

作者： Dai Cheng Qianqian Yu Kexin Zhu Dingdong Bu Zijian Wu State Key Laboratory of food Nutrition and Safety Tianjin University of Science&TechnologyTianjin 300457China School of Biotechnology and food Science Tianjin University of CommerceTianjin 300134China

Epicatechin(EC)was used in this study to antagonize the cognitive dysfunction caused by lead(Pb)exposure in ***-week-old male Kunming mice were treated with PbCl_(2)(20 mg/kg)and/or EC(50 mg/kg)by gavage administration for 4 *** water maze test showed that EC could improve memory dysfunction induced by *** antagonized Ca^(2+)overload,activated Nrf2 signaling pathway and reduced the accumulation of Pb in the brain and serum,which suggested that EC might alter Pb distribution in *** vitro,spectroscopic analysis,potentiometric titration and docking studies were applied to inquiry into the interaction between bovine serum albumin(BSA)and Pb^(2+)in presence or absence of *** was proved to chelate Pb^(2+)and reduced the interaction between BSA and Pb^(2+).In summary,EC might protect Pb-induced cognitive impairment by activating Nrf2 signaling pathway,and suppressing Pb accumulation via interference on the binding of Pb to albumin.

关键词： Lead Epicatechin Bovine serum albumin Interaction Oxidative stress

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A review on WO_(3)-based composite photocatalysts:synthesis,catalytic mechanism and diversified applications

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Rare Metals 2024年第8期43卷 3441-3459页

作者： Xue Zhang Zi-Qi Zhang Yan-Dong Sun Xiao-Jia Ma Feng-Xian Jin Fang-Yuan Zhang Wei-Guang Han Bo-Xiong Shen Sheng-Qi Guo College of Energy and Environmental Engineering Hebei University of TechnologyTianjin 300401China Department of food and Chemical Engineering Liuzhou Institute of TechnologyLiuzhou 545616China

Photocatalysis as an emerging "green" energy conversion technology has attracted domestic and international *** technology uses semiconductor photocatalysts to convert solar energy into directly usable chemical energy,showing great potential for application in environmental pollutant purification and clean energy production,with broad development *** many semiconductor materials,tungsten trioxide(WO_(3)) is favored by researchers in the field of photocatalysis because of its good visible light response and excellent valence band hole oxidation ***,a large number of photocatalysts based on WO_(3),in particular W03-based composite photocatalysts,have been reported,and their applications cover a wide range of *** order to promote the development of WO_(3)-based photocatalysts and provide a reference for colleagues,we present a systematic summary of the applications and research progress of W03-based composites in the field of photocatalysis in recent *** from the structural properties of WO_(3)itself,this article summarizes the preparation methods and structure-activity relationships of WO_(3)-based composite ***,it introduces the current application status of existing WO_(3)-based composite photocatalysts in CO_(2) reduction,hydrogen production,nitrogen fixation,and pollutant ***,the development prospects were analyzed.

关键词： WO_(3)-based composite photocatalysts Intrinsic characteristic Preparation method Reaction mechanism Applications

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Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation

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food Science and Human Wellness 2024年第4期13卷 1951-1961页

作者： Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen State Key Laboratory of food Science and Resources Jiangnan UniversityWuxi 214122China School of food Science and technology Jiangnan UniversityWuxi 214122China National Engineering Research Center for Functional food Jiangnan UniversityWuxi 214122China Institute of food Biotechnology(Yangzhou) Jiangnan UniversityYangzhou 225004China

Gut microbiome is indispensable for maintaining normal brain ***,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive *** this study,neurobehavioral effects of the Bifidobacterium breve strain(CCFM1025)were assessed in sleep-deprived ***1025 improved the body weight and food and water intake of the *** also alleviated SD-induced cognitive behavioural abnormalities(in the novel object recognition test),but did not show beneficial effects on mood-and spatial memory-related ***1025 significantly altered the gut microbial composition and genome *** microbial metabolites that may regulate sleep function were also identified,such as isovaleric acid andγ-aminobutyric acid in the gut and purine metabolites in the *** metabolites may participate in gutbrain communication by acting on the striatal melatonin system,for example to increase melatonin levels,and by regulating the expression of circadian clock genes such as those encoding the adenosine A2A receptor and period circadian regulator ***,administration of probiotics alleviated cognitive impairment and circadian rhythm disturbance induced by SD via modulation of gut microbiome and its *** findings may help guide the treatment of insomnia or other sleep disorders via dietary strategies.

关键词： Bifidobacterium Sleep Circadian rhythm Purine Gut microbiome

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Effects of coating formulation on structural changes of turkey nugget during frying:MRI evaluation

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Journal of Future foods 2024年第2期4卷 142-148页

作者： Arash Ghaitaranpour Mohebbat Mohebbi Seyed Amir Oleyaei Department of food Science and technology Faculty of AgricultureUrmia UniversityUrmia ***Iran Advanced Frying Research Core Department of Food Science and TechnologyFerdowsi University of MashhadMashhad ***Iran Department of food Science and technology Ferdowsi University of MashhadMashhad ***Iran

Application of nondestructive techniques combined with image processing techniques has been increasing in investigating the internal structure of food *** resonance imaging(MRI)is one of these *** aim of this research is to investigate the effect of coating formulation on structural properties of turkey nugget samples(turkey nugget with typical batter,tragacanth-containing batter and tragacanth)by *** revealed that the changes caused by the batter formulation could also be examined using the tomographic *** results also indicated that the brightness of the MRI images of the nugget core and crust decreased during *** core of the nugget with the tragacanth-containing batter was brighter revealing its higher moisture ***,the nugget core was less reduced in this sample compared with the other *** research aimed to present a valuable knowledge about nugget frying pertaining to quality evaluation.

关键词： NuggetDeep fat frying Structural characterization Magnetic resonance imaging(MRI) Image processing

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Distribution of antioxidants and phenolic compounds in flour milling fractions from hard red winter wheat

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Grain & Oil Science and technology 2024年第2期7卷 71-78页

作者： Lauren Renee Brewer Jittawan Kubola Sirithon Siriamornpun Yong-Cheng Shi Department of Grain Science and Industry Kansas State UniversityManhattanKS 66506USA Department of food Innovation and Processing Faculty of Agricultural TechnologyBuriram Rajabhat UniversityBuriram 31000Thailand Research Unit of Thai food innovation Department of Food Technology and NutritionMahasarakham UniversityMahasarakham 44000Thailand

Mature wheat kernels contain three main parts:endosperm,bran,and *** milling results in multiple streams that are chemically different;however,the distribution of antioxidants and phenolic compounds has not been well documented in terms of conventional milling by-product *** this study,multiple analytical methods were used to investigate antioxidant activity and phenolic compound compositions of hard red winter wheat(whole ground wheat),the parts of a wheat kernel(bran,flour,germ),and wheat by-product streams(mill feed,red dog,shorts)for the first *** each mill stream,phenolic compounds(total,flavonoid,and anthocyanin contents)were determined and antioxidant activities were evaluated with 1,1-diphenyl-2-picrylhydrazyl(DPPH)radical-scavenging activity,ferric reducing/antioxidant power(FRAP),and total antioxidant capacity *** differences(Pfoods with improved nutritional properties.

关键词： Wheat Milling streams Antioxidants Phenolic acids Flavonoid Anthocyanin

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Antibacterial mechanism of kojic acid and tea polyphenols against Escherichia coli O157:H7 through transcriptomic analysis

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food Science and Human Wellness 2024年第2期13卷 736-747页

作者： Yilin Lin Ruifei Wang Xiaoqing Li Keren Agyekumwaa Addo Meimei Fang Yehui Zhang Yigang Yu School of food Sciences and Engineering South China University of TechnologyGuangzhou 510640China Sericulture&Agri-food Research Institute Guangdong Academy of Agricultural Sciences Key Laboratory of Functional FoodsMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Agricultural Products ProcessingGuangzhou 510610China Research Center of food Safety and Detection College of Food Science and EngineeringSouth China University of TechnologyGuangzhou 510640China

Escherichia coli O157:H7 is one of the major foodborne pathogenic bacterial that cause infectious diseases in *** previous found that a combination of kojic acid and tea polyphenols exhibited better activity against *** O157:H7 than using either *** study aimed to explore responses underlying the antibacterial mechanisms of kojic acid and tea polyphenols from the gene *** functional enrichment analysis by comparing kojic acid and tea polyphenols individually or synergistically against *** O157:H7 found that acid resistance systems in kojic acid were activated,and the cell membrane and genomic DNA were destructed in the cells,resulting in“oxygen starvation”.The oxidative stress response triggered by tea polyphenols inhibited both sulfur uptake and the synthesis of ATP,which affected the bacteria's life metabolic ***,we found that kojic acid combined with tea polyphenols hindered the uptake of iron that played an essential role in the synthesis of DNA,respiration,tricarboxylic acid *** results suggested that the iron uptake pathways may represent a novel approach for kojic acid and tea polyphenols synergistically against *** O157:H7 and provided a theoretical basis for bacterial pathogen control in the food industry.

关键词： Kojic acid Tea polyphenols Antibacterial mechanism Escherichia coli O157:H7 RNA-seq

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