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Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps

World Journal of Gastroenterology 2021年第38期27卷 6430-6441页

作者： Giulia Nannini Gaia Meoni Leonardo Tenori Maria Novella Ringressi Antonio Taddei Elena Niccolai Simone Baldi Edda Russo Claudio Luchinat Amedeo Amedei Department of Clinical and Experimental Medicine University of FlorenceFlorence 50134Italy Department of Chemistry“Ugo Schiff” University of FlorenceFlorence 50134Italy Department of Chemistry&Magnetic Resonance Center(CERM) University of FlorenceFlorence 50134Italy

BACKGROUND Colorectal cancer(CRC),the third most common cause of death in both males and females worldwide,shows a positive response to therapy and usually a better prognosis when detected at an early ***,the survival rate declines when the diagnosis is late and the tumor spreads to other ***,the measures widely used in the clinic are fecal occult blood test and evaluation of serum tumor markers,but the lack of sensitivity and specificity of these markers restricts their use for CRC *** to its high sensitivity and precision,colonoscopy is currently the gold-standard screening technique for CRC,but it is a costly and invasive ***,the implementation of custom-made methodologies including those with minimal invasiveness,protection,and reproducibility is highly *** regard to other screening methods,the screening of fecal samples has several benefits,and metabolomics is a successful method to classify the metabolite shift in living systems as a reaction to pathophysiological influences,genetic modifications,and environmental *** To characterize the variation groups and potentially recognize some diagnostic markers,we compared with healthy controls(HCs)the fecal nuclear magnetic resonance(NMR)metabolomic profiles of patients with CRC or adenomatous polyposis(AP).METHODS Proton nuclear magnetic resonance spectroscopy was used in combination with multivariate and univariate statistical approaches,to define the fecal metabolic profiles of 32 CRC patients,16 AP patients,and 38 HCs well matched in age,sex,and body mass *** NMR metabolomic analyses revealed that fecal sample profiles differed among CRC patients,AP patients,and HCs,and some discriminatory metabolites including acetate,butyrate,propionate,3-hydroxyphenylacetic acid,valine,tyrosine and leucine were *** In conclusion,we are confident that our data can be a forerunner for future studies on CRC management,especially the di

关键词： Colorectal cancer Adenomatous polyps Nuclear magnetic resonance metabolomics Fecal samples Fecal metabolomics

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Morbidity and psychological impact of prostate biopsy： the future calls for a change

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Asian Journal of Andrology 2014年第3期16卷 415-417页

作者： Andrea Minervini Gianni Vittori Giampaolo Siena Marco Carini Department of Urology University of FlorenceCareggi Hospital Florence Italy.

Currently transrectal ultrasound-guided prostate biopsy （TRUS-Bx） is one of the most common urological procedures, with more than 1 million performed per year in Europe and the United States. Among patients undergoing TRUS-Bx, approximately one-third will receive a diagnosis of prostate cancer （PCa）, while two-thirds receive a negative result on initial biopsy. Negative biopsy patients maintain an estimated risk of repeated biopsy of 12% at I year and 38% at 5 years. 2 Standard TRUS-Bx is likely to systematically miss significant tumors, particularly in the anterior and apical parts of the gland.3 A crucial aim of urologists in the next decade is to increase the accuracy of the procedure and avoid the use of inappropriate biopsies.

关键词： Morbidity psychological impact prostate biopsy

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GEOSS Platform data content and use

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International Journal of Digital Earth 2023年第1期16卷 715-740页

作者： Enrico Boldrini Stefano Nativi Jiri Hradec Mattia Santoro Paolo Mazzetti Max Craglia National Research Council of Italy Institute of Atmospheric Pollution ResearchFlorenceIltaly Joint Research Centre B6 UnitIspraItaly

The GEOSS Platform is a key contribution to the goal of building the Global Earth Observation System of Systems(GEOSS).It enables a harmonized discovery and access of Earth observation data,shared online by heterogeneous organizations *** work analyzes both what is made available in the GEOSS Platform by the data providers and how users are utilizing it including multiyear trends,updating a previous analysis published in *** present statistics derive from a 2021 EOValue report funded by the European *** offer of GEOSS Platform data has been the object of various analyses,including data provider characterization,data sharing trends,and data characterization(comprising metadata quality analysis,thematic analysis,responsible party identification,spatial–temporal coverage).GEOSS data demand has also been the object of several analyses,including data consumer characterization,utilization trends,and requested data characterization(comprising thematic analysis,spatial–temporal coverage,and popularity).Among thefindings,a large amount of shared data,mostly from satellite sources,emerges with an issue of low metadata quality and related discovery ***,the trend in usage is ***,the progressive disconnection of the GEOSS platform from its data Providers and Users and other possible causes are also reported.

关键词： Earth observations GEOSS System-of-Systems geospatial data quality discovery service

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Auxo-endocrinological features in a cohort of internationally adopted children in Italy

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World Journal of Pediatrics 2019年第3期15卷 297-305页

作者： Barbara Bortone Camilla Totaro Pasqua Putignano Sara Sollai Luisa Galli Maurizio de Martino Elena Chiappini Department of Health Sciences University of FlorenceAnne Meyer Children’s University HospitalFlorenceItaly Department of Health Sciences University of FlorenceAnne Meyer Children’s University HospitalFlorenceItaly

Background Internationally adopted children (IAC) can present growth impairment at arrival,which usually recovers over ***,a major prevalence of precocious puberty has been reported in this *** All IAC referred to a tertiary level hospital in Italy from January 2016 to June 2017,underwent a standardized screening protocol and were prospectively enrolled in the *** analyses of possible risk factors for growth impairment and precocious puberty were *** Overall,422 children were included (males 59.5%),with median age of 6.5 years (IQR 9.4-3.9),29.9% adopted from Europe,26.8% from Asia,23.9% from Africa and 19.4% from Latin *** were in Italy from a median of 75 days (IQR 137.0-38.7).Stunting was observed in 12.9% of children,wasting in 4.3%,underweight in 12.9%.Precocious puberty was diagnosed in 2.2% of children.17.1% IAC had diagnosis of special *** alcohol spectrum disorders represented the 41.7% of children with special needs and 48.1% of Russian *** predictive factors for stunting were age < 5 years,a diagnosis of special need and having been living in Italy for < 60 days since the *** Stunting among IAC is a frequent finding especially in children < 5 years and in those with special needs,independently from their geographical origin.

关键词： Fetal alcohol syndrome Growth delay Internationally adopted children Precocious puberty Special needs

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Haemodynamic management in brain death donors:Influence of aetiology of brain death

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World Journal of Transplantation 2023年第4期13卷 183-189页

作者： Chiara Lazzeri Manuela Bonizzoli Stefano Batacchi Cristiana Guetti Walter Vessella Alessandra Valletta Alessandra Ottaviano Adriano Peris Department of Emergency Intensive Care Unit and Extracorporeal Membrane Oxygenation CenterFlorence 50134Italy

BACKGROUND In brain death donors(BDDs),donor management is the key in the complex donation *** management goals,which are standards of care or clinical parameters,have been considered an acceptable barometer of successful donor *** To test the hypothesis that aetiology of brain death could influence haemodynamic management in *** Haemodynamic data(blood pressure,heart rate,central venous pressure,lactate,urine output,and vasoactive drugs)of BDDs were recorded on intensive care unit(ICU)admission and during the 6-h observation period(Time 1 at the beginning;Time 2 at the end).RESULTS The study population was divided into three groups according to the aetiology of brain death:Stroke(n=71),traumatic brain injury(n=48),and postanoxic encephalopathy(n=19).On ICU admission,BDDs with postanoxic encephalopathy showed the lowest values of systolic and diastolic blood pressure associated with higher values of heart rate and lactate and a higher need of norepinephrine and other vasoactive *** the beginning of the 6-h period(Time 1),BDDs with postanoxic encephalopathy showed higher values of heart rate,lactate,and central venous pressure together with a higher need of other vasoactive *** According to our data,haemodynamic management of BDDs is affected by the aetiology of brain *** with postanoxic encephalopathy have higher requirements for norepinephrine and other vasoactive drugs.

关键词： Brain death donor Postanoxic encephalopathy Stroke Acute traumatic injury Haemodynamic management Utilization rate

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Nonlinear Identification and Control of Laser Welding Based on RBF Neural Networks

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Computer Systems Science & Engineering 2022年第4期41卷 51-65页

作者： Hongfei Wei Hui Zhao Xinlong Shi Shuang Liang Henan Polytechnic Institute Nanyang473000China Zhengzhou Railway Vocational&Technical College Zhengzhou450000China University of florence Firenze50041Italy

A laser beam is a heat source with a high energy density;this technol-ogy has been rapidly developed and applied in theﬁeld of welding owing to its potential advantages,and supplements traditional welding *** in-depth analysis of its operating process could establish a good foundation for its application in *** is widely understood that the welding process is a highly nonlinear and multi-variable coupling process;it comprises a signiﬁcant number of complex processes with random uncertain *** of their nonlinear mapping and self-learning characteristics,artiﬁcial neural networks(ANNs)have certain advantages in comparison to traditional methods in theﬁeld of *** welding is a nonlinear dynamic process;these processes still pose a major challenge in theﬁeld of ***,establishing a stable model is a pre-requisite for achieving accurate *** this study,the identiﬁcation and con-trol of radial basis function neural networks in laser welding processes and self-tuning PID control methods are proposed to improve weld *** a MATLAB simulation,it is shown that the proposed method can obtain a good description of the level of nonlinear dynamic control,and that the algorithm iden-tiﬁcation accuracy is high,practical,and *** this method,the weld width quickly reaches the expected value and the system remains stable,with good ***,it ensures the stability and dynamic performance of the welding process and improves weld quality.

关键词： Laser welding radial basis function neural networks self-tuning nonlinear identification

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A simplified pneumatic model for air brake of passenger trains

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Railway Engineering Science 2023年第2期31卷 145-152页

作者： Luciano Cantone Andrea Ottati Department of Enterprise Engineering“Mario Lucertini” University of Rome Tor VergataRomeItaly Technical Direction TrenitaliaFSI GroupFlorenceItaly

Braking system performance is relevant for both railway safety and network optimization. Most trains employ air brake systems;air brake systems of freight trains mostly cannot achieve a synchronous application of brake forces, which is usually customary for passenger trains. The paper generalizes a previous air brake pneumatic model to passenger trains and describes the needed modifications. Among them, the way the pressure reduces in the brake pipe is generalized. Moreover, this paper reports an analytical bi-dimensional function for calculating the nozzle diameter equivalent to the electro-pneumatic(EP) or the electronically controlled pneumatic(ECP)brake valve as a function of the wagon length and the time to vent the brake pipe locally. The numerical results of the new model are compared against several experimental tests of high-speed passenger trains of Trenitalia, namely ETR500 and ETR1000. The model is suitable to be integrated into the UIC software TrainDy, aiming to extend its computational field to passenger trains and to simulate the safety of trains during a recovery.

关键词： EP or ECP modeling Model validation TrainDy Train brake Air brake

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Cannabidiol preferentially binds TRPV2: a novel mechanism of action

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Neural Regeneration Research 2022年第12期17卷 2693-2694页

作者： Elisa Landucci Domenico E.Pellegrini-Giampietro Alessandra Gianoncelli Giovanni Ribaudo Department of Health Sciences Section of Clinical Pharmacology and OncologyUniversity of FlorenceFirenzeItaly Department of Molecular and Translational Medicine University of BresciaBresciaItaly

Plants from the genus Cannabis,and strains of Cannabis sativa in particular,have been used in medicine since ancient *** Cannabis plant contains more than 500 chemical compounds,with two main phytocannabinoids consisting of Δ9-tetrahydrocannabinol(THC),the psychoactive constituent,and cannabidiol(CBD),which does not bear this *** paper aims at providing a perspective on the potential therapeutic effects of CBD based on its preferential interaction with transient potential receptor V2(TRPV2).Many formulations based on Cannabis extract have been licensed for therapeutic use in some Western *** these,the most relevant are Sativex(THC+CBD,used mainly for the treatment of spasticity in multiple sclerosis)and Epidyolex(purified plant-derived CBD,used for some rare childhood epilepsies).

关键词： effect mechanism formulation

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Rockfall localization from seismic polarization considering multiple triaxial geophones and frequency bands

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Journal of Mountain Science 2020年第7期17卷 1541-1552页

作者： Liang FENG Veronica PAZZI Emanuele INTRIERI Teresa GRACCHI Giovanni GIGLI Grazia TUCCI Department of Earth Sciences University of FlorenceVia G.La Pira 450121FlorenceItaly Department of Civil and Environment Engineering University of FlorenceVia Santa Marta 350139FlorenceItaly

Boulder/rock mass movements generate ground vibrations that can be recorded by geophone ***,there are two methods applied to rockfall trajectory reconstruction or rockfall seismic *** method uses seismic wave arrival times and is achieved by minimizing the differences in signal arrival times between multiple stations by grid map *** other method uses seismic polarization and is achieved by calculating eventsource back azimuths from the seismic polarizations of rockfall *** this study,we proposed the use of an overdetermined matrix for joint localization based on the polarization *** overdetermined matrix considers the contributions of all geophones in the network,and at each geophone is assigned a different weight according to the recorded signal qualities and the reliability of the calibrated back *** method shows a great advantage relative to the case in which only two sensors are ***,we suggested three marker parameters for proper frequency band selection in back azimuth calculations:energy,rectilinearity,and a special permanent frequency band(SPF).We found that the back azimuths calculated with energy and an SPF are generally close to the real back azimuths measured in the field,while the SPF is limited by seismic attenuation due to a long-distance *** localization results of rockfalls were validated by using field camera videos and in situ *** typical cases and 43 artificially released rockfalls are presented in this *** proposed method provides an interesting way to locate rockfall events and track rockfall trajectories and avoids the difficulties of obtaining accurate arrival times,as required by the arrival times method.

关键词： Rockfall Localization Seismic polarization Seismic monitoring Early warning

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Impact of microbiota-immunity axis in pancreatic cancer management

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World Journal of Gastroenterology 2022年第32期28卷 4527-4539页

作者： Ilenia Bartolini Giulia Nannini Matteo Risaliti Francesco Matarazzo Luca Moraldi Maria Novella Ringressi Antonio Taddei Amedeo Amedei Department of Experimental and Clinical Medicine HPB Surgery UnitAzienda Ospedaliero-Universitaria CareggiFlorence 50134Italy Department of Experimental and Clinical Medicine SOD of Interdisciplinary Internal MedicineAzienda Ospedaliera-Universitaria CareggiFlorence 50134Italy Division of Oncologic Surgery Department of OncologyCareggi University HospitalFirenze 50134Italy

The microbiota impact on human diseases is well-known,and a growing body of literature is providing evidence about the complex interplay between microbiotaimmune system-human physiology/pathology,including *** with the defined risk factors(e.g.,smoke habits,diet,diabetes,and obesity),the oral,gut,biliary,and intrapancreatic microbiota contribute to pancreatic cancer development through different pathways including the interaction with the immune ***,a great majority of the pancreatic cancer patients received a diagnosis in advanced stages not amenable to be radically treated and potentially *** the poor pancreatic cancer prognosis,complete knowledge of these complicated relationships could help researchers better understand the disease pathogenesis and thus provide early potential noninvasive biomarkers,new therapeutic targets,and tools for risk stratification that might result in greater therapeutic possibilities and eventually in a better and longer patient survival.

关键词： Gastrointestinal tumors Hepatopancreatobiliary tumors Pancreatic cancer Gut microbiota Dysbiosis Cancer development Carcinogenesis

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