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Correlation between thrombopoietin and inflammatory factors,platelet indices,and thrombosis in patients with sepsis:A retrospective study

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World Journal of Clinical Cases 2022年第13期10卷 4072-4083页

作者： Wan-Hua Xu Li-Chan Mo Mao-Hua shi Hui Rao Xiao-Yong Zhan Mo Yang Department of Hematology Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Emergency Medicine The First People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina Department of Emergency Medicine Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Rheumatology and Immunology The First People’s Hospital of FoshanFoshan 528000Guangdong ProvinceChina scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Pediatrics Nanfang Hospital/The First School of Clinical MedicineSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina

BACKGROUND Thrombopoietin(TPO)is a primary regulator of thrombopoiesis in physiological ***,in combination with its specific cytokine receptor c-Mpl,drives platelet production by inducing the proliferation and differentiation of ***,the role of TPO in sepsis is not well *** elevated levels of TPO are often accompanied by a decrease of platelet count(PLT)in systemic infected conditions,which is contrary to the view that TPO promotes platelet production under physiological *** addition,whether TPO mediates organ damage in sepsis remains *** To explore the relationships between TPO and inflammatory factors,platelet indices,and thrombotic indicators in *** A total of 90 patients with sepsis diagnosed and treated at the emergency medicine department of The first people’s hospital of foshan between January 2020 and March 2021 were enrolled in this *** addition,110 patients without sepsis who came to the emergency medicine department were included as *** and laboratory parameters including age,gender,TPO,blood cell count in peripheral blood,platelet indices,inflammatory factors such as high-sensitivity Creactive protein(hs-CRP),interleukin(IL)-21,and IL-6,organ damage indicators,and thrombotic indicators were collected and analyzed by using various statistical *** The results showed that the TPO levels were higher in the sepsis group than in controls[86.45(30.55,193.1)vs 12.45(0.64,46.09)pg/mL,Ps lower(Psis showed that white blood cell count(WBC)[odds ratio(OR)=1.32;95%confidence interval(CI):1.01-1.722;P=0.044],TPO(OR=1.02;95%CI:1.01-1.04;P=0.009),IL-21(OR=1.02;95%CI:1.00-1.03;P=0.019),troponin I(OR=55.20;95%CI:5.69-535.90;P=0.001),and prothrombin time(PT)(OR=2.24;95%CI:1.10-4.55;P=0.027)were independent risk factors associated with *** levels were positively correlated with IL-21,IL-6,hs-CRP,creatinine,D-dimer,P

关键词： sepsis Thrombopoietin Interleukin-21 Platelets Thrombosis

shenzhen stroke emergency map improves access to rt-PA for patients with acute ischaemic stroke

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stroke & Vascular Neurology 2019年第3期4卷 115-122页

作者： shisheng Ye shiyu Hu Zhihao Lei Zhichao Li Weiping Li Yi sui Lijie Ren Department of Neurology Shenzhen University First Affiliated HospitalShenzhen Second People’s HospitalShenzhenChina Department of Neurology Shenyang First People’s HospitalShenyang Medical CollegeShenyangChina

Prehospital delay is one of the major causes of low rate of intravenous recombinant tissue plasminogen activator(rt-PA)thrombolysis for acute ischaemic stroke in *** emergency systems have been proven a successful approach to improve access to *** is a high population density city with great geographical disparity of healthcare resources,leading to limited access to rt-PA thrombolysis for most patients with acute ischaemic *** improve rapid access to rt-PA thrombolysis in shenzhen,a shenzhen stroke emergency map was implemented by shenzhen healthcare *** map comprised certification of qualified local hospitals,identification of patients with stroke,acute stroke transport protocol and maintenance of the *** conducted a retrospective observational study to compare consecutive patients with acute stroke arriving at qualified local hospitals before and after implementation of the shenzhen stroke emergency *** implementation of the map,the rate of patients receiving rt-PA thrombolysis increased from 8.3%to 9.7%(p=0.003),and the rate of patients treated with endovascular thrombectomy increased from 0.9%to 1.6%(psixteen of 20 hospitals have an increase in the number of patients with stroke treated with rt-PA *** median time between receipt of the call and arrival on the scene reduced significantly(17.0 min vs 9.0 min,pshenzhen second people's hospital,the median onset-to-needle time and door-to-needle time were reduced(175.5 min vs 149.5 min,p=0.039;71.5 min vs 51.5 min,pstatistically significant differences were found in the proportion of rt-PA-treated patients within various geographical ***,there are more than 40 cities in China implementing a stroke emergency *** shenzhen stroke emergency map improves access to rt-PA thrombolysis for acute ischaemic stroke,and the novel model has been expanded to multiple areas in *** efforts should be co

关键词： patients needle acute

searching for new drugs to treat Alzheimer’s disease dementia through multiple pathways

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World Journal of Clinical Cases 2025年第1期13卷 22-28页

作者： Hua Bai Xiao-Feng Feng Department of Neurology The Third Affiliated Hospital of Guizhou Medical UniversityDuyun 558099Guizhou ProvinceChina Department of Neurology Wulong Branch of the People's Hospital Affiliated to Chongqing UniversityWulong 408500ChongqingChina Department of Neurology Guizhou Medical UniversityGuiyang 550004Guizhou ProvinceChina

Dementia is a group of diseases,including Alzheimer's disease(AD),vascular dementia,Lewy body dementia,frontotemporal dementia,Parkinson's disease dementia,metabolic dementia and toxic *** treatment of dementia mainly includes symptomatic treatment by controlling the primary disease and accompanying symptoms,nutritional support therapy for repairing nerve cells,psychological auxiliary treatment,and treatment that improves cognitive function through *** them,drug therapy to improve cognitive function is *** review focuses on introducing and commenting on some recent progress in exploring drugs to improve cognitive function,especially the new progress in drug treatment for *** mainly discuss the opportunities and challenges in finding and developing new therapeutic drugs from the aspects of acetylcholinesterase,N-methyl-D-aspartate glutamate receptor,amyloid protein,tau protein and chronic immune inflammation.

关键词： Alzheimer's disease Dementia Cholinesterase inhibitor Beta amyloid Tau protein

Association of CD14/-260 polymorphism with gastric cancer risk in Highland Tibetans

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World Journal of Gastroenterology 2014年第10期20卷 2688-2694页

作者： Kang Li Zeng Dan Xue-Jun Hu Luo-Bu Gesang Yong-Ge Ze Zha-Xi Bianba Cuo-Mu Ciren Yu-Qiang Nie Department of Gastroenterology People’s Hospital of Tibet Autonomous Region Department of Oncology People’s Hospital of Tibet Autonomous Region Department of Gastroenterology Guangzhou First People’s Hospital Guangzhou Medical University

AIM: To investigate the relationship between CD14-260 and -651 polymorphisms and the risk of developing gastric cancer.

关键词： CD14 single nucleotide polymorphisms Cancer susceptibility Gastric cancer Tibetans

Comment on:“stereotactic body radiation therapy versus radiofrequency ablation in patients with small hepatocellular carcinoma:a systematic review and meta-analysis”

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Hepatobiliary surgery and Nutrition 2022年第4期11卷 647-648页

作者： Xiangyu Liu Meilin Zhu Department of Gastroenterology Jining First People’s HospitalJiningChina Department of Geriatrics Jining First People’s HospitalJiningChina

We are grateful to Hepatobiliary surg Nutr for publishing the study entitled“stereotactic body radiation therapy versus radiofrequency ablation in patients with small hepatocellular carcinoma:a systematic review and meta-analysis”.In this well-designed study,the authors concluded that in patients with small hepatocellular carcinoma,stereotactic body radiation therapy has a higher local control rate but poorer prognosis than radiofrequency ablation;in addition,the local toxicity of the two treatments was comparable(1).While we read the article with pleasure,it must be noted that this study raises some thought-provoking issues.

关键词： patients stereo analysis

Liver metastasis as the initial clinical manifestation of sublingual gland adenoid cystic carcinoma: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5238-5244页

作者： Xiao-Hong Li Yu-Tao Zhang Hao Feng Department of Pathology The First People’s Hospital of ZigongZigong 643099Sichuan ProvinceChina Department of Radiology The First People’s Hospital of ZigongZigong 643099Sichuan ProvinceChina

BACKGROUND Adenoid cystic carcinoma(ACC)is a common malignant tumor of salivary *** lung and liver are frequent sites of distant *** metastasis as the initial clinical manifestation of sublingual gland ACC is very *** sUMMARY A 51-year-old Chinese woman presented with a painless mass in the right lobe of *** tumor was composed of ductal cells and myoepithelial cells with a morphology including tubiform and cribriform *** results showed ductal cells positive for CK7,CK14,CK19,CD117,and 34βE12,and negative for MYB,vimentin,ER,PR,and *** myoepithelial cells were positive for p63,calponin and CK5/*** salivary ACC was considered,and a sublingual gland mass was revealed by computed *** evaluation confirmed primary sublingual gland *** in situ hybridization(FIsH)did not find an MYB-NFIB fusion gene in specimens from either the primary or metastatic ACC *** sublingual gland ACC relapsed in 20 *** recurrent lesion disappeared following local radiation therapy and computed tomography-guided radioactive seed *** patient remains in good condition until *** Metastatic sublingual gland ACC with initial clinical manifestation as a liver mass is very rare,and was pathologically confirmed in this patient by its histological *** hepatic tumors and metastatic carcinomas should be included in the differential *** detection of MYB protein and MYB-NFIB fusion gene detection by FIsH can be helpful,but occasional negative results confuse the diagnosis.

关键词： Liver metastasis Adenoid cystic carcinoma sublingual gland Differential diagnosis Immunohistochemistry Fluorescence in situ hybridization Case report

Comparison of clinical efficacy and postoperative inflammatory response between laparoscopic and open radical resection of colorectal cancer

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World Journal of Clinical Cases 2022年第13期10卷 4042-4049页

作者： Long-Hai He Bo Yang Xiao-Qin su Yue Zhou Zhen Zhang Department of General surgery The First People’s Hospital of Wanzhou DistrictChongqing 404040China Department of Clinical Nutrition The First People’s Hospital of Wanzhou DistrictChongqing 404040China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has increased annually,which has seriously threatened the health and quality of life of *** the treatment of CRC,both laparoscopic and radical resection are widely *** To explore and discuss clinical efficacy and postoperative inflammatory response of laparoscopic and open radical resection of *** A total of 96 patients with CRC diagnosed in our hospital from March 2016 to April 2021 were selected,and were divided into the study group(n=48)and control group(n=48)using a simple random *** control group was treated with open radical resection of CRC,and the study group was treated with laparoscopic radical resection of *** perioperative conditions(operation time,intraoperative blood loss,the recovery time of gastrointestinal function,number of lymph node dissections and length of hospital stay),inflammatory response index levels[interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP)]before and after operation,pain stress response indices[levels of neuropeptide(NPY),prostaglandin E2(PGE2),5-hydroxytryptamine(5-HT)],and the incidence of the complications between the two groups were *** The operation time in the study group was(186.18±33.54 min),which was longer than that of the control group(129.38±26.83 min),but the intraoperative blood loss(111.34±21.45 mL),recovery time of gastrointestinal function(25.35±4.55 h),and hospital stay(10.09±2.38 d)were better than those in the control group(163.77±32.41 mL,36.06±7.13 h,13.51±3.66 d)(Ps no significant difference in the number of lymph node dissections between the study group(15.19±3.04)and the control group(16.20±2.98)(P>0.05).There was no significant difference between the levels of serum IL-6(9.79±4.11 ng/mL),IL-8(3.79±1.71 ng/L),IL-10(48.96±12.51 ng/L)and CRP(7.98±2.33 mg/L)in the study group and the control group(10.56±3.78 ng/mL,4.08±1.45 ng/L,50.13±11.67 ng/L,8.29±2.60 mg/L)before the operation(P

关键词： Laparoscope Open surgery Colorectal cancer Inflammatory response Pain stress response

Up-to-date meta-analysis of long-term evaluations of mesenchymal stem cell therapy for complex perianal fistula

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World Journal of stem Cells 2023年第8期15卷 866-875页

作者： Fang Cheng Huang Zhong Zhong Huang Zhi Li Division of Gastroenterology Zigong First People’s HospitalZigong 643000Sichuan ProvinceChina Department of Gastroenterology Zigong First People’s HospitalZigong 643000Sichuan ProvinceChina

BACKGROUND Local mesenchymal stem cell(MsC)therapy for complex perianal fistulas(PFs)has shown considerable ***,the long-term safety and efficacy of MsC therapy in complex PFs remain *** To explore the long-term effectiveness and safety of local MsC therapy for complex *** sources included the PubMed,EMBAsE,and Cochrane Library databases.A standard meta-analysis was performed using RevMan *** After screening,6 studies met the inclusion *** therapy was associated with an improved long-term healing rate(HR)compared with the control condition[odds ratio(OR)=2.13;95%confidence interval(95%CI):1.34 to 3.38;P=0.001].Compared with fibrin glue(FG)therapy alone,MsC plus FG therapy was associated with an improved long-term HR(OR=2.30;95%CI:1.21 to 4.36;P=0.01).When magnetic resonance imaging was used to evaluate fistula healing,MsC therapy was found to achieve a higher long-term HR than the control treatment(OR=2.79;95%CI:1.37 to 5.67;P=0.005).There were no significant differences in long-term safety(OR=0.77;95%CI:0.27 to 2.24;P=0.64).CONCLUsION Our study indicated that local MsC therapy promotes long-term and sustained healing of complex PFs and that this method is safe.

关键词： Complex perianal fistula Mesenchymal stem cells Long-term evaluation Meta-analysis

Interventional endoscopic ultrasound for a symptomatic pseudocyst secondary to gastric heterotopic pancreas

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World Journal of Gastroenterology 2017年第34期23卷 6365-6370页

作者： hang-bin jin lei lu jian-feng yang qi-feng lou jing yang hong-zhang shen xiao-wei tang xiao-feng zhang Department of Gastroenterology Hangzhou First People’s HospitalNanjing Medical University

Heterotopic pancreas(HP) is a relatively uncommon entity that is defined as pancreatic tissue without a true anatomical or vascular connection to the pancreas. HP does not cause symptoms in most cases but can occasionally produce various manifestations, including nausea, vomiting, abdominal pain, and even heterotopic pancreatitis. Here, we report an unusual case in which heterotopic pancreatitis complicated by the formation of a pseudocyst that caused gastric outlet obstruction was diagnosed based on serum hyperamylasemia and findings from endoscopic ultrasonography(EUs)-guided fine needle aspiration(EUs-FNA) cytology. EUs-guided single pigtail stent insertion was successfully performed for recurrent gastric outlet obstruction. The patient has remained healthy and symptom-free during 4 years of surveillance. In the context of the relevant literature, the described case is a rare case of HP complicated by a pseudocyst treated via EUs-FNA and stent insertion.

关键词： Heterotopic pancreas Pseudocyst gastric outlet obstruction Endoscopic ultrasound-guided fine needle aspiration