Gastric cancer stem cells in gastric carcinogenesis,progression,prevention and treatment
Gastric cancer stem cells in gastric carcinogenesis,progression,prevention and treatment作者机构：Department of GastroenterologyPeople’s Hospital of Tibet Autonomous Region Department of GastroenterologyGuangzhou First People’s HospitalGuangzhou Medical University
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2014年第20卷第18期
页 面：5420-5426页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Cancer stem cells Gastric cancer Drug resistance Cancer treatment Molecular mechanism
摘 要：In recent decades,the study of the mechanism of tumorigenesis has brought much progress to cancer ***,cancer stem cell(CSC)theory has changed previous views of tumors,and has provided a new method for treatment of *** discovery of CSCs and their characteristics have contributed to understanding the molecular mechanism of tumor genesis and development,resulting in a new effective strategy for cancer *** CSCs(GCSCs)are the basis for the onset of gastric *** may be derived from gastric stem cells in gastric tissues,or bone marrow mesenchymal stem *** with other stem cells,GCSCs highly express drug-resistance genes such as aldehyde dehydrogenase and multidrug resistance,which are resistant to chemotherapy and thus form the basis of drug *** specific molecular markers such as CD44 and CD133 have been used for identification and isolation of GCSCs,diagnosis and grading of gastric cancer,and research on GCSC-targeted therapy for gastric ***,discussion of the recent development and advancements in GCSCs will be helpful for providing novel insight into gastric cancer treatment.
维普期刊数据库