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Apoptosis of endothelial cells of cerebral basilar arteries in symptomatic cerebral vasospasm rabbit models Electron microscopic observation

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Neural Regeneration Research 2007年第8期2卷 479-482页

作者： Guojun Shi Guodong Gao Zhenwei Zha fifth endemic area the 89 Hospital of Chinese PLA Weifang 261021 Shandong Province China Minimally Invasive Neurosurgical Center Tangdu Hospital Fourth Military Medical University of Chinese PLA Xi＇an 710038 ShaanxiProvince China

BACKGROUND： Recent researchers report that vasospasm is caused by that, on one hand, damage of endothelial cells reduces synthesis and liberation of vessel dilator; on the other hand, defluxion of endothelial cells directly exposure vascular smooth muscles in active materials of vasoconstriction in blood. OBJECTIVE： To study whether apoptosis of cerebrovascular cells occurs in symptomatic cerebral vasospasm （CVS） rabbit models by using transmission electron microscope. DESIGN： Contrast observation. SETTINGS： The fifth endemic area, the 89 Hospital of Chinese PLA; Minimally Invasive Neurosurgical Center, Tangdu Hospital, the Fourth Military Medical University of Chinese PLA. MATERIALS： A total of 24 New Zealand rabbits, of either sex, weighing 2.4 - 3.0 kg, of clear grade, were selected from the Experimental Animal Center of the Fourth Military Medical University of Chinese PLA. JEM-2000EX transmission electron microscope was made in Japan. METHODS： The experiment was carried out in the Laboratory of Anatomy （National Key Laboratory）, the Fourth Military Medical University of Chinese PLA from April 2001 to April 2002. ①Preparation of symptomatic CVS models： Eighteen animals which were successfully modeled were randomly divided into experimental group （n =13） and control group （n =5）. Animals in the experimental group were poured with blood into cavitas subarachnoidealis; while, animals in the control group were poured with the same volume of saline into cavitas subarachnoidealis. At the 5^th day injection, three rabbits selected from the experimental group were anesthetized and perfused into left ventricle. And then, aorta pectoralis and caval vein were blocked by using ring clamp. Cranium was rapidly cut open to obtain cerebral basilar artery and a few of brain tissues. Both of them were fixed for 8 hours. Two rabbits selected from the control group were perfused with the same method to obtain basilar artery and brain tissues and fix. ②After fixation by using optic

关键词： encephalomyelitis models, animal autoimmunity

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Assessment of circulating levels of microRNA-326,microRNA-424,and microRNA-511 as biomarkers for hepatocellular carcinoma in Egyptians

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World Journal of Hepatology 2022年第8期14卷 1562-1575页

作者： Samar Samir Youssef Asmaa Elfiky Mohamed M Nabeel Hend Ibrahim Shousha Tamer Elbaz Dalia Omran Mohammad Saeed Marie Mohammad A Elzahry Amr Abul-Fotouh Ahmed Hashem Mohamed F Guda Ashraf O Abdelaziz Department of Microbial Biotechnology National Research CentreCairo 1211Egypt Department of Environmental and Occupational Medicine National Research CentreCairo 1211Egypt Department of endemic Medicine and Hepatogastroenterology Faculty of MedicineCairo UniversityCairo 11562 Egypt Department of endemic Medicine Faculty of MedicineCairo UniversityCairo 1256Egypt Theodor Bilharz Research Institute Cairo 1256Egypt

BACKGROUND Hepatocellular carcinoma(HCC)is the fifth most common *** expression of microRNAs(miRNAs)-326,miRNA-424,and miRNA-511 has been associated with the diagnosis and prognosis of HCC in different ***,limited information is available regarding their expression in Egyptian HCC *** To assess the role of circulating miRNAs-326,miRNA-424,and miRNA-511 in Egyptian HCC *** This prospective observational study included 70 HCC patients and 25 healthy *** circulating levels of these three miRNAs were evaluated by real-time *** operating characteristic curve analysis was used to test the diagnostic accuracy of micro RNA expression *** All miRNAs were differentially expressed in HCC patients;miRNAs326 and miRNA-424 were upregulated,while miRNA-511 was *** miRNA-326 and miRNA-424 showed sensitivity and specificity of 97%,71.4%,and 52%,60%,respectively,to differentiate HCC from ***,miRNA-326 was associated with survival and could differentiate between Child grades(A vs B);miRNA-424 significantly differentiated early vs intermediate stages of HCC;while miRNA-511 was significantly correlated with response to modified Response Evaluation Criteria in Solid Tumors(m RECIST).CONCLUSION We conclude that miRNA-326,miRNA-424,and miRNA-511 have diagnostic and prognostic roles in Egyptian patients with hepatitis C virus-related HCC and should be considered for better disease management.

关键词： Hepatocellular carcinoma miRNAs-326 miRNA-424 miRNA-511 Modified response evaluation criteria in solid tumors

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A large-scale fatal outbreak of Pasteurella multocida among wild rodents in southwestern China

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Journal of Biosafety and Biosecurity 2020年第2期2卷 91-98页

作者： Chun-Hong Du Yong Huang Jia-Fu Jiang Zi-Hou Gao Na Jia Shan Yang Chao-Nian Chen Shun-Gao Ma Yu-Ying Liang Bao-Gui Jiang Wei-Hong Sang Peng Wang Yun Liang Yun-Zhi Zhang Ji-Hua Zhou Shui-Ping Chen Frans Jongejan Zhi-Zhong Song Yi-Gang Tong Wu-Chun Cao State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijingPR China Yunnan Institute for endemic Diseases Control and Prevention Dali YunnanPR China Puer Center for Disease Control and Prevention PuerYunnanPR China Simao Prefecture Center for Disease Control and Prevention PuerYunnanPR China DaLi Bai Autonomous Prefecture People’Hospital YunnanPR China fifth Medical Center of PLA General Hospital BeijingPR China Utrecht Centre for Tick-borne Diseases(UCTD) Faculty of Veterinary MedicineUtrecht UniversityYalelaan 13584 CL UtrechtThe Netherlands College of Life Science and Technology Beijing University of Chemical Technology.BeijingPR China

Background:Pasteurella multocida is an important and old zoonotic pathogen worldwide which has an impressive host spectrum including numerous domestic and wild animals as well as birds,causing specific diseases or outbreak with great economic *** has never been reported that *** can cause an epidemic in wild *** June 5–17,2016,more than 1000 rodent deaths of an unknown cause quickly spread in the PuEr City,Yunnan province,southwestern ***:The rodents in affected areas and outside of the epidemic areas were collected and screened for possible known pathogens including Yersinia pestis,rabies virus and hantavirus as well as other *** possible bacterial pathogens were isolated both by culture medium and by mouse inoculation in *** isolates were identified by the Vitek GNI card and PCR assays for 16S rRNA *** pathogen strains were selected for whole genome sequencing ***:A total of 123 rodents were collected from 25 sample sites at affected area,among of which,all 119 dead rodents were negative for the pathogen under consideration except ***,and all four live rodents were negative for *** addition,480 rodents collected from other 23 counties outside of the epidemic area in Yunnan were negative for with ***.A total of 14 strains of ***(six directly isolated from the field rodents and eight from the experimental mice that were injected with the organ substrates from the dead rodents)belonged to serogroup A and serogroup F represented by 9 N and 20 N were identified in these epidemic *** genome sequencing revealed that the serogroup F strain shared 99%similarity to *** Pm70 from chicken,but contained a 50 k bp insertion *** serogroup A strain shared 95%similarity to *** FDAARGOS_385 from a human patient,but contained four large structural *** abnormalities were identified in the livers,lungs,hearts and brains of the ino

关键词： Pasteurella multocida Serotypes A Serotypes F Rodents Outbreak China

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单个蝙蝠病毒组分析揭示了蝙蝠间的共感染和溢出以及病毒的人畜共患潜力

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中华实验和临床病毒学杂志 2024年第4期38卷 480-480页

作者：王娟(编译) State Key Laboratory for Biocontrol School of Medicine Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University Shenzhen China Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University Shenzhen China Guangzhou National Laboratory Guangzhou International Bio-Island Guangzhou Guangdong Province China Ministry of Education Key Laboratory of Biodiversity Science and Ecological Engineering School of Life Sciences Fudan University Shanghai China Department of Viral and Rickettsial Disease Control Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention Yunnan Institute of Endemic Disease Control and Prevention Dali Yunnan China School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat-sen University Sun Yat-sen University Shenzhen China Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Centre for Invasion Biology School of Ecology and Environmental Science Yunnan University Kunming Yunnan China Molecular Imaging Center Central Laboratory The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai 519000 Guangdong China State Key Laboratory of Infectious Disease Prevention and Control National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong China Sydney Institute for Infectious Diseases School of Medical Sciences The University of Sydney Sydney NSW 2006 Australia

蝙蝠是许多人畜共患病病毒的储备宿主。但是关于个体蝙蝠内病毒的多样性和丰度的了解还较少,因此它们之间病毒共感染和溢出的频率也不清楚。我们用无偏的元转录组学方法,对中国云南省采样的149只个体蝙蝠中携带的哺乳动物相关病毒进行... 详细信息

蝙蝠是许多人畜共患病病毒的储备宿主。但是关于个体蝙蝠内病毒的多样性和丰度的了解还较少,因此它们之间病毒共感染和溢出的频率也不清楚。我们用无偏的元转录组学方法,对中国云南省采样的149只个体蝙蝠中携带的哺乳动物相关病毒进行了表征。结果显示研究的动物中病毒的高频共感染(即蝙蝠个体同时感染多种病毒物种)和溢出,这可能进一步促进病毒的重组和再组合。

关键词：人畜共患病共感染病毒组蝙蝠溢出多样性云南省

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Lack of estrogen receptors expression in malignant and pre-malignant colorectal lesions in Egyptian patients

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Open Journal of Gastroenterology 2013年第2期3卷 155-163页

作者： Mohamed Said Marwa Khairy Aly El-Hendawy Osama A. Khalf Mohamed S. Abdelbary Yasmin Saadi Ayman Yosry Departement of endemic Medicine and Hepatogastroenterology Faculty of Medicine Cairo University Cairo Egypt Department of Clinical Pathology Faculty of Medicine Cairo University Cairo Egypt Department of Pathology Faculty of Medicine Cairo University Cairo Egypt

Background: incidence of Colorectal cancer (CRC) is increasing globally. In Egypt, CRC ranks the sixth most common cancer in males and the fifth in females. Aim: To assess the expression of estrogen receptors (alpha and beta) in pre-malignant (adenomatous polyps and IBD), malignant colorectal lesions and normal colonic mucosa in group of Egyptian patients. Methods: This prospective study was done on 45 patients presenting with colonic symptoms, patients were divided into four groups;15 CRC patients, 10 patients with adenomatous polyps, 10 IBD patients and 10 patients in the control group. Patients subjected to: Stool analysis, FOBT, CBC, CEA, Abdominal ultrasound & colonoscopy and biopsy (number = 80), Pathological, immunohistochemistry and RT- PCR quantification of ERα and ERβ were done. Results: Mean age: 39.2 (12 - 73), gender: M/F: 28/17. Bleeding per rectum was the commonest presentation;29/45 (64.4%). CEA was significantly elevated in the CRC group compared with other studied groups (1692 mg/L vs. 4.0, 4.0 and 4.4 mg/L). Ultrasonography of the studied patients showed that metastatic CRC: 3/15 (20%);Colonic wall thickening: 5/15 (33.3%), 1/10 showed colonic polypoidal lesions in adenomatous polyps groups, in IBD group: 4/10 (40%) showed colonic and ileocecal thicknening. All the studied patients showed negative results for estrogen receptors (alpha and beta) by the use of immunohistochemistry staining and RT-PCR technique. Conclusion: Role of estrogen receptors in the colonic mucosa, precancerous and colorectal cancer is doubtful, contradictory results with some literature data could be due to racial and genetic difference in the studied population.

关键词： Colorectal Cancer Premalignant Lesions Estrogen Receptors

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Snail-borne parasitic diseases:an update on global epidemiological distribution,transmission interruption and control methods

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Infectious Diseases of Poverty 2018年第1期7卷 285-300页

作者： Xiao-Ting Lu Qiu-Yun Gu Yanin Limpanont Lan-Gui Song Zhong-Dao Wu Kamolnetr Okanurak Zhi-Yue Lv School of Public Health Sun Yat-sen UniversityGuangzhou 510080China Faculty of Tropical Medicine Mahidol UniversityBangkok 10400Thailand fifth Affiliated Hospital Zhongshan School of MedicineSun Yat-sen UniversityGuangdongChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhou 510080China Provincial Engineering Technology Research Center for Biological Vector Control Guangzhou 510080China

Background:Snail-borne parasitic diseases,such as angiostrongyliasis,clonorchiasis,fascioliasis,fasciolopsiasis,opisthorchiasis,paragonimiasis and schistosomiasis,pose risks to human health and cause major socioeconomic problems in many tropical and sub-tropical *** this review we summarize the core roles of snails in the life cycles of the parasites they host,their clinical manifestations and disease distributions,as well as snail control *** body:Snails have four roles in the life cycles of the parasites they host:as an intermediate host infected by the first-stage larvae,as the only intermediate host infected by miracidia,as the first intermediate host that ingests the parasite eggs are ingested,and as the first intermediate host penetrated by miracidia with or without the second intermediate host being an aquatic ***-borne parasitic diseases target many organs,such as the lungs,liver,biliary tract,intestines,brain and kidneys,leading to overactive immune responses,cancers,organ failure,infertility and even *** countries in Africa,Asia and Latin America have the highest incidences of these diseases,while some endemic parasites have developed into worldwide epidemics through the global spread of ***,chemical and biological methods have been introduced to control the host snail populations to prevent ***:In this review,we summarize the roles of snails in the life cycles of the parasites they host,the worldwide distribution of parasite-transmitting snails,the epidemiology and pathogenesis of snail-transmitted parasitic diseases,and the existing snail control measures,which will contribute to further understanding the snail-parasite relationship and new strategies for controlling snail-borne parasitic diseases.

关键词： Snail-borne parasitic diseases Epidemiology Pathogenesis Snail control

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Human Atypical Monkeypox:Early Warning for Global Outbreak?

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Infectious Diseases & Immunity 2022年第4期2卷 239-241页

作者： Hui-Fang Wang Yang Zhang Ji-Yuan Zhang Fu-Sheng Wang Senior Department of Infectious Diseases and Hepatology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Senior Department of Infectious Diseases the Fifth Medical Center of Chinese PLA General HospitalNational Clinical Research Center for Infectious DiseasesBeijing 100039China

Monkeypox is usually considered as a zoonosis caused bymonkeypox viruswith potential threat to public health in the post-smallpox *** recent outbreak ofmonkeypox began inMay 7,2022,and has been found in many countries out of *** Organization declared that this endemic is an“atypical”phenomenon with definite human-to-human *** understand the situation more clearly,this review briefly summarizes the epidemiologic and clinical characteristics of the disease and highlights the clinical management and preventive strategies.

关键词： Monkeypox Atypical Human-to-human transmission Zoonosis

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