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Depression of the elderly revealing a primary hypothyroidism

Advances in Generial Practice of Medicine 2019年第1期2卷 1-4页

作者： Salem Bouomrani Mouna Guermazi Souad Yahyaoui Safa Trabelsi Latifa Ghanmi Department of Internal medicine Military Hospital of Gabes Gabes 6000 Tunisia Sfax faculty of Medicine University of Sfax Sfax 3029 Tunisia Department of Psychiatry Gabes Regional Hospital Gabes 6000 Tunisia

Introduction Psychiatric manifestations are exceptional during hypothyroidism and are not always easy to diagnose, especially since the clinical signs of hypothyroidism can be confused with those of the depressive syndrome. We report an original observation of depression of the elderly revealing an isolated primary hypothyroidism. Observation A 78-year-old patient, followed for essential hypertension, well-balanced under monotherapy with calcium channel blockers, and without degenerative complications, was referred by her family doctor for depressive syndrome not improved by the specific treatment prescribed and correctly taken for six months. The clinical examination noted in particular macroglossia with dental impressions and dry and cracked skin. The biological assessment showed hypothyroidism with TSH at 28μmol/l. Thyroid ultrasound showed atrophy of the thyroid gland. The thyroid autoimmunity (anti-thyroglobulin and anti-thyroperoxidase antibodies) was negative. The rest of the biological tests were in the normal range. The diagnosis of Riedel’s thyroiditis was retained and the patient was treated with levothyroxine in progressive doses until TSH normalization was achieved. The evolution on the psychiatric level was also favorable with disappearance of the signs of the depression and the anti-depressive treatment was discontinued. Conclusion Depression is rare, complicating only 4% of overt hypothyroidism and its diagnosis is not always easy, especially in the elderly. Hormone replacement therapy significantly improves the depressive syndrome and protects against cognitive decline. Thus, hypothyroidism screening seems appropriate for any depressive syndrome in the elderly.

关键词： depression hypothyroidism elderly

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丙肝病毒和人的免疫不全病毒传播发送: 差别和类似

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World Journal of Hepatology 2013年第5期5卷 234-236页

作者： Francesca Cainelli Department of Internal Medicine School of MedicineFaculty of Health SciencesUniversity of Botswana

Bouare et al found that hepatitis C virus (HCV) infection in Malian women is mainly transmitted through medical procedures with contaminated supplies, and that human immunodeficiency virus (HIV) transmission is predominantly sexual. The results of this study confirm those of a recent case-control study in New York and Oregon which demonstrated that healthcare exposures represent an important source of new HCV infections in United States. HCV seroprevalence was only 0.2% in pregnant, young Malian women, indicating that hygiene improved in healthcare facilities over time. Heterosexual transmission of HCV is exceptional, and can occur, from males to females, in extremely rare occasions in case of vaginal mucosal damage or less rarely through anal intercourse. The Malian study did not show an association between HIV infection and hospitalization, transfusion, tattoo, dental care. Transmission by needle-stick injury occurs in 0.9%-2.2% of exposures from HCV-infected subjects and in 0.1%-0.3% of exposures from HIV-infected in- dividuals. HCV is therefore more transmissible through percutaneous exposure.

关键词： Hepatitis C virus Human immunodeficiency virus Transmission Sub-Saharan Africa Pregnant women

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如何设计高质量针刺临床研究:基于证据的专家共识

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英国医学杂志中文版 2022年第6期25卷 325-337页

作者：张誉清焦睿珉 Claudia M Witt 劳力行刘建平 Lehana Thabane Karen J Sherman Mike Cummings Dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim Myeong Soo Lee Michael E Wechsler Benno Brinkhaus Jun J Mao Caroline A Smith 岗卫娟刘保延刘志顺刘岩郑晖吴佳霓 AloBSO Carrasco-Labra Mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 中国中医科学院针灸研究所中国中医科学院广安门医院中加整合医学循证医学研究合作中心 Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonONCanada 宁波诺丁汉大学宁波诺丁汉GRADE中心中国中医药循证医学中心 Institute for Complementary and Integrative Medicine University Hospital Zurich and University of ZurichZurichSwitzerland Virginia University of Integrative Medicine FairfaxVAUSA 北京中医药大学循证医学中心北京中医药大学国际循证中医药研究院 Department of Medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada Kaiser Permanente Washington Health Research Institute Seattle WAUSA Department of Epidemiology University of WashingtonSeattle WAUSA British Medical Acupuncture Society LondonUK Patient and Public Engagement Clinical Trials OntarioTorontoONCanada Department of Western Medicine Virginia University of Integrative MedicineFairfaxVAUSA Korean Medicine Clinical Trial Center SeoulRepublic of Korea Korean Medicine Hospital SeoulRepublic of Korea Kyung Hee University SeoulRepublic of Korea Clinical Medicine Division Korea Institute of Oriental MedicineDaejeonRepublic of Korea Korean Convergence Medicine University of Science and TechnologyDaejeonRepublic of Korea National Jewish Health DenverCOUSA Institute of Social Medicine Epidemiology and Health EconomicsCharitéUniversit?ts medizin BerlinFreie Universit?t Berlin and Humboldt-Universittzu BerlinBerlinGermany Integrative Medicine Service Memorial Sloan Kettering Cancer CenterBendheim Integrative Medicine CenterNew YorkNY USA Translational Health Research Institute Western Sydney UniversityPenrithNew South WalesAustralia 中国中医科学院中国中医科学院广安门医院北京中医药大学东直门医院中医内科学教育部重点实验室成都中医药大学针灸推拿学院/第三附属医院 Center for Integrative Global Oral Health School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究... 详细信息

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。

关键词：临床流行病学针刺试验临床试验临床医生专家共识随机对照试验资助者期刊编辑

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Human genetic and immunological determinants of critical COVID-19 pneumonia

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四川生理科学杂志 2021年第11期43卷 1947-1947页

作者： Qian Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France University of Paris Imagine Institute Paris France Howard Hughes Medical Institute Paris France The Rockefeller University & Howard Hughes Medical Institute New York NY USA Necker Hospital for Sick Children & INSERM Paris France Department of Pediatrics Necker Hospital for Sick Children Paris France Cemil Taşcıoglu City Hospital Istanbul Turkey Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France Imagine Institute University of Paris Paris France Al Jalila Children’s Hospital Dubai United Arab Emirates San Raffaele Telethon Institute for Gene Therapy IRCCS Ospedale San Raffaele and Vita Salute San Raffaele University Milan Italy Hospices Civils de Lyon Lyon France Helix San Mateo CA USA Department of Intensive Care Medicine Critical Care Center CHU Lille Lille France Univ. Lille CNRS Inserm CHU Lille Institut Pasteur de Lille U1019-UMR9017-CIIL-Centre d’Infection et d’Immunité deLille Lille France Shupyk National Medical Academy for Postgraduate Education Kiev Ukraine Department of Medical Microbiology University Medical Center Utrecht Utrecht The Netherlands Sidra Medicine Doha Qatar Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia Medellín Colombia School of Microbiology University of Antioquia Medellín Colombia IIBB-CSIC IDIBAPS Barcelona Spain Department of Immunology Second Faculty of Medicine Charles University University Hospital in Motol Prague Czech Republic Department of Immunology Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia Pulmonology Department Cliniques Universitaire

SARS-CoV-2 infection is benign in most individuals but,in-10%of cases,it triggers hypoxemic COVID-19 pneumonia,which becomes critical in-3%of *** ensuing risk of death(-1%)doubles every five years from childhood onward and is-1.5 times greater in men than in *** are the molecular and cellular determinants of critical COVID-19 pneumonia?Inborn errors of type I IFNs,including autosomal TLR3 and X-linked TLR7 deficiencies,are found in-1-5%of patients with critical pneumonia under 60 years old.

关键词： pneumonia critical cases

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Empathy Levels of dental Students of Central America and the Caribbean

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Health 2015年第12期7卷 1678-1686页

作者： Víctor Patricio Díaz-Narváez Ana María Erazo Coronado Jorge Luis Bilbao Farith González Mariela Padilla Madeline Howard Guadalupe Silva Joel Arboleda Mirian Bullen Robert Utsman Elizabeth Fajardo Luz Marina Alonso Marcos Cervantes Facultad de Odontología Universidad San Sebastián Santiago Chile Universidad Autónoma de Chile Santiago Chile Universidad Metropolitana Barranquilla Colombia Facultad de Medicina Universidad Libre Seccional Barranquilla y Fundación Universitaria San Martín Sede Puerto Colombia Barranquilla Colombia Facultad de Odontología Universidad de Cartagena Cartagena Colombia Universidad Latinoamericana de Ciencia y Tecnología San José Costa Rica Facultad de Odontología Universidad de Costa Rica San José Costa Rica Universidad Central del Este San Pedro de Macorís República Dominicana Facultad de Odontología Universidad de Panamá Ciudad de Panamá República de Panamá faculty of Health Sciences Universidad del Tolima Ibagué Colombia División de Salud Universidad del Norte Barranquilla Colombia Facultad de Ciencias Sociales Universidad del Norte Barranquilla Colombia

Objective: The aim of this study is to check whether there are differences in the distribution of empathy levels in dental students from nine faculties of dentistry Colombia, Panama, Costa Rica and Dominican Republic. Methods: The levels of empathy and matrices of empathy construct matrices are estimated dental students by using the Jefferson Scale of Physician Empathy, the Spanish version for students (S version) culturally validated in Colombia, Panama, Costa Rica and Dominican Republic measured by arbitrator criteria. Cronbach α is estimated. Data of empathic orientation of the studied factors between faculties are analyzed and compared by ANOVA and Duncan test and matrices of empathy construct using discriminant analysis. Results: We find that there are differences in levels of empathy between universities, courses, gender and interaction between the dental faculty (University) and Course. The comparison between matrices shows unexplained variances and differences observed between the levels of empathy in student populations. Conclusions: Variability in empathy is observed in the studied factors and among student populations. The variability is an empirical finding, but is not possible in this work, to explain why.

关键词： Empathy Jefferson Scale of Physician Empathy (JSPE) Levels of Empathy

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牙齿分析帮助年龄确定：应用计算机程序测定牙齿硬化

牙齿分析帮助年龄确定：应用计算机程序测定牙齿硬化

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第十五届国际法庭科学大会

作者： Maria Lusia Amariti M.Restori F.De Ferrari C.Paganelli dental Clinic Rudolfo Faglia G.Legnani M.Tiboni 杨玉璞任嘉诚刘华 Institute of Forensic Medicine BresciaItaly Institute of Forensic Medicine BresciaItaly Institute of Forensic Medicine BresciaItaly University of Brescia Piazzale Spedali Civili 125123BresciaItaly University of Brescia Piazzale Spedali Civili 125123BresciaItaly Engineering faculty University of BresciaVia Branze 3825123BresciaItaly Institute of Forensic Medicine Brescia Italy. Institute of Forensic Medicine Brescia Italy.

目前,应用多种不同的技术通过对牙齿的细微和大体结构的研究来分析受害者的年龄。本研究通过对牙质小管硬化的测量（在牙齿的横切片上）来鉴定年龄,用特殊设计的计算机程序对所得数据进行分析。

关键词：年龄评估牙齿硬化度测量神经网络方法

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Empathy Gender in dental Students in Latin America: An Exploratory and Cross-Sectional Study

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Health 2015年第11期7卷 1527-1535页

作者： Víctor Patricio Díaz-Narváez Ana María Erazo Coronado Jorge Luis Bilbao Farith González Mariela Padilla Madeline Howard María Guadalupe Silva Mirian Bullen Fredy Gutierrez Teresa Varela de Villalba Mercedes Salcedo Rioja Joyce Huberman Doris Carrasco Robert Utsman School of Dentistry Universidad San Sebastián Santiago Chile Associate Investigator Universidad Autónoma de Chile Santiago Chile Universidad Metropolitana Barranquilla Colombia School of Medicine Universidad Libre Seccional Barranquilla y Fundación Universitaria San Martín Sede Puerto Colombia Barranquilla Colombia School of Dentistry Universidad de Cartagena Campus de la Salud Barrio Zaragocilla Cartagena Colombia School of Health Sciences Universidad Latinoamericana de Ciencia y Tecnología San José Costa Rica School of Dentistry Universidad de Costa Rica San Pedro de Montes de Oca San José Costa Rica Institute for Scientific Research Universidad Central del Este San Pedro de Macorís Dominican Republic School of Dentistry Universidad de Panamá Panama City Panama Facultad de Estomatología Roberto Beltrán Universidad Peruana Cayetano Heredia Lima Peru School of Medicine Universidad Católica de Córdoba Córdoba Argentina Department of Pediatric Dentistry School of Dentistry Universidad Nacional Mayor de San Marcos Lima Peru School of Dentistry Faculty of Clinical Medicine Universidad del Desarrollo Santiago Chile School of Dentistry Universidad de Concepción Concepción Chile Investigation of the School of Health Sciences Universidad Latinoamericana de Ciencia y Tecnología San José Costa Rica

Background: It is well-founded that empathy is an attribute that increases the likelihood of good communication between health professionals and patients, and it is usual that there is the conviction that empathy levels are higher in women than in men. Aims: A study comparing levels of empathy gender of students in 18 schools of dentistry from six Latin American countries was conducted. Method: An exploratory cross-sectional study of which empathy levels were measured by the Jefferson Scale of Empathy for dental students (S version) and these levels were compared between genders by t-student test, after verification of normal distribution and homoscedasticity. Results: Variability was found in the results of the comparisons. In some cases, empathy levels were higher in women, others in men and in most of them there were no differences between genders. Conclusions: The observed results do not support the belief that women are more empathetic than men. However, more studies must be performed in more powers and countries to verify that the results described constitute a scientific fact and not just a feature of dental students specifically in the countries studied.

关键词： Empathy Gender dental Students

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