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Role of T-cell receptor V beta 8.3 peptide vaccine in the prevention of experimental autoimmune uveoretinitis

Chinese Medical Journal 2006年第9期119卷 740-748页

作者： ZHANG Rui YANG Pei-zeng WU Chang-you JIN Hao-li LI Bing HUANG Xiang-kun ZHOU Hong-yan GAO Yang ZHU Lian-xiang Aize Kijlstra Zhongshan Ophthalmic Centre Sun Yat-sen University Guangzhou 510060 China Department of Immunology Sun Yat-sen University Guangzhou 510089 China Division of Immunology Children＇s Hospital Boston Harvard Medical School Boston MA 02115 USA animal Sciences Group Wageningen University and Research Centre Lelystad Eye Research Institute Maastricht and Department of Ophthalmology Academic Medical Centre University of Amsterdam the Netherlands

Background T-cell receptor （TCR） plays an important role in the development of autoimmune diseases. Recently, it was reported that immunization of animals with TCR peptide derived from the pathogenic cells could prevent autoimmune diseases. The aim of this study was to investigate whether vaccination with a synthetic peptide from the hypervariable region of TCR Vβ 8.3, an experimental autoimmune uveoretinitis （EAU）-associated gene, was able to prevent the disease. Methods EAU was induced in Lewis rats by immunization with IRBP R16 peptide emulsified in complete Freund＇s adjuvant （CFA）. The clinical and histological appearances were scored. Delayed type hypersensitivity （DTH） and lymphocyte proliferation were detected. Cytokine levels of aqueous humour, supernatants of cells from spleen and draining lymph nodes were measured by enzyme linked immunosorbent assay （ELISA）. Gene expression of TCR Vβ8.3 on CD4^＋ T cells was examined by real time quantitative polymerase chain reaction （PCR）. Results After vaccination, the intraocular inflammation was significantly mitigated, antigen specific DTH and lymphocyte proliferation responses were suppressed, interleukin （IL）-2 in aqueous humour, interferon （IFN）-γ and IL-2 produced by the spleen and draining lymph node cells were significantly decreased, whereas the production of IL-4 and IL-10 were increased. The response of draining lymph node cells to TCR Vβ 8.3 peptide was enhanced after vaccination. Inoculation with CFA alone did not affect the severity of EAU and the above parameters. The suppression of EAU was much stronger in the group of four fold inoculations than the group of two fold inoculations. The expression of TCR Vβ 8.3 gene was significantly reduced in the group of fourfold inoculations. Conclusion Vaccination with the synthetic TCR Vβ 8.3 peptide could remarkably inhibit the development of EAU.

关键词： uveoretinitis autoimmune T-cell receptor peptide vaccine

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A Proposal of Hyperbolic Fitting Method by Applying the Properties of Functions for Plateau Surface Analysis in ISO 13565-3

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Nanomanufacturing and Metrology 2021年第2期4卷 86-96页

作者： Ryo Sakakibara Ichiro Yoshida Yuki Kondo Munetoshi Numada Kenichi Yamashita HOSEI University Graduate School 3-7-2 KajinochoKoganei-shiTokyo184-8584Japan faculty of Science and Engineering HOSEI University3-7-2 KajinochoKoganei-shiTokyo184-8584Japan faculty of Engineering Chukyo University101-2 YagotohonmachiNagoyaShowa-kuAichi466-8666Japan ISUZU Advanced Engineering Center LTD8 TsuchidanaFujisawa-shiFujisawa-shiKanagawa252-0881Japan

ISO 13565-3 provides an evaluation method for plateau structure surfaces used as sliding surfaces in machine tools and automobile *** evaluation method for plateau structure surfaces of ISO 13565-3 has problems,such as the processing procedure has an ambiguous basis,and the calculation method is not *** existing evaluation method that solves these problems requires the implementation of a difficult *** subsequent evaluation methods,these problems were resolved,and the implementation of complicated calculation algorithms became ***,these methods use algorithms that do not conform to the evaluation method of ISO *** lack of adherence to the ISO standard may hinder their application in the industrial ***,in this study,a new method that conforms to the evaluation method of ISO 13565-3 with a more concise algorithm was *** concluded that this proposed method can contribute to the formation of plateau surfaces and production control in the industrial world.

关键词： Stratified functional properties Plateau surface Surface texture Surface roughness Material probability curve

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Allele Frequency Distribution in PNLIP Promoter SNP Is Different between High-Marbled and Low-Marbled Japanese Black Beef Cattle

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Open Journal of animal Sciences 2016年第2期6卷 137-141页

作者： Youji Muramatsu Hideki Tanomura Takeshi Ohta Hiroyuki Kose Takahisa Yamada Department of Nutritional Sciences for Well-Being Faculty of Health Sciences for Welfare Kansai University of Welfare Sciences Osaka Japan Laboratory of animal Genetics Graduate School of Science and Technology Niigata University Niigata Japan Central Pharmaceutical Research Institute Japan Tobacco Inc. Osaka Japan Department of Life Science Division of Natural Sciences International Christian University Tokyo Japan

Marbling defined by the amount and distribution of intramuscular fat is regarded as an economically important trait of beef cattle in Japan. The pancreatic lipase gene (PNLIP) is located within the genomic region of a bovine marbling quantitative trait locus. The rat homologue of PNLIP has been previously shown to be regarded as a possible candidate for the gene responsible for intramuscular fat content. These findings suggested that PNLIP was a positional and functional candidate for the marbling gene. In this study, we detected a single nucleotide polymorphism (SNP), g.37288470A > G, at 1917 bp upstream of the PNLIP transcription initiation site between Holstein steers and somatic nuclear-derived cloned steers from a Japanese Black sire with a very high estimated breeding value for marbling by sequencing analysis. Further, we found statistically significant difference in the allelic distribution of the SNP between 17 Japanese Black unrelated sires with extremely high predicted breeding values for marbling and 17 sires with extremely low ones (P = 0.0332). Our findings suggest that g.37288470A > G SNP in the promoter region of PNLIP might be associated with marbling by altering its gene expression, and be useful for effective marker-assisted selection to increase the levels of marbling in Japanese Black beef cattle.

关键词： PNLIP Japanese Black Breed Marbling Single Nucleotide Polymorphism

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Preliminary survey of implementing target costing in the thai manufacturing firms

Preliminary survey of implementing target costing in the tha...

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APMAA 2012 Annual Conference Management Accounting: The Optimization of Management Control

作者： Nimnual Visedsun Kanitsorn Terdpaopong faculty of Accountancy Rangsit University

This article presents the potentialities in using a target costing strategy in the Thai market. The questionnaire survey was initially sent to a selection of four hundred and twenty manufacturing firms,with the final sample consisting of fifty-seven respondents（13.57 per cent response rate）. A focus group was also conducted to collect in-depth information. It was found that about 50 per cent of the respondents practiced target costing as a tool to manage the firms’ targeted profits and the majority of them implemented target costing for their new launch products and for developing and planning of existing production. The most important factor in implementing target costing was the support from the firm’s management. The results from the focus group and questionnaire survey provide us with evidence that using target costing is one of the strategies employed by business in an advanced competitive market of Thailand.

关键词： Target costing Manufacturing firms Competitive advantage Thailand

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Type 2 epithelial mesenchymal transition in vivo： truth or pitfalls？

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Chinese Medical Journal 2012年第18期125卷 3312-3317页

作者： XU Xue-feng DAI Hua-ping Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory Medicine faculty of RespiratoryMedicine Capital Medical University Department of Respiratoryand Critical Care Medicine Beijing Chao-Yang Hospital CapitalMedical University China Beijing 100020

Epithelial-mesenchymal transition （EMT） is a process by which fully differentiated epithelial cells undergo a phenotypic conversion and assume a mesenchymal cell phenotype, including elongated morphology, enhanced migratory and invasiveness capacity, and greatly increased production of extracellular matrix （ECM） components. The EMTs associated with wound healing, tissue regeneration, and organ fibrosis are termed as type 2 EMT. Over the past two decades, emerging evidence suggested that injured epithelial cells, via type 2 EMT, may serve as important sources of fibroblasts and contribute to organ fibrosis, such as kidney, liver, lung and eyes. There is perhaps no doubt that adult epithelial cells can undergo EMT in vitro in response to transforming growth factor （TGF）-131 and other inflammatory or pro-fibrotic stimuli. However, whether type 2 EMT really occurs in vivo, whethers it is actually a source of functional and activated interstitial fibroblasts and whether it contributes to tissue fibrosis have already been the subjects of heated debate. In this review, we will describe the main features of EMT, the major findings of type 2 EMT in vitro, the evidences for and against type 2 EMT in vivo and discuss the heterogeneity and pitfalls of the techniques used to detect EMT during fibrotic diseases. We suggest that in order to ascertain the existence of type 2 EMT in vivo, different proper phenotype markers of epithelial and mesenchymal cells should be jointly used and cell lineage tracking techniques should be standardized and avoid false positives. Finally, we believe that if EMT really occurs and contributes to tissue fibrosis, efforts should be made to block or reverse EMT to attenuate fibrotic process.

关键词： epithelial mesenchymal transition tissue fibrosis fibroblast

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Diabetes mellitus contribution to the remodeling of the tumor microenvironment in gastric cancer

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 1997-2012页

作者： Armando Rojas Cristian Lindner Iván Schneider Ileana Gonzàlez Hernan Araya Erik Morales Milibeth Gómez Nelson Urdaneta Paulina Araya Miguel Angel Morales Biomedical Research Lab. Medicine FacultyCatholic University of MauleTalca 34600000Chile Department of Clinical Sciences Medicine FacultyCatholic University of MauleTalca 34600000Chile Servicio de Oncología Hospital Regional de TalcaTalca 34600000Chile Servicio de Anatomía Patologica Hospital Regional de TalcaTalca 34600000Chile Department of Molecular and Clinical Pharmacology Program Institute of Biomedical SciencesUniversity of ChileSantiago 8320000Chile

Compelling pieces of evidence derived from both clinical and experimental research has demonstrated the crucial contribution of diabetes mellitus(DM)as a risk factor associated with increased cancer incidence and mortality in many human neoplasms,including gastric cancer(GC).DM is considered a systemic inflammatory disease and therefore,this inflammatory status may have profound effects on the tumor microenvironment(TME),particularly by driving many molecular mechanisms to generate a more aggressive *** is an active driver in the modification of the behavior of many cell components of the TME as well as altering the mechanical properties of the extracellular matrix(ECM),leading to an increased ECM ***,DM can alter many cellular signaling mechanisms and thus favoring tumor growth,invasion,and metastatic potential,as well as key elements in regulating cellular functions and cross-talks,such as the microRNAs network,the production,and cargo of exosomes,the metabolism of cell stroma and resistance to *** the present review,we intend to highlight the mechanistic contributions of DM to the remodeling of TME in GC.

关键词： Diabetes mellitus Gastric cancer Tumor microenvironment Hyperglycemia Chronic inflammation

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Biochar from sawmill residues:characterization and evaluation for its potential use in the horticultural growing media

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Biochar 2021年第2期3卷 201-212页

作者： Dilani Rathnayake Hamish Creber Reinhart Van Poucke Saran Sohi Erik Meers Ondřej Mašek Frederik Ronsse Thermochemical Conversion of Biomass Research Group Department of Green Chemistry and TechnologyFaculty of Bioscience EngineeringGent University653Coupure Links9000 GentBelgium UK Biochar Research Centre School of GeoSciencesUniversity of EdinburghCrew BuildingThe King’s BuildingsEdinburgh EH93FFUK Laboratory of Analytical Chemistry and Applied Ecochemistry Department of Green Chemistry and TechnologyFaculty of Bioscience EngineeringGent University653Coupure Links9000 GentBelgium

Peat remains the primary constituent of horticultural growing media in professional ***,use of peat in horticultural growing media results in greenhouse gas emissions and biodiversity loss due to excavation of natural *** is gaining attention as a sustainable alternative to peat use in *** study examined the potential of biochar produced from a particular type of sawmill residue,as a partial replacement for peat in horticultural growing *** treatments including peat only,biochar only,biochar and peat in 1:1,1:3,and 3:1(V/V)ratios were *** addition of biochar into growing media increased the pH and EC of the ***,physical properties(air-filled porosity and water holding capacity)were negatively affected with the increase in biochar content in the *** to the germination test results,biochar significantly improved germination and the shoot and root length of germinated seeds of cress,lettuce and tomato when compared to peat-only and biochar-only *** inclusion of biochar in 25-50%volume ratio improved plant growth parameters compared to peat-only and biochar-only *** obtained from this study suggest that sawmill residue offers great potential as a feedstock for biochar production and inclusion of biochar has positive effects on seed germination and plant growth that might compete with modified peat.

关键词： Sawmill residue Biochar Peat replacement Growing media Germination

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Influences of Cross Pollination on Pollen Tube Growth and Fruit Set in Zuili Plums (Prunus salicina)

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Journal of Integrative Plant Biology 2008年第2期50卷 203-209页

作者： Hui-Juan Jia Feng-Jie He Cai-Zhen Xiong Fu-Rong Zhu Goro Okamoto Department of Horticulture Zhejiang University Hangzhou 310029 China Fores and Silkworm Station Xiuzhou District Jiaxing 314000 China Department of Agriculture and Economy Tongxiang 314500 China faculty of Agriculture Okayama University Okayama 700-8530 Japan

Zuili plum （Prunus salicina L.） trees usually set fruit poorly, although they produce high quality fruit. To elucidate the causes of the poor fruit set, pollen tube growth into pistils and fruit set percentage were investigated after cross-, self- and open-pollination. Ovule development in Zuili pistils was also investigated. Pollen tube penetration into the ovules via the obturator and micropyle was best when Zuili pistils were pollinated by cv. Black Amber （P. domestica） pollen grains, although cross-pollinations with Hongxinli and Miili （P. salicina） pollen were more effective than self- and open-pollination. The fruit set percentage was also highest in pistils pollinated with Black Amber pollen grains. Morphological observation of Zuili pistils revealed that the trees produce ＂double pistils＂, developing two ovaries from a basal pistil, at a rate as high as 28%. In such abnormal pistils, most ovules were lacking an embryo sac or were entirely degenerated. The percentage of normally developed ovules was 24.3% and 8.9% in normal and double pistils, respectively. From these results, we conclude that the main causes of poor fruit set of Zuili plums are a lack of effective cross-pollination and the production of high percentages of double pistils in which normally developed ovules are scarcely formed.

关键词： double pistils pollen tube pollination poor fruit set Zuili plum.

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Application of Fuzzy-MRP2 in Fast Moving Consumer Goods Manufacturing Industry

Application of Fuzzy-MRP2 in Fast Moving Consumer Goods Manu...

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中国电子学会第十五届信息论学术年会暨第一届全国网络编码...

作者： John Dartnall faculty of Engineering University of Technology

In today’s global marketplace,the information associated with a product is fast becoming a critical link in the supply *** in fast moving consumer goods industry(FMCG),there is more fierce competition and more unstable require- *** plants use Manufacturing Resource Planning(MRP-Ⅱ)system to manage the process of *** how to deal with the uncertain and imprecise requirement in the middle term production schedule and make a best plan for best profit is a main problem in this *** this paper,we investigate the method named Fuszy-MRP-Ⅱ to deal with the uncertainty and im- ***-MRP-Ⅱ shows all of the information for the decision makers allowing them to consider all possibilities of the or- ders.

关键词： Fuzzy MRP Fast Moving Consumer Goods Manufacturing Industry

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Effect of the Austempering Process on Thin Wall Ductile Iron

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材料科学与工程（中英文A版） 2011年第2X期1卷 236-242页

作者： Johny Wahyuadi Soedarsono Tresna Priyana Soemardi Bambang Suhamo Rianti Dewi Sulamet-Ariobimo Elwado Zulfikar Damanik Wahyu Dwi Haryono Department of Metallurgy and Materials Faculty of Engineering University of lndonesia Jakarta Indonesia State Polytechnic of Jakarta Jakarta Indonesia Department of Mechanical Engineering Faculty of Engineering University of lndonesia Jakarta Indonesia Mechanical Engineering Department Faculty of lndustrial Technology Trisakti University Jakarta Indonesia

The needs of material that consumed low of energy during its production and saved energy during its used enhance the use of austempered ductile Iron (ADI), especially when ADI is made as thin wall austempered ductile Iron (TWADI). This research is conducted to see effect of thin wall ductile iron (TWDI) chemical composition to microstructure, UTS, and elongation of TWADI. TWDI plates were produced by vertical casting. The dimension of the plate is 150 × 75 mm with the thickness of 1 mm. Number of plate produced in 1 mould are 5. The difference of the plates lay on its position during the pouring. Chemical composition was checked before the liquid treatment process. All the plates then austempered in fluidized bed furnace with austenisation temperature 960 °C for 30 min and austempered temperature 350 °C for 10 min. This research found that the chemical composition of TWDI did not prevent austempering process to increase the ultimate tensile strength (UTS) and elongation.

关键词：等温淬火工艺奥贝球墨铸铁薄壁化学成分极限拉伸强度铸造生产淬火温度奥贝球铁

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