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Drosophila X virus-like particles as delivery carriers for improved oral insecticidal efficacy of scorpion Androctonus australis peptide against the invasive fruit fly,Drosophila suzukii

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Insect Science 2024年第3期31卷 847-858页

作者： Qi Xue Luc Swevers Clauvis Nji Tizi Taning faculty of Bioscience engineering Department of Plants and CropsGhent UniversityGhentBelgium Insect Molecular Genetics and Biotechnology Institute of Biosciences and ApplicationsNational Centre for Scientific Research"Demokritos"AthensGreece

Insect-specific neurotoxic peptides derived from the venoms of scorpions and spiders can cause acute paralysis and death when injected into insects,offering a promising insecticidal component for insect pest ***,effective delivery systems are required to help neurotoxic peptides pass through the gut barrier into the hemolymph,where they can ***,we investigated the potential of a novel nanocarrier,Drosophila X virus-like particle(DXV-VLP),for delivering a neurotoxin from the scorpion Androctonus australis Hector(AaIT)against the invasive pest fruit fly,Drosophila *** results show that the fusion proteins of DXV polyproteins with AalT peptide at their Ctermini could be sufficiently produced in Lepidoptera Hi5 cells in a soluble form using the recombinant baculovirus expression system,and could self-assemble into VLPs with similar particle morphology and size to authentic DXV *** addition,the AalT peptides displayed on DXV-VLPs retained their toxicity,as demonstrated in injection bioassays that resulted in severe mortality(72%)in adults after 72 *** fed to adults,mild mortality was observed in the group treated with DXV-AalT(38%),while no mortality occurred in the group treated with AaIT peptide,thus indicating the significant role of DXV-VLPs in delivering AalT ***,this proof-of-concept study demonstrates for the first time that VLPs can be exploited to enhance oral delivery of insect-specific neurotoxic peptides in the context of pest ***,it provides insights for further improvements and potentially the development of neurotoxin-based bioinsecticides and/or transgenic crops for insect pest control.

关键词： AalT Drosophila suzuki nanocarrier neurotoxic peptides pest control virus-like particle(VLP)

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Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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Earthquake engineering and engineering Vibration 2024年第3期23卷 663-675页

作者： Mohamed Naguib Abouelsaad Mohammed Shaaban Salah El Bagalaty Mohamed E.El Madawy Structural engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt faculty of engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX

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NextPolish2:A Repeat-aware Polishing Tool for Genomes Assembled Using HiFi Long Reads

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 105-109页

作者： Jiang Hu Zhuo Wang Fan Liang Shan-Lin Liu Kai Ye De-Peng Wang School of Automation Science and engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China GrandOmics biosciences Beijing 102206China Department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

The high-fidelity(HiFi)long-read sequencing technology developed by PacBio has greatly improved the base-level accuracy of genome ***,these assemblies still contain base-level errors,particularly within the error-prone regions of HiFi long *** genome polishing tools usually introduce overcorrections and haplotype switch errors when correcting errors in genomes assembled from HiFi long ***,we describe an upgraded genome polishing tool-NextPolish2,which can fix base errors remaining in those“highly accurate”genomes assembled from HiFi long reads without introducing excessive overcorrections and haplotype switch *** believe that NextPolish2 has a great significance to further improve the accuracy of telomere-to-telomere(T2T)***2 is freely available at https://***/Nextomics/NextPolish2.

关键词： Telomere-to-telomere Genome assembly Genome polishing Error correction HiFi long read

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Compression properties of cost-efficient porous expanded clay reinforced AA7075 syntactic foams fabricated by industrial-oriented die casting technology

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China Foundry 2024年第1期21卷 60-70页

作者： İsmail Cem Akgün Çağın Bolat Ali Gökşenli faculty of Mechanical engineering Istanbul Technical University34437İstanbulTurkey faculty of engineering Samsun University55420SamsunTurkey

In today’s manufacturing industries,hard competition between rival firms makes it compulsory for researchers to design lighter and cheaper machine components due to the megatrends of cost-effectiveness and *** this point,aluminum syntactic foams(ASFs)are new-generation engineering composites and come into the upfront as a *** to their features like low density,sufficient elongation,and perfect energy absorption ability,these advanced foams have been considerably seductive for many industrial sectors *** this study,an industrial-oriented automatic die casting technology was used for the first time to manufacture the combination of AA7075/porous expanded clay(PEC).Micro evaluations(optical and FESEM)reveal that there is a homogenous particle distribution in the foam samples,and inspections are compatible with the other ASF ***,T6 aging heat treatment was operated on one half of the produced foams to explore the probable impact of aging on the compressive *** results show that PEC particles can be an alternative to expensive hollow spheres used in the previous ***,a favorable relationship is ascertained between the aging treatment and mechanical properties such as compression strength and plateau strength.

关键词： die casting porous materials metal matrix sytanctic foams expanded clay compressive deformation

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Applying the Protective Mn-Co-La_(2)O_(3)Coating on Crofer 22 APU Ferritic Stainless Steel Used as Solid Oxide Fuel Cell Interconnects

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Acta Metallurgica Sinica(English Letters) 2024年第5期37卷 872-888页

作者： Farhad Mohsenifar Hadi Ebrahimifar Ahmad Irannejad Department of Materials engineering and Metallurgy Faculty of EngineeringShahid Bahonar University of KermanKermanIran Mechanical engineering Department Faculty of EngineeringHigher Education Complex of Bam76615-314BamIran Department of Materials engineering Faculty of Mechanical and Materials EngineeringGraduate University of Advanced TechnologyKerman ***Iran

This research studies the effect of Mn-Co-La_(2)O_(3) coating synthesized by the electrodeposition method on the oxidation resistance and electrical conductivity of the Crofer 22 APU stainless steel interconnect plates in solid oxide fuel *** test samples were characterized by a field emission scanning electron microscope(FESEM)equipped with energy dispersive spectroscopy(EDS),X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS).The oxidation kinetics of the coated and uncoated samples were studied by tracking their weight changes over time at 800°C,showing that the oxidation mechanism for all samples follows the parabolic *** oxidation rate constant(k_(p))values of the coated sample compared with that of the uncoated one indicated a reduction in the oxidation rate of the steel substrate in the presence of the Mn-Co-La_(2)O_(3) *** examination of the cross-section of different samples after the isothermal oxidation for 500 h at 800°C exhibited that applying the composite coating leads to a decrease in the thickness of the chromia layer formed on the steel ***,under these conditions,the area-specific resistance(ASR)of the coated sample(13.11 mΩcm^(2))is significantly lower than that of the uncoated one(41.45 mΩcm^(2)).

关键词： Area specific resistance Oxidation Fuel cell Composite coating

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Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals

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Chinese Journal of Integrative Medicine 2024年第1期30卷 75-84页

作者： Anchal Trivedi Adria Hasan Rumana Ahmad Sahabjada Siddiqui Aditi Srivastava Aparna Misra Snober S.Mir Department of Biochemistry Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Molecular Cell Biology Laboratory Integral Information and Research Centre-4(IIRC-4)Department of BioengineeringFaculty of EngineeringIntegral UniversityLucknow(226026)India Department of Biotechnology Era's Lucknow Medical College&HospitalEra UniversityLucknow(226003)India Department of biosciences Faculty of ScienceIntegral UniversityLucknow(226026)India

Good nutrition plays a crucial role in maintaining a balanced lifestyle. The beneficial effects of nutrition have been found to counteract nutritional disturbances with the expanded use of nutraceuticals to treat and manage cardiovascular diseases, cancer, and other developmental defects over the last decade. Flavonoids are found abundantly in plant-derived foods such as fruits, vegetables, tea, cocoa, and wine. Fruits and vegetables contain phytochemicals like flavonoids, phenolics, alkaloids, saponins, and terpenoids. Flavonoids can act as anti-inflammatory, anti-allergic, anti-microbial(antibacterial, antifungal, and antiviral) antioxidant, anti-cancer, and anti-diarrheal agents. Flavonoids are also reported to upregulate apoptotic activity in several cancers such as hepatic, pancreatic, breast, esophageal, and colon. Myricetin is a flavonol which is naturally present in fruits and vegetables and has shown possible nutraceutical value. Myricetin has been portrayed as a potent nutraceutical that may protect against cancer. The focus of the present review is to present an updated account of studies demonstrating the anticancer potential of myricetin and the molecular mechanisms involved therein. A better understanding of the molecular mechanism(s) underlying its anticancer activity would eventually help in its development as a novel anticancer nutraceutical having minimal side effects.

关键词： myricetin flavonoids anticancer nutraceuticals Chinese medicine Ayurveda complementary and alternative medicine

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Dynamics of a rotating ring-stiffened sandwich conical shell with an auxetic honeycomb core

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 963-982页

作者： S.JAHANGIRI A.GHORBANPOUR ARANI Z.KHODDAMI MARAGHI Department of Solid Mechanics Faculty of Mechanical EngineeringUniversity of KashanKashan ***Iran faculty of engineering Mahallat Institute of Higher EducationMahallat ***Iran

The free vibration analysis of a rotating sandwich conical shell with a reentrant auxetic honeycomb core and homogenous isotropic face layers reinforced with a ring support is *** shell is modeled utilizing the first-order shear deformation theory(FSDT)incorporating the relative,centripetal,and Coriolis accelerations alongside the initial hoop tension created by the *** governing equations,compatibility conditions,and boundary conditions are attained using Hamilton’s *** trigonometric functions,an analytical solution is derived in the circumferential direction,and a numerical one is presented in the meridional direction via the differential quadrature method(DQM).The effects of various factors on the critical rotational speeds and forward and backward frequencies of the shell are *** present work is the first theoretical work regarding the dynamic analysis of a rotating sandwich conical shell with an auxetic honeycomb core strengthened with a ring support.

关键词： free vibration conical shell rotating shell ring support auxetic honeycomb

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An Adaptive Strategy-incorporated Integer Genetic Algorithm for Wind Farm Layout Optimization

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Journal of Bionic engineering 2024年第3期21卷 1522-1540页

作者： Tao Zheng Haotian Li Houtian He Zhenyu Lei Shangce Gao faculty of engineering University of ToyamaToyama9300887Japan

Energy issues have always been one of the most significant concerns for scientists *** the ongoing over exploitation and continued outbreaks of wars,traditional energy sources face the threat of *** energy is a readily available and sustainable energy *** farm layout optimization problem,through scientifically arranging wind turbines,significantly enhances the efficiency of harnessing wind ***-heuristic algorithms have been widely employed in wind farm layout *** paper introduces an Adaptive strategy-incorporated Integer Genetic Algorithm,referred to as AIGA,for optimizing wind farm layout *** adaptive strategy dynamically adjusts the placement of wind turbines,leading to a substantial improvement in energy utilization efficiency within the wind *** this study,AIGA is tested in four different wind conditions,alongside four other classical algorithms,to assess their energy conversion efficiency within the wind *** results demonstrate a notable advantage of AIGA.

关键词： Wind farm layout optimization problem Meta-heuristic algorithms Adaptive Integer genetic algorithm

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Dendritic Learning and Miss Region Detection-Based Deep Network for Multi-scale medical Segmentation

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Journal of Bionic engineering 2024年第4期21卷 2073-2085页

作者： Lin Zhong Zhipeng Liu Houtian He Zhenyu Lei Shangce Gao faculty of engineering University of ToyamaToyama9300887Japan

Automatic identification and segmentation of lesions in medical images has become a focus area for *** for medical image provides professionals with a clearer and more detailed view by accurately identifying and isolating specific tissues,organs,or lesions from complex medical images,which is crucial for early diagnosis of diseases,treatment planning,and efficacy *** paper introduces a deep network based on dendritic learning and missing region detection(DMNet),a new approach to medical image *** combines a dendritic neuron model(DNM)with an improved SegNet framework to improve segmentation accuracy,especially in challenging tasks such as breast lesion and COVID-19 CT scan *** work provides a new approach to medical image segmentation and confirms its *** have demonstrated that DMNet outperforms classic and latest methods in various performance metrics,proving its effectiveness and stability in medical image segmentation tasks.

关键词： medical image segmentation Dendritic learning Deep supervision Dynamic focal loss

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An application of 1D convolution and deep learning to remote sensing modelling of Secchi depth in the northern Adriatic Sea

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Big Earth Data 2024年第1期8卷 82-114页

作者： Antonia Ivanda LjiljanaŠerić DušanŽagar Krištof Oštir faculty of Electrical engineering Mechanical Engineering and Naval ArchitectureUniversity of SplitSplitCroatia faculty of Civil and Geodetic engineering University of LjubljanaLjubljanaSlovenia

This paper presents a novel approach for predicting the water quality indicator-Secchi disk depth(Z_(SD)).Z_(SD)indirectly reflects water clarity and serves as a proxy for other quality *** study utilizes Deep Neural Network(DNN)trained on satellite remote sensing and measured data from three sources:two datasets obtained from official agencies in Croatia and Slovenia,and one citizen science data source,all covering the northern coastal region of the Adriatic *** proposed model uses 1D Convolutional Neural Network(CNN)in the spectral dimension to predict Z_(SD).The model’s performance indicates a strong fit to the observed data,proving capability of 1D-CNN to capture changes in water *** the test dataset,the model achieved a high R-squared value of 0.890,a low root mean squared error(RMSE)of 0.023 and mean absolute error(MAE)of *** results demonstrate that employing a 1D-CNN in the spectral dimension of Sentinel-3 OLCI data is an effective approach for predicting water *** findings have significant implications for monitoring Z_(SD)in coastal *** integrating diverse data sources and leveraging advanced machine learning algorithms,a more accurate and comprehensive assessment of water quality can be achieved.

关键词： Secchi Sentinel-3 OLCI 1DCNN Adriatic sea

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