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Exosomes from adipose tissue-derived stem/stromal cells:A key to future regenerative medicine

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BIOCELL 2022年第12期46卷 2701-2704页

作者： JÉRÔME LALOZE ALEXIS DESMOULIÈRE University of Limoges Neuropathies and Therapeutic Innovations(UR 20218)Faculties of Medicine and PharmacyLimogesF-87000France Department of Maxillo-Facial and Reconstructive Surgery and Stomatology University Hospital DupuytrenLimogesF-87000France

Advances in regenerative medicine correlate strongly with progress in the use of adipose tissue-derived mesenchymal stem/stromal *** range of therapeutic indications has also expanded over recent *** recent studies have highlighted the primary importance of paracrine secretion by these *** it is interesting to compare the different types of such secretions,we believe that exosomes(extra-cellular vesicles possessing the same properties as their source cells)will likely be the main key in tomorrow’s cell *** also have many advantages compared to the direct use of cells,making these particles amajor target in fundamental and translational research.

关键词： Adipose-derived mesenchymal stem/stromal cell Exosome Regenerative medicine Secretome

Non-Hermitian topological coupler for elastic waves

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Science China(Physics,Mechanics & Astronomy) 2022年第2期65卷 57-65页

作者： Yan Meng Xiaoxiao Wu Yaxi Shen Dong Liu Zixian Liang Xiang Zhang Jensen Li Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen 518060China Department of Physics The Hong Kong University of Science and TechnologyClear Water BayHong Kong 999077China faculties of Sciences and Engineering The University of Hong KongHong Kong 999077China

Non-Hermitian topological systems,by combining the advantages of topological robustness and sensitivity induced by nonHermiticity,have recently emerged and attracted much research ***,we propose a device based on the topological coupler in elastic waves with non-Hermiticity,which contains two topological domain walls and four *** this device,topological robustness routes the transmission of waves,while non-Hermiticity controls the gain or loss of waves as they *** mechanisms result in continuous and quantitative control of the energy distribution ratio of each port.A nonHermitian Hamiltonian is introduced to reveal the coupling mechanism of the topological coupler,and a scattering matrix is proposed to predict the energy distribution ratio of each *** proposed topological coupler,which provides a new paradigm for the non-Hermitian topological systems,can be employed as a sensitive beam splitter or a coupler ***,the topological coupler has potential applications in information processing and logic operation in elastic circuits or networks,and the paradigm also applies to other classical systems.

关键词： topological edge states non-Hermitian systems topological coupler

Peripheral nerve regeneration and intraneural revascularization

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Neural Regeneration Research 2019年第1期14卷 24-33页

作者： Martial Caillaud Laurence Richard Jean-Michel Vallat Alexis Desmoulière Fabrice Billet University of Limoges Myelin Maintenance and Peripheral Neuropathies Faculties of Medicine and Pharmacy University Hospital of Limoges Department of Neurology "Reference Center for Rare Peripheral Neuropathies" Department of Neurology

Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. The current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.

关键词：神经生长新生动物模型 Ihe 组织学损害学习老鼠

Identifying the Targets for Treatment of Liver Fibrosis and Hepatocellular Carcinoma from Both Western medicine and Chinese medicine

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Chinese Journal of Integrative medicine 2012年第4期18卷 245-249页

作者： Yuewen GONG faculties of Pharmacy and medicine University of Manitoba 750 McDermot Avenue Winnipeg Manitoba Canada R3E 0T5

Liver fibrosis and hepatocellular carcinoma （HCC） are emerging health problems worldwide. Number of death due to HCC was steadily increased during the last decade. Although liver fibrosis and HCC have been investigated extensively, there are no successful and/or satisfactory therapies especially for patients with HCC. From our understanding of both Western medicine and Chinese medicine, it could identify the targets in liver fibrosis and HCC for intervention with Chinese medicine such as bone morphogenetic protein 4 （BMP-4）. BMP-4 expression was significantly increased in both liver fibrosis and HCC and saponin class of certain Chinese herbs could regulate its expression. Therefore, BMP-4 could be one of the targets for treatment of liver fibrosis and HCC from integrative medicine.

关键词： liver fibrosis hepatocellular carcinoma bone morphogenetic protein integrative medicine

Mechanical properties of nerve roots and rami radiculares isolated from fresh pig spinal cords

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Neural Regeneration Research 2015年第11期10卷 1869-1873页

作者： Norihiro Nishida Tsukasa Kanchiku Junji Ohgi Kazuhiko Ichihara Xian Chen Toshihiko Taguchi Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine Faculty of Engineering Yamaguchi University Non-Profit Organization Corporation Japan Orthopedic Biomechanics Institute faculties of Engineering Yamaguchi University

No reports have described experiments designed to determine the strength characteristics of spinal nerve roots and rami radiculares for the purpose of explaining the complexity of symptoms of medullary cone lesions and cauda equina syndrome. In this study, to explain the pathogenesis of cauda equina syndrome, monoaxial tensile tests were performed to determine the strength characteristics of spinal nerve roots and rami radiculares, and analysis was conducted to evaluate the stress-strain relationship and strength characteristics. Using the same tensile test device, the nerve root and ramus radiculares isolated from the spinal cords of pigs were subjected to the tensile test and stress relaxation test at load strain rates of 0.1, 1, 10, and 100 s-1 under identical settings. The tensile strength of the nerve root was not rate dependent, while the ramus radiculares tensile strength tended to decrease as the strain rate increased. These findings provide important insights into cauda equina symptoms, radiculopathy, and clinical symptoms of the medullary cone.

关键词： nerve regeneration cauda equina syndrome monoaxial tensile tests radiculopathy strength characteristics stress-strain relationship lumbar spinal canal stenosis paralysis spinal cord neural degeneration

Hydrogeological Characterization and Approach to a Conceptual Model of the Aquifer of the Cuvette Basin, Republic of Congo

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International Journal of Geosciences 2022年第11期13卷 997-1023页

作者： Noida Janesia Lebela Mouakoumbat Urbain Mbilou Gampio Guy Moukandi Nkaya Chesther Gatsé Ebotehouna Armel Obami Ondon Romain Richard Niere National Polythecnic School Marien Ngouabi University Brazzaville Congo Department of Geology Faculties of Science and Technology Marien Ngouabi University Brazzaville Congo

The continuous aquifers of the Congolese Cuvette basin constitute the seat of significant water tables reversibly supplying the Congo River basin as well as the water tables they drain. Consisting mainly of sandy-clayey-sandstone formations, these aquifers contain groundwater which is the main source of drinking water supply for communities in this sector of the departments Cuvette and Cuvette-Ouest. The need for water being more and more acute, these aquifers have been subjected to drilling operations in order to supply drinking water to these populations. The information obtained from these operations is data which made it possible to obtain information relating to the lithology, the hydrogeological parameters of these aquifers and information on the depth and on the lateral variations of the water table. The purpose of this present work is to contribute to the hydrogeological characterization of the aquifer of the Cuvette basin in the departments of Cuvette and Cuvette-Ouest via data from the analysis of the technical sheets of drillings carried out by the ASPERBRAS Company, collected at the Ministry of Major Works and territory planning. This characterization was made using Visual MODFLOW Flex 2015.1 software coupled with Surfer 10 software and Rock Works 17 software. The hydrogeological interpretation of the data shows that this aquifer, whose constitution is essentially made up of sands, clayey sands and clay, is continuous, porous and free. This composition gives the aquifer of Cuvette basin a heterogeneous character. In addition, a piezometric map was produced in order to indicate the direction of the water flows which turned out to be from west to east towards the lowest areas occupied by the valleys of the rivers and rivers. The conceptual model shows that the depth of the aquifer deceases considerably from the Cuvette-Ouest towards the Cuvette.

关键词： Cuvette Basin Hydrogeology Aquifer Piezometric Map Conceptual Model

Immunological Characterization in Malaria Patients with and without the Sickle-Cell Trait

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Advances in Infectious Diseases 2014年第3期4卷 152-164页

作者： Howaida A. Nafady Amany M. Eida Omima M. Eida Department of Internal medicine Faculties of Medicine Assuit University Assiut Egypt Jazan University Jazan KSA

Background: Malaria is one of the main causes of mortality in tropical zone. Specific immune responses are induced by parasite, including the release of cytokines from peripheral blood mononuclear cells. Sickle cell trait confers a high degree of resistance to severe and complicated malaria. The present study aims to assess immunological response of P. falciparum infection by measuring of total IgG level and IL-6, IL-12 & IL-18 levels for P. falciparum among Saudi Arabian patients with and without sickle-cell trait. Patients and Methods: Thirty patients who had clinical suspicion of malaria and sickle-cell trait attending Jazan general hospital in KSA were included in the study. Malaria patients with sickle-cell trait will be matched with a control (thirty patients diagnosed to have malaria but without sickle-cell trait). Diagnosis of malaria was done by Immunochromatography strip and blood film. Diagnosis of Sickle-cell trait was done by hemoglobin electrophoresis assessment of total IgG titre and Interleukin 6, 12, 18 levels using ELIZA. Results: Cytokines and IgG in uncomplicated clinical malaria (n = 22) and severe malaria (n = 7) were IL6 (83.1 pg/mL) versus (75.2 pg/mL), IL12 (19.4 pg/mL) versus (16.3 pg/mL), IL18 (22.45 pg/mL) versus (24.2 pg/mL) and IgG (13.3 SD) versus (4.5 SD). Differences in the IL6, IL12 and IgG were statistically significant (p value >0.02, >0.004 & >0.002 respectively). Among malaria patients with sickle cell trait, Cytokines and IgG in asymptomatic (n = 19) and uncomplicated clinical malaria (n = 11) were IL6 (88.9 pg/mL) versus (79.2 pg/mL), IL12 (24 pg/mL) versus (22.9 pg/mL), IL18 (24.2 pg/mL) versus (31.2 pg/mL) and IgG (27 SD) versus (7.35 SD). Differences in IgG were statistically significant (p value ≥ 0.003). Serum IL6 levels were higher in patients with uncomplicated clinical malaria without sickle cell trait (median 83.1 ± 5.1 pg/mL) than in patients with uncomplicated clinical malaria with sickle cell trait (medians 79.2 ±

关键词： Malaria Sickle Cell Trait IL-6 IL-12 IL-18 and IgG

Amelioration of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty(OLETF) rats by a group of Chinese herbs(Tangshen Formula)

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Amelioration of diabetic nephropathy in Otsuka Long-Evans To...

Electron-hole hybridization in bilayer graphene

第十一届全国中西医结合肾脏病学术会议

作者： Frank J.Burczynski faculties of medicine & Pharmacy University of Manitoba WinnipegManitobaCanada

Introduction Diabetic nephropathy is one of the most important microvascular complications associated with type 2 diabetic patients and has emerged as a leading cause of end stage renal disease in developed *** this study,we investigated the effect of the Tangshen Formula treatment on renal function,morphometric changes,serum lipid,and hemorheology in the OLETF rat,which is thought to be a good animal model for the study of type 2 diabetic nephropathy.

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National Science Review 2020年第2期7卷 248-253页

作者： Siqi Wang Mervin Zhao Changjian Zhang Sui Yang Yuan Wang Kenji Watanabe Takashi Taniguchi James Hone Xiang Zhang NSF Nanoscale Science and Engineering Center (NSEC) University of California Materials Sciences Division Lawrence Berkeley National Laboratory Department of Mechanical Engineering Columbia University National Institute for Materials Science faculties of Sciences and Engineering University of Hong Kong

Band structure determines the motion of electrons in a solid, giving rise to exotic phenomena when properly engineered. Drawing an analogy between electrons and photons, artificially designed optical lattices indicate the possibility of a similar band modulation effect in graphene systems. Yet due to the fermionic nature of electrons, modulated electronic systems promise far richer categories of behaviors than those found in optical lattices. Here, we uncovered a strong modulation of electronic states in bilayer graphene subject to periodic potentials. We observed for the first time the hybridization of electron and hole sub-bands, resulting in local band gaps at both primary and secondary charge neutrality points. Such hybridization leads to the formation of flat bands, enabling the study of correlated effects in graphene systems. This work may provide a novel way to manipulate electronic states in layered systems, which is important to both fundamental research and application.

关键词： band modulation periodic potential bilayer graphene