Peripheral nerve regeneration and intraneural revascularization

作     者：Martial Caillaud Laurence Richard Jean-Michel Vallat Alexis Desmoulière Fabrice Billet 

作者机构：University of Limoges Myelin Maintenance and Peripheral Neuropathies Faculties of Medicine and Pharmacy University Hospital of Limoges Department of Neurology "Reference Center for Rare Peripheral Neuropathies" Department of Neurology 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第1期

页      面：24-33页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by a doctoral fellowship from the ‘Conseil Régional du Limousin’ to MC 

主　　题：compression crush transection Sunderland's classification Wallerian degeneration angiogenesis traumatic glycerol 

摘      要：Peripheral nerves are particularly vulnerable to injuries and are involved in numerous pathologies for which specific treatments are lacking. This review summarizes the pathophysiological features of the most common traumatic nerve injury in humans and the different animal models used in nerve regeneration studies. ~Ihe current knowledge concerning Wallerian degeneration and nerve regrowth is then described. Finally, the involvement of intraneural vascularization in these processes is addressed. As intraneural vascularization has been poorly studied, histological experiments were carried out from rat sciatic nerves damaged by a glycerol injection. The results, taken together with the data from literature, suggest that revascularization plays an important role in peripheral nerve regeneration and must therefore be studied more carefully.