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^(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls:a cross-sectional study

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Neural Regeneration Research 2021年第12期16卷 2494-2498页

作者： Aline Morais de Souza Milena Sales Pitombeira Larissa Estessi de Souza Fabio Luiz Navarro Marques Carlos Alberto Buchpiguel Caroline Cristiano Real Daniele de Paula Faria Laboratory of Nuclear Medicine(LIM43) Department of Radiology and OncologyFaculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil department of Neurology Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil

^(11)C-PK11195 is a positron emitter tracer used for Positron Emission Tomography(PET)imaging of innate immune cell activation in studies of neuroinflammatory *** the image quantitative analysis,it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition(plasma intact fraction).Due to the complexity and costs involved in this analysis it is important to evaluate the real necessity of individual analysis in each 11C-PK11195 PET imaging *** purpose of this study is to compare 11CPK11195 plasma metabolization rate between healthy controls and multiple sclerosis(MS)patients and evaluate the interference of sex,age,treatment,and disease phenotype in the tracer intact fraction measured in arterial plasma samples.11C-PK11195 metabolization rate in arterial plasma was quantified by high performance liquid chromatography in samples from MS patients(n=50)and healthy controls(n=23)at 20,45,and 60 minutes after 11C-PK11195 *** were also stratified by sex,age,treatment type,and MS *** results showed no significant differences in the metabolization rate of healthy controls and MS patients,or in the stratified *** conclusion,11C-PK11195 metabolization has the same rate in patients with MS and healthy controls,which is not affected by sex,age,treatment,and disease ***,these findings could contribute to exempting the necessity for tracer metabolization determination in all 11C-PK11195 PET imaging acquisition,by using a population metabolization rate *** study procedures were approved by the Ethics Committee for Research Projects Analysis of the Hospital das Clinicas of the University of Sao Paulo Medical School(approval No.624.065)on April 23,2014.

关键词： ^(11)C-PK11195 HPLC kinetic modeling metabolization multiple sclerosis neuroinflammation PET imaging PET tracer radiometabolites

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SARS-CoV-2 infection in liver transplant recipients:A complex relationship

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World Journal of Gastroenterology 2021年第44期27卷 7734-7738页

作者： Ricardo Wesley Alberca Gil Benard Gabriela Gama Freire Alberca Maria Notomi Sato Laboratorio de dermatologia e Imunodeficiencias(LIM-56) Departamento de Dermatologia e Institute de Medicina TropicalFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil Laboratorio de dermatologia e Imunodeficiencias(LIM-56) Departamento de DermatologiaFaculdade de Medicina FMUSPUniversidade de São PauloSão Paulo 01246-903Brazil

The recent manuscript reviewed investigations involving liver damage in coronavirus disease 2019(COVID-19)patients,and COVID-19 in patients with previous chronic hepatological diseases,such as patients with liver *** literature presents several conflicting results concerning the anti-SARS-CoV-2 response in patients with solid organ transplants,in liver transplant ***,we would like to humbly state a few points for consideration involving liver transplant recipients and COVID-19,such as the time since transplantation,comorbidities,and immunosuppressive regimens.

关键词： COVID-19 SARS-CoV-2 Liver transplant Immunosuppression Infection Comorbidities

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Association between the CYBA and NOX4 genes of NADPH oxidase and its relationship with metabolic syndrome in non-alcoholic fatty liver disease in Brazilian population

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Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 330-335页

作者： Fabiola Rabelo Jose Tadeu Stefano Ana Mercedes Cavaleiro Rodrigo Vieira Costa Lima Daniel Ferraz de Campos Mazo Flair Jose Carrilho Maria Lúcia Correa-Giannellac Claudia P.Oliveiraa departamento de Gastroenterologia Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil Hospital das Clinicas HCfmusp Departamento de GastroenterologiaLIM07Faculdade de MedicinaUniversidade de Sao PauloSao PauloSPBrazil Laboratório de Carboidratos e Radioimunensaio LIM18Hospital das Clinicas HCFMUSP(LIM07)Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Programa de Pos-Graduacao em medicina Universidade Nove de Julho(UNINOVE)Sao PauloBrazil

Background: Oxidative stress has been implicated in the progression of severe forms of non-alcoholic fatty liver disease(NAFLD). NADPH oxidase produces reactive oxygen species. In the present study, we investigated for the first time two single nucleotide polymorphisms(SNPs) in the regulatory region of genes encoding NADPH oxidase 4(NOX4) and p22 phox(CYBA) in ***: A total of 207 biopsy-proven NAFLD patients [simple steatosis(n = 27); nonalcoholic steatohepatitis(NASH)(n = 180)] were evaluated. Genomic DNA was extracted from peripheral blood cells, and polymorphisms in CYBA(unregistered) and NOX4(rs3017887) were determined by direct sequencing of ***: Associations of CYBA-675 T/A with high-density lipoprotein(HDL)(TT vs TA vs AA; P des(TGL)(TT vs XA; P degrees of fibrosis occurred in patients diagnosed with type 2 diabetes mellitus(66.9% vs 37.5%, P degrees of fibrosis in NAFLD patients.

关键词： Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Genetic polymorphism Metabolic syndrome

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Large primary hepatic gastrinoma in young patient treated with trisegmentectomy: A case report and review of the literature

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World Journal of Hepatology 2018年第7期10卷 517-522页

作者： Leonardo Zumerkorn Pipek Yuri Justi Jardim Gustavo Heluani Antunes de Mesquita Fernanda Nii Kayo Augusto de Almeida Medeiros Bárbara Justo Carvalho Diego Ramos Martines Leandro Ryuchi Iuamoto Daniel Reis Waisberg Luiz Augusto Carneiro D'Albuquerque Alberto Meyer Wellington Andraus faculdade de medicina fmusp Universidade de Sa?o Paulo Program in Global Surgery and Social Change Department of Global Health and Social Medicine Harvard Medical School departamento de Gastroenterologia Hospital das Clinicas HCFMUSP Faculdade de Medicina Universidade de Sao Paulo

Primary hepatic gastrinoma is a rare disease, with fewer than 40 cases reported in the medical literature. Because it is located in an organ in which metastases are common, its diagnosis is difficult. We report a case of a 19 years old male patient with a history of gastric ulcers since the age of nine. Following gastric surgery, an antrectomy and a vagotomy, there was some alleviation of symptoms. Subsequently, the patient reported various intermittent episodes of diarrhea, diffuse abdominal pain, and vomiting. The patient underwent tomography, which revealed the presence of a hepatic mass measuring 19.5 cm × 12.5 cm × 17 cm. Primary hepatic gastrinoma was diagnosed based on laboratory examinations that indicated hypergastrinemia and a positron emission tomography/magnetic resonance study with somatostatin analogue that confirmed the liver as the primary site. After hepatic trisegmentectomy(Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅷ), the patient's symptoms improved. The case is notable for the presence of a rare tumor with uncommon dimensions.

关键词： Gastrinoma Primary hepatic gastrinoma Zollinger-Ellison syndrome Hepatic trisegmentectomy Gastric surgery

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Living-donor liver transplantation in Budd-Chiari syndrome with inferior vena cava complete thrombosis:A case report and review of the literature

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World Journal of Hepatology 2021年第1期13卷 151-161页

作者： Vinicius Rocha-Santos Daniel Reis Waisberg Rafael Soares Pinheiro Lucas Souto Nacif Rubens Macedo Arantes Liliana Ducatti Rodrigo Bronze Martino Luciana Bertocco Haddad Flavio Henrique Galvao Wellington Andraus Luiz Augusto Carneiro-D'Alburquerque department of Gastroenterology Abdominal Organs Transplantation DivisionHospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo(HC-FMUSP)Sao Paulo 05403900SPBrazil department of Gastroenterology Laboratory of Medical Investigation 37(LIM-37)Faculdade de Medicina da Universidade de Sao Paulo(FMUSP)Sao Paulo 01246903Brazil

BACKGROUND Budd-Chiari syndrome(BCS)is a challenging indication for liver transplantation(LT)due to a combination of massive liver,increased bleeding,retroperitoneal fibrosis and frequently presents with stenosis of the inferior vena cava(IVC).Occasionally,it may be totally thrombosed,increasing the complexity of the procedure,as it should also be *** challenge is even greater when performing living-donor LT as the graft does not contain the retrohepatic IVC;thus,it may be necessary to reconstruct *** SUMMARY A 35-year-old male patient with liver cirrhosis due to BCS and hepatocellular carcinoma beyond the Milan criteria underwent living-donor LT with IVC *** was necessary to remove the IVC as its retrohepatic portion was completely thrombosed,up to almost the right atrium.A right-lobe graft was retrieved from his sister,with outflow reconstruction including the right hepatic vein and the branches of segment V and VIII to the middle hepatic *** to massive subcutaneous collaterals in the abdominal wall,venovenous bypass was implemented before incising the *** right atrium was reached via a transdiaphragramatic *** was performed en bloc with the retrohepatic vena *** was reconstructed with an infra-hepatic vena cava graft obtained from a deceased *** patient remains well on outpatient clinic follow-up 25 mo after the procedure,under an anticoagulation protocol with *** Living-donor LT in BCS with IVC thrombosis is feasible using a meticulous surgical technique and tailored strategies.

关键词： Liver transplantation Living donors Budd-Chiari syndrome Hepatic venoocclusive disease Inferior vena cava Case report

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Pain and Fatigue Perceptions of Patients with Systemic Autoimmune Myopathies before and during the COVID-19 Pandemic Period

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Open Journal of Rheumatology and Autoimmune Diseases 2022年第4期12卷 83-98页

作者： Rafael Giovani Missé Isabela Bruna Pires Borges Bruna Lindoso Correia Lorenza Rosa Silvério da Silva Marlise Sítima Mendes Simões Alexandre Moura dos Santos Samuel Katsuyuki Shinjo Division of Rheumatology Faculdade de Medicina FMUSP Universidade de Sao Paulo Brazil

Objective: To assess general pain and fatigue and their association with the disease status of patients with systemic autoimmune myopathies (SAMs), in terms of the impact of the COVID-19 pandemic on these parameters. Methods: This is a cross-sectional and prospective cohort study that included 72 patients with SAMs who were matched by age and gender with 67 healthy individuals. The patients engaged in an interview via a validity survey to measure disease status, and assess a visual analog scale (VAS) for pain and fatigue in two periods: before (phase I) and during (phase II) of the Brazilian COVID-19 pandemic. For cross-sectional analysis, patients’ data from phase I were compared to healthy individuals’ information, whereas for prospective analysis, data of the patients who were assessed in phase II were compared to the same patients’ data from phase I. Results: The patients had significantly more pain perception, comparable fatigue perception and fatigue severity, when compared to the healthy individuals. During the COVID-19 pandemic period, the disease activity, pain and fatigue perceptions, and fatigue severity remained unchanged. despite this, the pain and fatigue perceptions correlated significantly with patients’ VAS, the patient health outcome, and fatigue severity. In addition, the pain perception correlated to creatine phosphokinase, whereas fatigue perceptions correlated to physicians' VAS. Conclusions: The study showed that patients with SAMs have significantly increased pain perceptions compared to healthy individuals. During the COVID-19 pandemic period, the pain and fatigue perceptions remained unchanged in patients with SAMs but they correlated to several disease status parameters.

关键词： COVID-19 Pandemic Fatigue Inflammatory Myopathies Myositis Physical Activity

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The aryl hydrocarbon receptor and the gut–brain axis

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Cellular & Molecular Immunology 2021年第2期18卷 259-268页

作者： Andreia Barroso João Vitor Mahler Pedro Henrique Fonseca-Castro Francisco J.Quintana Ann Romney Center for Neurologic Diseases Brigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA faculdade de medicina fmusp Universidade de São PauloSão PauloSPBrazil Broad Institute of MIT and Harvard CambridgeMAUSA

The aryl hydrocarbon receptor(AHR)is a ligand-activated transcription factor initially identified as the receptor for *** half a century after its discovery,AHR is now recognized as a receptor for multiple physiological ligands,with important roles in health and *** this review,we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.

关键词： Aryl hydrocarbon receptor Autoimmune diseases Infectious diseases cancer

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Traditional and Non-Traditional Risk Factors Involved with Endothelial Dysfunction and Arterial Stiffness in Autoimmune Rheumatic Diseases

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Open Journal of Rheumatology and Autoimmune Diseases 2019年第3期9卷 85-100页

作者： Rafael Giovani Misse Isabela Bruna Pires Borges Samuel Katsuyuki Shinjo Division of Rheumatology Faculdade de Medicina FMUSP Universidade de Sao Paulo Sao Paulo Brazil

Autoimmune rheumatic diseases (ARDs) have been closely associated with accelerated plaque progression and the development of atherosclerosis, which lead to high morbidity and mortality rates for cardiovascular diseases. Endothelial dysfunction and arterial stiffness are greatly evidenced in several studies in the early phase of atherosclerosis. In ARDs, endothelial dysfunction and arterial stiffness are related to traditional and non-traditional risk factors. To date, no studies have clearly analyzed the main parameter involved in endothelial dysfunction and arterial stiffness. In this context, the present narrative review’s purpose was to describe the main factor in endothelial dysfunction and arterial stiffness in different ARDs. Endothelial dysfunction and arterial stiffness are related to traditional risk factors (i.e., hypertension, diabetes, dyslipidemia, metabolic syndrome, sedentary behavior) and non-traditional risk factors (linked to the immune mechanisms involved in these diseases). Moreover, in the present study, these associations were systemically analyzed in ankylosing spondylitis, antiphospholipid syndrome, rheumatoid arthritis, psoriatic arthritis, systemic autoimmune myopathies, systemic lupus erythematosus and systemic sclerosis. The present review shows that the relationship of traditional risk factors and non-traditional risk factors related to ARDs works in the worsening of function and structural properties of arterial vessels, leading to high cardiovascular morbidity and mortality.

关键词： Arterial Stiffness Atherosclerosis Autoimmune Endothelial Dysfunction Rheumatic Diseases

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Tofacitinib as a Treatment for Refractory dermatomyositis: A Case Report

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Open Journal of Rheumatology and Autoimmune Diseases 2020年第1期10卷 39-43页

作者： Samuel Katsuyuki Shinjo Fernando Henrique Carlos de Souza Division of Rheumatology Faculdade de Medicina FMUSP Universidade de Sao Paulo Sao Paulo Brazil

In very scarce case reports and case series, tofacitinib has been a therapeutic alternative for dermatomyositis. To corroborate the literature, we described a refractory dermatomyositis that had a good outcome with tofacitinib. Case Report: An adult female patient presented with definite dermatomyositis and with refractoriness to high doses of intravenous and oral glucocorticoids, intravenous human immunoglobulin, several immunosuppressive drugs (methotrexate, azathioprine, and leflunomide) and two previous immunobiological drugs (rituximab and abatacept). However, the patient had a good outcome with tofacitinib. Conclusions: Tofacitinib appears to be a promising alternative therapy for refractory dermatomyositis.

关键词： dermatomyositis Immunosuppressive Agents Muscle Diseases Myositis Therapeutics

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Antipsychotics preserve telomere length in peripheral blood mononuclear cells after acute oxidative stress injury

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Neural Regeneration Research 2022年第5期17卷 1156-1160页

作者： Gabriel B.Polho Giancarlo M.Cardillo Daniel S.Kerr Thais Chile Wagner F.Gattaz Orestes V.Forlenza Helena P.Brentani Vanessa J.de-Paula Laboratório de Neurociências(LIM-27) Departamento e Instituto de PsiquiatriaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSPBrasil Laboratório de Psicobiologia(LIM-23) Departamento e Instituto de PsiquiatriaHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSPBrasil

Antipsychotics may prolong or retain telomere length,affect mitochondrial function,and then affect the metabolism of nerve *** validate the hypothesis that antipsychotics can prolong telomere length after oxidative stress injury,leukocytes from healthy volunteers were extracted using Ficoll-Histopaque density *** mononuclear cells layer was resuspended in cell culture *** stress was induced with hydrogen peroxide in cultured *** days later,leukocytes were treated with aripiprazole,haloperidol or clozapine for 7 ***-time PCR revealed that treatments with aripiprazole and haloperidol increased the telomere length by 23%and 20%in peripheral blood mononuclear cells after acute oxidative stress *** results suggest that haloperidol and aripiprazole can reduce the damage to telomeres induced by oxidative *** experiment procedure was approved by the Ethics Committee of Faculty of Medicine of the University of Sao Paulo(fmusp/CAAE approval No.52622616.8.0000.0065).

关键词： antipsychotic aripiprazole cell culture clozapine haloperidol oxidative stress peripheral blood mononuclear cell telomere length

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