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Assessment of the bioaccessibility and bioavailability prediction of omega 3 and conjugated fatty acids by in vitro standardized digestion model (INFOGEST) and cell model

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FOOD BIOSCIENCE 2023年第3期53卷 1678-1691页

作者： Salsinha, Ana Sofia Cunha, Sara A. Machado, Manuela Rodriguez-Alcala, Luis Miguel Relvas, Joao B. Pintado, Manuela univ Catolica Portuguesa CBQF Ctr Biotecnol & Quim Fina Escola Super Biotecnol Lab Associado Rua Diogo Botelho 1327 P-4169005 Porto Portugal univ porto Inst Invest & Inovacao Saude Rua Alfredo Allen 208 P-4200135 Porto Portugal univ porto Inst Biol Mol & Celular IBMC Rua Alfredo Allen 208 P-4200135 Porto Portugal fac med univ porto fmup Dept Biomed P-4200319 Porto Portugal

Omega 3 EPA and DHA are polyunsaturated fatty acids with relevant health benefits. Conjugated linoleic and linolenic acids are known for their anti-carcinogenic effect, anti-inflammatory properties and body weight reduction. To achieve therapeutical doses, high amounts of these fatty acids' food sources must be consumed. Thus, the intake of enriched oils with a high concentration of these fatty acids is often used. But several factors influence their bioavailability. Here, by using the INFOGEST static in vitro protocol of gastrointestinal tract digestion it was studied the bioaccessibility of these fatty acids in different matrixes: Pomegranate and Fish oil and omega 3, CLA and CLNA soft-gel enriched capsules. After digestion, the Recovery Index for the major bioactive PUFAs are very low: Pomegranate oil is 2%, Fish oil 11-13%, CLNA 17%, CLA 6% and Omega 3 capsules 3%. Higher initial concentrations of these PUFAs seem to be related to higher degrees of oxidation. In Pomegranate oil, CLNA and Omega 3 capsules, the digestion process negatively influenced the antioxidant potential. The opposite was verified for the Fish oil and CLA capsules. Importantly, bioaccessibility studies of similar matrixes are very scarce and intestinal permeability is absent in most of the studies. Intestinal permeability studies were performed using a Caco-2/HT29-MTX co-culture: there is significative incorporation of the bioactive fatty acids into the intestinal cells, which may affect their permeability performance. Interestingly, most fatty acids remain in the non-bioaccessible fraction which may be relevant when designing oral routes of administration and in gut microbiota modulation.

关键词： Fish oil Pomegranate oil INFOGEST digestion Method Bioaccessibility Intestinal permeability Bioactive fatty acids

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Sympathetic activity in breast cancer and metastasis:partners in crime

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Bone Research 2021年第1期9卷 26-36页

作者： Francisco Conceição Daniela M.Sousa Joana Paredes Meriem Lamghari I 3S-Instituto de Investigação e Inovação em Saúde Universidade do Porto4200-135 PortoPortugal INEB-Instituto Nacional de Engenharia Biomédica Universidade do Porto4200-135 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313 PortoPortugal IPATIMUP-Instituto de Patologia e Imunologia Molecular da universidade do porto 4200-135 PortoPortugal fmup-faculdade de medicina da universidade do porto 4200-319 PortoPortugal

The vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of *** cancer cells are characterized by a strong tropism to the bone *** engraftment and colonization of bone,breast cancer cells interact with native bone cells to hinder the normal bone remodeling process and establish an osteolytic“metastatic vicious cycle”.The sympathetic nervous system has emerged in recent years as an important modulator of breast cancer progression and metastasis,potentiating and accelerating the onset of the vicious cycle and leading to extensive bone ***,sympathetic neurotransmitters and their cognate receptors have been shown to promote several hallmarks of breast cancer,such as proliferation,angiogenesis,immune escape,and invasion of the extracellular *** this review,we assembled the current knowledge concerning the complex interactions that take place in the tumor microenvironment,with a special emphasis on sympathetic modulation of breast cancer cells and stromal ***,the differential action of epinephrine and norepinephrine,through eitherα-orβ-adrenergic receptors,on breast cancer progression prompts careful consideration when designing new therapeutic *** addition,the contribution of sympathetic innervation to the formation of bone metastatic foci is *** particular,we address the remarkable ability of adrenergic signaling to condition the native bone remodeling process and modulate the bone vasculature,driving breast cancer cell engraftment in the bone ***,clinical perspectives and developments on the use ofβ-adrenergic receptor inhibitors for breast cancer management and treatment are discussed.

关键词： breast metastasis invasion

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Zinc and Copper Status in Urban Thai PregnantWomen and Their Pregnancy Outcome

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Biomedical and Environmental Sciences 1998年第2期11卷 156-164页

作者： SRIWATANA SONGCHITSOMBOON, D. Sc. SURAT KOMINDR,MD. WINIT PHUAPRADIT, MD.,MPH., AND JINTANA SIRIVARASAI, M. Sc.(Research Center, Department of medicine, and Department of Obstetric and Gynecology, faculty of medicine, Ramathibodi Hospital, Mahidol univer Mahidol univ Ramathibodi Hosp Fac Med Res Ctr Bangkok 10400 Thailand Mahidol univ Ramathibodi Hosp Fac Med Dept Med Bangkok 10400 Thailand Mahidol univ Ramathibodi Hosp Fac Med Dept Obstet & Gynecol Bangkok 10400 Thailand

Zinc and copper intakes and serum concentrations were determined at the 32th and 36th week of pregnancy in 96 healthy Thai women attending a prenatal clinic. Dietary data from 3-day food records revealed that the mean dietary zinc and copper intakes in Thai pregnant women were 6. 9 and 1. 7mg/d (equivalent to 34 and 69% of Thai RDA), respectively. Fifty-five percent of zinc intake was from animal origin, whereas 59% of copper intake was from plant *** infants of the 64 women who were in the study until delivery, were all *** (>96%) of the maternal serum zinc and copper concentrations were within normal ranges. Only one woman at 32th week had low serum zinc level (<6. 4μmol/L). There were no significant correlations between the maternal serum zinc or copper levels and pregnancy outcome (birth weight and birth length). In this study, although the zinc and copper intake in most Thai pregnant women (99 and 58%, respectively) were less than two-thirds of the Thai RDAs, they were not at risk of suffering from zinc and copper deficiencies as determined by serum zine and copper concentrations, abnormal parturition and abnormal pregnancy outcome.

关键词： Am In Zinc and Copper Status in Urban Thai PregnantWomen and Their Pregnancy Outcome

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PD-1 and LAG-3: synergistic fostering of T cell exhaustion

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 291页

作者： Hofmann, Maike Thimme, Robert Schamel, Wolfgang W. univ Freiburg Fac Med Med Ctr Dept Med 2 Freiburg Germany univ Freiburg Signaling Res Ctr BIOSS & CIBSS Freiburg Germany univ Freiburg Fac Biol Dept Immunol Freiburg Germany univ Freiburg Fac Med Ctr Chron Immunodeficiency CCI Freiburg Germany

In the August issue of Cell 2024,three back-to-back papers disentangled non-redundant inhibitory mechanisms of PD-1 and LAG-3 in exhausted murine and human CD8+T cells.^(1-3) These findings will have a clear impact on... 详细信息

关键词： synergistic redundant finding

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Discovery of biosynthetic enzymes for β-D-manno-heptoses across kingdoms: novel agonists for ALPK1/NF-κB-dependent immune response

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 277页

作者： Maubach, Gunter Lim, Michelle C. C. Naumann, Michael Otto Guericke univ Inst Expt Internal Med Med Fac Magdeburg Germany

A recent study by Tang et al.1 in Science reveals the crosskingdom widespread occurrence of functional nucleotidediphosphate(NDP)-heptose biosynthetic enzymes(HBEs)that accounts for the synthesis of NDP-heptoses to activate the alphaprotein kinase 1(ALPK1)-dependent innate immune *** study not only highlights the importance of the metaboliteβ-D-manno-heptose as pathogen-associated molecular patterns(PAMPs)but also raises the question of possibly other biological roles,especially in the different kingdoms(Fig.1).

关键词： king response. raise

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A microglial compliment: controlling neuronal function from within

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 267页

作者： Hasavci, Dilara Blank, Thomas univ Freiburg Inst Neuropathol Fac Med Freiburg Germany

A recent study published in Cell revealed that in the aging brain,the microglia-derived complement component C1q is internalized into neurons through endocytosis,integrates into ribonucleoprotein(RNP)complexes where it inhibits neuronal protein synthesis and alters the protein *** findings demonstrate an unexpected intracellular function of C1q in neurons with significant implications for understanding age-related changes in brain function and potentially neurodegenerative diseases.

关键词： C1q function controlling

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Therapeutic interfering particles against HIV: molecular parasites reducing viremia

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 287页

作者： Gruell, Henning Odidika, Stanley Schommers, Philipp univ Cologne Inst Virol Fac Med Cologne Germany univ Cologne Univ Hosp Cologne Cologne Germany univ Cologne Fac Med Dept Internal Med 2 Cologne Germany univ Cologne Ctr Mol Med Cologne CMMC Cologne Germany German Ctr Infect Res DZIF Partner Site Bonn Cologne Cologne Germany

In a recent article in Science,Leon Weinberger and colleagues report on successful proof-of-concept studies of a novel strategy to control HIV-1 infection by using interfering viral particles.1 This approach radically differs from small-molecule antiretroviral drugs that can prevent disease progression and transmission by inhibiting viral replication but require life-long use.

关键词： particles. drugs inhibiting

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Beyond borders: the choroid plexus-immune communication during neuroinflammation

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 278页

作者： Dumas, Anaelle Aurelie Gasull, Adria Dalmau Prinz, Marco univ Freiburg Inst Neuropathol Fac Med Freiburg Germany univ Freiburg Signalling Res Ctr BIOSS & CIBSS Freiburg Germany

In their paper published in Cell,1 Xu et *** single-cell sequencing and cell lineage tracing tools combined with two-photon live imaging to characterise the spatiotemporal immune recruitment and infiltration to the choroid plexus(ChP).They provide seminal insights into the communication between specialised ChP epithelial and macrophage populations,which coordinate the stepwise response to inflammation and its resolution.

关键词： inflammation plexus al.

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Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN

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World Journal of Gastroenterology 1999年第3期5卷 209-212页

作者： Yin, T Tong, SQ Xie, YC Lu, DY Shanghai Second med univ Fac Med Lab Sci Ruijin Hosp Shanghai 200025 Peoples R China Shanghai Second med univ Dept Microbiol Shanghai 200025 Peoples R China Shanghai Second med univ Dept Internal Med Ruijin Hosp Shanghai 200025 Peoples R China

AIM To investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic *** After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (TNF-a, IFN--y ) and mice mortalitywithin 24h was ***’LTS The SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were *** Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. The effects induced bySEB and D--GaiN on hepatocytes might bemediated by T cells, and could be prevented bycyclosporin A.

关键词： SEB CSA Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN

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Chemical composition, nutritional values, elemental analysis and biological properties of Prunus mahaleb L.: From waste to new potential sources for food, cosmetic and drug industry

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FOOD BIOSCIENCE 2023年第3期53卷 3189-3196页

作者： Guven, Zuhal Bayrakceken Alshehri, Osama Yuce, Neslihan Bakan, Ebubekir Demirci, Betul Yilmaz, Mustafa Abdullah Ertas, Abdulselam Basaran, A. Ahmet Hacettepe univ Fac Pharm Dept Pharmacognosy Ankara Turkiye Saudi FDA Nafal Unit 1 N Ring Rd Al Riyadh 03292 Saudi Arabia Ataturk univ Fac Med Dept Biochem Erzurum Turkiye Anadolu univ Fac Pharm Dept Pharmacognosy Eskisehir Turkiye Dicle univ Fac Pharm Dept Analyt Chem Diyarbakir Turkiye Baskent univ Fac Pharm Dept Pharmacognosy Ankara Turkiye Erzincan Binali Yildirim univ Fac Pharm Dept Pharmacognosy Erzincan Turkiye

Prunus mahaleb L. seeds are widely used in the baking industry as spice for flavouring. While achieving the mahaleb powder for commercial use in local companies, the seeds are sometimes mixed unintentionally with their kernels (stony shell) during sieving procedure. As the chemical and biological properties of the kernel of seeds are not well known, the kernel, seeds and the market sample obtained from a local supplier are decided to investigate individually. The antioxidant capacity and the trace element analyses of the seeds and kernels were performed by TEAC and CUPRAC assays and ICP-MS. The market sample was analysed for nutrient and oil composition. Fatty acid composition of the oil was determined with GC-FID and GC-MS methods. The chemical composition of the methanol extract of the seeds and kernels was studied by LC-MS/MS. Trace elements Mn, Co, Ni, Cu, Zn and Se were determined in the methanol extracts, ethyl acetate and water fractions. Mushroom tyrosinase enzyme inhibitions of 33 different extracts and fractions of various waste parts of the plant (kernel, fruit, twigs, flos, leaves) were investigated. The nutritional values showed that the market sample had high nutritious properties. The fatty acid content of the oil was found to be valuable in remedying dysfunctions of the body. Kernel ethylacetate fraction showed the highest tyrosinase enzyme inhibition. The role of copper element on enzyme activity was determined. The kernels are accepted as a waste material may also be evaluated as a good promising choice for food, cosmetic and drug industry.

关键词： Prunus mahaleb L seeds Kernels Tyrosinase Trace elements Nutritional value Fatty acid content

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