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Autonomic and sensory nerve dysfunction in primary biliary cirrhosis

中国医师协会内镜医师分会成立大会、中国第十四届内镜医学学术大会、《中国内镜杂志》创刊十周年学术讨论会、恩德思奖（Endoscopics Award）颁奖大会

作者： Paulo M.Hoff facp assoclate professor of medicine md

关键词：结肠癌 FOLFOX FOLFIRI

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World Journal of Gastroenterology 2004年第20期10卷 3039-3043页

作者： Katalin Keresztes lldikó Istenes Aniko Folhoffer Peter L Lakatos Andrea Horvath Timea Csak Peter Varga Peter Kempler Ferenc Szalay Ist Department of medicine Semmelweis UniversityBudapestHungary Ist Department of medicine Semmelweis UniversityBudapestHungary Professor MDPhD

AIM:Cardiovascular autonomic and peripheral sensoryneuropathy is a known complication of chronic alcoholicand non-alcoholic liver *** aimed to assess theprevalence and risk factors for peripheral sensory nerveand autonomic dysfunction using sensitive methods inpatients with primary biliary cirrhosis (PBC).METHODS:Twenty-four AMA M2 positive female patientswith clinical,biochemical and histological evidence of PBCand 20 age matched healthy female subjects were *** standard cardiovascular reflex tests and 2d-h heartrate variability(HRV)analysis were performed to defineautonomic *** sensory nerve function onmedian and peroneal nerves was characterized by currentperception threshold(CPT),measured by a neuroselectivediagnostic stimulator(Neurotron,Baltimore,md).RESULTS:Fourteen of 24 patients(58%)had at least oneabnormal cardiovascular reflex test and thirteen(54%)had peripheral sensory *** heart rateresponse to deep breathing(P=0.001),standing(P=0.03)and Valsalva manoeuvre(P=0.01),and more profounddecrease of blood pressure after standing(P=0.03)wasfound in PBC patients than in *** a novel findingwe proved that both time domain and frequency domainparameters of 24-h HRV were significantly reduced in PBCpatients compared to *** patient had at leastone abnormal parameter of *** CPT values indicatedhyperaesthesia as a characteristic feature at peronealnerve testing at three frequencies(2000 Hz:P=0.005;250 Hz:P=0.002;5 Hz:P=0.004)in PBC compared *** of autonomic dysfunction with theseverity and duration of the disease was *** power of HRV correlated with lower CPT values atmedian nerve testing at 250 Hz(P=0.0001)and at 5 Hz(P=0.002),as well as with those at peroneal nerve testingat 2000 Hz(P=0.01).CONCLUSION:Autonomic and sensory nerve dysfunctionsare frequent in ***-four-hour HRV analysis is moresensitive than standard cardiovascular tests for detectingof both pa

关键词： Aged Autonomic Nervous System Diseases Cross-Sectional Studies Female Humans Liver Cirrhosis, Biliary Median Nerve Middle Aged Peripheral Nervous System Diseases Sensory Thresholds

Changing face of irritable bowel syndrome

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World Journal of Gastroenterology 2006年第1期12卷 1-5页

作者： Eamonn MM Quigley md FACGProfessor of Medicine and Human PhysiologyHead of the Medical SchoolNational University of Ireland CorkIreland

Recent years have witnessed tremendous progress in our understanding of irritable bowel syndrome （IBS）. It is evident that this is a truly global disease associated with significant symptoms and impairments in personal and social functioning for afflicted individuals. Advances in our understanding of gut flora-mucosal interactions, the enteric nervous system and the brain-gut axis have led to substantial progress in the pathogenesis of symptoms in IBS and have provided some hints towards the basic etiology of this disorder, in some subpopulations, at the very least. We look forward to a time when therapy will be addressed to pathophysiology and perhaps, even to primary etiology. In the meantime, a model based on a primary role for intestinal inflammation serves to integrate the various strands, which contribute to the presentation of IBS

关键词： Irritable bowel syndrome Functional gastrointestinal disease Intestinal inflammation

Introducing the Concept of Blood Stasis Pattern to Modern Healthcare Based on the Biomedical Model:Some Strategic Considerations.

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Introducing the Concept of Blood Stasis Pattern to Modern He...

Cell Therapy: Pharmacological Intervention Enters a Third Era

第六次全国中西医结合血瘀证及活血化瘀研究学术大会

作者： Ka-Kit Hui md FACPCenterforEast-WestMedicineDepartmentofMedicineDavidGeffenSchoolofMedicineUCLA

The increased popularity of complementary and alternative medicine (CAM), of which Traditional Chinese medicine (TCM) is the most commonly used, is also indicative of Americans’ increased interest in wellness and more personal control over one’ s own health. However, most of health professionals focus more on TCM modalities, such as acupuncture, massage and herbal medicine rather than one of the core concepts of TCM: Zheng (pathophysiological pattern). The research on Blood Stasis (BS) pattern is one of the most active academic fields of integrative medicine in China. Introducing this pattern to the biomedical establishment is conducive to promoting better understanding of TCM and facilitates the marketing of traditional Chinese drugs (TCD). Suggested strategies include:

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Engineering 2019年第1期5卷 5-9页

作者： Wei He professor MD Chairman of the Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College China

On August 30, 2017, the US Food and Drug Administration (FDA) released a news statement on its website titled ‘‘FDA approval brings first gene therapy to the United States”[1]. The article disclosed the use of FDA-approved Kymriah (tisagenlecleucel), a cell-based gene therapy developed by Novartis Pharmaceuticals Corporation, for certain pediatric and young adult patients with refractory or relapse acute lymphoblastic leukemia (ALL). ALL is a cancer of the bone marrow and blood, which progresses quickly and is the most common childhood cancer in the United States. Kymriah, which is a genetically modified autologous T cell immunotherapy, is approved for use in those up to 25 years of age with B cell precursor ALL. The individual patient’s own T cells are genetically modified with a new gene that contains a specific protein (chimeric antigen receptor, CAR) directing the T cells to target and kill leukemia cells with a specific antigen (cluster of differentiation 19, i.e. CD19) on the surface. In fact, Kymriah represents a kind of adoptive cellular immunotherapy using geneengineered T cells.“We’re entering a new frontier in medical innovation with the ability to reprogram a patient’s own cells to attack a deadly cancer,” said FDA Commissioner Scott Gottlieb, md. From a historic point of view, cell therapy—or, more accurately, cellbased gene therapy—represents an important marker indicating that pharmacological disease intervention has entered a new era. The first era of disease intervention by drugs was based on chemical medicine, and the second era was based on biological drugs. Now the third era has arrived: cell therapy. This article outlines the historical progress and characteristics of three eras of pharmacological disease intervention, and analyzes the prospects for cell therapy.

关键词： Drug Administration Pharmaceuticals Corporation historical progress

普通内科与三级学科及初级医疗的关系(英文)

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普通内科与三级学科及初级医疗的关系(英文)

Strongyloides hyper-infection causing life-threatening gastrointestinal bleeding

中华医学会第11届全国内科学术会议

作者： Hans P．Kohler md facp professor of medicine Secretary GeneralInternational Society of Internal Medicine

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World Journal of Gastroenterology 2006年第39期12卷 6401-6404页

作者： Lajos Csermely Hassan Jaafar Jorgen Kristensen Antonio Castella Waldemar Gorka Ahmed Ali Chebli Fawaz Trab Hussain Alizadeh Béla Hunyady County Hospital Zalaegerszeg Hungary Tawam Hospital Al-Ain Abu Dhabi United Arab Emirates First Department of medicine University of Pécs Hungary Correspondence to: Professor Béla Hunyady MD PhD DSc

A 55-year old male patient was diagnosed with strongy- loides hyper-infection with stool analysis and intestinal biopsy shortly after his chemotherapy for myeloma. He was commenced on albendazole anthelmintic therapy. After initiation of the treatment he suffered life- threatening gastrointestinal (GI) bleeding. Repeated endoscopies showed diffuse multi-focal intestinal bleeding. The patient required huge amounts of red blood cells and plasma transfusions and correction of haemostasis with recombinant activated factor Ⅶ. Abdominal aorto-angiography showed numerous micro- aneurysms (‘berry aneurysms’) in the superior and inferior mesenteric arteries’ territories. While the biopsy taken prior to the treatment with albendazole did not show evidence of vasculitis, the biopsy taken after initiation of therapy revealed leukoclastic aggregations around the vessels. These findings suggest that, in addition to direct destruction of the mucosa, vasculitis could be an important additive factor causing the massive GI bleeding during the anthelmintic treatment. This might result from substances released by the worms that have been killed with anthelmintic therapy. Current guidelines advise steroids to be tapered and stopped in case of systematic parasitic infections as they might reduce immunity and precipitate parasitic hyper-infection. In our opinion, steroid therapy might be of value in the management of strongyloides hyper- infection related vasculitis, in addition to the anthelmintic treatment. Indeed, steroid therapy of vasculitis with other means of supportive care resulted in cessation of the bleeding and recovery of the patient.

关键词： Myeloma Immunosuppression Strongyloides stercoralis Exudative enteropathy Gastrointestinal bleeding Vasculitis

Targeted therapy in non-small cell lung cancer

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中国肺癌杂志 2004年第4期7卷 284-289页

作者： Shou-Ching Tang Solid Tumor Oncology University of Miami Sylvester Comprehensive Cancer Center Associate Professor of Medicine Division of Hematology and Oncology University of Miami MD PhD FACP FRCPC

1 IntroductionRecent progress in molecular biology has enabled us to better understand the molecular mechanism underlying pathogenesis of human malignancy including lung cancer. Sequencing of human genome has identified many oncogenes and tumor suppressor genes,giving us a better understanding of the molecular events leading to the formation, progression, metastasis, and the development of drug resistance in human lung cancer. In addition, many signal transduction pathways have been discovered that play important roles in lung cancer. Novel strategy of anti-cancer drug development now involves the identification and development of targeted therapy that interrupts one or more than one pathways or cross-talk among different signal transduction pathways. In addition, efforts are underway that combine the traditional cytotoxic (non-targeted) agents with the biological (targeted) therapy to increase the response rate and survival in patients with lung cancer, especially advanced non-small cell lung cancer (NSCLC).

关键词：非小细胞肺癌肿瘤靶向治疗 EGFR 生物学

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Introduction

Journal of Geriatric Cardiology 2005年第2期2卷 66-67页

作者： Brian Olshansky md Guest Editor professor of medicine Director of Electrophysiology Iowa University Medical Center The University of Iowa Iowa City IA

　　It is a great honor to introduce the first arrhythmia issue of the Journal of Geriatric Cardiology. One goal of this Issue is to encourage discourse between East and West and to provide contrasts in management philosophies. The contributors representing some of the prominent in their field from the East and from the West do just this. Several contributors from the West have had prior experience in the East so they can understand cultural difference that might affect medical management approaches.……

关键词： honor encourage representing arrhythmia discourse prior overview Introduction fibrillation dissemination

How To Become A Model Center of Medical Rehabilitation--The Experience of the Kessler Institute for Rehabilitation

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中国康复医学杂志 2013年第6期28卷 487-488页

作者： Joel A. DeLisa md, MSI professor Emeritus Department of Physical Medicine and Rehabilitation University of Medicine & Dentistry of New Jersey-New Jersey Medical School

In this article I will describe a model medical rehabilitation center in the United States based on my experience as the Medical Director of the Kessler Institute for Rehabilitation (KIR) located in West Orange, New *... 详细信息

关键词：医疗康复美国医疗卫生行业患者护理