检索结果-南通市图书馆

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hemoglobin induces colon cancer cell proliferation by release of reactive oxygen species

引用

World Journal of Gastroenterology 2006年第35期12卷 5644-5650页

作者： Ryung-Ah Lee Hyun-Ah Kim Bo-Young Kang Kwang-Ho Kim ewha Medical Institute Department of Surgery College of Medicine Ewha Womans University Seoul Korea Department of Surgery College of Medicine Ewha Womans University Seoul Korea ewha Medical Institute Ewha Womans University Seoul Korea

AIM: To study whether hemoglobin could amplify colon cancer cell proliferation via reactive oxygen species (ROS) production. METHODS: Colon cancer cell line HT-29 was grown in the conventional method using RPMI1640 media. The viability of the cells was measured using the colorimetric MTT [3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazo- lium bromide] assay after adding hemoglobin. We de- termined reactive oxygen species levels to be indicators of oxidative stress in HT 29 cell lines with and without hemoglobin and/or 5-fluorouracil (5-FU), 5’-deoxy-5-flu- orouridine (5-DFUR) using fluorometric dichlorofluorescin diacetate (DCFH-DA) assay. RESULTS: Cellular proliferation was increased with he- moglobin in a concentration-dependent manner. A signif- icant increment on ROS levels was found in HT 29 cells following hemoglobin incubation. The cytotoxic effects of 5-FU and 5-DFUR were significantly blunted by admin- istration of hemoglobin. There was a slight increase of peroxiredoxin 1, superoxide dismutase 1 concentration according to different hemoglobin concentrations. CONCLUSION: Hemoglobin has a cellular proliferative effect on HT-29 colon cancer cell line by production of ROS. Also, hemoglobin abates cytotoxic effects of che- motherapeutic agents such as 5-FU and 5-DFUR.

关键词： Colon cancer Hemoglobin Reactive oxygen species

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Finite Group Action and Gromov-Witten Invariants in Symplectic Four-Manifolds

引用

Acta Mathematica Sinica,English Series 2010年第12期26卷 2325-2334页

作者： Yong Seung CHO Department of Mathematics Ewha Womans University

Let a finite group act semi-freely on a closed symplectic four-manifold with a 2-dimensional fixed point set. Then we show that the relative Gromov-Witten invariants are the same as the invariants on the quotient set-... 详细信息

关键词： Finite group action Gromov-Witten invariant symplectic four-manifold

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel AIE-NIR-II nano-contrast agent for monitoring and evaluating kidney transplant

引用

National Science Review 2024年第4期11卷 15-16页

作者： Yuan-Yuan Zhao Bokyeong Hwang Yeju Lee Juyoung Yoon Department of Chemistry and Nanoscience Ewha Womans University

Kidney transplantation is a life-saving approach for treating end-stage renal diseases (ESRDs)[1]. However, the scarcity of donor kidneys has resulted in an increasing number of ESRD patients being stuck on the transp... 详细信息

关键词： agent kidney novel evaluating monitoring nano-contrast transplant

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

siRNA targeting Livin decreases tumor in a xenograft model for colon cancer

引用

World Journal of Gastroenterology 2011年第20期17卷 2563-2571页

作者： Bo-Young Oh Ryung-Ah Lee Kwang Ho Kim Department of Surgery Ewha Womans University School of Medicine

AIM： To evaluate the effect of silencing Livin gene expression with siRNA to apoptosis and proliferation in a colon cancer cell line. METHODS： To investigate the anticancer effect of silencing Livin gene expression, we established an siRNA transfected cell line using the HCT116 colon cancer cell line. After confirming the successful transfection, MTT assay, flow cytometry and annexin V staining were em- ployed to evaluate the antiapoptotic effect. To confirm the in vivo effect of Livin-siRNA, different doses of LivinsiRNA were injected into xenografted tumors in BALB/c nude mice model. RESULTS： Livin expression was dramatically decreased after siRNA transfection, especially at 25 umol/L of siRNA, but this suppression was not dose-dependent. The cell count at 18 h after transfection was significantly reduced as compared with controls （P 〈 0.01）, but tended not to decrease proportionally depending on transfected dose or time. MTT assay revealed that silencing the Livin gene suppressed cellular proliferation at 18 h after transfection （P = 0.04）; however, the inhibitory effect disappeared thereafter. Also, there was no significant difference in cellular proliferation depending on siRNA dose. The rate of apoptosis also increased with silencing of the Livin gene. In vivo, the tumor size significantly decreased after Livin- siRNA injection at 20 umol/L concentration （P = 0.03）. There were no significant body weight changes of mice after siRNA injection. Histologic examination revealed no significant toxic reaction in kidney, liver and brain of mice. CONCLUSION： siRNA-mediated downregulation of Livin expression can induce apoptosis in colon cancer in vitro and in vivo, which suggests the possibility of new cancer therapeutics using siRNA.

关键词： siRNA Livin Inhibitor of apoptosis Coloncancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis

引用

Cellular & Molecular Immunology 2019年第11期16卷 851-867页

作者： Yong-Bae Kim Young-Ho Ahn Ji-Hae Jung Ye-Ji Lee Jin-Hwa Lee Jihee Lee Kang Tissue Injury Defense Research Center College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Physiology College of MedicineEwha Womans UniversitySeoul 07804Korea Department of Internal Medicine College of MedicineEwha Womans UniversitySeoul 07804Korea

Apoptotic cell clearance by phagocytes is essential in tissue *** demonstrated that conditioned medium(CM)from macrophages exposed to apoptotic cancer cells inhibits the TGFβ1-induced epithelial–mesenchymal transition(EMT),migration,and invasion of cancer *** 344SQ(ApoSQ)cell-induced PPARγactivity in macrophages increased the levels of PTEN,which was secreted in *** PTEN was taken up by recipient lung cancer ***-exposed CM from PTEN knockdown cells failed to enhance PTEN in 344SQ cells,restore cellular polarity,or exert anti-EMT and anti-invasive *** CM that was deficient in PPARγligands,including 15-HETE,lipoxin A4,and 15d-PGJ2,could not reverse the suppression of PPARγactivity or the PTEN increase in 344SQ cells and consequently failed to prevent the EMT ***,a single injection of ApoSQ cells inhibited lung metastasis in syngeneic immunocompetent mice with enhanced PPARγ/PTEN signaling both in tumorassociated macrophages and in tumor ***γantagonist GW9662 reversed the signaling by PPARγ/PTEN;the reduction in EMT-activating transcription factors,such as Snai1 and Zeb1;and the antimetastatic effect of the ApoSQ ***,the injection of apoptotic lung cancer cells may offer a new strategy for the prevention of lung metastasis.

关键词： Apoptotic cell clearance EMT Metastasis Exosomal PTEN PPARγligands

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Learning feature alignment and dual correlation for few‐shot image classification

引用

CAAI Transactions on Intelligence Technology 2024年第2期9卷 303-318页

作者： Xilang Huang Seon Han Choi Department of Electronic and Electrical Engineering Ewha Womans UniversitySeoulSouth Korea Graduate Program in Smart Factory Ewha Womans UniversitySeoulSouth Korea

Few‐shot image classification is the task of classifying novel classes using extremely limited labelled *** perform classification using the limited samples,one solution is to learn the feature alignment(FA)information between the labelled and unlabelled sample *** FA methods use the feature mean as the class prototype and calculate the correlation between prototype and unlabelled features to learn an alignment ***,mean prototypes tend to degenerate informative features because spatial features at the same position may not be equally important for the final classification,leading to inaccurate correlation ***,the authors propose an effective intraclass FA strategy that aggregates semantically similar spatial features from an adaptive reference prototype in low‐dimensional feature space to obtain an informative prototype feature map for precise correlation ***,a dual correlation module to learn the hard and soft correlations was developed by the *** module combines the correlation information between the prototype and unlabelled features in both the original and learnable feature spaces,aiming to produce a comprehensive cross‐correlation between the prototypes and unlabelled *** both FA and cross‐attention modules,our model can maintain informative class features and capture important shared features for *** results on three few‐shot classification benchmarks show that the proposed method outperformed related methods and resulted in a 3%performance boost in the 1‐shot setting by inserting the proposed module into the related methods.

关键词： image classification machine learning metric learning

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner

引用

Cellular & Molecular Immunology 2017年第11期14卷 895-908页

作者： Kyung-Ah Cho Jun-Kyu Lee Yu-Hee Kim Minhwa Park So-Youn Woo Kyung-Ha Ryu Department of Microbiology School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea Department of Pediatrics School of MedicineEwha Womans UniversitySeoul 07985Republic of Korea

Effector B cells are central contributors to the development of autoimmune disease by activating autoreactive T cells,producing pro-inflammatory cytokines and organizing ectopic lymphoid ***,IL-10-producing regulatory B(Breg)cells have pivotal roles in maintaining immunological tolerance and restraining excessive inflammation in autoinflammatory ***,regulating the equilibrium between antibody-producing effector B cells and Breg cells is critical for the treatment of autoimmune *** this study,we investigated the effect of human palatine tonsil-derived mesenchymal stem cells(T-MSCs)on estradiol(E2)-induced B-cell responses in vivo and in *** of T-MSC into E2-treated mice alleviated B-cell-mediated immune responses and increased the population of IL-10-producing Breg cells.T-MSCs regulated the B-cell populations by producing Epstein–Barr virus(EBV)-induced 3(EBI3),one of the two subunits of IL-35 that is the well-known inducer of Breg *** demonstrate a critical role of EBI3(IL-35)in vitro by depleting EBI3 in T-MSCs and by adding exogenous IL-35 to the culture *** together,our data suggest that IL-35-secreting MSCs may become an attractive therapeutic to treat B-cell-mediated autoimmune diseases via expanding Breg cells.

关键词： autoimmune disease B cells IL-35 mesenchymal stem cells

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combined silicosis and mixed dust pneumoconiosis with rapid progression: A case report and literature review

引用

World Journal of Clinical Cases 2018年第16期6卷 1164-1168页

作者： Hee-Young Yoon Yookyung Kim Heae Surng Park Chung-Won Kang Yon Ju Ryu Division of Pulmonary and Critical Care Medicine Department of Internal Medicine College of Medicine Ewha Womans University Department of Radiology Ewha Womans University College of Medicine Department of Pathology Ewha Womans University College of Medicine Department of Occupational and Environmental Medicine Ewha Womans University College of Medicine

BACKGROUND Rapidly progressive pneumoconiosis(RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP. CASE SUMMARY The patient had a persistent cough for one month and had been clinically diagnosed with pulmonary tuberculosis in 2011. He worked in a stone processing factory from the ages of 20 through 37 and has owned his own mill for the past 25 years. His chest radiograph showed significant increases in the size and number of lung nodules since his last follow-up in 2013. By percutaneous needle lung biopsy, the nodular lesions showed diffuse infiltration of phagocytic macrophages and birefringent crystals by polarizing microscopy. He was finally diagnosed with RPP of mixed dust pneumoconiosis combined with silicosis. CONCLUSION In this case, mixed dust pneumoconiosis with silicosis might be accelerated by persistent exposure to graindust from working in a mill environment.

关键词： Pathology Case report Pneumoconiosis Silicosis Dust Occupational diseases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

引用

Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐Ji Lee Sieun Lee Sung Yong Ahn Young‐Ho Ahn Jihee Lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：