Combined silicosis and mixed dust pneumoconiosis with rapid progression: A case report and literature review

作     者：Hee-Young Yoon Yookyung Kim Heae Surng Park Chung-Won Kang Yon Ju Ryu 

作者机构：Division of Pulmonary and Critical Care Medicine Department of Internal Medicine College of Medicine Ewha Womans University Department of Radiology Ewha Womans University College of Medicine Department of Pathology Ewha Womans University College of Medicine Department of Occupational and Environmental Medicine Ewha Womans University College of Medicine 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2018年第6卷第16期

页      面：1164-1168页

核心收录：

学科分类：10[医学] 

主　　题：Pathology Case report Pneumoconiosis Silicosis Dust Occupational diseases 

摘      要：BACKGROUND Rapidly progressive pneumoconiosis(RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP. CASE SUMMARY The patient had a persistent cough for one month and had been clinically diagnosed with pulmonary tuberculosis in 2011. He worked in a stone processing factory from the ages of 20 through 37 and has owned his own mill for the past 25 years. His chest radiograph showed significant increases in the size and number of lung nodules since his last follow-up in 2013. By percutaneous needle lung biopsy, the nodular lesions showed diffuse infiltration of phagocytic macrophages and birefringent crystals by polarizing microscopy. He was finally diagnosed with RPP of mixed dust pneumoconiosis combined with silicosis. CONCLUSION In this case, mixed dust pneumoconiosis with silicosis might be accelerated by persistent exposure to graindust from working in a mill environment.