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Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with Pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study

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Frontiers of Medicine 2022年第5期16卷 736-744页

作者： Jiansheng Li Hulei Zhao Yang Xie Jieya Li Qingwei Li Xuexin Chen Weiyu Zhang Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province&Education Ministry of China Henan University of Chinese MedicineZhengzhou 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Disease Henan University of Chinese MedicineZhengzhou 450046China Department of Respiratory Diseases The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 450000China Department of Pneumoconiosis Henan Hospital for Occupational DiseasesZhengzhou 450052China Department of Respiratory Diseases Jiaozuo Coal Industry Group Co.Ltd.Central HospitalJiaozuo 454000China Department of Pneumoconiosis Yima Coal Industry Group Co.Ltd.General HospitalYima 472300China

Effective therapy options for Pneumoconiosis are lacking.Traditional Chinese medicine(TCM)presents a favorable prospect in the treatment of Pneumoconiosis.A pilot study on TCM syndrome differentiation can evaluate the clinical efficacy and safety of TCM and lay a foundation for further clinical research.A double-blind,randomized,and placebo-controlled trial was conducted for 24 weeks,in which 96 patients with Pneumoconiosis were randomly divided into the control and treatment groups.Symptomatic treatment was conducted for the two groups.The treatment group was treated with TCM syndrome differentiation,and the control group was treated with placebo.The primary outcomes were the six-minute walking distance(6MWD)and the St.George Respiratory Questionnaire(SGRQ)score.The secondary outcomes were the modified British Medical Research Council Dyspnea Scale(mMRC),Chronic Obstructive Pulmonary Disease Assessment Test(CAT),Hospital Anxiety and Depression Scale(HADS),and pulmonary function.Only 83 patients from the 96 patients with Pneumoconiosis finished the study.For the primary outcome,compared with the control groups,the treatment group showed a significantly increased 6MWD(407.90 m vs.499.51 m;95%confidence interval(CI)47.25 to 135.97;PPneumoconiosis.

关键词： Pneumoconiosis randomized controlled trials traditional Chinese medicine

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Epidemiological characteristics of pulmonary tuberculosis in patients with Pneumoconiosis based on its social determinants and risk factors in China:a cross-sectional study from 27 provinces

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Chinese Medical Journal 2022年第24期135卷 2984-2997页

作者： Huanqiang Wang Huaping Dai Jiayu He Xiangpei Lyu Xinran Zhang Tao Li Department of Occupational Respiratory Disease National Institute for Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China National Center for Respiratory Medicine National Clinical Research Center for Respiratory DiseasesInstitute of Respiratory MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100029China Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China Department of Clinical Research and Data Management Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background:Patients with Pneumoconiosis have an elevated risk of contracting pulmonary tuberculosis(PTB)and need particular attention.However,extensive population-based studies on the prevalence of PTB in patients with Pneumoconiosis have not been reported in China since 1992.This study aimed to investigate the epidemiological characteristics of PTB in patients with Pneumoconiosis based on its social determinants and risk factors in China.Methods:Based on the Commission on Social Determinants of Health(CSDH)framework,data were obtained from a questionnaire survey of patients with Pneumoconiosis from China’s 27 provinces(autonomous regions,municipalities)from December 2017 to June 2021.By chi-square and multivariate logistic regression analyses,the epidemiological characteristics of PTB in the patients were identified based on its prevalence and odds ratio(OR)and associated social determinants and risk factors.The population attributable fractions(PAFs)of significant risk factors were also calculated.Results:The prevalence of PTB in patients with Pneumoconiosis(n=10,137)was 7.5%(95%confidence interval[CI]:7.0-8.0%).Multivariate logistic regression analysis showed that risk factors included in-hospital exposure to patients with PTB(OR=3.30,95%CI:2.77-3.93),clinically diagnosed cases(OR=3.25,95%CI:2.42-4.34),and northeastern regions(OR=2.41,95%CI:1.76-3.31).In addition,lack of work-related injury insurance(WRII),being born in a rural area,being unemployed,living in western regions,household exposure to patients with PTB,smoking,being underweight,complications of pulmonary bullae or pneumothorax,hospitalization history,and former drinkers among the rural patients were also statistically significant risk factors.Being born in a rural area,lack of WRII and in-hospital exposure to patients with PTB had higher PAFs,which were 13.2%(95%CI:7.9-18.5%),12.5%(95%CI:8.3-16.7%),and 11.6%(95%CI:8.8-14.3%),respectively.Conclusion:The prevalence of PTB in Pneumoconiosis remains high in China;it is basically in line with the CSDH m

关键词： Pulmonary tuberculosis Pneumoconiosis Social determinants Risk factors

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Pneumoconiosis: current status and future prospects

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Chinese Medical Journal 2021年第8期134卷 898-907页

作者： Xian-Mei Qi Ya Luo Mei-Yue Song Ying Liu Ting Shu Ying Liu Jun-Ling Pang Jing Wang Chen Wang Department of Pathophysiology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Beijing University of Chinese Medicine Beijing 100029China Department of Physiology State Key Laboratory of Medical Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

Pneumoconiosis refers to a spectrum of pulmonary diseases caused by inhalation of mineral dust,usually as the result of certain occupations.The main pathological features include chronic pulmonary inflammation and progressive pulmonary fibrosis,which can eventually lead to death caused by respiratory and/or heart failure.Pneumoconiosis is widespread globally,seriously threatening global public health.Its high incidence and mortality lie in improper occupational protection,and in the lack of early diagnostic methods and effective treatments.This article reviews the epidemiology,safeguard procedures,diagnosis,and treatment of Pneumoconiosis,and summarizes recent research advances and future research prospects.

关键词： Pneumoconiosis Epidemiology Diagnosis Treatment Emerging technologies

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Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006–2015

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Biomedical and Environmental Sciences 2020年第3期33卷 191-195页

作者： LI Xu Dong TU Hong Wei LIU Yi Ming WEN Xian Zhong YU Hong Wei QU Hong Ying CHEN Qing Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515GuangdongChina Guangdong Province Hospital for Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina Guangodng Provincial Center for Diseases Control and Prevention Guangzhou 511430GuangdongChina Guangzhou No.12 Hospital Guangzhou 510620GuangdongChina Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment Guangzhou 510300GuangdongChina

Pneumoconiosis is a restrictive lung disease mostly caused by occupational exposure to dust,including silica dust,asbestos,and other fibers.Inhalable particles smaller than 10μm can enter the bronchioles,injure lung ... 详细信息

关键词： Spatial and Temporal Variations of Pneumoconiosis in the Pearl River Delta Region in 2006 Delta

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Association between Genetic Variants of Transforming Growth Factor-β1 and Susceptibility of Pneumoconiosis： A Meta-analysis

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Chinese Medical Journal 2017年第3期130卷 357-364页

作者： Chang-Wen Deng Xing-Xing Zhang Jin-Huan Lin Li-Fei Huang Yu-Lan Qu Chong Bai Department of Respiratory and Critical Care Medicine Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Cell Biology and Stem Cell Research Center School of Basic Medical Sciences Peking University Health Science Center Beijing 100191 China Department of Gastroenterology Changhai Hospital The Second Military Medical University Shanghai 200433 China Department of Respiratory Haining People's Hospital Jiaxing Zhejiang 314400 China

Background： Transforming growth factor-beta 1 （TGF-β 1） and gene variants have been extensively studied in various human diseases. For example, TGF-β1 polymorphisms were associated with fibrosis and Pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-β1-509 C〉T [rs 1800469], ＋869 T〉C [rs 1800470], and ＋915 G〉C [rs 1800471 ] polymorphisms and Pneumoconiosis, Methods： A comprehensive literature search was conducted through searching in PubMed, Embase, the Chinese Biomedical Database, and the Wei Pu （Chinese） Database by the end of April 2016. Eleven publications with 21 studies were included in this recta-analysis, covering a total of 4333 patients with Pneumoconiosis and 3478 controls. Study quality was assessed, and heterogeneity and publication bias were measured. All statistical analyses were performed using STATA version 12.0 （StataCorp, College Station, TX, USA） software. Results： The data showed significant associations between TGF-β1-509 C〉T polymorphism and the risk ofPneumoconiosis development （T vs. C, odds ratio [OR] = 1.35, 95% confidence interval [CI]： 1.00-1.81, P = 0.046）; between TGF-fll ＋915 G〉C polymorphism and the Pneumoconiosis risk （C vs. G, OR = 1.69, 95% CI： 1.19-2.40, P = 0.004; CG vs. GG, OR = 1.79, 95% CI： 1.23-2.60, P = 0.002; CC＋CG vs. GG, OR = 1.80, 95% CI： 1.24-2.61, P = 0.002）. In addition, the subgroup analysis of ethnicity versus Pneumoconiosis types indicated a significant association of silicosis among Asian populations but not that of coal workers＇ Pneumoconiosis in Caucasian populations. In contrast, no significant association was exhibited between TGF-β1 ＋869 T〉C polymorphism and risk ofPneumoconiosis. Conclusion： The polymorphisms of both TGF-β1 -509 C〉T and ＋915 G〉C are associated with increased risk of Pneumoconiosis. Key words： Meta analysis; Pneumoconiosis; Polymorphism; Transforming Growth Factor-betal

关键词： Meta analysis Pneumoconiosis Polymorphism Transforming Growth Factor-betal

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Combined silicosis and mixed dust Pneumoconiosis with rapid progression: A case report and literature review

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World Journal of Clinical Cases 2018年第16期6卷 1164-1168页

作者： Hee-Young Yoon Yookyung Kim Heae Surng Park Chung-Won Kang Yon Ju Ryu Division of Pulmonary and Critical Care Medicine Department of Internal Medicine College of Medicine Ewha Womans University Department of Radiology Ewha Womans University College of Medicine Department of Pathology Ewha Womans University College of Medicine Department of Occupational and Environmental Medicine Ewha Womans University College of Medicine

BACKGROUND Rapidly progressive Pneumoconiosis(RPP) occasionally occurs in coal workers, particularly those with high exposure to silica. Here, we report the case of a 64-year-old male miller with RPP. CASE SUMMARY The patient had a persistent cough for one month and had been clinically diagnosed with pulmonary tuberculosis in 2011. He worked in a stone processing factory from the ages of 20 through 37 and has owned his own mill for the past 25 years. His chest radiograph showed significant increases in the size and number of lung nodules since his last follow-up in 2013. By percutaneous needle lung biopsy, the nodular lesions showed diffuse infiltration of phagocytic macrophages and birefringent crystals by polarizing microscopy. He was finally diagnosed with RPP of mixed dust Pneumoconiosis combined with silicosis. CONCLUSION In this case, mixed dust Pneumoconiosis with silicosis might be accelerated by persistent exposure to graindust from working in a mill environment.

关键词： Pathology Case report Pneumoconiosis Silicosis Dust Occupational diseases

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Changes of Tumor Necrosis Factor, Surfactant Protein A, and Phospholipids in Bronchoalveolar Lavage Fluid in the Development and Progression of Coal Workers’ Pneumoconiosis

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Biomedical and Environmental Sciences 2006年第2期19卷 124-129页

作者： JING-CAI XING WEI-HONG CHEN WEN-HUI HAN MEI-FENG GUO STEFFENI REHN JOACHIM BRUCH Department of Occupanona ＆ Environmental Health School of Public Health Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030 Hubei China Institute of Hygiene and Occupational Medicine Medical School University of Essen Essen Germany The Central Hospital of Xishan Coal ＆ Power Company Shanxi China

Objective To evaluate the alterations of biomarkers in the development and progression of coal workers＇ Pneumoconiosis （CWP）. Methods The type and number of cells, and the levels of tumor necrosis factor-alpha （TNF-α）, pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. Results Compared to active coal miners without CWP （8,23μg/mL）, TNF-α concentration was gradually decreased when dust exposure was stopped （5.90 μg/mL）. Elevated surfactant protein A （SP-A） level and phosphatidylglycerol （PG） to phosphatidylinositol （PI） ratio were found in miners actively exposed to coal dust （6528 μg/mL for SP-A and 10. for PG/P1）, and both parameters decreased when CWP progressed from CWP （0/1）（3419μg/mL for SP-A and 5.9 for PG/PI） to CWP （1/1）（1654 μg/mL for SP-A and 5.5 for PG/PI）. Conclusion Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers＇ Pneumoconiosis.

关键词： Pneumoconiosis TNF-alpha Pulmonary surfactant-associated protein A Phospholipids

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合作治理视角下慈善组织参与尘肺病医疗救助模式研究

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社会保障制度 2019年第2期 73-86页

作者：何兰萍王晟昱傅利平

近年来，我国尘肺病的持续高发造成了严重的公共卫生问题和社会问题，需引起各方广泛关注。本研究旨在探索如何提高我国尘肺病防治及其困难群体救助水平，减少社会救助领域不平衡、不充分的因素。本文基于合作治理理论，利用统计分析法... 详细信息

近年来，我国尘肺病的持续高发造成了严重的公共卫生问题和社会问题，需引起各方广泛关注。本研究旨在探索如何提高我国尘肺病防治及其困难群体救助水平，减少社会救助领域不平衡、不充分的因素。本文基于合作治理理论，利用统计分析法摸清我国采矿业生产及职业病发病情况的特点，以参与尘肺病防治的典型慈善项目——D基金、Z基金会项目为研究对象，对其近年来工作成效及参与尘肺病医疗救助工作模式进行比较分析。研究发现：不同类型的慈善救助主体在救助模式上存在多方面的差异；慈善主体的资源整合水平有待提高，慈善救助资源分布不平衡，慈善主体间缺少横向沟通与合作，慈善救助与社会救助的衔接及合作不够充分。基于此，本文从构建和完善合作治理框架、合作网络、合作角色、合作桥梁四方面提出政策建议。

关键词：合作治理尘肺病慈善医疗救助 collaborative governance Pneumoconiosis charity medical assistance

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Epidemiology of coal miners’Pneumoconiosis and its social determinants:An ecological study from 1949 to 2021 in China

Chinese Medical Journal Pulmonary and Critical Care Medicine

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2023年第1期1卷 46-55页

作者： Huanqiang Wang Qiao Ye Yun Chen Tao Li Department of Occupational Respiratory Diseases National Institute of Occupational Health and Poison ControlChinese Center for Disease Control and PreventionBeijing 100050China Department of Occupational Medicine and Toxicology Clinical Center for Interstitial Lung DiseasesBeijing Institute of Respiratory MedicineBeijing Chao-Yang Hospital Capital Medical UniversityBeijing 100020China

Background:Pneumoconiosis is the most widely distributed occupational disease worldwide.China is currently the largest coal producer and consumer and the country with the most coal miners and cases of coal workers’Pneumoconiosis(CWP).Despite more than 70 years of effort,the problem of CWP and silicosis remains serious.There is a lack of analysis of direct data on coal miners’Pneumoconiosis from all over the country.This study aimed to describe the epidemiology of coal miners’Pneumoconiosis and reveal some important clues regarding its social determinants.Methods:The annual incidence rate,20-year prevalence rate,and incidence rate of coal miners’Pneumoconiosis per million tons in China from 1949 to 2021 were calculated by using the data of annual number of coal miners’Pneumoconiosis diagnosed and reported from the coal mining and dressing industry,the number of coal miners,and the raw coal production,and the relationship between the incident cases of coal miners’Pneumoconiosis and the death toll from coal mine safety accidents was analyzed using Pearson correlation analysis,with the aim of exploring the relationship between the incident cases of coal miners’Pneumoconiosis and its social determinants with an ecological study.Results:From 1949 to 2021,there have been more than 462,000 patients with coal miners’pneumoconio-sis in China,showing double U-shaped distributions with an increasing trend,accounting for about 50.5%(462,000/915,000)of all diagnosed Pneumoconiosis in China,while the incidencet rate of coal miners’pneu-moconiosis presents a large W shaped distribution with three peaks over a time span of more than 50 years.From 1949 to 1986,there was a strong correlation between the incident cases of coal miners’Pneumoconiosis and raw coal production,the number of coal miners,and the number of deaths from coal mine accidents(r=0.849,P<0.001;r=0.817,P<0.001;r=0.697,P<0.001,respectively),but there was no such correlation found from 1987 to 2006.It was estimated that the annual incidence rate of coal miners’pneumo

关键词： Miners Pneumoconiosis Social determinants of health(SDH) Risk factors

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Analysis of the prevalence and social security situation of Pneumoconiosis in non-coal mine industry in Jiangsu Province

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China Medical Abstracts(Internal Medicine) 2023年第3期40卷 144-144页

作者：赵圆 Occup Dis Prev&Contr Instit Jiangsu Prov Dis Contr&Prev CenterNanjing 21002

Objective To understand the social security situation of current cases of Pneumoconiosis in non-coal mine industries in Jiangsu Province,and to provide reference for the treatment and security work of Pneumoconiosis patients.Methods From January to October 2020,a follow-up survey was conducted on4038 cases of Pneumoconiosis in non-coal mine industries of the province from October 1949 to December 2019.

关键词： Jiangsu Pneumoconiosis security

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