Changes of Tumor Necrosis Factor, Surfactant Protein A, and Phospholipids in Bronchoalveolar Lavage Fluid in the Development and Progression of Coal Workers’ Pneumoconiosis

作     者：JING-CAI XING WEI-HONG CHEN WEN-HUI HAN MEI-FENG GUO STEFFENI REHN JOACHIM BRUCH JING-CAI XING*,?, WEI-HONG CHEN*’2, WEN-HUI HAN?, MEI-FENG GUO?, STEFFENI REHN#, AND JOACHIM BRUCH#*Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China;#Institute of Hygiene and Occupational Medicine, Medical School, University of Essen, Essen, Germany;?The Central Hospital of Xishan Coal & Power Company, Shanxi, China

作者机构：Department of Occupanona ＆ Environmental Health School of Public Health Tongji Medical CollegeHuazhong University of Science and Technology Wuhan 430030 Hubei China Institute of Hygiene and Occupational Medicine Medical School University of Essen Essen Germany The Central Hospital of Xishan Coal ＆ Power Company Shanxi China 

出 版 物：《Biomedical and Environmental Sciences》 (生物医学与环境科学（英文版）)

年 卷 期：2006年第19卷第2期

页      面：124-129页

核心收录：

学科分类：0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100402[医学-劳动卫生与环境卫生学] 10[医学] 

基　　金：This research was supported by University of Essen in Germany and Xishan Coal & Power Company 

主　　题：Pneumoconiosis TNF-alpha Pulmonary surfactant-associated protein A Phospholipids 

摘      要：Objective To evaluate the alterations of biomarkers in the development and progression of coal workers＇ pneumoconiosis （CWP）. Methods The type and number of cells, and the levels of tumor necrosis factor-alpha （TNF-α）, pulmonary surfactant protein, phospholipids and fibronectin in bronchoalveolar lavage fluid were assayed in 14 health active coal miners, 21 coal miners without CWP and 13 miners with CWP of 0/1 to 1/1. Results Compared to active coal miners without CWP （8,23μg/mL）, TNF-α concentration was gradually decreased when dust exposure was stopped （5.90 μg/mL）. Elevated surfactant protein A （SP-A） level and phosphatidylglycerol （PG） to phosphatidylinositol （PI） ratio were found in miners actively exposed to coal dust （6528 μg/mL for SP-A and 10. for PG/P1）, and both parameters decreased when CWP progressed from CWP （0/1） （3419μg/mL for SP-A and 5.9 for PG/PI） to CWP （1/1） （1654 μg/mL for SP-A and 5.5 for PG/PI）. Conclusion Biomarkers in bronchoalveolar lavage fluid can be used to screen coal miners at high risk of developing coal workers＇ pneumoconiosis.