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Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study

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Military Medical Research 2020年第2期7卷 157-165页

作者： Lan Wu Bing-Hui Li Yun-Yun Wang Chao-Yang Wang Hao Zi Hong Weng Qiao Huang You-Jia Zhu Xian-Tao Zeng Center for evidence-based and Translational medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China department of Stomatology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for evidence-based medicine Institute of Evidence-Based Medicine and Knowledge TranslationHenan UniversityKaifeng 475000China Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China

Background:Both periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people ***,this study aimed to investigate the association between periodontal disease and the risk of benign prostatic ***:A total of 4930 participants were selected from an available health examination that was carried out in 2017,only males were considered for further *** eligible males were divided into benign prostatic hyperplasia and normal groups,the benign prostatic hyperplasia group was then divided into prostate volume≤60 g and>60 g subgroups;all their periodontal status was extracted and then into normal(CPI score of 0),periodontal disease(CPI score between 1 and 4),and periodontitis(CPI score between 3 and 4)*** correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control *** analysis based on prostate volume was also *** analyses were conducted with SAS 9.4 ***:A total of 2171 males were selected for this *** presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times(OR=1.68,95%CI:1.26–2.24),and individuals with periodontitis showed a higher risk(OR=4.18,95%CI:2.75–6.35).In addition,among matched cases and controls,this association remained robust(periodontal disease:OR=1.85,95%CI:1.30–2.64;periodontitis:OR=4.83,95%CI:2.57–9.07).Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well(for prostate volume≤60 g:OR=1.64,95%CI:1.22–2.20;for volume>60 g:OR=2.17,95%CI:1.04–4.53),and there was a higher risk in the group with a prostate volume greater than 60 ***:Periodontal disease is significantly and positively associated with an increased risk of benign prostatic *** validation studies should be performed to explore the re

关键词： Benign prostate hyperplasia Periodontal disease Periodontitis Risk factor Inflammatory disease

Methodological quality(risk of bias) assessment tools for primary and secondary medical studies: What are they and which is better?

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Military Medical Research 2020年第3期7卷 359-370页

作者： Lin-Lu Ma Yun-Yun Wang Zhi-Hua Yang Di Huang Hong Weng Xian-Tao Zeng Center for evidence-based and Translational medicine Zhongnan HospitalWuhan University169 Donghu RoadWuchang DistrictWuhan 430071HubeiChina Department of evidence-based medicine and Clinical Epidemiology the Second Clinical CollegeWuhan UniversityWuhan 430071China Center for evidence-based and Translational medicine Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China

Methodological quality(risk of bias)assessment is an important step before study initiation ***,accurately judging study type is the first priority,and the choosing proper tool is also *** this review,we introduced methodological quality assessment tools for randomized controlled trial(including individual and cluster),animal study,non-randomized interventional studies(including follow-up study,controlled before-and-after study,before-after/pre-post study,uncontrolled longitudinal study,interrupted time series study),cohort study,case-control study,cross-sectional study(including analytical and descriptive),observational case series and case reports,comparative effectiveness research,diagnostic study,health economic evaluation,prediction study(including predictor finding study,prediction model impact study,prognostic prediction model study),qualitative study,outcome measurement instruments(including patient-reported outcome measure development,content validity,structural validity,internal consistency,cross-cultural validity/measurement invariance,reliability,measurement error,criterion validity,hypotheses testing for construct validity,and responsiveness),systematic review and meta-analysis,and clinical practice *** readers of our review can distinguish the types of medical studies and choose appropriate *** one word,comprehensively mastering relevant knowledge and implementing more practices are basic requirements for correctly assessing the methodological quality.

关键词： Methodological quality Risk of bias Quality assessment Critical appraisal Methodology checklist Appraisal tool Observational study Qualitative study Interventional study Outcome measurement instrument

Kangfuxin(Periplaneta americana)Lotion for Adjunctive Treatment of Ulcerative Colitis:A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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World Journal of Traditional Chinese medicine 2018年第3期4卷 77-84页

作者： Xin-Lin Li Ya-Jing Zhang Bao-Yong Lai Rui-Xue Hu Nan-Qi Zhao Mei Han Jian-Ping Liu Center for evidence based Chinese medicine Beijing University of Chinese Medicine

Objective: The objective of the study is to investigate the effect of Kangfuxin lotion as adjunctive therapy for treating ulcerative colitis(UC) through a systematic review and meta?analysis of randomized controlled trials(RCTs). Materials and Methods: RCTs comparing Kangfuxin lotion with no treatment, placebo, western medications or combination therapy for treatment of UC were included in this study. Two English and three Chinese electronic databases were searched. All searches ended in December 2017. Data and quality assessment carried out respectively. Rev Man 5.2 software(Copenhagen, The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) was used to analyze with effect estimate presented as mean difference(MD), risk ratio(RR) and 95% confidence interval(CI). Results: Fifteen trials with 1050 participants were included in this review. Overall, 13 trials were eligible for meta?analysis. Kangfuxin lotion combined with Mesalazine was better than Mesalazine on clinical cure rate(RR 1.45, 95% CI 1.24–1.70, 7 trials), recurrence rate of UC(RR 0.22, 95% CI 0.07–0.72, 2 trials), or endoscopic mucosal recovery(RR 8.05, 95% CI 2.64–24.57, 2 trials). And Kangfuxin lotion combined with triple live bacteria tablets(Bifidobacterium-Lactobacillus? Streptococcus thermophilus)was superior with regard to symptoms remission rate(RR 5.36, 95% CI 1.73–16.60, 3 trials), endoscopic disease activity score(MD-2.30, 95% CI-2.64–-1.96, 1 trial). There were no reports on the serious adverse events of Kangfuxin lotion. Conclusion: Kangfuxin lotion as adjunctive treatment appears more effective than medications alone on clinical cure rate, recurrence rate, endoscopic mucosal recovery and improvement rate of related symptoms.

关键词： Kangfuxin lotion meta-analysis randomized controlled trials systematic review ulcerative colitis

Treatment of Lung Cancer with Orally Administered Chinese Herbal medicine: An evidence Map between 1970–2020

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Chinese Journal of Integrative medicine 2022年第10期28卷 930-938页

作者： GUI Yue-rong ZHANG Ying WANG Xue-qian FAN Bing-jie LI Jing-lei ZHANG Lan-xin FAN Fen CAO Kang-di ZHANG Xiao-gang HOU Wei Department of Oncology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China Cancer Project team of China Center for evidence-based Traditional Chinese medicine Beijing(100053)China

Objective: Through showing the full picture of double-arm controlled clinical research and systematic review evidence in the field of orally administrated Chinese herbal medicine(CHM) for treatment of lung cancer, to provide a reference for future clinical research and to indicate a direction for future systematic reviews. Methods: A comprehensive search of clinical controlled studies was performed regarding orally administered CHM treatment for lung cancer published from January 1970 to September 2020. The language was restricted to Chinese and English. Relevant data were extracted, the quality of systematic reviews was evaluated, and the research evidence was visually displayed. Results: Randomized controlled trials were the most common type of research design. The research sample sizes were typically small. Oral CHM showed certain curative advantages in treating lung cancer. The key stages in oral CHM intervention for lung cancer are chemotherapy, radiotherapy, and late palliative treatment. The advantageous outcomes of oral CHM treatment of lung cancer are the short-term efficacy, quality of life, and adverse reactions. The perioperative stage, overall survival, pharmacoeconomic evaluation, and Chinese medicine decoctions are weak research areas. Conclusions: CHM has staged and therapeutic advantages in treating lung cancer. The overall methodological quality is poor, and the level of evidence requires improvement. It is necessary to carry out large-scale, standardized, and higherquality research in the superior and weak areas of CHM treatment of lung cancer.

关键词： Chinese medicine clinical study evidence map evidence visualization lung cancer

Research on the development methodology for clinical practice guidelines for organic integration of traditional Chinese medicine and Western medicine

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Military Medical Research 2024年第3期11卷 313-322页

作者： Ying-Hui Jin Yan-Ping Wang Ying-Lan Xie Gui-Hua Tian Xiao-Yu Zhang Nan-Nan Shi Ke-Hu Yang Xin Sun Yao-Long Chen Da-Rong Wu Xin-Feng Guo Long Ge Chen Zhao Cheng Lu Yin Jiang Jing Guo Si-Yu Yan Yong-Bo Wang Qiao Huang Xiang-Ying Ren Ying-Yue Rao Yun-Yun Wang Meng-Qian Yuan Xian-Tao Zeng Hong-Cai Shang Center for evidence-based and Translational medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Basic Research in Clinical medicine China Academy of Chinese Medical SciencesBeijing 100700China China Center for evidence based Traditional Chinese medicine Beijing 100029China Hubei Provincial Hospital of Traditional Chinese medicine Wuhan 430074China Key Laboratory of Chinese Internal medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China evidence-based medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China China Center for evidence-based medicine West China Hospital of Sichuan UniversityChengdu 610041China State Key Laboratory of Dampness Syndrome of Chinese medicine the Second Affliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120China evidence-based medicine team Guangdong Provincial Hospital of Traditional Chinese MedicineGuangzhou 510120China Nanjing University of Chinese medicine Nanjing 210023China Jiangsu Province Hospital of Chinese medicine Nanjing 210029China

Integrated traditional Chinese medicine(TCM)and Western medicine(WM)is a new medical science grounded in the knowledge bases of both TCM and WM,which then forms a unique modern medical system in *** TCM and WM has a long history in China,and has made important achievements in the process of clinical diagnosis and ***,the methodological defects in currently published clinical practice guidelines(CPGs)limit its *** organic integration of TCM and WM is a deeper integration of TCM and *** realize the progression of"integration"to"organic integration",a targeted and standardized guideline development methodology is ***,the purpose of this study is to establish a standardized development procedure for clinical practice guidelines for the organic integration of TCM and WM to promote the systematic integration of TCM and WM research results into clinical practice guidelines in order to achieve optimal results as the whole is greater than the sum of the parts.

关键词： Methodology Traditional Chinese medicine Western medicine Organic integration Clinical practice guidelines(CPGs)

Epidemiological trends of urinary tract infections,urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019

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Military Medical Research 2022年第4期9卷 432-443页

作者： Cong Zhu Dan-Qi Wang Hao Zi Qiao Huang Jia-Min Gu Lu-Yao Li Xing-Pei Guo Fei Li Cheng Fang Xiao-Dong Li Xian-Tao Zeng Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Center for evidence-based and Translational medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of evidence-based medicine and Clinical Epidemiology Second School of Clinical MedicineWuhan UniversityWuhan 430071China Institutes of evidence-based medicine and Knowledge Translation Henan UniversityKaifeng 475000HenanChina Department of Urology Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina

Background:Urinary tract infections(UTI),urolithiasis,and benign prostatic hyperplasia(BPH)are three of the most common nonmalignant conditions in ***,there is still a lack of comprehensive and updated epidemiological *** study aimed to investigate the disease burden of UTI,urolithiasis,and BPH in 203 countries and territories from 1990 to ***:Data were extracted from the Global Burden of Disease 2019,including incident cases,deaths,disabilityadjusted life-years(DALYs)and corresponding age-standardized rate(ASR)from 1990 to *** annual percentage changes(EAPC)were calculated to evaluate the trends of *** associations between disease burden and social development degrees were analyzed using a sociodemographic index(SDI).Results:Compared with 1990,the incident cases of UTI,urolithiasis,and BPH increased by 60.40%,48.57%,and 105.70%in 2019,*** age-standardized incidence rate(ASIR)of UTI increased(EAPC=0.08),while urolithiasis(EAPC=–0.83)and BPH(EAPC=–0.03)decreased from 1990 to *** 2019,the age-standardized mortality rate(ASMR)of UTI and urolithiasis were 3.13/100,000 and 0.17/100,000,*** had the largest increase(110.56%)in DALYs in the past three decades,followed by UTI(68.89%)and urolithiasis(16.95%).The burden of UTI was mainly concentrated in South Asia and Tropical Latin America,while the burden of urolithiasis and BPH was recorded in Asia and Eastern ***,the ASIR and SDI of urolithiasis in high-SDI regions from 1990to 2019 were negatively correlated,while the opposite trend was seen in low-SDI *** 2019,the ASIR of UTI in females was 3.59 times that of males,while the ASIR of urolithiasis in males was 1.96 times higher than that in *** incidence was highest in the 30–34,55–59,and 65–69 age groups among the UTI,urolithiasis,and BPH groups,***:Over the past three decades,the disease burden has increased for UTI but decreased for urolithiasis and BPH

关键词： Urinary tract infections Urolithiasis Benign prostatic hyperplasia Disease burden Incidence Mortality Disability-adjusted life-years

Risk assessment model for endpoints of ischemic stroke: A study protocol for a registry study

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Journal of Traditional Chinese medicine 2018年第6期38卷 936-942页

作者： Zhang Yin Liu Yue Wang Guiqian Sun Shuailing Gao Yang Xie Yanming Institute of Basic Research in Clinical medicine China Academy of Chinese Medical Sciences Center for evidence-based Chinese medicine School of Chinese Medicine Beijing University of Chinese Medicine

OBJECTIVE: To evaluate the risk of ischemic stroke endpoints by establishing risk assessment models that combine Traditional Chinese medicine(TCM)and modern medicine ***/DESIGN: The proposed study is a registry-based participant survey conducted in seven hospitals nationwide in China. After obtaining informed consent, 3000 patients diagnosed with ischemic stroke will be recruited. One-year follow-ups will be performed on-site in hospitals and by telephone to track endpoint events. Comparative analysis of the prevalence of endpoint events and other TCM or modern medicine features in different groups will be conducted using frequency analysis and χ2tests, and the results will be expressed as composition ratios. Comparative analysis of quantitative scores and related patterns or symptoms will be conducted using a rank-sum test. Correlation analysis of endpoint events and TCM or modern medicine factors will be performed using a multivariate Cox proportional hazard ***: Previous reports have described modern medicine indicator-based risk assessment models for ischemic stroke endpoint events, but no such studies have included TCM features. Our new risk assessment model combines TCM and modern medicine indicators and thus has the potential to facilitate early warning, early intervention, and early control of ischemic stroke endpoint events.

关键词： Stroke medicine,Chinese traditional Secondary prevention Endpoint determination Risk assessment Protocol Registry study

Retrieval,reporting and methodological characteristics for systematic reviews/meta-analyses of animal models:a meta-epidemiological study

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BIOCELL 2019年第4期43卷 233-251页

作者： SHUZHEN SHI MING LIU WENJUAN MA YA GAO LONG GE XIPING SHEN JIARUI WU JUNHUA ZHANG JINHUI TIAN evidence-based medicine Center School of Basic Medical SciencesLanzhou UniversityLanzhouChina Key Laboratory of evidence-based medicine and Knowledge Translation of Gansu Province LanzhouChina School of Public Health Lanzhou UniversityLanzhouChina Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina evidence-based medicine Center Tianjin University of Traditional Chinese MedicineTianjinChina

The study aimed to analyze the reporting and methodological quality of systematic reviews(SRs)/meta-analyses(MAs)of animal models to provide references for later studies and avoid the waste of medical *** and MEDLINE databases were searched from inception to November 2017,with no language *** reviewers selected inclusion dependently and extracted the basic *** Manager 5.3,stata 12.0,and SPSS 21 software were used to conduct analyses.A total of 46 SRs/MAs were *** results showed that the English databases with high retrieval frequency are PubMed/MEDLINE,EMBASE,and Web of Science.67.31%(31/46)of the articles reported the search strategy in the full text or the appendix.65.22%(30/46)reported the literature screening flow diagram,and only 19.57%(9/46)reported the number of works of literature retrieved in each database.60.87%(28/46)illustrated supplement *** 2 subgroup analyses,it was found that there were no significant differences in the quality of reports of PRISMA *** referring to the methodological quality or reporting of PRESS items,SCI was better than that of non-SCI,while there seemed a source of funding to have no significant impact on the methodological quality or the items of *** results of PRESS,AMSTAR 2,and PRISMA were correlated,and the correlation between PRISMA and AMSTAR 2 was *** results demonstrated that search strategies of animal model SRs/MAs are still not enough comprehensive,report specification and methodological quality still need to be *** show users the scientificity and rigor of the study,future research should focus on these various guidelines like PRESS,PRISMA,and AMSTAR 2 checklists that have been issued,it can help to increase the value of research and improve the utilization of medical resources.

关键词： Animal models AMSTAR 2 Meta-epidemiological Study PRESS PRISMA Systematic review/Meta-analysis

Bloodletting puncture in the treatment of acute ischemic stroke:protocol for a mixed-method study of a multi-center randomized controlled trial and focus group

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Journal of Traditional Chinese medicine 2023年第6期43卷 1259-1267页

作者： DAI Zeqi LIAO Xing GUAN Yueyue ZENG Zixiu TANG Jun HU Jing Center for evidence based Chinese medicine Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Encephalopathy Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China evidence-based medicine Center Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing Institute of Traditional Chinese MedicineBeijing 100010China

This study is to investigate the effectiveness and safety of bloodletting puncture(BP)for acute ischemic stroke(AIS)when used in combination with standard treatment,as well as the patients'feelings and attitudes toward the *** is a mixed method research which includes a multi-center,superiority,randomized controlled clinical trial,and focus group interview.A total of 360 AIS participants will be *** will be randomized into one of the following two groups for 7 d:(a)BP with standard treatment group(n=180);(b)standard treatment group(n=180).The primary outcome will be National Institute of Health stroke scale(NIHSS)score at day 7 after *** outcomes will be changes of Glasgow Coma Scale score,NIHSS score,mRS and Traditional Chinese medicine syndrome score from baseline to 7,14,and 30 d after treatment,recurrence rate and all-cause mortality rate within 30 d,and the safety *** focus group will be conducted with a purposive sample of 1-2 acupuncturists and 1-2 patients respectively at each center at 7 and 30 d after *** designed a mixed method study to evaluate the effect of BP,an acupuncture therapy for patients with *** the findings of this study confirm the effectiveness of BP to reduce the NIHSS score and other related outcomes and patients are willing to accept the therapy,we believe this study will help the implementation of this therapy in clinical practice,and provide new evidence for the treatment of AIS.

关键词： bloodletting punctures ischemic stroke equivalence trial randomized controlled trial focus groups clinical protocols