Biotransformation Effect of Bombyx Mori L. May Play An Important Role in Treating Diabetic Nephropathy

作     者：张蕾 张腊 李茵 郭新峰 刘旭生 

作者机构：Department of Nephrology Guangdong Provincial Hospital of Chinese Medicine Guangzhou University of Chinese Medicine Evidence-Based Medicine and Clinical Research Service TeamGuangdong Provincial Hospital of Chinese Medicine 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2016年第22卷第11期

页      面：872-879页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 10[医学] 

基　　金：Supported by the Industry Special Scientific Research Project of the State Chinese Medicine Administration Bureau(No.201007005 and No.201407005) 

主　　题：diabetic nephropathy Bombyx Mori L 1-deoxynojirimycin quercetin biotransformation Chinese medicine 

摘      要：Compared with herbal drugs, medicine processed from animals(animal medicine) was thought to have more bioactive substances and higher activities. Biotransformation effect often plays an important role in their effect. However, researches about effect of animal medicine on diabetic nephropathy and applying animal medicine as natural bio-transformer were seldom reported. The purpose of this paper was to reveal the use of Bombyx Mori L. on diabetic nephropathy from ancient to modern times. The classical literature indicated that Saosi Decoction(缫丝汤), which contains Bombyx Mori L. or silkworm cocoon, was applied to treat disorders congruent with modern disease diabetic nephropathy from the Ming to Qing Dynasty in ancient China. Modern studies showed that Bombyx Mori L. contains four main active constituents. Among these, 1-deoxynojirimycin(1-DNJ) and quercetin showed promising potential to be new agents in diabetic nephropathy treatment. The concentrations of 1-DNJ and the activities of quercetin in Bombyx Mori L. are higher than in mulberry leaves, because of the biotransformation in the Bombyx Mori L. body. However, these specific components need further human and mechanistic studies to determine their therapeutic potential for this challenging condition.